Results 91 to 100 of about 4,523 (159)

Unraveling the genetic landscape of susceptibility to multiple primary cancers. [PDF]

With advances in cancer screening and treatment, there is a growing population of cancer survivors who may develop subsequent primary cancers. While hereditary cancer syndromes account for only a portion of multiple cancer cases, we sought to explore the
Alexeeff, Stacey, Cavazos, Taylor, Corley, Douglas, Graff, Rebecca, Habel, Laurel, Hoffmann, Thomas, Kachuri, Linda, Kushi, Lawrence, Middha, Pooja, Nierenberg, Jovia, Sakoda, Lori, Van Den Eeden, Stephen, Witte, John, Zhang, Jie, Ziv, Elad   +14 more
core   +1 more source

TWAS facilitates gene-scale trait genetic dissection through gene expression, structural variations, and alternative splicing in soybean [PDF]

A genome-wide association study (GWAS) identifies trait-associated loci, but identifying the causal genes can be a bottleneck, due in part to slow decay of linkage disequilibrium (LD). A transcriptome-wide association study (TWAS) addresses this issue by
Gao, Huawei, Hong, Huilong, Li, Delin, Li, Yan-Fei, Li, Ying-Hui, Liu, Bin, Lyv, Xiangguang, Qiu, Li-Juan, Schnable, James C., Schnable, Patrick S., Tian, Yu, Wang, Jiajun, Wang, Qi, Wang, Ruizhen, Yang, Jinliang, Zhang, Hao, Zhao, Chaosen   +16 more
core   +1 more source

Transcriptome-wide association studies associated with Crohn’s disease: challenges and perspectives

Cell & Bioscience
Crohn’s disease (CD) is regarded as a lifelong progressive disease affecting all segments of the intestinal tract and multiple organs. Based on genome-wide association studies (GWAS) and gene expression data, transcriptome-wide association studies (TWAS)
Keyu Jia, Jun Shen
doaj   +1 more source

Transcriptome‐wide association study identifies multiple genes and pathways associated with pancreatic cancer

Cancer Medicine, 2018
Aim To identify novel candidate genes for pancreatic cancer. Methods We performed a transcriptome‐wide association study (TWAS) analysis of pancreatic cancer (PC).
Liuyun Gong, Dan Zhang, Yutiantian Lei, Yuanjie Qian, Xinyue Tan, Suxia Han   +5 more
doaj   +1 more source

Unraveling NEK4 as a Potential Drug Target in Schizophrenia and Bipolar I Disorder: A Proteomic and Genomic Approach [PDF]

Background and Hypothesis: Investigating the shared brain protein and genetic components of schizophrenia (SCZ) and bipolar I disorder (BD-I) presents a unique opportunity to understand the underlying pathophysiological processes and pinpoint potential ...
Deng, Wei, Guo, Wanjun, Hu, Xun, Li, Ming, Li, Tao, Li, Xiaojing, Sham, Pak Chung, Wang, Qiang, Xiao, Xiao, Yang, Zhi Hui, Zhang, Chengcheng, Zhao, Liansheng   +11 more
core   +1 more source

Multi-tissue expression and splicing data prioritise anatomical subsite- and sex-specific colorectal cancer susceptibility genes

Nature Communications
Genome-wide association studies have suggested numerous colorectal cancer (CRC) susceptibility genes, but their causality and therapeutic potential remain unclear.
Emma Hazelwood, Daffodil M. Canson, Benedita Deslandes, Xuemin Wang, Pik Fang Kho, Danny Legge, Andrei-Emil Constantinescu, Matthew A. Lee, D. Timothy Bishop, Andrew T. Chan, Stephen B. Gruber, Jochen Hampe, Loic Le Marchand, Michael O. Woods, Rish K. Pai, Stephanie L. Schmit, Jane C. Figueiredo, Wei Zheng, Jeroen R. Huyghe, Neil Murphy, Marc J. Gunter, Tom G. Richardson, Vicki L. J. Whitehall, Emma E. Vincent, Dylan M. Glubb, Tracy A. O’Mara   +25 more
doaj   +1 more source

Transcriptome-Wide Association Study of Metabolic Dysfunction-Associated Steatotic Liver Disease Identifies Relevant Gene Signatures

The Turkish Journal of Gastroenterology
Background/Aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) is considered the most widespread chronic liver condition globally. Genome-wide association studies (GWAS) have pinpointed several genetic loci correlated to MASLD, yet the
Jianxiu Wang, Qian Gao
doaj   +1 more source

Identification of novel proteins associated with intelligence by integrating genome-wide association data and human brain proteomics.

PLoS ONE
While genome-wide association studies (GWAS) have identified genetic variants associated with intelligence, their biological mechanisms remain largely unexplored.
Zheng Zhang, Yousong Zhu, Junlong Zhang, Wenbin He, Cheng Han   +4 more
doaj   +1 more source

Transcriptome-wide association study identifies genes associated with bladder cancer risk

Scientific Reports
Genome-wide association studies (GWAS) have detected several susceptibility variants for urinary bladder cancer, but how gene regulation affects disease development remains unclear.
Siting Li, Jiang Gui, Margaret R. Karagas, Michael N. Passarelli   +3 more
doaj   +1 more source

Trans-Ancestry Analysis of Psychosis Biotypes: Shared Polygenic Risk and Unique Genomic Associations [PDF]

The Bipolar-Schizophrenia Network for Intermediate Phenotypes (B-SNIP) has categorized psychosis disorders (Schizophrenia, Schizoaffective Disorder and Bipolar Disorder) into three distinct Biotypes, based on neurobiological measurements in a multi ...
Alliey-Rodriguez, Ney, Bishop, Jeffrey R., Gershon, Elliot S., Hill, Scot, Keedy, Sarah K., Keshavan, Matcheri S., Lencer, Rebekka, Parker, David, Pearlson, Godfrey D., Tamminga, Carol A   +9 more
core   +1 more source