Results 101 to 110 of about 41,900,780 (178)

Transcriptome-wide association studies: opportunities and challenges

, 2017
Transcriptome-wide association studies (TWAS) integrate GWAS and gene expression datasets to find gene-trait associations. In this Perspective, we explore properties of TWAS as a potential approach to prioritize causal genes, using simulations and case ...
Arno Ruusalepp, Alvaro N. Barbeira, David Golan, Nasa Sinnott-Armstrong, Thomas Quertermous, Ke Hao, Anshul Kundaje, Hae Kyung Im, Manuel A Rivas, Raili Ermel, Bogdan Pasaniuc, Johan LM Björkegren, Nicholas Mancuso, Michael Wainberg, David A Knowles   +14 more
core   +1 more source

Transcriptome-Wide Association Study of Metabolic Dysfunction-Associated Steatotic Liver Disease Identifies Relevant Gene Signatures

The Turkish Journal of Gastroenterology
Background/Aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) is considered the most widespread chronic liver condition globally. Genome-wide association studies (GWAS) have pinpointed several genetic loci correlated to MASLD, yet the
Jianxiu Wang, Qian Gao
doaj   +1 more source

Multi-tissue expression and splicing data prioritise anatomical subsite- and sex-specific colorectal cancer susceptibility genes

Nature Communications
Genome-wide association studies have suggested numerous colorectal cancer (CRC) susceptibility genes, but their causality and therapeutic potential remain unclear.
Emma Hazelwood, Daffodil M. Canson, Benedita Deslandes, Xuemin Wang, Pik Fang Kho, Danny Legge, Andrei-Emil Constantinescu, Matthew A. Lee, D. Timothy Bishop, Andrew T. Chan, Stephen B. Gruber, Jochen Hampe, Loic Le Marchand, Michael O. Woods, Rish K. Pai, Stephanie L. Schmit, Jane C. Figueiredo, Wei Zheng, Jeroen R. Huyghe, Neil Murphy, Marc J. Gunter, Tom G. Richardson, Vicki L. J. Whitehall, Emma E. Vincent, Dylan M. Glubb, Tracy A. O’Mara   +25 more
doaj   +1 more source

TWAS-CTL: A robust and efficient method for multi-tissue transcriptome-wide association studies using cross-tissue learners [PDF]

Md Mutasim Billah, Hairong Wei, Fengzhu Sun, Kui Zhang   +3 more
openalex   +1 more source

Integrative analysis of Transcriptome-wide and Proteome-wide association study for non-Mendelian disorders

Genome-wide association studies (GWAS) have uncovered numerous variants linked to a wide range of complex traits. However, understanding the mechanisms underlying these associations remains a challenge.
Sudhanshu Shekhar (18430305)
core   +1 more source

Identification of novel proteins associated with intelligence by integrating genome-wide association data and human brain proteomics.

PLoS ONE
While genome-wide association studies (GWAS) have identified genetic variants associated with intelligence, their biological mechanisms remain largely unexplored.
Zheng Zhang, Yousong Zhu, Junlong Zhang, Wenbin He, Cheng Han   +4 more
doaj   +1 more source

Power Analysis of Transcriptome-Wide Association Studies (TWAS)

, 2020
Bowei Ding
openalex   +2 more sources

Transcriptome-wide association study identifies genes associated with bladder cancer risk

Scientific Reports
Genome-wide association studies (GWAS) have detected several susceptibility variants for urinary bladder cancer, but how gene regulation affects disease development remains unclear.
Siting Li, Jiang Gui, Margaret R. Karagas, Michael N. Passarelli   +3 more
doaj   +1 more source

Identifying microRNA Biomarkers in Prostate Cancer: A Transcriptome-Wide Association Studies (TWAS) [PDF]

, 2020
Dulari K. Jayarathna, Miguel E. Rentería, Jyotsna Batra, Emilie Sauret, Samaneh Farashi, Neha S. Gandhi   +5 more
openalex  

Transcriptome-wide association study reveals candidate causal genes for lung cancer.

, 2019
We have recently completed the largest GWAS on lung cancer including 29,266 cases and 56,450 controls of European descent. The goal of our study has been to integrate the complete GWAS results with a large-scale expression quantitative trait loci (eQTL ...
Zienolddiny, Shan, Gabriel, Aurélie, Bossé, Yohan, Hung, Rayjean J, Chen, Chu, Johansson, Mikael, Brunnstrom, Hans, Houlston, Richard, Bojesen, Stig E, Christiani, David C, Amos, Christopher I, McKay, James D, Rennert, Gadi, Lam, Stephen, Field, John K, Lazarus, Philip, Shete, Sanjay, Albanes, Demetrius, Joubert, Philippe, Li, Zhonglin, Caporaso, Neil, Obeidat, Ma\u27en, Risch, Angela, Andrew, Angeline, Woll, Penella, Melander, Olle, Timens, Wim, Stevens, Victoria L, Gaudreault, Nathalie, Carreras-Torres, Robert, Manem, Venkata, Arnold, Susanne, Xia, Jun, Johansson, Mattias, Le Marchand, Loic, Schabath, Matthew B, Bickeböller, Heike, Brennan, Paul, Goodman, Gary E, Liu, Geoffrey, Landi, Maria T, Aldrich, Melinda C, Song, Zhuoyi, Tardon, Adonina, Wichmann, H-Erich, Grankvist, Kjell, Kiemeney, Lambertus A, Rosenberg, Susan M   +47 more
core