Results 21 to 30 of about 67,612 (348)

Polygenic Risk Scores Augment Stroke Subtyping [PDF]

Neurology Genetics, 2021
To determine whether the polygenic risk score (PRS) derived from MEGASTROKE is associated with ischemic stroke (IS) and its subtypes in an independent tertiary health care system and to identify the PRS derived from gene sets of known biological pathways associated with IS.Controls (n = 19,806/7,484, age ≥69/79 years) and cases (n = 1,184/951 for ...
Jiang Li, Durgesh P. Chaudhary, Ayesha Khan, Christoph Griessenauer, David J. Carey, Ramin Zand, Vida Abedi   +6 more
openaire   +2 more sources

Polygenic transcriptome risk scores (PTRS) can improve portability of polygenic risk scores across ancestries [PDF]

Genome Biology, 2022
Abstract Background Polygenic risk scores (PRS) are valuable to translate the results of genome-wide association studies (GWAS) into clinical practice. To date, most GWAS have been based on individuals of European-ancestry leading to poor performance in populations of non-European ancestry.
Yanyu Liang, Milton Pividori, Ani Manichaikul, Abraham A. Palmer, Nancy J. Cox, Heather E. Wheeler, Hae Kyung Im   +6 more
openaire   +4 more sources

On cross-ancestry cancer polygenic risk scores [PDF]

PLOS Genetics, 2021
Polygenic risk scores (PRS) can provide useful information for personalized risk stratification and disease risk assessment, especially when combined with non-genetic risk factors. However, their construction depends on the availability of summary statistics from genome-wide association studies (GWAS) independent from the target sample.
Lars G. Fritsche, Ying Ma, Daiwei Zhang, Maxwell Salvatore, Seunggeun Lee, Xiang Zhou, Bhramar Mukherjee   +6 more
openaire   +4 more sources

Identifying individuals with high risk of Alzheimer’s disease using polygenic risk scores

Nature Communications, 2021
While polygenic risk scores have been shown to be correlated with disease risk, there is little agreement on how the score should be calculated. Here the authors investigate risk scores for Alzheimer’s disease, finding that the most effective approach ...
Ganna Leonenko, Emily Baker, Joshua Stevenson-Hoare, Annerieke Sierksma, Mark Fiers, Julie Williams, Bart de Strooper, Valentina Escott-Price   +7 more
doaj   +1 more source

Evaluating the Performance of the WHO International Reference Standard for Osteoporosis Diagnosis in Postmenopausal Women of Varied Polygenic Score and Race [PDF]

, 2020
Background: Whether the bone mineral density (BMD) T-score performs differently in osteoporosis classification in women of different genetic profiling and race background remains unclear.
Wu, Qing, Xiao, Xiangxue, Xu, Yingke
core   +2 more sources

Twelve Variants Polygenic Score for Low‐Density Lipoprotein Cholesterol Distribution in a Large Cohort of Patients With Clinically Diagnosed Familial Hypercholesterolemia With or Without Causative Mutations

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background A significant proportion of individuals clinically diagnosed with familial hypercholesterolemia (FH), but without any disease‐causing mutation, are likely to have polygenic hypercholesterolemia.
Elena Olmastroni, Marta Gazzotti, Marcello Arca, Maurizio Averna, Angela Pirillo, Alberico Luigi Catapano, Manuela Casula   +6 more
doaj   +1 more source

The correlation between inflammatory biomarkers and polygenic risk score in Alzheimer's Disease [PDF]

, 2017
Plasma biomarkers to aid the early diagnosis of Alzheimer’s disease (AD) or to monitor disease progression have long been sought and continue to be widely studied.
Escott-Price, Valentina, Jones, Lesley, Majounie, Elisa, Morgan, Angharad, Morgan, Bryan, O'Hagan, Caroline, Sims, Rebecca, Touchard, Samuel, Williams, Julie   +8 more
core   +1 more source

Physical activity, polygenic risk score, and colorectal cancer risk

Cancer Medicine, 2023
Introduction Whether and to what extent the relationship between physical activity (PA) and colorectal cancer (CRC) differs according to CRC‐related genetic risk remains to be determined, and no studies to date have quantified how much genetically ...
Xuechen Chen, Feng Guo, Jenny Chang‐Claude, Michael Hoffmeister, Hermann Brenner   +4 more
doaj   +1 more source

Design and user experience testing of a polygenic score report: a qualitative study of prospective users

BMC Medical Genomics, 2021
Background Polygenic scores—which quantify inherited risk by integrating information from many common sites of DNA variation—may enable a tailored approach to clinical medicine. However, alongside considerable enthusiasm, we and others have highlighted a
Deanna G. Brockman, Lia Petronio, Jacqueline S. Dron, Bum Chul Kwon, Trish Vosburg, Lisa Nip, Andrew Tang, Mary O’Reilly, Niall Lennon, Bang Wong, Kenney Ng, Katherine H. Huang, Akl C. Fahed, Amit V. Khera   +13 more
doaj   +1 more source

Construction and Application of Polygenic Risk Scores in Autoimmune Diseases

Frontiers in Immunology, 2022
Genome-wide association studies (GWAS) have identified hundreds of genetic variants associated with autoimmune diseases and provided unique mechanistic insights and informed novel treatments.
Chachrit Khunsriraksakul, Chachrit Khunsriraksakul, Havell Markus, Havell Markus, Nancy J. Olsen, Laura Carrel, Bibo Jiang, Dajiang J. Liu, Dajiang J. Liu   +8 more
doaj   +1 more source