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Polygenic Risk Score Prediction for Endometriosis [PDF]
Frontiers in Reproductive Health, 2021 Endometriosis is a major health care challenge because many young women with endometriosis go undetected for an extended period, which may lead to pain sensitization.
Kirstine Kloeve-Mogensen +15 more
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Polygenic risk score translation across diverse populations [PDF]
Frontiers in Cardiovascular MedicinePolygenic risk scores (PRSs) are increasingly being considered as tools to refine risk stratification in cardiovascular and cardiometabolic disease, but their clinical translation remains constrained by a central limitation: most currently available PRSs
Jose E. Krieger
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Communications BiologyPolygenic risk score (PRS) is useful for capturing an individual’s genetic susceptibility. However, previous studies have not fully exploited the potential of the risk factor PRS (RFPRS) for disease prediction.
Hyein Jung +6 more
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Physical activity, polygenic risk score, and colorectal cancer risk
Cancer Medicine, 2023 Introduction Whether and to what extent the relationship between physical activity (PA) and colorectal cancer (CRC) differs according to CRC‐related genetic risk remains to be determined, and no studies to date have quantified how much genetically ...
Xuechen Chen +4 more
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Polygenic Risk Score and Risk Factors for Gestational Diabetes
Journal of Personalized Medicine, 2022 Gestational diabetes mellitus (GDM) is a common complication of pregnancy that adversely affects maternal and offspring health. A variety of risk factors, such as BMI and age, have been associated with increased risks of gestational diabetes. However, in many cases, gestational diabetes occurs in healthy nulliparous women with no obvious risk factors ...
Marija Majda Perisic, Mario Štorga
exaly +5 more sources
Global trajectories of polygenic risk score research: a systematic bibliometric review of precision medicine, equity, and clinical translation [PDF]
Frontiers in MedicineIntroductionPolygenic risk scores (PRS) have emerged as a central tool in genomic medicine, enabling risk prediction for common, complex diseases. Despite rapid methodological and clinical advances, concerns remain regarding the structural organization ...
Fouad Bitar +10 more
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ApplyPolygenicScore: An R package for applying polygenic risk score models [PDF]
Genetics in Medicine OpenPurpose: A polygenic score (PGS) predicts an individual’s genetic predisposition to a complex trait. A PGS is created by estimating the relative contributions of multiple common variants to the overall trait, creating a polygenic risk model (PGM).
Nicole Zeltser +5 more
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Philosophy of Medicine, 2023 This paper explores the interpretation and use of polygenic risk scores (PRSs). We argue that PRSs generally do not directly embody causal information. Nonetheless, they can assist us in tracking other causal relationships concerning genetic effects.
James Woodward, Kenneth Kendler
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Polygenic Risk Scores and Physical Activity [PDF]
Medicine & Science in Sports & Exercise, 2020 ABSTRACT Purpose Polygenic risk scores (PRS) summarize genome-wide genotype data into a single variable that produces an individual-level risk score for genetic liability. PRS has been used for prediction of chronic diseases and some risk factors. As PRS has been studied less for physical activity (PA), we constructed
Kujala, Urho M. +13 more
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Polygenic Score Models for Alzheimer’s Disease: From Research to Clinical Applications
Frontiers in Neuroscience, 2021 The high prevalence of Alzheimer’s disease (AD) among the elderly population and its lack of effective treatments make this disease a critical threat to human health.
Xiaopu Zhou +9 more
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