Results 1 to 10 of about 7,071,839 (288)

Polygenic risk score: use in migraine research [PDF]

The Journal of Headache and Pain, 2018
Background The latest Genome-Wide Association Study identified 38 genetic variants associated with migraine. In this type of studies the significance level is very difficult to achieve (5 × 10− 8) due to multiple testing.
Mona Ameri Chalmer, Ann-Louise Esserlind, Jes Olesen, Thomas Folkmann Hansen   +3 more
doaj   +2 more sources

Physical activity, polygenic risk score, and colorectal cancer risk

Cancer Medicine, 2023
Introduction Whether and to what extent the relationship between physical activity (PA) and colorectal cancer (CRC) differs according to CRC‐related genetic risk remains to be determined, and no studies to date have quantified how much genetically ...
Xuechen Chen, Feng Guo, Jenny Chang‐Claude, Michael Hoffmeister, Hermann Brenner   +4 more
doaj   +1 more source

Twelve Variants Polygenic Score for Low‐Density Lipoprotein Cholesterol Distribution in a Large Cohort of Patients With Clinically Diagnosed Familial Hypercholesterolemia With or Without Causative Mutations

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background A significant proportion of individuals clinically diagnosed with familial hypercholesterolemia (FH), but without any disease‐causing mutation, are likely to have polygenic hypercholesterolemia.
Elena Olmastroni, Marta Gazzotti, Marcello Arca, Maurizio Averna, Angela Pirillo, Alberico Luigi Catapano, Manuela Casula   +6 more
doaj   +1 more source

Design and user experience testing of a polygenic score report: a qualitative study of prospective users

BMC Medical Genomics, 2021
Background Polygenic scores—which quantify inherited risk by integrating information from many common sites of DNA variation—may enable a tailored approach to clinical medicine. However, alongside considerable enthusiasm, we and others have highlighted a
Deanna G. Brockman, Lia Petronio, Jacqueline S. Dron, Bum Chul Kwon, Trish Vosburg, Lisa Nip, Andrew Tang, Mary O’Reilly, Niall Lennon, Bang Wong, Kenney Ng, Katherine H. Huang, Akl C. Fahed, Amit V. Khera   +13 more
doaj   +1 more source

A multi-ethnic polygenic risk score is associated with hypertension prevalence and progression throughout adulthood

Nature Communications, 2022
Polygenic risk scores have potential to predict an individual’s risk of disease based on genetic markers. Here, the authors develop a polygenic risk score for hypertension and test it in a multi-ethnic cohort, finding that the score is associated with ...
Nuzulul Kurniansyah, Matthew O. Goodman, Tanika N. Kelly, Tali Elfassy, Kerri L. Wiggins, Joshua C. Bis, Xiuqing Guo, Walter Palmas, Kent D. Taylor, Henry J. Lin, Jeffrey Haessler, Yan Gao, Daichi Shimbo, Jennifer A. Smith, Bing Yu, Elena V. Feofanova, Roelof A. J. Smit, Zhe Wang, Shih-Jen Hwang, Simin Liu, Sylvia Wassertheil-Smoller, JoAnn E. Manson, Donald M. Lloyd-Jones, Stephen S. Rich, Ruth J. F. Loos, Susan Redline, Adolfo Correa, Charles Kooperberg, Myriam Fornage, Robert C. Kaplan, Bruce M. Psaty, Jerome I. Rotter, Donna K. Arnett, Alanna C. Morrison, Nora Franceschini, Daniel Levy, the NHLBI Trans-Omics in Precision Medicine (TOPMed) Consortium, Tamar Sofer   +37 more
doaj   +1 more source

Construction and Application of Polygenic Risk Scores in Autoimmune Diseases

Frontiers in Immunology, 2022
Genome-wide association studies (GWAS) have identified hundreds of genetic variants associated with autoimmune diseases and provided unique mechanistic insights and informed novel treatments.
Chachrit Khunsriraksakul, Chachrit Khunsriraksakul, Havell Markus, Havell Markus, Nancy J. Olsen, Laura Carrel, Bibo Jiang, Dajiang J. Liu, Dajiang J. Liu   +8 more
doaj   +1 more source

GenoRisk: A polygenic risk score for Alzheimer's disease

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2021
Introduction Recent clinical trials are considering inclusion of more than just apolipoprotein E (APOE) ε4 genotype as a way of reducing variability in analysis of outcomes.
Samuel P. Dickson, Suzanne B. Hendrix, Bruce L. Brown, Perry G. Ridge, Jessie Nicodemus‐Johnson, Marci L. Hardy, Allison M. McKeany, Steven B. Booth, Ryan R. Fortna, John S.K. Kauwe, NIAGADS   +10 more
doaj   +1 more source

Polygenic risk score penetrance & recurrence risk in familial Alzheimer disease

Annals of Clinical and Translational Neurology, 2023
Objective To compute penetrance and recurrence risk using a genome‐wide PRS (including and excluding the APOE region) in families with Alzheimer's disease. Methods Genotypes from the National Institute on Aging Late‐Onset Alzheimer's Disease Family‐Based
Min Qiao, Annie J. Lee, Dolly Reyes‐Dumeyer, Giuseppe Tosto, Kelley Faber, Alison Goate, Alan Renton, Michael Chao, Brad Boeve, Carlos Cruchaga, Margaret Pericak‐Vance, Jonathan L. Haines, Roger Rosenberg, Debby Tsuang, Robert A. Sweet, David A. Bennett, Robert S. Wilson, Tatiana Foroud, Richard Mayeux, Badri N. Vardarajan   +19 more
doaj   +1 more source

Polygenic risk score, healthy lifestyles, and risk of incident depression

Translational Psychiatry, 2021
Genetic factors increase the risk of depression, but the extent to which this can be offset by modifiable lifestyle factors is unknown. We investigated whether a combination of healthy lifestyles is associated with lower risk of depression regardless of ...
Zhi Cao, Hongxi Yang, Yixuan Ye, Yuan Zhang, Shu Li, Hongyu Zhao, Yaogang Wang   +6 more
doaj   +1 more source

Global trajectories of polygenic risk score research: a systematic bibliometric review of precision medicine, equity, and clinical translation

Frontiers in Medicine
IntroductionPolygenic risk scores (PRS) have emerged as a central tool in genomic medicine, enabling risk prediction for common, complex diseases. Despite rapid methodological and clinical advances, concerns remain regarding the structural organization ...
Fouad Bitar, Fouad Bitar, Rana Zareef, Roukoz Abou-Karam, Roukoz Abou-Karam, Georges Nemer, Fadi F. Bitar, Akl C. Fahed, Akl C. Fahed, Akl C. Fahed, Zahi Abdul Sater   +10 more
doaj   +1 more source