Results 131 to 140 of about 43,083,361 (310)
Unlocking the potential of cell‐permeable nanobodies for intracellular applications
FEBS Letters, EarlyView.This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger +2 morewiley +1 more sourceLarge-Scale Genome-Wide Association Studies and Meta-Analyses of Longitudinal Change in Adult Lung Function [PDF]
, 2014 Background: Genome-wide association studies (GWAS) have identified numerous loci influencing cross-sectional lung function, but less is known about genes influencing longitudinal change in lung function.Wenbo Tang (110161), Joyanna G. Hansen (591398), Heinrich, J (Joachim), Thomas Lumley (57337), London, S.J. (Stephanie), Alan James (528475), Sood, A, R Graham Barr, Matthew Kowgier (120923), Brusselle, Guy G., Loth, Daan W, Akshay Sood (71826), O'Connor, George T, Susan R. Heckbert, Liu, YM, Rivadeneira Ramirez, F. (Fernando), Hodge, E., Harris, Tamara B, Michael Allerhand, Loth Daan W., Morrison, A.C. (Alanna), Fornage, Myriam, Morris Andrew P., Ingo Ruczinski, Stephanie J. London (62450), Josée Dupuis (28859), James, Alan, Völzke Henry, Ruczinski, I., London Stephanie J., Voorman, A, Patricia A. Cassano (110298), Joachim Heinrich (60421), Guy G Brusselle, Gu, Xiangjun, Mathias, Rasika A, John M Starr, Smith, AV, Couper, DJ, Lenore J. Launer (110269), Arend Voorman, Myriam Fornage (45591), Sina A. Gharib, Smith, Lewis J, Gao, W, Wei Gao, Liu, Y, Morrison Alanna C., Kari E. North, Musk, B, Heinrich, J. (Joachim), Musk Bill, Uitterlinden, André G, Hansel, C.R.W. (Christian), Dupuis, Jos�e, John M. Starr, Heinrich, Joachim, Foy, Millennia, Lind, Lars, Cassano, P.A. (Patricia), Probst-Hensch, Nicole M, Palmer, Lyle J., O Dale Williams, Joyanna G. Hansen, Allerhand, Michael, Martin D. Tobin, Deary, Ian J, Hall, I.P. (Ian), Uitterlinden, AG, Heckbert, Susan R, David P Strachan, Tamara B Harris, Harris, T.B. (Tamara), Smith, Albert V, Launer, Lenore J, Stricker, Bruno H, Starr John M., Heckbert, Susan R., Holger Schulz (13022), Tamara B. Harris, James, A. (Alan), Tobin, M.D. (Martin), Michael Allerhand (591399), Martin T. Wells, Kari E. North (68131), Aldrich, Melinda C., Couper, David J., North, Kari E, Louise V Wain, Starr, John M., Rivadeneira, F, Jerome I. Rotter, Barnes, Kathleen C, O'Connor, G.T. (George), Smith, Lewis J., Kowgier, M., Karrasch Stefan, Strachan, David P., Henry Völzke (64286), Williams O. Dale, Ingelsson, Erik, Hodge Emily, Soler Artigas, Mar�a, Bernd Meibohm (110267), Gu Xiangjun, Ingelsson Erik, Cecilia Lindgren (258113), Daan W Loth, Hofman Albert, Gl�ser, Sven, Starr, J.M. (John), Deary, I.J. (Ian), Ashish Kumar, et al., Kurt Lohman, Bonnie R. Joubert, Alanna C Morrison, Melinda C. Aldrich (110234), Meibohm, B, Ruczinski Ingo, Imboden, Medea, Gharib, Sina A, Wilk, Jemma B., Hansen, JG, Fall, Tove,, Franceschini, N. (Nora), Lahousse Lies, Kowgier Matthew, Foy Millennia, Hansel, Nadia N., Kurt Lohman (110218), O. Dale Williams (110242), Völzke, H. (Henry), Alanna C. Morrison (110248), Lenore J Launer, Gao Wei, Franceschini, N, Hansen, J., Hancock, D.B. (Dana), Probst-Hensch, NM, Morris, AP, Launer, Lenore J., R. Graham Barr, Couper David J., Gläser, S. (Sven), Li, G. (Guo), O. Connor, George T., Allerhand, M., Fernando Rivadeneira, Joubert, B.R. (Bonnie), Sina A. Gharib (63265), Eva Albrecht (174584), Heckbert Susan R., Imboden, M. (Medea), Dupuis, Josée, Gudnason, V. (Vilmundur), Gharib, S.A. (Sina), Williams, O.D. (Dale), Mathias, Rasika A., Morris, Andrew P, Tamara B. Harris (110195), Voorman Arend, Musk, Bill, Bonnie R. Joubert (110252), Probst-Hensch, Nicole M., Rotter, Jerome I, Gharib, S., Matthew Kowgier, Dana B. Hancock (110121), R. Graham Barr (109958), Lewis J. Smith, Franceschini, Nora, Hansen Joyanna G., Kathleen C. Barnes, Ruczinski, I. (Ingo), Soler Artigas, M., Loth, Daan W., Josée Dupuis, Alan James, Wei Gao (2085), Medea Imboden, Gharib Sina A., Gao, Wei, Lohman, K, Ruczinski, I, Wain, Louise V., Allerhand, M.M. (Michael), Lewis J Smith, Alan James, Rasika A. Mathias, Lohman Kurt, Wells, Martin T., Uitterlinden, A.G. (André), Andrew P Morris, Sood, A. (Akshay), George T O'Connor, McArdle, Wendy L., Barr, R. Graham, Dupuis, J, Palmer, Lyle J, Koch, B, Fall, M. (Magnus), Ian J Deary, Tobin, Martin D, Jemma B Wilk, Meibohm Bernd, Völzke, H, Davies, Gail, Artigas, Maria Soler, Lahousse, Lies, Morris, A.P. (Andrew), Melinda C Aldrich, Gudnason, V, Kumar, Ashish, Eva Albrecht, Rasika A Mathias, Gharib, SA, Wain, L.V. (Louise), Musk, A.W. (Arthur), Palmer, LJ, Franceschini Nora, Albert V Smith, Aldrich Melinda C., Uitterlinden, André G., Martin D Tobin, Guy G. Brusselle (110236), Smith Lewis J., Fall, T, Kowgier, M, Bruce M Psaty, Probst-Hensch Nicole M., Palmer, C. (Cameron), Smith, Albert V., Teumer, A, Soler Artigas, M. (Maria), Hodge, Emily, Nicole M Probst-Hensch, Morris, Andrew P., Gu, X, Louise V. Wain, Rotter Jerome I., Brusselle, G.G. (Guy), McArdle, W.L. (Wendy), Hall, IP, Meibohm, Bernd, Alanna C. Morrison, Psaty, B.M. (Bruce), Harris, TB, Kathleen C. Barnes (134420), Xiangjun Gu, Akshay Sood, Lind Lars, Lind, L, Harris, T., Daan W. Loth (110140), Curjuric, I. (Ivan), Mathias, J. (Jasmine), Starr, JM, Fall Tove, Li, Guo, Lumley, Thomas, Sven Gläser, Jemma B. Wilk, André G. Uitterlinden (2213413), Ian J. Deary, Lars Lind (88400), Barr, R., Smith, A.V. (Davey), Foy, M. (Millennia), Hofman, Albert, Deary, Ian J., Jerome I. Rotter (103729), Hansel, Nadia N, Yongmei Liu, Myriam Fornage, Cassano, Patricia A, James Alan, Teumer Alexander, Schulz Holger, André G. Uitterlinden, Xiangjun Gu (73651), Davies Gail, Tang, W, Brusselle, GG, Soler Artigas María, Bruno H. Stricker, Tang, Wenbo, Voelzke, Henry, Stricker, Bruno H., Ingelsson, E, Strachan, D.P. (David), Smith, A., Stephen B Kritchevsky, Dana B Hancock, Vilmundur Gudnason (8873), Strachan, DP, Lumley Thomas, Patricia A Cassano, Susan R. Heckbert (110293), Martin D. Tobin (110311), Andrew P. Morris, Imboden Medea, North, KE, Dupuis, J. (Josée), David J Couper, Bruno H. Stricker (336134), Rotter, JI, Davies, G. (Gail), Tove Fall, John M. Starr (107707), Lind, Lars,, Psaty, Bruce M., Wells, MT, Dupuis Josée, Lohman, Kurt, Hodge, E, Lars Lind, Gail Davies, Hancock Dana B., Gudnason, V., Hansen, Joyanna G, Henry Völzke, Bruce M. Psaty, Morrison, Alanna C, Tobin, MD, Wain, LV, Mathias, RA, Stricker, Bruno, Barr, RG, Wells, M.T. (Martin), Lies Lahousse, Alexander Teumer (112757), Lies Lahousse (548910), Strachan David P., Bill Musk, Palmer Lyle J., Schulz, H. (Holger), Strachan, David P, Schulz, H, Brusselle, Guy, Mathias, R., Stephen B. Kritchevsky, George T. O′Connor (591401), O′Connor, George