Results 131 to 140 of about 40,713,960 (307)
Genome-Wide Association Studies of Allergic Diseases
Allergology International, 2013 Allergic diseases are complex diseases caused by a combination of genetic and environmental factors. To determine the genetic components of these diseases and to discover the genes and cellular pathways underlying them, a large number of genetic studies have been conducted.
Mayumi Tamari, ShotaTanaka, Tomomitsu Hirota +2 more
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KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan +16 more
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Large-Scale Genome-Wide Association Studies and Meta-Analyses of Longitudinal Change in Adult Lung Function [PDF]
, 2014 Background: Genome-wide association studies (GWAS) have identified numerous loci influencing cross-sectional lung function, but less is known about genes influencing longitudinal change in lung function.
Wenbo Tang (110161), Joyanna G. Hansen (591398), Heinrich, J (Joachim), Thomas Lumley (57337), London, S.J. (Stephanie), Alan James (528475), Sood, A, R Graham Barr, Matthew Kowgier (120923), Brusselle, Guy G., Loth, Daan W, Akshay Sood (71826), O'Connor, George T, Susan R. Heckbert, Liu, YM, Rivadeneira Ramirez, F. (Fernando), Hodge, E., Harris, Tamara B, Michael Allerhand, Loth Daan W., Morrison, A.C. (Alanna), Fornage, Myriam, Morris Andrew P., Ingo Ruczinski, Stephanie J. London (62450), Josée Dupuis (28859), James, Alan, Völzke Henry, Ruczinski, I., London Stephanie J., Voorman, A, Patricia A. Cassano (110298), Joachim Heinrich (60421), Guy G Brusselle, Gu, Xiangjun, Mathias, Rasika A, John M Starr, Smith, AV, Couper, DJ, Lenore J. Launer (110269), Arend Voorman, Myriam Fornage (45591), Sina A. Gharib, Smith, Lewis J, Gao, W, Wei Gao, Liu, Y, Morrison Alanna C., Kari E. North, Musk, B, Heinrich, J. (Joachim), Musk Bill, Uitterlinden, André G, Hansel, C.R.W. (Christian), Dupuis, Jos�e, John M. Starr, Heinrich, Joachim, Foy, Millennia, Lind, Lars, Cassano, P.A. (Patricia), Probst-Hensch, Nicole M, Palmer, Lyle J., O Dale Williams, Joyanna G. Hansen, Allerhand, Michael, Martin D. Tobin, Deary, Ian J, Hall, I.P. (Ian), Uitterlinden, AG, Heckbert, Susan R, David P Strachan, Tamara B Harris, Harris, T.B. (Tamara), Smith, Albert V, Launer, Lenore J, Stricker, Bruno H, Starr John M., Heckbert, Susan R., Holger Schulz (13022), Tamara B. Harris, James, A. (Alan), Tobin, M.D. (Martin), Michael Allerhand (591399), Martin T. Wells, Kari E. North (68131), Aldrich, Melinda C., Couper, David J., North, Kari E, Louise V Wain, Starr, John M., Rivadeneira, F, Jerome I. Rotter, Barnes, Kathleen C, O'Connor, G.T. (George), Smith, Lewis J., Kowgier, M., Karrasch Stefan, Strachan, David P., Henry Völzke (64286), Williams O. Dale, Ingelsson, Erik, Hodge Emily, Soler Artigas, Mar�a, Bernd Meibohm (110267), Gu Xiangjun, Ingelsson Erik, Cecilia Lindgren (258113), Daan W Loth, Hofman Albert, Gl�ser, Sven, Starr, J.M. (John), Deary, I.J. (Ian), Ashish Kumar, et al., Kurt Lohman, Bonnie R. Joubert, Alanna C Morrison, Melinda C. Aldrich (110234), Meibohm, B, Ruczinski Ingo, Imboden, Medea, Gharib, Sina A, Wilk, Jemma B., Hansen, JG, Fall, Tove,, Franceschini, N. (Nora), Lahousse Lies, Kowgier Matthew, Foy Millennia, Hansel, Nadia N., Kurt Lohman (110218), O. Dale Williams (110242), Völzke, H. (Henry), Alanna C. Morrison (110248), Lenore J Launer, Gao Wei, Franceschini, N, Hansen, J., Hancock, D.B. (Dana), Probst-Hensch, NM, Morris, AP, Launer, Lenore J., R. Graham Barr, Couper David J., Gläser, S. (Sven), Li, G. (Guo), O. Connor, George T., Allerhand, M., Fernando Rivadeneira, Joubert, B.R. (Bonnie), Sina A. Gharib (63265), Eva Albrecht (174584), Heckbert Susan