Performance of polygenic risk scores in screening, prediction, and risk stratification: secondary analysis of data in the Polygenic Score Catalog [PDF]
BMJ Medicine, 2023 Objective To clarify the performance of polygenic risk scores in population screening, individual risk prediction, and population risk stratification.Design Secondary analysis of data in the Polygenic Score Catalog.Setting Polygenic Score Catalog, April ...
Harry Hemingway +10 more
doaj +9 more sources
The Polygenic Risk Score Knowledge Base offers a centralized online repository for calculating and contextualizing polygenic risk scores [PDF]
Communications Biology, 2022 The Polygenic Risk Score Knowledge Base (PRSKB) is a web-based interface that stores data from >2,300 distinct genome-wide association studies, and can estimate polygenic risk scores for general use.
Madeline L. Page +8 more
doaj +6 more sources
Polygenic Risk Score Prediction for Endometriosis [PDF]
Frontiers in Reproductive Health, 2021 Endometriosis is a major health care challenge because many young women with endometriosis go undetected for an extended period, which may lead to pain sensitization.
Kirstine Kloeve-Mogensen +15 more
doaj +8 more sources
Polygenic risk score translation across diverse populations [PDF]
Frontiers in Cardiovascular MedicinePolygenic risk scores (PRSs) are increasingly being considered as tools to refine risk stratification in cardiovascular and cardiometabolic disease, but their clinical translation remains constrained by a central limitation: most currently available PRSs
Jose E. Krieger
doaj +2 more sources
Polygenic risk score for type 2 diabetes shows context-dependent effects across populations [PDF]
Nature CommunicationsPolygenic risk scores hold prognostic value for identifying individuals at higher risk of type 2 diabetes. However, further characterization is needed to understand the generalizability of type 2 diabetes polygenic risk scores in diverse populations ...
Boya Guo +72 more
doaj +5 more sources
Communications BiologyPolygenic risk score (PRS) is useful for capturing an individual’s genetic susceptibility. However, previous studies have not fully exploited the potential of the risk factor PRS (RFPRS) for disease prediction.
Hyein Jung +6 more
doaj +3 more sources
Polygenic risk score for early identification of coronary artery disease in a real-world clinical setting within the Latvian patient population [PDF]
American Heart Journal PlusStudy objective: Polygenic risk scores (PRS) are increasingly recognized for their potential to improve coronary artery disease (CAD) prediction beyond traditional clinical models. This study evaluated the utility of genome-wide association study (GWAS) -
Evija Kanašniece +8 more
doaj +2 more sources
Psychosis Endophenotypes: A Gene-Set-Specific Polygenic Risk Score Analysis [PDF]
, 2023 BACKGROUND AND HYPOTHESIS: Endophenotypes can help to bridge the gap between psychosis and its genetic predispositions, but their underlying mechanisms remain largely unknown.
Genetic Risk and Outcome of Psychosis (GROUP) Study +2 more
core +11 more sources
Schizophrenia polygenic risk score influence on white matter microstructure [PDF]
, 2020 Schizophrenia (SZ) and bipolar disorder (BD) are highly heritable, share symptomatology, and have a polygenic architecture. The impact of recent polygenic risk scores (PRS) for psychosis, which combine multiple genome-wide associated risk variations ...
Sukhi Shergill +10 more
core +3 more sources
Philosophy of Medicine, 2023 This paper explores the interpretation and use of polygenic risk scores (PRSs). We argue that PRSs generally do not directly embody causal information. Nonetheless, they can assist us in tracking other causal relationships concerning genetic effects.
James Woodward, Kenneth Kendler
openaire +3 more sources