T., Ian J. Deary (107724), Wendy L. McArdle (110155), Bill Musk (591400), Bernd Meibohm, Karrasch, S, Tove Fall (201258), Fornage Myriam, Hansen, J.G. (Joyanna), Teumer, A. (Alexander), Barr, R Graham, Voorman, J.M. (Jeanine), Ruczinski, Ingo, Hofman, Bert, Arend Voorman (221264), Lindgren, Cecilia, Stephen B. Kritchevsky (110259), Liu, Y. (YongMei), Bonnie R Joubert, Ingo Ruczinski (15765), David J. Couper (110257), Hansel, NN, Davies, G, V�lzke, Henry, Erik Ingelsson, Rasika A. Mathias (134405), Rotter, J.I. (Jerome), Psaty, Bruce M, Sven Gläser (110276), Koch Beate, Albrecht Eva, Aldrich, MC, Hancock, DB, Albrecht, E. (Eva), Heckbert, SR, Mathias Rasika A., North, Kari E., Wilk Jemma B., Probst-Hensch, N.M. (Nicole M.), Lumley, T, Aldrich, M., Kowgier, Matthew, Stefan Karrasch (412837), Ashish Kumar (152984), Rivadeneira Fernando, Wenbo Tang, Beate Koch (110151), Hansel, N., Fall, Tove, Albert V. Smith, Koch, B. (Beate), Tobin Martin D., Williams, O. Dale, Hancock, Dana B., Heckbert, S.R. (Susan), Ian P. Hall (110307), Karrasch, S. (Stefan), David P. Strachan, Kumar, A, Kritchevsky, SB, Nora Franceschini, Jemma B. Wilk (110164), Curjuric, Ivan, Emily Hodge (460149), Brusselle Guy G., Dana B. Hancock, North, K.E. (Kari), Vilmundur Gudnason, Andrew P. Morris (145709), Emily Hodge, Artigas, MS, Rivadeneira, Fernando, Aldrich, M.C. (Melinda), Bruno H Stricker, Loth, D.W. (Daan), Guy G. Brusselle, Stricker, B.H.Ch. (Bruno), Albert V. Smith (103644), Morrison, Alanna C., Stephanie J. London, Lewis J. Smith (156533), Stefan Karrasch, Loth, DW, Wilk, J.B. (Jemma), London, SJ, Curjuric Ivan, Launer Lenore J., Deary, IJ, Karrasch, Stefan, Lindgren Cecilia, Kathleen C Barnes, Völzke, Henry, Lyle J Palmer, Lindgren, C, Barnes, KC, Lenore J. Launer, Li, G, O'Connor, GT, Schulz, Holger, Lindgren, C.M. (Cecilia), Heinrich, J, Tang, W. (Wenbo), Barnes, K., Joubert, B., Bruce M. Psaty (103721), Loth, D., Uitterlinden, Andr� G., Nadia N Hansel, Gu, XJ, Millennia Foy (211777), Ivan Curjuric (110179), Nadia N. Hansel (359186), Hansen, Joyanna G., Susan R Heckbert, Sina A Gharib, Gläser, Sven, Cecilia Lindgren, McArdle Wendy L., Medea Imboden (110145), Thomas Lumley, Teumer, Alexander, Martin T. Wells (122541), Harris, Tamara B., London, Stephanie J, Albrecht, E., Joubert, BR, O?Connor, George T., Allerhand, M, Jerome I Rotter, David J. Couper, Wendy L. McArdle, Launer, LJ (Lenore), Gudnason, Vilmundur, Tang Wenbo, Martin T Wells, Smith, L.J. (Lewis), Lohman, K. (Kurt), Uitterlinden, André; id_orcid, Smith Albert V., Loth, Daan, Hall, Ian P, Barr R. Graham, Liu, Yongmei, Guo Li (174860), Nicole M. Probst-Hensch (110284), Wilk, JB, Kritchevsky Stephen B., Chen, Lin, Gail Davies (107670), Ivan Curjuric, Gudnason Vilmundur, Curjuric, I, Allerhand Michael, Sood Akshay, Lahousse, L, Lahousse, L. (Lies), Nicole M. Probst-Hensch, Soler Artigas, María, Williams, O Dale, Launer, L., Kumar Ashish, Guo Li, Gläser, S, Heinrich Joachim, Morrison, AC, Hofman, A. (Albert), Fornage, M. (Myriam), Albert Hofman, Hall Ian P., London, Stephanie J., Fornage, M, Harris Tamara B., Uitterlinden André G., Stricker Bruno H., Gharib, Sina A., André G Uitterlinden, North Kari E., Daan W. Loth, O Connor, George T, María Soler Artigas (110124), Hansel Nadia N., Gläser Sven, O'Connor, George T., Joyanna G