Results 91 to 100 of about 41,900,780 (178)

Transcriptome-Wide Association Supplements Genome-Wide Association in Zea mays [PDF]

, 2019
Modern improvement of complex traits in agricultural species relies on successful associations of heritable molecular variation with observable phenotypes. Historically, this pursuit has primarily been based on easily measurable genetic markers.
Gore, Michael A, Buckler, Edward S, Bandillo, Nonoy B, Kremling, Karl AG, Diepenbrock, Christine H   +4 more
core   +1 more source

Genome-Wide Association Study Identifies Candidate Genes for Body Size Traits in Wanyue Black Pigs

Animals
This study aimed to elucidate the genetic basis of body-size-related traits in Wanyue Black pigs, including body length, chest circumference, forearm circumference, and hip circumference. Phenotypic data were collected from 139 four-month-old female pigs,
Haibo Ye, Wei Li, Fang Tian, Qianqian Wang, Zhonghua Ma, Jinyu Guan, Yueyun Ding, Xianrui Zheng, Zongjun Yin, Xiaodong Zhang   +9 more
doaj   +1 more source

Transcriptome-wide association study identifies candidate genomic regions for lactation persistency in Murrah buffaloes

Indian Journal of Animal Sciences
Lactation persistency is an important economic trait of dairy animals. Understanding the genetic architecture underlying lactation persistency remains a challenge, as conventional genome-wide association studies (GWAS) often lack functional ...
PANKAJ CHAYAL, VIKAS VOHRA, SUPRIYA CHHOTARAY, AKSHATA PATIL, HEMLATA VALMIKI, DAMINI SHARMA   +5 more
doaj   +1 more source

Brain transcriptome wide association study (TWAS) implicates 8 genes across 6 loci in Alzheimer’s disease [PDF]

, 2020
Jake Gockley, Kelsey S. Montgomery, William L. Poehlman, Yue Liu, Ekaterina Sergeevna Gerasimov, Anna K. Greenwood, Aliza P. Wingo, Thomas S. Wingo, Lara M. Mangravite, Benjamin A. Logsdon   +9 more
openalex   +1 more source

UTMOST, A Novel Single And Cross-Tissue TWAS (Transcriptome Wide Association Study), Reveals New ASD (Autism Spectrum Disorder) Associated Genes [PDF]

, 2020
Cristina Rodriguez‐Fontenla, Angel Carracedo   +1 more
openalex   +1 more source

Transcriptome-wide association studies associated with Crohn’s disease: challenges and perspectives

Cell & Bioscience
Crohn’s disease (CD) is regarded as a lifelong progressive disease affecting all segments of the intestinal tract and multiple organs. Based on genome-wide association studies (GWAS) and gene expression data, transcriptome-wide association studies (TWAS)
Keyu Jia, Jun Shen
doaj   +1 more source

Endothelial Vasoactive Pathways and Renal Outcomes: A Drug-Target Mendelian Randomization and Transcriptome-Wide Association Study

Kidney Diseases
Introduction: Endothelium-mediated regulation of vascular tone plays a crucial role in modulating vascular functions, especially in the kidney, a highly vascularized organ.
Yixin Ma, Lubin Xu, Yitao Lin, Jiahao Zhu, Jin Liu, Li Wang, Limeng Chen   +6 more
doaj   +1 more source

Brain and Blood Transcriptome-Wide Association Studies Identify Five Novel Genes Associated with Alzheimer's Disease

Transcriptome-wide Association Studies (TWAS) extend genome-wide association studies (GWAS) by integrating genetically-regulated gene expression models. We performed the most powerful AD-TWAS to date, using summary statistics from -eQTL meta-analyses and
Bush, William S, Naj, Adam C, Alzheimer’s Disease Genetics Consortium, Below, Jennifer E, Griswold, Anthony J, Mews, Makaela A   +5 more
core   +2 more sources

FarmGTEx TWAS-server: An Interactive Web Server for Customized TWAS Analysis [PDF]

Transcriptome-wide association study (TWAS) is a powerful approach for investigating the molecular mechanisms linking genetic loci to complex phenotypes.
Zhang, Zhenyang, Gao, Yahui, Pan, Yuchun, Fang, Lingzhao, Liu, Shuli, Zhang, Zhe, Teng, Jinyan, Li, Bingjie; id_orcid, Lin, Qing, Wu, Jun, Chen, Zitao, Bai, Zhonghao, Liu, George, Wang, Qishan   +13 more
core   +1 more source

Transcriptome-wide association study reveals candidate causal genes for lung cancer.

, 2020
We have recently completed the largest GWAS on lung cancer including 29,266 cases and 56,450 controls of European descent. The goal of our study has been to integrate the complete GWAS results with a large-scale expression quantitative trait loci (eQTL ...
Zienolddiny, Shan, Gabriel, Aurélie, Bossé, Yohan, Hung, Rayjean J, Chen, Chu, Johansson, Mikael, Brunnstrom, Hans, Houlston, Richard, Bojesen, Stig E, Christiani, David C, Amos, Christopher I, McKay, James D, Rennert, Gadi, Lam, Stephen, Field, John K, Lazarus, Philip, Shete, Sanjay, Albanes, Demetrius, Joubert, Philippe, Li, Zhonglin, Caporaso, Neil, Obeidat, Ma\u27en, Risch, Angela, Andrew, Angeline, Woll, Penella, Melander, Olle, Timens, Wim, Stevens, Victoria L, Gaudreault, Nathalie, Carreras-Torres, Robert, Manem, Venkata, Arnold, Susanne, Xia, Jun, Johansson, Mattias, Le Marchand, Loic, Schabath, Matthew B, Bickeböller, Heike, Brennan, Paul, Goodman, Gary E, Liu, Geoffrey, Landi, Maria T, Aldrich, Melinda C, Song, Zhuoyi, Tardon, Adonina, Wichmann, H-Erich, Grankvist, Kjell, Kiemeney, Lambertus A, Rosenberg, Susan M   +47 more
core