Results 21 to 30 of about 7,071,839 (288)

Polygenic Risk Scores and Physical Activity [PDF]

Medicine & Science in Sports & Exercise, 2020
ABSTRACT Purpose Polygenic risk scores (PRS) summarize genome-wide genotype data into a single variable that produces an individual-level risk score for genetic liability. PRS has been used for prediction of chronic diseases and some risk factors. As PRS has been studied less for physical activity (PA), we constructed
Kujala, Urho M., Palviainen, Teemu, Pesonen, Paula, Waller, Katja, Sillanpää, Elina, Niemelä, Maisa, Kangas, Maarit, Vähä-Ypyä, Henri, Sievänen, Harri, Korpelainen, Raija, Jämsä, Timo, Männikkö, Minna, Kaprio, Jaakko   +13 more
openaire   +6 more sources

Polygenic Score Models for Alzheimer’s Disease: From Research to Clinical Applications

Frontiers in Neuroscience, 2021
The high prevalence of Alzheimer’s disease (AD) among the elderly population and its lack of effective treatments make this disease a critical threat to human health.
Xiaopu Zhou, Xiaopu Zhou, Xiaopu Zhou, Yolanda Y. T. Li, Amy K. Y. Fu, Amy K. Y. Fu, Amy K. Y. Fu, Nancy Y. Ip, Nancy Y. Ip, Nancy Y. Ip   +9 more
doaj   +1 more source

Development of risk prediction models for depression combining genetic and early life risk factors

Frontiers in Neuroscience, 2023
BackgroundBoth genetic and early life risk factors play important roles in the pathogenesis and progression of adult depression. However, the interplay between these risk factors and their added value to risk prediction models have not been fully ...
Tianyuan Lu, Patrícia Pelufo Silveira, Patrícia Pelufo Silveira, Celia M. T. Greenwood, Celia M. T. Greenwood, Celia M. T. Greenwood, Celia M. T. Greenwood   +6 more
doaj   +1 more source

Prostate cancer risk prediction using a polygenic risk score [PDF]

, 2022
Hereditary factors have a strong influence on prostate cancer (PC) risk and poorer outcomes, thus stratification by genetic factors addresses a critical need for targeted PC screening and risk-adapted follow-up.
Kimmo Taari, Kirsi M. Talala, Csilla Sipeky, Teuvo L. J. Tammela, Anssi Auvinen & Johanna Schleutker   +4 more
core   +3 more sources

Calculating Polygenic Risk Scores (PRS) in UK Biobank: A Practical Guide for Epidemiologists

Frontiers in Genetics, 2022
A polygenic risk score estimates the genetic risk of an individual for some disease or trait, calculated by aggregating the effect of many common variants associated with the condition.
Jennifer A. Collister, Xiaonan Liu, Lei Clifton   +2 more
doaj   +1 more source

Association of Joint Genetic and Social Environmental Risks With Incident Myocardial Infarction: Results From the Health and Retirement Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background Myocardial infarction (MI) is a significant clinical and public health problem worldwide. However, little research has assessed the interplay between genetic susceptibility and social environment in the development of MI.
Junhan Tang, Chen Sheng, Yan Yan Wu, Lijing L. Yan, Chenkai Wu   +4 more
doaj   +1 more source

Polygenic risk score improves the accuracy of a clinical risk score for coronary artery disease

BMC Medicine, 2022
Background The value of polygenic risk scores (PRSs) towards improving guideline-recommended clinical risk models for coronary artery disease (CAD) prediction is controversial.
Austin King, Lang Wu, Hong-Wen Deng, Hui Shen, Chong Wu   +4 more
doaj   +1 more source

Polygenic Risk Scores for Subtyping of Schizophrenia [PDF]

Schizophrenia Research and Treatment, 2020
Schizophrenia is a complex disorder with many comorbid conditions. In this study, we used polygenic risk scores (PRSs) from schizophrenia and comorbid traits to explore consistent cluster structure in schizophrenia patients. With 10 comorbid traits, we found a stable 4-cluster structure in two datasets (MGS and SSCCS).
Jingchun Chen, Travis Mize, Jain-Shing Wu, Elliot Hong, Vishwajit Nimgaonkar, Kenneth S. Kendler, Daniel Allen, Edwin Oh, Alison Netski, Xiangning Chen   +9 more
openaire   +3 more sources

On cross-ancestry cancer polygenic risk scores [PDF]

PLOS Genetics, 2021
Polygenic risk scores (PRS) can provide useful information for personalized risk stratification and disease risk assessment, especially when combined with non-genetic risk factors. However, their construction depends on the availability of summary statistics from genome-wide association studies (GWAS) independent from the target sample.
Lars G. Fritsche, Ying Ma, Daiwei Zhang, Maxwell Salvatore, Seunggeun Lee, Xiang Zhou, Bhramar Mukherjee   +6 more
openaire   +4 more sources

Genetic markers used in the polygenic risk score calculation.

, 2023
Genetic markers used in the polygenic risk score calculation.
Christofer Toumazou (571395), Francesca Romana Cavallo (10218765)   +1 more
core   +1 more source