Hansen, Wells Martin T., Smith, LJ, Lyle J. Palmer (95287), Gao, W. (Wei), McArdle, Wendy L, Foy, M, Ingelsson, E. (Erik), Deary Ian J., Kritchevsky, Stephen B, Lyle J. Palmer, Glaeser, Sven, Aldrich, Melinda C, Brusselle, Guy G, Liu Yongmei, Joubert, Bonnie R., Imboden, M, Barnes, Kathleen C., Ian P Hall, Alexander Teumer, Sood, Akshay, McArdle, WL, Couper, D.J. (David), Soler Artigas, M, Wain Louise V., Kari E North, Couper, David J, Starr, John M, Psaty, BM, Wenbo Tang, Albrecht, E, Louise V. Wain (110260), Hancock, Dana B, Li Guo, Koch, Beate, David P. Strachan (110302), Cassano, PA, Barnes Kathleen C., Joubert, Bonnie R, Stephanie J London, Ian P. Hall, Gu, X. (Xiangjun), Tang, W., Kritchevsky, Stephen B., Lind, L. (Lars), O. Dale Williams, Hofman, A, Lumley, T. (Thomas), Melinda C. Aldrich, Launer, L.J. (Lenore), James, A, Cassano Patricia A., Holger Schulz, Albert Hofman (107303), Voorman, Arend, O′Connor George T., Stricker, BH, Beate Koch, Launer, LJ, George T. O′Connor, Psaty Bruce M., Cassano, Patricia A., Wells, Martin T, Joachim Heinrich, Tang, WB, Ingelsson, Erik,, Barnes, K.C. (Kathleen), Albrecht, Eva, Hodge, E. (Emily), Hall, Ian P., Nora Franceschini (91434), Tobin, Martin D., Barr, R.G. (Graham), Wain, Louise V, Rotter, Jerome I., Kritchevsky, S.B. (Stephen), Joubert Bonnie R., Nadia N. Hansel, Wendy L McArdle, Millennia Foy, Williams, OD, Erik Ingelsson (232651), Kowgier, M. (Matthew), Patricia A. Cassano, Wilk, Jemma B, Meibohm, B. (Bernd), María Soler Artigas, Yongmei Liu (104713), Fernando Rivadeneira (61551), Kumar, A. (Ashish), Tang, Wenbo;Kowgier, Matthew;Loth, Daan W;Soler Artigas, Maria;Joubert, Bonnie R;Hodge, Emily;Gharib, Sina A;Smith, Albert V;Ruczinski, Ingo;Gudnason, Vilmundur;Mathias, Rasika A;Harris, Tamara B;Hansel, Nadia N;Launer, Lenore J;Barnes, Kathleen C;Hansen, Joyanna G;Albrecht, Eva;Aldrich, Melinda C;Allerhand, Michael;Barr, R Graham;Brusselle, Guy G;Couper, David J;Curjuric, Ivan;Davies, Gail;Deary, Ian J;Dupuis, Josée;Fall, Tove;Foy, Millennia;Franceschini, Nora;Gao, Wei;Gläser, Sven;Gu, Xiangjun;Hancock, Dana B;Heinrich, Joachim;Hofman, Albert;Imboden, Medea;Ingelsson, Erik;James, Alan;Karrasch, Stefan;Koch, Beate;Kritchevsky, Stephen B;Kumar, Ashish;Lahousse, Lies;Li, Guo;Lind, Lars;Lindgren, Cecilia;Liu, Yongmei;Lohman, Kurt;Lumley, Thomas;McArdle, Wendy L;Meibohm, Bernd;Morris, Andrew P;Morrison, Alanna C;Musk, Bill;North, Kari E;Palmer, Lyle J;Probst-Hensch, Nicole M;Psaty, Bruce M;Rivadeneira, Fernando;Rotter, Jerome I;Schulz, Holger;Smith, Lewis J;Sood, Akshay;Starr, John M;Strachan, David P;Teumer, Ale, Uitterlinden AG, Wain LV, Karrasch S, Schulz H, McArdle WL, Musk B, Wilk JB, Barr RG, Smith AV, Rivadeneira F, Brusselle GG, Dupuis J, Koch B, Franceschini N, Wells MT, Lahousse L, Lumley T, Liu Y, Foy M, Lind L, Ruczinski I, Launer LJ, Hodge E, Aldrich MC, Joubert BR, Kritchevsky SB, Harris TB, Albrecht E, Lohman K, Hofman A, Heckbert SR, Hansel NN, Williams OD, Loth DW, Gao W, Kowgier M, Ingelsson E, Gu X, Heinrich J, Fall T, Barnes KC, North KE, Psaty BM, James A, Soler Artigas M, Hall IP, Hansen JG, Rotter JI, O'Connor GT, Li G, Imboden M, Lahousse, Lies; id_orcid, Fornage M, Sood A, Meibohm B, Morris AP, Völzke H, Allerhand M, Lindgren C, Gudnason V, Morrison AC, Deary IJ, Smith LJ, Stricker BH, Palmer LJ, Gharib SA, Davies G, Tobin MD, Cassano PA, Probst-Hensch NM, Hancock DB, Tang W, Gläser S, Mathias RA, Starr JM, Teumer A, Curjuric I, Couper DJ, Voorman A, Strachan DP, London SJ, Kumar A +698 morecore +1 more sourceTIMP4 as a Potential Complementary Biomarker and Therapeutic Target in Membranous Nephropathy: A Multi-Omics Investigation with Clinical Validation
