Results 41 to 50 of about 39,899,172 (210)

Phenome-Wide Association Study of Actigraphy in the UK Biobank [PDF]

, 2021
Abstract Wrist-worn accelerometer actigraphy devices present the opportunity for large-scale data collection from people during their daily lives. Using data from approximately 100,000 participants in the UK Biobank, actigraphy-derived measures of physical activity, sleep, and diurnal rhythms were associated in exploration and ...
Thomas G. Brooks, Nicholas F. Lahens, Gregory R. Grant, Yvette I. Sheline, Garret A. FitzGerald, Carsten Skarke   +5 more
openaire   +1 more source

Profiling phenome-wide associations: a population-based observational study [PDF]

Journal of the American Medical Informatics Association, 2015
Abstract Objectives To objectively characterize phenome-wide associations observed in the entire Taiwanese population and represent them in a meaningful, interpretable way. Study Design In this population-based observational study, we analyzed 782 million outpatient visits and 15 394 unique phenotypes that were observed in
Syed Abdul Shabbir, Max Moldovan, Phung Anh Nguyen, Ruslan Enikeev, Wen-Shan Jian, Usman Iqbal, Min-Huei Hsu, Yu-Chuan Li   +7 more
openaire   +2 more sources

Visually integrating and exploring high throughput Phenome-Wide Association Study (PheWAS) results using PheWAS-View

BioData Mining, 2012
Background Phenome-Wide Association Studies (PheWAS) can be used to investigate the association between single nucleotide polymorphisms (SNPs) and a wide spectrum of phenotypes.
Pendergrass Sarah A, Dudek Scott M, Crawford Dana C, Ritchie Marylyn D   +3 more
doaj   +1 more source

Biobanking across the phenome - at the center of chronic disease research [PDF]

, 2013
Recognized public health relevant risk factors such as obesity, physical inactivity, smoking or air pollution are common to many non-communicable diseases (NCDs). NCDs cluster and co-morbidities increase in parallel to age.
Nicole M Probst-Hensch, Imboden, Medea, Medea Imboden, Probst-Hensch, Nicole M.   +3 more
core   +2 more sources

HCLC-FC: a novel statistical method for phenome-wide association studies

PLOS ONE, 2022
Abstract The emergence of genetic data coupled to longitudinal electronic medical records (EMRs) offers the possibility of phenome-wide association studies (PheWAS). In PheWAS, the whole phenome can be divided into numerous phenotypic categories according to the genetic architecture across phenotypes.
Xiaoyu Liang, Xuewei Cao, Qiuying Sha, Shuanglin Zhang   +3 more
openaire   +3 more sources

Phenome-wide associations with genetically predicted height in non-Hispanic White individuals.

, 2022
Plot of phecodes versus -log10(p-value) for association with genetically-predicted height in non-Hispanic White participants in MVP. Phecodes were limited to single decimal place for clarity (e.g., 427.2 for atrial fibrillation or flutter is shown but ...
Kyong-Mi Chang (267170), Hongyu Zhao (4728), Eirini Marouli (4585735), Kari E. North (6733304), Themistocles L. Assimes (7658045), Kelly Cho (289664), J. Michael Gaziano (12032696), Saiju Pyarajan (66900), Chang Liu (35901), Leslie A. Lange (8661951), Christopher J. O’Donnell (110479), Jie Huang (104235), Elizabeth Litkowski (10821435), Philip S. Tsao (8636055), Catherine Tcheandjieu (8379342), Jennifer E. Huffman (7665404), Benjamin F. Voight (8543690), Elizabeth R. Hauser (10713513), Sridharan Raghavan (83847), Yuk-Lam A. Ho (12732738), Haley Hunter-Zinck (711979), Ethan Lange (3457229), Yan V. Sun (7437632), Peter W. F. Wilson (8636052)   +23 more
core   +1 more source

Allergy-specific Phenome-Wide Association Study for Immunogenes in Turkish Children [PDF]

Scientific Reports, 2016
AbstractTo dissect the role of immunogenetics in allergy and asthma, we performed a phenome-wide association study in 974 Turkish children selected from a cross-sectional study conducted using ISAAC (International Study of Asthma and Allergies in Children) Phase II tools.
Karaca, Sefayet, Civelek, Ersoy, Karaca, Mehmet, Sahiner, Umit M., Ozgul, Riza K., Kocabas, Can N., Polimanti, Renato, Sekerel, Bulent E.   +7 more
openaire   +5 more sources

Phenome-wide associations with genetically predicted height in non-Hispanic Black individuals.

, 2022
Plot of phecodes versus -log10(p-value) for association with genetically-predicted height in non-Hispanic Black participants in MVP. Phecodes were limited to single decimal place for clarity (e.g., 427.2 for atrial fibrillation or flutter is shown but ...
Kyong-Mi Chang (267170), Hongyu Zhao (4728), Eirini Marouli (4585735), Kari E. North (6733304), Themistocles L. Assimes (7658045), Kelly Cho (289664), J. Michael Gaziano (12032696), Saiju Pyarajan (66900), Chang Liu (35901), Leslie A. Lange (8661951), Christopher J. O’Donnell (110479), Jie Huang (104235), Elizabeth Litkowski (10821435), Philip S. Tsao (8636055), Catherine Tcheandjieu (8379342), Jennifer E. Huffman (7665404), Benjamin F. Voight (8543690), Elizabeth R. Hauser (10713513), Sridharan Raghavan (83847), Yuk-Lam A. Ho (12732738), Haley Hunter-Zinck (711979), Ethan Lange (3457229), Yan V. Sun (7437632), Peter W. F. Wilson (8636052)   +23 more
core   +1 more source

A multi-population phenome-wide association study of genetically-predicted height in the Million Veteran Program [PDF]

, 2022
Background Height has been associated with many clinical traits but whether such associations are causal versus secondary to confounding remains unclear in many cases.
Raghavan, S., Lange, E., Tsao, P.S., Hunter-Zinck, H., Marouli, E., Sun, Y.V., Huffman, J.E., Pyarajan, S., Voight, B.F., Tcheandjieu, C., Cho, K., North, K.E., Lange, L.A., Assimes, T.L., Gaziano, J.M., Wilson, P.W.F., Ho, Y.-L.A., O'Donnell, C.J., Liu, C., Chang, K.-M., Zhao, H., Huang, J., Litkowski, E., Hauser, E.R.   +23 more
core   +1 more source

Revealing polygenic pleiotropy using genetic risk scores for asthma

HGG Advances, 2023
Summary: In this study we examined how genetic risk for asthma associates with different features of the disease and with other medical conditions and traits.
Matthew Dapas, Yu Lin Lee, William Wentworth-Sheilds, Hae Kyung Im, Carole Ober, Nathan Schoettler   +5 more
doaj   +1 more source