Results 1 to 10 of about 31,405 (257)

Polygenic Risk Score Prediction for Endometriosis [PDF]

Frontiers in Reproductive Health, 2021
Endometriosis is a major health care challenge because many young women with endometriosis go undetected for an extended period, which may lead to pain sensitization.
Kirstine Kloeve-Mogensen, Kirstine Kloeve-Mogensen, Palle Duun Rohde, Palle Duun Rohde, Simone Twisttmann, Marianne Nygaard, Kristina Magaard Koldby, Rudi Steffensen, Christian Møller Dahl, Dorte Rytter, Michael Toft Overgaard, Axel Forman, Lene Christiansen, Lene Christiansen, Mette Nyegaard, Mette Nyegaard   +15 more
doaj   +8 more sources

Global trajectories of polygenic risk score research: a systematic bibliometric review of precision medicine, equity, and clinical translation [PDF]

Frontiers in Medicine
IntroductionPolygenic risk scores (PRS) have emerged as a central tool in genomic medicine, enabling risk prediction for common, complex diseases. Despite rapid methodological and clinical advances, concerns remain regarding the structural organization ...
Fouad Bitar, Fouad Bitar, Rana Zareef, Roukoz Abou-Karam, Roukoz Abou-Karam, Georges Nemer, Fadi F. Bitar, Akl C. Fahed, Akl C. Fahed, Akl C. Fahed, Zahi Abdul Sater   +10 more
doaj   +2 more sources

Physical activity, polygenic risk score, and colorectal cancer risk

Cancer Medicine, 2023
Introduction Whether and to what extent the relationship between physical activity (PA) and colorectal cancer (CRC) differs according to CRC‐related genetic risk remains to be determined, and no studies to date have quantified how much genetically ...
Xuechen Chen, Feng Guo, Jenny Chang‐Claude, Michael Hoffmeister, Hermann Brenner   +4 more
doaj   +2 more sources

Integration of risk factor polygenic risk score with disease polygenic risk score for disease prediction

Communications Biology
Polygenic risk score (PRS) is useful for capturing an individual’s genetic susceptibility. However, previous studies have not fully exploited the potential of the risk factor PRS (RFPRS) for disease prediction.
Hyein Jung, Hae-Un Jung, Eun Ju Baek, Shin Young Kwon, Ji-One Kang, Ji Eun Lim, Bermseok Oh   +6 more
doaj   +3 more sources

Polygenic risk score prediction accuracy convergence [PDF]

HGG Advances
Summary: Polygenic risk scores (PRSs) models trained from genome-wide association study (GWAS) results are set to play a pivotal role in biomedical research addressing multifactorial human diseases.
Léo Henches, Jihye Kim, Zhiyu Yang, Simone Rubinacci, Gabriel Pires, Clara Albiñana, Christophe Boetto, Hanna Julienne, Arthur Frouin, Antoine Auvergne, Yuka Suzuki, Sarah Djebali, Olivier Delaneau, Andrea Ganna, Bjarni Vilhjálmsson, Florian Privé, Hugues Aschard   +16 more
doaj   +2 more sources

ApplyPolygenicScore: An R package for applying polygenic risk score models [PDF]

Genetics in Medicine Open
Purpose: A polygenic score (PGS) predicts an individual’s genetic predisposition to a complex trait. A PGS is created by estimating the relative contributions of multiple common variants to the overall trait, creating a polygenic risk model (PGM).
Nicole Zeltser, Rachel M.A. Dang, Rupert Hugh-White, Daniel Knight, Jaron Arbet, Paul C. Boutros   +5 more
doaj   +2 more sources

Polygenic Risk Score and Risk Factors for Gestational Diabetes

Journal of Personalized Medicine, 2022
Gestational diabetes mellitus (GDM) is a common complication of pregnancy that adversely affects maternal and offspring health. A variety of risk factors, such as BMI and age, have been associated with increased risks of gestational diabetes. However, in many cases, gestational diabetes occurs in healthy nulliparous women with no obvious risk factors ...
Mario Štorga
exaly   +5 more sources

Risk score roulette: A cautionary tale of polygenic risk score reliability. [PDF]

J Alzheimers Dis
Genetic risk prediction for Alzheimer's disease (AD) has high potential impact, yet few studies have assessed the reliability of various polygenic risk score (PRS) methods at the individual level. Here, we evaluated the reliability of AD PRS estimates among 6338 participants from the Multi-Ethnic Study of Atherosclerosis.
Xue D, Blue EE, Wood AC, Rotter JI, Fohner AE.   +4 more
europepmc   +4 more sources

Polygene Risk Scores

Philosophy of Medicine, 2023
This paper explores the interpretation and use of polygenic risk scores (PRSs). We argue that PRSs generally do not directly embody causal information. Nonetheless, they can assist us in tracking other causal relationships concerning genetic effects.
James Woodward, Kenneth Kendler
openaire   +3 more sources

Polygenic Risk Scores and Physical Activity [PDF]

Medicine & Science in Sports & Exercise, 2020
ABSTRACT Purpose Polygenic risk scores (PRS) summarize genome-wide genotype data into a single variable that produces an individual-level risk score for genetic liability. PRS has been used for prediction of chronic diseases and some risk factors. As PRS has been studied less for physical activity (PA), we constructed
Kujala, Urho M., Palviainen, Teemu, Pesonen, Paula, Waller, Katja, Sillanpää, Elina, Niemelä, Maisa, Kangas, Maarit, Vähä-Ypyä, Henri, Sievänen, Harri, Korpelainen, Raija, Jämsä, Timo, Männikkö, Minna, Kaprio, Jaakko   +13 more
openaire   +5 more sources