Journal of Inflammation ResearchQingsong Chen, Gang Wang, Ruo Zhao, Qiyuan Hu, Jiayun Li, Yuting Wang, Jingyang Ran, Qi Huang, Guiquan Yu, Yanjia Luo, Xiaohui Liao Department of Nephrology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of ...Chen Q, Wang G, Zhao R, Hu Q, Li J, Wang Y, Ran J, Huang Q, Yu G, Luo Y, Liao X +10 moredoaj Enhancer RNA Transcriptome‐Wide Association Study Reveals a Distinctive Class of Pan‐Cancer Susceptibility eRNAs
Advanced ScienceMany cancer risk variants are located within enhancer regions and lack sufficient molecular interpretation. Here, we constructed the first comprehensive atlas of enhancer RNA (eRNA)‐mediated genetic effects from 28 033 RNA sequencing samples across 11 ...Wenyan Chen, Zeyang Wang, Yinuo Wang, Jianxiang Lin, Shuxin Chen, Hui Chen, Xuelian Ma, Xudong Zou, Xing Li, Yangmei Qin, Kewei Xiong, Xixian Ma, Qi Liao, Yunbo Qiao, Lei Li +14 moredoaj +1 more sourceDevelopmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley +13 morewiley +1 more sourcePharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins [PDF]
, 2014 Statins effectively lower LDL cholesterol levels in large studies and the observed interindividual response variability may be partially explained by genetic variation.Herrington, D.M., Postmus, Iris, Trompet, S., Ridker, P.M., O'Donnell, C.J. (Christopher J.), Ballantyne, C. (Christie), Liu, YM, Kastelein, JJP, Rivadeneira Ramirez, F. (Fernando), Pearson, Richard, Arnold, A.M. (Alice), O???donnell, Christopher J., Palmer, Colin N.A., Boerwinkle, E., Wei, W.-Q. (Wei-Qi), Barnes, M.R., Viswanathan, Ananth C., Potter, S.C. (Simon), Arnold, A.M., Caulfield, M. (Mark), Groop, L, Viswanathan, A.C. (Ananth), McKeigue, Paul M., Eiriksdottir, Gudny, Pirinen, M. (Matti), Palmer, Colin N. A., Barratt, BJ, Edkins, Sarah, Waller, Matthew, Smith, AV, Whitsel, E.A. (Eric), de Keyser, Catherine E., Buckley, BM, Arsenault, B.J. (Benoit J.), Whitsel, E.A., Hammond, Naomi, Sever, P, Franco Duran, OH, Liu, Y, Corvin, A. (Aiden), Palmer, CN, Barratt, B.J., Liu, Ching-Ti, Kastelein, J.J.P. (John), Groop, L., de Keyser, Toke, Zhou, Kaixin, Ford, I, Trompet, S. (Stella), Su, Zhan, Boerwinkle, Eric, Chu, A.Y., Sotoodehnia, Nona, Franco, O.H., Band, G. (Gavin), Wiggins, Kerri L., Eiriksdottir, G, O'Donnell, CJ, Boerwinkle, E, Uitterlinden, AG, Potter, Simon C., Heckbert, Susan R, Feng, Q. (Qiping), Hofman, A., Bis, JC, Krauss, Ronald M., Nickerson, D.A. (Deborah), Harris, T.B. (Tamara), Evans, DS, Palmer, C.N.A. (Colin), Blackburn, H. (Hannah), Stanton, A. (Alice), Wood, N.W. (Nicholas), Tardif, J-C, Wiggins, K.L. (Kerri), Johnson, A.D. (Andrew), Giulianini, F., Jukema, JW, Kritchevsky, S.B., Munroe, PB, Pierre Dubé, Marie, Cupples, L.A. (Adrienne), Blackwell, K.L. (Kimberly), Griffin, P., Keyser, C.E. de, Pirinen, Matti, Morris, A., Sattar, N, Rivadeneira, F, Griffin, P. (Paula), Shields, Denis C., Herrington, DM, Hellenthal, Garrett, Plomin, R. (Robert), Stafford, J.M. (Jeanette M.), Bellenguez, C??line, Betteridge, J, Shields, D.C., Widaa, S. (Sara), Stürmer, Til, Hitman, G, Wiggins, K.L., Bumpstead, Suzannah J., Hovingh, G.K., Neil, A. (Andrew), Tardif, J.