R., Imboden, M. (Medea), Dupuis, Josée, Gudnason, V. (Vilmundur), Gharib, S.A. (Sina), Williams, O.D. (Dale), Mathias, Rasika A., Morris, Andrew P, Tamara B. Harris (110195), Voorman Arend, Musk, Bill, Bonnie R. Joubert (110252), Probst-Hensch, Nicole M., Rotter, Jerome I, Gharib, S., Matthew Kowgier, Dana B. Hancock (110121), R. Graham Barr (109958), Lewis J. Smith, Franceschini, Nora, Hansen Joyanna G., Kathleen C. Barnes, Ruczinski, I. (Ingo), Soler Artigas, M., Loth, Daan W., Josée Dupuis, Alan James, Wei Gao (2085), Medea Imboden, Gharib Sina A., Gao, Wei, Lohman, K, Ruczinski, I, Wain, Louise V., Allerhand, M.M. (Michael), Lewis J Smith, Alan James, Rasika A. Mathias, Lohman Kurt, Wells, Martin T., Uitterlinden, A.G. (André), Andrew P Morris, Sood, A. (Akshay), George T O'Connor, McArdle, Wendy L., Barr, R. Graham, Dupuis, J, Palmer, Lyle J, Koch, B, Fall, M. (Magnus), Ian J Deary, Tobin, Martin D, Jemma B Wilk, Meibohm Bernd, Völzke, H, Davies, Gail, Artigas, Maria Soler, Lahousse, Lies, Morris, A.P. (Andrew), Melinda C Aldrich, Gudnason, V, Kumar, Ashish, Eva Albrecht, Rasika A Mathias, Gharib, SA, Wain, L.V. (Louise), Musk, A.W. (Arthur), Palmer, LJ, Franceschini Nora, Albert V Smith, Aldrich Melinda C., Uitterlinden, André G., Martin D Tobin, Guy G. Brusselle (110236), Smith Lewis J., Fall, T, Kowgier, M, Bruce M Psaty, Probst-Hensch Nicole M., Palmer, C. (Cameron), Smith, Albert V., Teumer, A, Soler Artigas, M. (Maria), Hodge, Emily, Nicole M Probst-Hensch, Morris, Andrew P., Gu, X, Louise V. Wain, Rotter Jerome I., Brusselle, G.G. (Guy), McArdle, W.L. (Wendy), Hall, IP, Meibohm, Bernd, Alanna C. Morrison, Psaty, B.M. (Bruce), Harris, TB, Kathleen C. Barnes (134420), Xiangjun Gu, Akshay Sood, Lind Lars, Lind, L, Harris, T., Daan W. Loth (110140), Curjuric, I. (Ivan), Mathias, J. (Jasmine), Starr, JM, Fall Tove, Li, Guo, Lumley, Thomas, Sven Gläser, Jemma B. Wilk, André G. Uitterlinden (2213413), Ian J. Deary, Lars Lind (88400), Barr, R., Smith, A.V. (Davey), Foy, M. (Millennia), Hofman, Albert, Deary, Ian J., Jerome I. Rotter (103729), Hansel, Nadia N, Yongmei Liu, Myriam Fornage, Cassano, Patricia A, James Alan, Teumer Alexander, Schulz Holger, André G. Uitterlinden, Xiangjun Gu (73651), Davies Gail, Tang, W, Brusselle, GG, Soler Artigas María, Bruno H. Stricker, Tang, Wenbo, Voelzke, Henry, Stricker, Bruno H., Ingelsson, E, Strachan, D.P. (David), Smith, A., Stephen B Kritchevsky, Dana B Hancock, Vilmundur Gudnason (8873), Strachan, DP, Lumley Thomas, Patricia A Cassano, Susan R. Heckbert (110293), Martin D. Tobin (110311), Andrew P. Morris, Imboden Medea, North, KE, Dupuis, J. (Josée), David J Couper, Bruno H. Stricker (336134), Rotter, JI, Davies, G. (Gail), Tove Fall, John M. Starr (107707), Lind, Lars,, Psaty, Bruce M., Wells, MT, Dupuis Josée, Lohman, Kurt, Hodge, E, Lars Lind, Gail Davies, Hancock Dana B., Gudnason, V., Hansen, Joyanna G, Henry Völzke, Bruce M. Psaty, Morrison, Alanna C, Tobin, MD, Wain, LV, Mathias, RA, Stricker, Bruno, Barr, RG, Wells, M.T. (Martin), Lies Lahousse, Alexander Teumer (112757), Lies Lahousse (548910), Strachan David P., Bill Musk, Palmer Lyle J., Schulz, H. (Holger), Strachan, David P, Schulz, H, Brusselle, Guy, Mathias, R., Stephen B. Kritchevsky, George T. O′Connor (591401), O′Connor, George T., Ian J. Deary (107724), Wendy L. McArdle (110155), Bill Musk (591400), Bernd Meibohm, Karrasch, S, Tove Fall (201258), Fornage Myriam, Hansen, J.G. (Joyanna), Teumer, A. (Alexander), Barr, R Graham, Voorman, J.M. (Jeanine), Ruczinski, Ingo, Hofman, Bert, Arend Voorman (221264), Lindgren, Cecilia, Stephen B. Kritchevsky (110259), Liu, Y. (YongMei), Bonnie R Joubert, Ingo Ruczinski (15765), David J. Couper (110257), Hansel, NN, Davies, G, V�lzke, Henry, Erik