Results 1 to 10 of about 35,658 (190)

Phenome-wide association study on miRNA-related sequence variants: the UK Biobank [PDF]

Human Genomics, 2023
Background Genetic variants in the coding region could directly affect the structure and expression levels of genes and proteins. However, the importance of variants in the non-coding region, such as microRNAs (miRNAs), remain to be elucidated.
Rima Mustafa, Mohsen Ghanbari, Ville Karhunen, Marina Evangelou, Abbas Dehghan   +4 more
doaj   +7 more sources

Air pollution and human health: a phenome-wide association study [PDF]

BMJ Open
Objectives To explore the associations of long-term exposure to air pollution with onset of all human health conditions.Design Prospective phenome-wide association study.Setting Denmark.Participants All Danish residents aged ≥30 years on 1 January 2000 ...
Laust Hvas Mortensen, Amar J Mehta, Kees de Hoogh, Gerard Hoek, Bert Brunekreef, Youn-Hee Lim, Steffen Loft, Zorana J Andersen, Emilie Rune Hegelund   +8 more
doaj   +6 more sources

Polygenic risk score phenome-wide association study reveals an association between endometriosis and testosterone [PDF]

BMC Medicine, 2023
Background Endometriosis affects 1 in 9 women, yet it is poorly understood with long diagnostic delays, invasive diagnoses, and poor treatment outcomes. Characterised by the presence of endometrial-like tissue outside of the uterus, its main symptoms are
Isabelle M. McGrath, International Endometriosis Genetics Consortium, Grant W. Montgomery, Sally Mortlock   +3 more
doaj   +5 more sources

Sex-specific Mendelian randomization phenome-wide association study of basal metabolic rate [PDF]

Scientific Reports
Observationally, higher basal metabolic rate (BMR) is associated with metabolism-related disorders, cancer, aging, and mortality. In this Mendelian randomization (MR) phenome-wide association study, using two-sample MR methods, we systematically and ...
Jack C. M. Ng, C. Mary Schooling
doaj   +4 more sources

Phenome‐Wide Association Study of Severe COVID‐19 Genetic Risk Variants [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
AbstractBackgroundGenetic loci associated with risk of severe COVID-19 infection have been identified and individuals with complicated COVID-19 infections often have multiple comorbidities.ObjectiveIdentify known and unidentified comorbidities associated with genetic loci linked to risk of severe COVID-19 infection.MethodsA Phenome Wide Association ...
Jessica A. Regan, Jawan W. Abdulrahim, Nathan A. Bihlmeyer, Carol Haynes, Lydia Coulter Kwee, Manesh R. Patel, Svati H. Shah   +6 more
doaj   +6 more sources

Phenome-wide association study identifies new clinical phenotypes associated with Staphylococcus aureus infections. [PDF]

PLoS ONE
BackgroundPhenome-Wide Association study (PheWAS) is a powerful tool designed to systematically screen clinical observations derived from medical records (phenotypes) for association with a variable of interest.
Patrick Allaire, Noha S Elsayed, Richard L Berg, Warren Rose, Sanjay K Shukla   +4 more
doaj   +4 more sources

A sex-specific Mendelian randomization-phenome-wide association study of body mass index [PDF]

eLife
Background: Trials of incretins are making it increasingly clear that body mass index (BMI) is linked to several diseases throughout life, but trials cannot easily provide a comprehensive assessment of the role of BMI in health-related attributes for men
Zhu Liduzi Jiesisibieke, Io Ieong Chan, Jack Chun Man Ng, C Mary Schooling   +3 more
doaj   +2 more sources

Comprehensive analysis of genetic associations and single-cell expression profiles reveals potential links between migraine and multiple diseases: a phenome-wide association study [PDF]

Frontiers in Neurology
Migraine is a common neurological disorder that affects more than one billion people worldwide. Recent genome-wide association studies have identified 123 genetic loci associated with migraine risk.
Di Ouyang, Di Ouyang, Chunying Huang, Huihua Liu, Weiming Xie, Chengsheng Chen, Ben Su, Lizhong Guo   +7 more
doaj   +2 more sources

Genetically mimicked effects of ASGR1 inhibitors on all-cause mortality and health outcomes: a drug-target Mendelian randomization study and a phenome-wide association study [PDF]

BMC Medicine, 2023
Background Asialoglycoprotein receptor 1 (ASGR1) is emerging as a potential drug target to reduce low-density lipoprotein (LDL)-cholesterol and coronary artery disease (CAD) risk.
Guoyi Yang, C. Mary Schooling
doaj   +2 more sources

A phenome-wide association study of polygenic scores for selected childhood cancer: Results from the UK Biobank [PDF]

HGG Advances
Summary: The aim of this study was to scan phenotypes in adulthood associated with polygenic risk scores (PRS) for childhood cancers with well-articulated genetic architectures—acute lymphoblastic leukemia (ALL), Ewing sarcoma, and neuroblastoma—to ...
Eun Mi Jung, Andrew R. Raduski, Lauren J. Mills, Logan G. Spector   +3 more
doaj   +2 more sources