Results 21 to 30 of about 31,405 (257)

Twelve Variants Polygenic Score for Low‐Density Lipoprotein Cholesterol Distribution in a Large Cohort of Patients With Clinically Diagnosed Familial Hypercholesterolemia With or Without Causative Mutations

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background A significant proportion of individuals clinically diagnosed with familial hypercholesterolemia (FH), but without any disease‐causing mutation, are likely to have polygenic hypercholesterolemia.
Elena Olmastroni, Marta Gazzotti, Marcello Arca, Maurizio Averna, Angela Pirillo, Alberico Luigi Catapano, Manuela Casula   +6 more
doaj   +1 more source

Polygenic Risk Scores for Subtyping of Schizophrenia [PDF]

Schizophrenia Research and Treatment, 2020
Schizophrenia is a complex disorder with many comorbid conditions. In this study, we used polygenic risk scores (PRSs) from schizophrenia and comorbid traits to explore consistent cluster structure in schizophrenia patients. With 10 comorbid traits, we found a stable 4-cluster structure in two datasets (MGS and SSCCS).
Jingchun Chen, Travis Mize, Jain-Shing Wu, Elliot Hong, Vishwajit Nimgaonkar, Kenneth S. Kendler, Daniel Allen, Edwin Oh, Alison Netski, Xiangning Chen   +9 more
openaire   +3 more sources

Design and user experience testing of a polygenic score report: a qualitative study of prospective users

BMC Medical Genomics, 2021
Background Polygenic scores—which quantify inherited risk by integrating information from many common sites of DNA variation—may enable a tailored approach to clinical medicine. However, alongside considerable enthusiasm, we and others have highlighted a
Deanna G. Brockman, Lia Petronio, Jacqueline S. Dron, Bum Chul Kwon, Trish Vosburg, Lisa Nip, Andrew Tang, Mary O’Reilly, Niall Lennon, Bang Wong, Kenney Ng, Katherine H. Huang, Akl C. Fahed, Amit V. Khera   +13 more
doaj   +1 more source

Construction and Application of Polygenic Risk Scores in Autoimmune Diseases

Frontiers in Immunology, 2022
Genome-wide association studies (GWAS) have identified hundreds of genetic variants associated with autoimmune diseases and provided unique mechanistic insights and informed novel treatments.
Chachrit Khunsriraksakul, Chachrit Khunsriraksakul, Havell Markus, Havell Markus, Nancy J. Olsen, Laura Carrel, Bibo Jiang, Dajiang J. Liu, Dajiang J. Liu   +8 more
doaj   +1 more source

Polygenic risk score: use in migraine research

The Journal of Headache and Pain, 2018
Background The latest Genome-Wide Association Study identified 38 genetic variants associated with migraine. In this type of studies the significance level is very difficult to achieve (5 × 10− 8) due to multiple testing.
Mona Ameri Chalmer, Ann-Louise Esserlind, Jes Olesen, Thomas Folkmann Hansen   +3 more
doaj   +1 more source

Polygenic risk scores

Seminars in Arthritis and Rheumatism
Polygenic risk scores (PRS) estimate an individual's genetic risk for a disease or trait compared to a matched population. For many rheumatic diseases PRS have been developed that have discriminatory capacity better than some widely used biomarkers, and in some cases are the most discriminatory tests available.
Brian T. Palmisano, Joshua W. Knowles
  +6 more sources

A multi-ethnic polygenic risk score is associated with hypertension prevalence and progression throughout adulthood

Nature Communications, 2022
Polygenic risk scores have potential to predict an individual’s risk of disease based on genetic markers. Here, the authors develop a polygenic risk score for hypertension and test it in a multi-ethnic cohort, finding that the score is associated with ...
Nuzulul Kurniansyah, Matthew O. Goodman, Tanika N. Kelly, Tali Elfassy, Kerri L. Wiggins, Joshua C. Bis, Xiuqing Guo, Walter Palmas, Kent D. Taylor, Henry J. Lin, Jeffrey Haessler, Yan Gao, Daichi Shimbo, Jennifer A. Smith, Bing Yu, Elena V. Feofanova, Roelof A. J. Smit, Zhe Wang, Shih-Jen Hwang, Simin Liu, Sylvia Wassertheil-Smoller, JoAnn E. Manson, Donald M. Lloyd-Jones, Stephen S. Rich, Ruth J. F. Loos, Susan Redline, Adolfo Correa, Charles Kooperberg, Myriam Fornage, Robert C. Kaplan, Bruce M. Psaty, Jerome I. Rotter, Donna K. Arnett, Alanna C. Morrison, Nora Franceschini, Daniel Levy, the NHLBI Trans-Omics in Precision Medicine (TOPMed) Consortium, Tamar Sofer   +37 more
doaj   +1 more source

Polygenic transcriptome risk scores (PTRS) can improve portability of polygenic risk scores across ancestries [PDF]

Genome Biology, 2022
Abstract Background Polygenic risk scores (PRS) are valuable to translate the results of genome-wide association studies (GWAS) into clinical practice. To date, most GWAS have been based on individuals of European-ancestry leading to poor performance in populations of non-European ancestry.
Yanyu Liang, Milton Pividori, Ani Manichaikul, Abraham A. Palmer, Nancy J. Cox, Heather E. Wheeler, Hae Kyung Im   +6 more
openaire   +4 more sources

Polygenic Risk Scores Expand to Obesity [PDF]

Cell, 2019
Obesity is one of the most serious health challenges of our time. In this issue of Cell, Khera and co-authors demonstrate the striking ability of genetics, in the form of a polygenic risk score, to identify those individuals at high risk for obesity.
Ali, Torkamani, Eric, Topol
openaire   +2 more sources

NAFLD‐related hepatocellular carcinoma: The growing challenge

Hepatology, EarlyView., 2022
Risk and protective factors for NAFLD‐related hepatocellular carcinoma Abstract Hepatocellular carcinoma (HCC) is a common cause of cancer‐related mortality and morbidity worldwide. With the obesity pandemic, NAFLD‐related HCC is contributing to the burden of disease exponentially.
Pir Ahmad Shah, Rashmee Patil, Stephen A. Harrison   +2 more
wiley   +1 more source