Ingelsson, Rasika A. Mathias (134405), Rotter, J.I. (Jerome), Psaty, Bruce M, Sven Gläser (110276), Koch Beate, Albrecht Eva, Aldrich, MC, Hancock, DB, Albrecht, E. (Eva), Heckbert, SR, Mathias Rasika A., North, Kari E., Wilk Jemma B., Probst-Hensch, N.M. (Nicole M.), Lumley, T, Aldrich, M., Kowgier, Matthew, Stefan Karrasch (412837), Ashish Kumar (152984), Rivadeneira Fernando, Wenbo Tang, Beate Koch (110151), Hansel, N., Fall, Tove, Albert V. Smith, Koch, B. (Beate), Tobin Martin D., Williams, O. Dale, Uitterlinden, André, Hancock, Dana B., Heckbert, S.R. (Susan), Ian P. Hall (110307), Karrasch, S. (Stefan), David P. Strachan, Kumar, A, Kritchevsky, SB, Nora Franceschini, Jemma B. Wilk (110164), Curjuric, Ivan, Emily Hodge (460149), Brusselle Guy G., Dana B. Hancock, North, K.E. (Kari), Vilmundur Gudnason, Andrew P. Morris (145709), Emily Hodge, Artigas, MS, Rivadeneira, Fernando, Aldrich, M.C. (Melinda), Bruno H Stricker, Loth, D.W. (Daan), Guy G. Brusselle, Stricker, B.H.Ch. (Bruno), Albert V. Smith (103644), Morrison, Alanna C., Stephanie J. London, Lewis J. Smith (156533), Stefan Karrasch, Loth, DW, Wilk, J.B. (Jemma), London, SJ, Curjuric Ivan, Launer Lenore J., Deary, IJ, Karrasch, Stefan, Lindgren Cecilia, Kathleen C Barnes, Völzke, Henry, Lyle J Palmer, Lindgren, C, Barnes, KC, Lenore J. Launer, Li, G, O'Connor, GT, Schulz, Holger, Lindgren, C.M. (Cecilia), Heinrich, J, Tang, W. (Wenbo), Barnes, K., Joubert, B., Bruce M. Psaty (103721), Loth, D., Uitterlinden, Andr� G., Nadia N Hansel, Gu, XJ, Millennia Foy (211777), Ivan Curjuric (110179), Nadia N. Hansel (359186), Hansen, Joyanna G., Susan R Heckbert, Sina A Gharib, Gläser, Sven, Cecilia Lindgren, McArdle Wendy L., Medea Imboden (110145), Thomas Lumley, Teumer, Alexander, Martin T. Wells (122541), Harris, Tamara B., London, Stephanie J, Albrecht, E., Joubert, BR, O?Connor, George T., Allerhand, M, Jerome I Rotter, David J. Couper, Wendy L. McArdle, Launer, LJ (Lenore), Gudnason, Vilmundur, Tang Wenbo, Martin T Wells, Smith, L.J. (Lewis), Lohman, K. (Kurt), Uitterlinden, André; id_orcid, Smith Albert V., Loth, Daan, Hall, Ian P, Barr R. Graham, Liu, Yongmei, Guo Li (174860), Nicole M. Probst-Hensch (110284), Wilk, JB, Kritchevsky Stephen B., Chen, Lin, Gail Davies (107670), Ivan Curjuric, Gudnason Vilmundur, Curjuric, I, Allerhand Michael, Sood Akshay, Lahousse, L, Lahousse, L. (Lies), Nicole M. Probst-Hensch, Soler Artigas, María, Williams, O Dale, Launer, L., Kumar Ashish, Guo Li, Gläser, S, Heinrich Joachim, Morrison, AC, Hofman, A. (Albert), Fornage, M. (Myriam), Albert Hofman, Hall Ian P., London, Stephanie J., Fornage, M, Harris Tamara B., Uitterlinden André G., Stricker Bruno H., Gharib, Sina A., André G Uitterlinden, North Kari E., Daan W. Loth, O Connor, George T, María Soler Artigas (110124), Hansel Nadia N., Gläser Sven, O'Connor, George T., Joyanna G Hansen, Wells Martin T., Smith, LJ, Lyle J. Palmer (95287), Gao, W. (Wei), McArdle, Wendy L, Foy, M, Ingelsson, E. (Erik), Deary Ian J., Kritchevsky, Stephen B, Lyle J. Palmer, Glaeser, Sven, Aldrich, Melinda C, Brusselle, Guy G, Liu Yongmei, Joubert, Bonnie R., Imboden, M, Barnes, Kathleen C., Ian P Hall, Alexander Teumer, Sood, Akshay, McArdle, WL, Couper, D.J. (David), Soler Artigas, M, Wain Louise V., Kari E North, Couper, David J, Starr, John M, Psaty, BM, Wenbo Tang, Albrecht, E, Louise V. Wain (110260), Hancock, Dana B, Li Guo, Koch, Beate, David P. Strachan (110302), Cassano, PA, Barnes Kathleen C., Joubert, Bonnie R, Stephanie J London, Ian P. Hall, Gu, X. (Xiangjun), Tang, W., Kritchevsky, Stephen B., Lind, L. (Lars), O. Dale Williams, Hofman, A, Lumley, T. (Thomas), Melinda C. Aldrich, Launer, L.J. (Lenore), James, A, Cassano Patricia A., Holger Schulz, Albert