-C. (Jean-Claude), Lumley, T., O'Brien, E. (Eoin), Munroe, P. (Patricia), ?, ?, de Craen, AJM, Liu, C-T, Wiggins, KL, Ford, Ian, De Craen, AJ, O’Donnell, Christopher J., Stafford, Jeanette M., Sotoodehnia, N. (Nona), McCarthy, MI, Bramon, E. (Elvira), Slagboom, PE, Casas, J.P. (Juan), Neil, Andrew, MacFadyen, J.G. (Jean G.), Shields, D.C. (Denis C.), Taylor, KD, Doney, A., Wei, Wei-Qi, Adrienne Cupples, L, Wilke, RA, Taylor, K.D., Strange, A. (Amy), Spencer, Chris C.A., McCann, O.T. (Owen), Morris, Andrew, Welcome Trust Case Control Consort, Postmus, D. (Douwe), Emilsson, V., Freeman, Colin, Launer, L.J., Guo, Xiuqing, Spencer, Chris C. A., Avery, C.L., Cupples, L.A., Rice, Kenneth, Krauss, RM, Gray, Emma, Chasman, Daniel I., Sever, P. (Peter), Caulfield, M.J., Li, G. (Guo), O'Brien, Eoin, Franco, OH, Gudnason, V. (Vilmundur), other, and, Sotoodehnia, N, Nickerson, D.A., Jayakumar, A. (Alagurevathi), Boekholdt, S.M., Chu, AY, Uitterlinden, Andr?? G., Wilke, R.A. (Russell A.), Doney, Alex; id_orcid, Li, XH, Sun, FG, Colhoun, HM, MacFadyen, J.G., Chasman, Daniel, Avery, CL, Rice, K., Betteridge, John, Carr, F, Durrington, P.N. (Paul), Ngwa, JS, Buckley, B.M., Post, Wendy, Deshmukh, H.A., Herrington, D.M. (David), Liu, C.-T. (Ching-Ti), Giulianini, F. (Franco), Munroe, Patricia B., Hammond, N. (Naomi), Uitterlinden, A.G. (André), Ahlqvist, E. (Emma), Ridker, PM, Jukema, J.W., Widaa, Sara, Betteridge, J., Duncanson, A. (Audrey), Ding, JZ (Jing Zhong), Adrienne Cupples, L., Sever, Peter, Poulter, N, Zhou, K. (Kaixin), Ballantyne, C.M., Matthijs Boekholdt, S., Carr, F., Liu, CT, Stott, D.J. (David. J.), Slagboom, P.E., Morris, A.D. (Andrew), Buckley, Brendan M., Mathew, C.G. (Christopher G.), Stanton, A, Gudnason, V, Li, Xiaohui, Shaw-Hawkins, S. (Sue), O???brien, Eoin, Ding, Jingzhong, Uitterlinden, André G., Cupples, LA, Nyberg, F, Mathew, Christopher G., Wellcome Trust Case Control Consortium, Warren, Helen R., Wei, WQ, Chu, A.Y. (Audrey), Warren, H.R., Stott, D.J., Smith, Albert V., Barratt, B.J. (Bryan J.), Westendorp, Rudi G. J., Vasan, Ramachandran S., Bramon, Elvira, Plomin, Robert, Nyberg, F. (Fredrik), Hellenthal, F.A., McCarthy, M.I., Tardif, Jean-Claude, Sawcer, S.J. (Stephen), Pierre Dub??, Marie, Chen, Y-DI, Munroe, P.B., Band, Gavin, Tardif, JC, Rotter, J.I., Post, W. (Wendy), Groop, L. (Leif), Wilke, R.A., Trompet, Stella, Psaty, B.M. (Bruce), Harris, TB, Casas, Juan P., Keyser, C.E. (Catherina Elisabeth) de, Stafford, JM, Deloukas, Panos, Li, X. (Xiaohui), Herrington, David M., Neil, A, Brown, Matthew, Ida Chen, Y.-D., Bellenguez, C. (Céline), Li, Guo, Barroso, Ines, Sun, F. (Fangui), McKeigue, P.M., Launer, Leonore J., Guo, XQ, Lumley, Thomas, Kastelein, John J. P., Chu, Audrey Y., Smith, Nicholas L., Smith, A.V. (Davey), Hofman, Albert, Donnelly, L.A. (Louise), Palmer, CNA, Barnes, M.J. (Michael), Doney, A, Tardif, J.C., Postmus, I, Shaw-Hawkins, S, de Craen, Anton J. M., Stricker, Bruno H., Poulter, N.R. (Neil), Stanton, A., Liddle, J. (Jennifer), Avery, Christy L., Vasan, R.S., Su, Z. (Zhan), Barroso, I.E. (Inês), Ding, J, Colhoun, H.M. (H.), Ngwa, Julius