Hofman (107303), Voorman, Arend, O′Connor George T., Stricker, BH, Beate Koch, Launer, LJ, George T. O′Connor, Psaty Bruce M., Cassano, Patricia A., Wells, Martin T, Joachim Heinrich, Tang, WB, Ingelsson, Erik,, Barnes, K.C. (Kathleen), Albrecht, Eva, Hodge, E. (Emily), Hall, Ian P., Nora Franceschini (91434), Tobin, Martin D., Barr, R.G. (Graham), Wain, Louise V, Rotter, Jerome I., Kritchevsky, S.B. (Stephen), Joubert Bonnie R., Nadia N. Hansel, Wendy L McArdle, Millennia Foy, Williams, OD, Erik Ingelsson (232651), Kowgier, M. (Matthew), Patricia A. Cassano, Wilk, Jemma B, Meibohm, B. (Bernd), María Soler Artigas, Yongmei Liu (104713), Fernando Rivadeneira (61551), Kumar, A. (Ashish), Tang, Wenbo;Kowgier, Matthew;Loth, Daan W;Soler Artigas, Maria;Joubert, Bonnie R;Hodge, Emily;Gharib, Sina A;Smith, Albert V;Ruczinski, Ingo;Gudnason, Vilmundur;Mathias, Rasika A;Harris, Tamara B;Hansel, Nadia N;Launer, Lenore J;Barnes, Kathleen C;Hansen, Joyanna G;Albrecht, Eva;Aldrich, Melinda C;Allerhand, Michael;Barr, R Graham;Brusselle, Guy G;Couper, David J;Curjuric, Ivan;Davies, Gail;Deary, Ian J;Dupuis, Josée;Fall, Tove;Foy, Millennia;Franceschini, Nora;Gao, Wei;Gläser, Sven;Gu, Xiangjun;Hancock, Dana B;Heinrich, Joachim;Hofman, Albert;Imboden, Medea;Ingelsson, Erik;James, Alan;Karrasch, Stefan;Koch, Beate;Kritchevsky, Stephen B;Kumar, Ashish;Lahousse, Lies;Li, Guo;Lind, Lars;Lindgren, Cecilia;Liu, Yongmei;Lohman, Kurt;Lumley, Thomas;McArdle, Wendy L;Meibohm, Bernd;Morris, Andrew P;Morrison, Alanna C;Musk, Bill;North, Kari E;Palmer, Lyle J;Probst-Hensch, Nicole M;Psaty, Bruce M;Rivadeneira, Fernando;Rotter, Jerome I;Schulz, Holger;Smith, Lewis J;Sood, Akshay;Starr, John M;Strachan, David P;Teumer, Ale +617 more
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley +13 more
wiley +1 more source
Genome-wide association analyses of child genotype effects and parent-of-origin effects in specific language impairment [PDF]
, 2014 Specific language impairment (SLI) is a neurodevelopmental disorder that affects linguistic abilities when development is otherwise normal. We report the results of a genome-wide association study of SLI which included parent-of-origin effects and child ...
Newbury, Dianne F, Bolton, Patrick F, A. O'Hare, Paracchini, S., Fisher, S E, Hennessy, E. R., Monaco, Anthony P, Simpson, N., Fisher, S. E., S. E. Fisher, Simpson, N H, Ring, S M, O'Hare, A., N. H. Simpson, Newbury, D., S. Paracchini, Bolton, P F, Ring, SM, Nudel, R, Smith, G D, Smith, G., Monaco, AP, P. F. Bolton, Simpson, N. H., Smith, George Davey, O'Hare, Anne, O'Hare, A, ?, ?, Hennessy, ER, E. R. Hennessy, G. Baird, Conti-Ramsden, G., Nudel, Ron, Francks, Clyde, O’Hare, A., S. M. Ring, Monaco, A., Paracchini, Silvia, Simpson, Nuala H, Nudel, R., Bolton, PF, Baird, Gillian, D. F. Newbury, Newbury, D F, Bolton, P. F., Hennessy, E., C. Francks, Newbury, D. F., Baird, G., The SLli consortium, Smith, G. Davey, G. Conti‐Ramsden, SLI Consortium, Fisher, Simon E, Cohen, Wendy, Ring, Susan M, Davey Smith, G, R. Nudel, Baird, G, Fisher, S., Bolton, P., The SLI Consortium, Fisher, SE, Conti-Ramsden, G, Simpson, NH, Conti-Ramsden, Gina, Francks, C., Monaco, A. P., Hennessy, Elizabeth R, A. P. Monaco, Paracchini, S, Francks, C, Monaco, A P, The SLI Consortium (includes Wendy Cohen), Ring, S. M., Newbury, DF, Ring, S., G. Davey Smith, Hennessy, E R +78 more
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra +16 more
wiley +1 more source
Targeting 160 candidate genes for blood pressure regulation with a genome-wide genotyping array [PDF]
, 2009 The outcome of Genome-Wide Association Studies (GWAS) has challenged the field of blood pressure (BP) genetics as previous candidate genes have not been among the top loci in these scans.