S., Ahlqvist, E, Corvin, Aiden, Rotter, J.I. (Jerome I.), Johnson, Andrew D., Rotter, JI, Ricketts, M. (Michelle), McCarthy, M.I. (Mark), Ahlqvist, Emma, Franco, O.H. (Oscar), Trembath, R.C. (Richard), Ballantyne, Christie M., Sotoodehnia, N., Psaty, Bruce M., Wei, W-Q, Carr, Fiona, Hitman, G.A. (Graham), Liu, C.T., Feng, Q, Barnes, Michael, Smith, N.L., Caulfield, Mark J., Westendorp, RGJ, MacFadyen, Jean G., Doney, Alex, Boekholdt, SM, Gudnason, V., Deshmukh, HA, Slagboom, P.E. (Eline), Boekholdt, S.M. (Matthijs), Freeman, C. 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(Ted), Blackburn, Hannah, Eiriksdottir, G. (Gudny), Smith, N.L. (Nicholas), Bis, J.C., Ravindrarajah, Radhi, Harris, T.B., Smith, J.D. (Joshua D.), Rice, K.M. (Kenneth), Barnes, MR, Wilke, Russell A., Hitman, G., Feng, QP, McCann, Owen T., Ding, J.Z., Sawcer, Stephen J., Vukcevic, D. (Damjan), Jukema, J.W. (Jan Wouter), Wouter Jukema, J, Liu, Y.M., Hitman, Graham, Strange, Amy, Li, G, Hunt, S.E. (Sarah), Eline Slagboom, P., Ding, J. (Jingzhong), Langford, C. (Cordelia), St??rmer, Til, Langford, Cordelia, Stricker, B.H., Shaw-Hawkins, S., Kastelein, JJ, Donnelly, P. (Peter), Evans, Daniel S., Deshmukh, H. (Harshal), Betteridge, J. (John), Boerwinkle, E.A. (Eric), Eiriksdottir, G., Westendorp, R.G.J., Johnson, AD, Bis, Joshua C., McCarthy, Mark I., Denny, Joshua C., Dronov, Serge, Emilsson, V. (Valur), Harris, Tamara B., Li, X, Westendorp, R.G.J. (Rudi), Warren, HR, Giulianini, Franco, Guo, X. (Xiuqing), Emilsson, Valur, Heckbert, S.R., Weston, P. 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(Alex), Rautanen, Anna, Buckley, B.M. (Brendan M.), Deshmukh, Harshal, Jankowski, Janusz, Colhoun, H.M., Ridker, P.M. (Paul), Nyberg, Fredrik, Vasan, R.S. (Ramachandran Srini), Emilsson, V, Krauss, R.M. (Ronald), Feng, Q.P., Arnold, Alice M., Brown, Matthew A., Psaty, BM, Arsenault, Benoit J., Zhou, K, Whittaker, P. (Pamela), Westendorp, RG, Sun, Fangui, Chen, YD, Slagboom, PE (Eline), Smith, J.D., Kritchevsky, Stephen B., Consort, WTCC, Nickerson, Deborah A., Evans, D.S. (Daniel), Smith, NL, Chen, Y.-D.I. (Ida), Taylor, K.D. (Kent), Stafford, J.M., Psaty, B.M., Griffin, Paula, Giannoulatou, Eleni, Hofman, A, Carr, F. (Fiona), Nyberg, F., Lumley, T. (Thomas), Giulianini, F, Duncanson, Audrey, Launer, L.J. (Lenore), Markus, Hugh S., Hovingh, GK, Trompet, S, Stricker, BH, Li, X.H., Ballantyne, CM, Launer, LJ, Chasman, D.I., Li, G., Kees Hovingh, G., Markus, H.S. 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A.; id_orcid, Vasan, Ramachandran S, Harris, Tamara B, McCarthy, Mark I, Uitterlinden, André G, Nyberg, Fredrik,, Whitsel, Eric A, Palmer, Colin NA, Warren, Helen R, Smith, Albert V, Stricker, Bruno H, MacFadyen, Jean G, Chu, Audrey Y, McKeigue, Paul M, Kastelein, John JP, Chasman, Daniel I, Denny, Joshua C, Wiggins, Kerri L, Ballantyne, Christie M, Launer, Leonore J, Avery, Christy L, Franco, Oscar H, de Craen, Anton J M, Rotter, Jerome I, Barnes, Michael R, Durrington, Paul N, Lund University., de Keyser, Catherine E, Kastelein, John J P, Colhoun, Helen M, Kees Hovingh, G, Ngwa, Julius S, Buckley, Brendan M, Johnson, Andrew D, Ahlqvist, Emma,, Stafford, Jeanette M, Munroe, Patricia B, Evans, Daniel S, Bis, Joshua C, Smith, Joshua D, Stott, David J, Deshmukh, Harshal A, Psaty, Bruce