Döring, Angela, Illig, T, Peeter Juhanson, Katrin Kepp, Juhanson, P., Juhanson, P, Samani, Nilesh, Philip Howard, Caulfield, Mark J., P. B. Munroe (7602386), Veldre, G, Farrall, Martin, Lichtner Peter, Dobson, RJ, Viigimaa, M., C. Gieger (7609259), Morris Brown, Putku Margus, Wichmann, H.-E., Illig, T., Siim Sõber, Gudrun Veldre, Shaw-Hawkins, Sue, Kelgo, Piret, Illig Thomas, R. J. Dobson (7602557), Samani, N, Samani Nilesh, Laan, Maris, HYPertens ESTonia Study, A. Dominiczak (7611551), Munroe, Patricia B., Kepp, K, John Connell, T. Illig (7609322), Samani, N., M. Putku (7602647), Viigimaa Margus, Farrall Martin, Brown, M, Peter Lichtner, Sober, S, A. Döring (7609562), Lichtner, Peter, P. Howard (7611350), Piret Kelgo, Juhanson Peeter, Dobson, Richard J.; id_orcid, Org, E, Farrall, M, Dobson, R.J., Meitinger, T, Veldre, Gudrun, E. Org (7602644), Kooperative Gesundheitsforschung in der Region Augsburg Study, Lichtner, P., H-Erich Wichmann, Martin Farrall, Kepp, Katrin, Gieger, Christian, HYPertension in ESTonia Study, Margus Putku, Newhouse, SJ, Onipinla Abiodun, Caulfield Mark J., Meitinger, T., M. Laan (7602659), Caulfield, MJ, Maris Laan, Eyheramendy, S., Onipinla, A., Newhouse, S.J., M. Viigimaa (7602620), Gieger, C, Dominiczak, A., Kelgo, P, Onipinla, A, Döring Angela, Newhouse, Stephen J.; id_orcid, Shaw-Hawkins Sue, Susana Eyheramendy, Munroe, PB, Klopp, Norman, Newhouse, Stephen J., Brown, Morris, Putku, Margus, M. Farrall (6522599), Wichmann, H.-Erich, Meitinger Thomas, S. Eyheramendy (7611197), Wichmann, Heinz-Erich, Putku, M, M. Brown (3020991), Gieger, C., Christian Gieger, Döring, A., Dobson, Richard J., Munroe, P.B., Juhanson, Peeter, Lichtner, P, Richard J Dobson, Org, E., H-E. Wichmann (7611602), Doering, Angela, Howard Philip, Kepp, K., Org, Elin, Kelgo Piret, Anna Dominiczak, Klopp, N., S. Shaw-Hawkins (7602380), Org Elin, Gieger Christian, Dominiczak Anna, Margus Viigimaa, Viigimaa, Margus, Newhouse Stephen J., K. Kepp (7611593), Sue Shaw-Hawkins, Stephen J Newhouse, Howard, P., Munroe Patricia B., Wichmann, H. Erich, P. Kelgo (7611596), Wichmann H.-Erich, Eyheramendy, S, Kooperative Gesundheitsforsch, Putku, M., M. J. Caulfield (7602383), Patricia B Munroe, Howard, P, Angela Döring, Eyheramendy, Susana, Nilesh Samani, Veldre Gudrun, Kepp Katrin, Sõber Siim, J. . Connell (7611608), Wichmann, HE, MRC British Genet Hypertens Study, Laan, M., Laan Maris, Elin Org, Connell, J, Illig, Thomas, Meitinger, Thomas, Doring, A, Viigimaa, M, Thomas Illig, N. Klopp (7611599), S. J. Newhouse (7602371), Connell John, S. Sõber (7602650), Shaw-Hawkins, S, Onipinla, Abiodun, Shaw-Hawkins, S., Dobson Richard J., Dominiczak, A, Klopp Norman, T. Meitinger (14191), Abiodun Onipinla, G. Veldre (7602656), Sõber, Siim, Thomas Meitinger, Eyheramendy Susana, P. Lichtner (7611605), A. Onipinla (7602377), Mark J Caulfield, Klopp, N, Caulfield, M.J., N. Samani (7611611), P. Juhanson (7602641), Dominiczak, Anna, Veldre, G., Connell, J., Connell, John, Norman Klopp, MRC British Genetics of Hypertension Study, Brown, M., Sõber, S., Howard, Philip, Brown Morris, Laan, M, Sõber, S;Org, E;Kepp, K;Juhanson, P;Eyheramendy, S;Gieger, C;Lichtner, P;Klopp, N;Veldre, G;Viigimaa, M;Döring, A;Putku, M;Kelgo, P;Shaw-Hawkins, S;Howard, P;Onipinla, A;Dobson, RJ;Newhouse, SJ;Brown, M;Dominiczak, A;Connell, J;Samani, N;Farrall, M;Caulfield, MJ;Munroe, PB;Illig, T;Wichmann, HE;Meitinger, T;Laan, M +183 more
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Myopia genetics in genome-wide association and post-genome-wide association study era
International Journal of Ophthalmology, 2019 Genome-wide association studies (GWAS) of myopia and refractive error have generated exciting results and identified novel risk-associated loci. However, the interpretation of the findings of GWAS of complex diseases is not straightforward and has remained challenging.
Xuan Liao, Qing-Qing Tan, Chang-Jun Lan
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer +10 more
wiley +1 more source
A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease [PDF]
, 2015 Existing knowledge of genetic variants affecting risk of coronary artery disease (CAD) is largely based on genome-wide association study (GWAS) analysis of common SNPs.
Seedorf, Udo, Stirrups, Kathleen E., Kleber, M.E., Mihailov, Evelin,, Zhao, Wei,, Epstein, S.E., Trompet, S., Ridker, P.M., Armasu, S., Assimes, Themistocles L., Ingelsson, E., Granger, Christopher B, Elosua, R., Rose, L., Auro, Kirsi,, Frossard, Philippe,, Boerwinkle, E., Seedorf, Udo,, Hengstenberg, Christian, Palmer, C., Peters, Annette, Stirrups, Kathleen E.,, Ripatti, Samuli,, F. Beutner (7780352), Kleber, Marcus E.,, Rose, LM, Smith, AV, K. S. Zaman (7809092), Harris, Tamara B.,, Webb, Thomas R, Armasu, Sebastian M.,, Nieminen, Markku S.,, R. Elosua (7605998), Palmer, CN, Lu, X., O'Donnell, C., Dedoussis, G., Loos, Ruth J F, Shah, Svati H, Yang, X., Franco, O.H., Chambers, John C, O'Donnell, CJ, Alver, M., Memon, FUR, G. Dedoussis (7626908), Stott, David J.,, Lu, Xiangfeng, Rose, Lynda M, Roberts, Robert, Hofman, A., P. Frossard (7605893), Smith, Albert V, Quertermous, T., V. Salomaa (7605350), Lau, King Wai, Gu, Dongfeng, L. Lind (7625984), Borecki, Ingrid B.,, Franzosi, Maria Grazia, Thompson, J., Granger, CB, Morris, A., Zalloua, Pierre A.,, P. A. Zalloua (7660361), Lu, Yingchang,, T. Kessler (7646111), Stirrups, K.E., Scholz, M, O. Gottesman (7646165), März, Winfried, E. Salfati (7780343), Mallick, N.H., Salomaa, Veikko, Hall, AS, de Vries, Paul S.,, Ingelsson, Erik, Lu, Y., Bertram, Lars, Gauguier, D, Kim, Yun Kyoung,, S. H. Shah (7627475), J. E. Buring (7809098), R. Saxena (7608878), Bjonnes, Andrew,, Karhunen, Pekka J, Hall, A., Granger, C., Assimes, Themistocles L.,, Kessler, Thorsten, Hall, L.M., Lu, Yingchang, Hopewell, Jemma C., Zhang, W., Ardissino, Diego, Reilly, Muredach P., Saxena, R, W. Zhao (696097), Iribarren, Carlos, Bjonnes, Andrew, van Zuydam, Natalie R., Franceschini, N, T. Meitinger (14191), Grace, Christopher, Cupples, L. Adrienne,, Cupples, L.A., C. B. Granger (7780361), Saleheen, Danish,, Chasman, Daniel I., Morris, AP, M. de Andrade (7646150), Zuydam, N.R. van, Franco, Oscar H.,, Kooner, J.S., Schunkert, H, Hazen, Stanley L.,, Magnusson, Patrik K., Thompson, JR, Frossard, P, Ardissino, Diego,, Sinisalo, J., N. J. Samani (7591811), Hopewell, Jemma C.,, de Andrade, Mariza, Uitterlinden, Andre, Hazen, Stanley L., Palmer, Colin N.,, Franco, Oscar H, Nelson, CP, O'Donnell, Catherine, P. K. Magnusson (7609379), Kooner, Jaspal S, Franzosi, MG, Sanghera, Dharambir K.,, Erdmann, Jeanette, Seedorf, U, Loos, Ruth J. F., Pedersen, Nancy L., Demuth, Ilja, Hall, LM, C. Iribarren (7626692), de Vries, P., Gu, D.F., Pedersen, Nancy L, Kessler, Thorsten,, Loos, RJF, Franzosi, M., Sanghera, D.K., Quertermous, Thomas, Kim, Bong-Jo,, Lu, X.F., de Andrade, M, Hall, L., CARDIoGRAMplusC4D Consortium, Nikpay, Majid, Dehghan, Abbas, Ripatti, S., J. S. Kooner (7605356), Smith, Albert V.,, Perola, Markus, Gudnason, Vilmundur,, Erdmann, J, Huang, JB, Nelson, C., Mlindgren, C, Huang, Jie,, Pervjakova, N, Lieb, W, Memon, F-U-R, Wang, Laiyuan, Feitosa, Mary F, S. Kanoni (7626542), Webb, Thomas R.,, Stott, D.J., Hengstenberg, Christian,, Huang, J., Melander, O, Qu, Liming, U. Seedorf (7602437), Magnusson, Patrik K, Gottesman, O., Samuel, M, C. J. O'Donnell (7605308), Lau, King Wai,, Schwartz, Stephen M, Nikpay, Majid,, Trompet, Stella, Jalilzadeh, Shapour,, Gu, D, D. Gu (7809095), Sinisalo, Juha,, J. W. Jukema (7625996), Marz, W, Stott, David, Hwang, Shih-Jen,, D. J. Stott (7645202), Saxena, Richa,, Palmer, CNA, H.