M, Westendorp, Rudi G J, Groop, Leif,, Donnelly, Louise A, Ida Chen, Y-D, Arnold, Alice M, Ridker, Paul M, Palmer, Colin N A, Smith, Nicholas L, Herrington, David M, Matthijs Boekholdt, S, Barratt, Bryan J, O'Donnell, Christopher J, O’Donnell, Christopher J, de Craen, Anton JM, Eline Slagboom, P, Kritchevsky, Stephen B, Shields, Denis C, Krauss, Ronald M, Nickerson, Deborah A, Westendorp, Rudi GJ, Arsenault, Benoit J, Caulfield, Mark J, Wilke, Russell A, Taylor, Kent D, O'Donnell, CJ, O'Brien, E, Dube, MP, MacFadyen, JG, de Keyser, CE, Sturmer, T +624 morecore +1 more sourceUnraveling genotype–phenotype relationships in hereditary hemochromatosis through integrated biobank data analysis
BMC GenomicsBackground Type I hereditary hemochromatosis (HH), caused by pathogenic HFE variants, is among the most common autosomal recessive disorders in Northern Europe.Miriam Nurm, Tarmo Annilo, Sebastian May-Wilson, Anu Reigo, Reedik Mägi, Urmo Võsa, Neeme Tõnisson, Estonian Biobank Research Team, Toomas Haller +8 moredoaj +1 more sourceGenome-wide Association Study of Kernel Carbohydrates in the Wisconsin Sweet Corn Diversity Panel Revealed Loci beyond Classic Endosperm Genes
Journal of the American Society for Horticultural ScienceSweet corn ranks among the top vegetable crops by production value in the United States. The sweetness, tenderness, and texture of sweet corn kernels are the most important traits for eating quality.Lillian M. Hislop, Matheus Baseggio, Alexa R. Wilson, Auden Parkinson, Carl Branch, Cathleen A. McCluskey, Patrick Flannery, Michael A. Gore, William F. Tracy +8 moredoaj +1 more sourceSpatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours +11 morewiley +1 more sourceGenome-wide association analyses of child genotype effects and parent-of-origin effects in specific language impairment [PDF]
, 2014 Specific language impairment (SLI) is a neurodevelopmental disorder that affects linguistic abilities when development is otherwise normal. We report the results of a genome-wide association study of SLI which included parent-of-origin effects and child ...Newbury, Dianne F, Bolton, Patrick F, A. O'Hare, Paracchini, S., Fisher, S E, Hennessy, E. R., Monaco, Anthony P, Simpson, N., Fisher, S. E., S. E. Fisher, Simpson, N H, Ring, S M, O'Hare, A., N. H. Simpson, Newbury, D., S. Paracchini, Bolton, P F, Ring, SM, Nudel, R, Smith, G D, Smith, G., Monaco, AP, P. F. Bolton, Simpson, N. H., Smith, George Davey, O'Hare, Anne, O'Hare, A, ?, ?, Hennessy, ER, E. R. Hennessy, G. Baird, Conti-Ramsden, G., Nudel, Ron, Francks, Clyde, O’Hare, A., S. M. Ring, Monaco, A., Paracchini, Silvia, Simpson, Nuala H, Nudel, R., Bolton, PF, Baird, Gillian, D. F. Newbury, Newbury, D F, Bolton, P. F., Hennessy, E., C. Francks, Newbury, D. F., Baird, G., The SLli consortium, Smith, G. Davey, G. Conti‐Ramsden, SLI Consortium, Fisher, Simon E, Cohen, Wendy, Ring, Susan M, Davey Smith, G, R. Nudel, Baird, G, Fisher, S., Bolton, P., The SLI Consortium, Fisher, SE, Conti-Ramsden, G, Simpson, NH, Conti-Ramsden, Gina, Francks, C., Monaco, A. P., Hennessy, Elizabeth R, A. P. Monaco, Paracchini, S, Francks, C, Monaco, A P, The SLI Consortium (includes Wendy Cohen), Ring, S. M., Newbury, DF, Ring, S., G. Davey Smith, Hennessy, E R, Paracchini, Silvia; id_orcid +79 morecore +1 more source