-H. Won (7809068), de Vries, PS, Ingelsson, E, Smith, A., Memon, Fazal-ur-Rehman, D. Gauguier (7780358), Lokki, Marja-Liisa,, C. N. Palmer (7611428), S. E. Epstein (7606061), Salfati, E, Shall, A, M. G. Franzosi (7602410), de Andrade, Mariza,, Gottesman, Omri, Schwartz, Stephen M., Sanghera, Dharambir K., Kim, YK, Schwartz, SM, Hwang, S-J, Hwang, Shih-Jen, Bertram, L, C. Willenborg (7605947), Hwang, SJ, Mihailov, Evelin, Scholz, M., M. Haber (7809074), Mallick, Nadeem H.,, Elosua, Roberto, M. S. Nieminen (7605854), Sanghera, DK, Kim, Bong Jo, Feitosa, MF, A. V. Smith (7605131), Koenig, Inke R.,, Morrison, Alanna C, C. Gieger (7609259), Rose, Lynda M.,, Deloukas, P, S. M. Schwartz (7606007), Kim, Y., P. M. Ridker (7605368), Ford, Ian,, Lokki, ML, Trompet, Stella,, Salomaa, V., Andrade, M. de, Jalilzadeh, Shapour, Lieb, W., Hall, Alistair S., CARDIoGRAMplusC4D Consortium (Nikpay, M. ; Goel, A. ; Won, H. ; Hall, L.M. ; Willenborg, C. ; Kanoni, S. ; Saleheen, D. ; Gieger, C. ; Meitinger, T. ; Peters, A. ; Watkins, H. ; Kathiresan, S. ; MacPherson, R.), N. Pervjakova (7647407), Shah, S.H., Salomaa, Veikko,, Farrall, M, Wang, Laiyuan,, Jukema, J. Wouter, D. Ardissino (7605992), Rasheed, Asif, Wang, L, Beutner, F., Deloukas, Panos,, Mallick, NH, Christopher Paul Nelson (7584644), Sanghera, Dharambir K, Cupples, L, P. S. de Vries (7809119), van Zuydam, N., Lyytikainen, L-P, Schwartz, S., Zeng, Lingyao,, Meitinger, T., Lehtimaki, Terho,, Stott, David J., Franco, Oscar H., Han, Bok-Ghee, van Zuydam, NR, Won, H.H., Bottinger, EP, Goel, Anuj,, Smith, A.V., Granger, C.B., Ripatti, S, Lindgren, Cecilia M, Hengstenberg, C, Mihailov, E., W. Lieb (7412738), Pedersen, N., Chasman, DI, CHopewell, Jemma, Bjonnes, A., L. Lannfelt (7652681), Franceschini, N., Epstein, SE, Chasman, D., N. H. Mallick (7809083), Stott, D., A. Peters (6004598), Thompson, J.R., Mallick, N., Bottinger, E., Mehra, Narinder,, Pedersen, N.L., Lyytikäinen, Leo-Pekka, Qu, L., A. Rasheed (7605908), Samani, N.J., Kullo, Iftikhar J, S.-J. Hwang (7760366), Rader, Daniel J., Kathiresan, S, Granger, Christopher B.,, Salfati, Elias, Pedersen, NL, Stewart, Alexandre F., Salfati, E., Han, Bok Ghee, Kleber, Marcus E., Gauguier, D., Epstein, S., Seedorf, U., T. R. Webb (2490886), A. Bjonnes (7780337), Collins, R, MArmasu, Sebastian, S. Ripatti (7606073), K. E. Stirrups (7626839), L. Wang (2327974), Lokki, M., Hwang, S.J., D. K. Sanghera (7780373), Kim, Bong-Jo, W. Zhang (820655), Hwang, S., Huang, Jie, Sanghera, D., L. Qu (822458), Collins, R., Y. K. Kim (7626704), Goodall, A.H., Farrall, M., Han, B-G, Karhunen, Pekka J.,, Lokki, Marja Liisa, Lyytikainen, L.P., Memon, Fazal Uur Rehman, Kullo, Iftikhar J., Willenborg, Christina,, Cupples, L Adrienne, Lau, KW, Samuel, M., A. S. Hall (7605176), Cupples, L. Adrienne, D. Saleheen (7605173), Zeng, L, Morrison, A., Franco, O., Chambers, J.C., M. Nikpay (7646114), J. C. Chambers (7605185), N. R. van Zuydam (7652276), Roberts, R., Kim, Yun Kyoung, Samani, Nilesh J, Rose, L.M., A. F. 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Grace (7809116), Saleheen, Danish, Schunkert, Heribert, Lindgren, CM, Ardissino, D, Lieb, Wolfgang, Kim, Y.K., Hall, Alistair S, Loos, R.J.F., Franzosi, M.G., Granger, Christopher B., Kathiresan, Sekar, Demuth, I, Perola, M., Haber, Marc,, Chasman, Daniel I.,, Lindgren, C., Marmasu, S, J. Erdmann (7603664), Thiery, J, O'Donnell, Christopher J.,, T. Quertermous (7626788), A. H. Goodall (7591808), Morris, A.P., Chasman, D.I., Borecki, I.B., X. Lu (2257870), Hwang, Shih Jen, K. W. Lau (7780340), Kooner, Jaspal S.,, A. P. Morris (7611419), A. C. Morrison (7625951), Lyytikainen, LP, Ripatti, Samuli, Armasu, SM, Hopewell, J.C., Danesh, John,, McPherson, R., Feitosa, M., Ridker, Paul M., Huang, Jianfeng,, Bertram, L., Jukema, J. Wouter,, Borecki, I., Samani, NJ, Meitinger, Thomas,, Danesh, J, I. J. Kullo (7646153), L.-P. Lyytikäinen (7725581), Harris, Tamara B, Zhao, W, Kathiresan, S., R. Roberts (2820928), T. 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Danesh (7605383), Hofman, Bert, Jukema, J Wouter, Watkins, H, Haber, Marc; id_orcid, Buring, Julie E., Dehghan, A, Lokki, M-L, Schwartz, Stephen M.,, Feitosa, Mary F., Webb, T., Buring, J.E., Armasu, S.M., Hall, Alistair S.,, Yang, Xueli,, Hamsten, A., Salfati, Elias,, Kleber, ME, Won, Hong-Hee,, Gieger, C., Alver, M, Kleber, M., Anand, Sonia S., Iribarren, C, Armasu, Sebastian M., Chambers, J., van Zuydam, Natalie R.,, Ridker, Paul M, S. S. Anand (7609130), Y. Lu (1469287), Lhazen, S, Mallick, Nadeem H, A. Dehghan (7626011), T. Lehtimäki (3495257), S. Chen (473170), Morrison, Alanna C., O'Donnell, Christopher J., X. Yang (2201716), Kessler, T, I. B. Borecki (7685702), D. I. Chasman (7605179), J. Sinisalo (6254942), Harris, T.B., Webb, TR, Auro, K, Clarke, Robert, Chambers, John C.,, Chambers, JC, Dedoussis, George, Samuel, Maria,, Hall, Alistair, Zaman, Khan S., L. A. Cupples (7605977), L. S. Rallidis (7626911), Gieger, Christian,, Lokki, M.L., L. M. 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Feitosa (7685738), O'Donnell, C.J., Rader, D.J., Lyytikäinen, L., Uitterlinden, Andre,, Dedoussis, George,, Grace, C., Loos, Ruth J. F.,, Haber, M, Meitinger, T, Bottinger, E.P., Zhao, W., Kim, B.J., Danesh, John, Hazen, S., König, I., Kim, BJ, Han, B.G., Hengstenberg, C., Zeng, L., Assimes, T.L., März, W., Hazen, SL, Pedersen, Nancy L.,, Lu, Y, König, IR, Kim, B., R. McPherson (7605974), N. Mehra (7809086), Lu, X, Rasheed, Asif,, D. J. Rader (7605215), Peters, A, Kyriakou, Theodosios, Thiery, Joachim,, Yang, X.L., Feitosa, M.F., Lannfelt, Lars,, McPherson, Ruth, Melander, Olle, P. Deloukas (7603691), Reilly, Muredach P, Lindgren, C.M., J. Huang (2342368), S. Jalilzadeh (7785812), Quertermous, T, E. Ingelsson (7605335), Alver, Maris,, Zhang, Weihua, O. H. Franco (7625993), Nieminen, Markku S., Sinisalo, J, Hofman, A, A. Hofman (4269889), Hopewell, Jemma C, H. Watkins (7602419), L. M. Hall (7809071), Hall, A.S., S. L. Hazen (7668347), Won, Hong-Hee, J. R. Thompson (6440546), W. März (7609394), Hopewell, JC, Trompet, S, Gustafsson, S, Kyriakou, T., Zalloua, PA, Stewart, Alexandre F, L. Bertram (3538832), M. Scholz (7780346), Elosua, Roberto,, Hamsten, Anders,, Chen, S.F., Maerz, Winfried, Webb, T.R., Chen, Shufeng, Ingelsson, Erik,, Hopewell, J., Rasheed, A, Metspalu, Andres,, Zalloua, P., Kim, B-J, Goodall, Alison H, Boerwinkle, Eric,, F.-U.-R. Memon (7809089), Clarke, Robert,, Hamsten, Anders, Reilly, M.P., Metspalu, Andres +928 more
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