Results 11 to 20 of about 31,405 (257)

Polygenic Score Models for Alzheimer’s Disease: From Research to Clinical Applications

Frontiers in Neuroscience, 2021
The high prevalence of Alzheimer’s disease (AD) among the elderly population and its lack of effective treatments make this disease a critical threat to human health.
Xiaopu Zhou, Xiaopu Zhou, Xiaopu Zhou, Yolanda Y. T. Li, Amy K. Y. Fu, Amy K. Y. Fu, Amy K. Y. Fu, Nancy Y. Ip, Nancy Y. Ip, Nancy Y. Ip   +9 more
doaj   +1 more source

Development of risk prediction models for depression combining genetic and early life risk factors

Frontiers in Neuroscience, 2023
BackgroundBoth genetic and early life risk factors play important roles in the pathogenesis and progression of adult depression. However, the interplay between these risk factors and their added value to risk prediction models have not been fully ...
Tianyuan Lu, Patrícia Pelufo Silveira, Patrícia Pelufo Silveira, Celia M. T. Greenwood, Celia M. T. Greenwood, Celia M. T. Greenwood, Celia M. T. Greenwood   +6 more
doaj   +1 more source

Calculating Polygenic Risk Scores (PRS) in UK Biobank: A Practical Guide for Epidemiologists

Frontiers in Genetics, 2022
A polygenic risk score estimates the genetic risk of an individual for some disease or trait, calculated by aggregating the effect of many common variants associated with the condition.
Jennifer A. Collister, Xiaonan Liu, Lei Clifton   +2 more
doaj   +1 more source

Performance of polygenic risk scores in screening, prediction, and risk stratification: secondary analysis of data in the Polygenic Score Catalog

BMJ Medicine, 2023
Objective To clarify the performance of polygenic risk scores in population screening, individual risk prediction, and population risk stratification.Design Secondary analysis of data in the Polygenic Score Catalog.Setting Polygenic Score Catalog, April ...
Harry Hemingway, Riyaz Patel, Joan K Morris, Aroon D Hingorani, Reecha Sofat, Claudia Langenberg, Nicholas J Wald, Valerie Kuan, Chris Finan, Jasmine Gratton, A Floriaan Schmidt   +10 more
doaj   +1 more source

Association of Joint Genetic and Social Environmental Risks With Incident Myocardial Infarction: Results From the Health and Retirement Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background Myocardial infarction (MI) is a significant clinical and public health problem worldwide. However, little research has assessed the interplay between genetic susceptibility and social environment in the development of MI.
Junhan Tang, Chen Sheng, Yan Yan Wu, Lijing L. Yan, Chenkai Wu   +4 more
doaj   +1 more source

Polygenic risk score improves the accuracy of a clinical risk score for coronary artery disease

BMC Medicine, 2022
Background The value of polygenic risk scores (PRSs) towards improving guideline-recommended clinical risk models for coronary artery disease (CAD) prediction is controversial.
Austin King, Lang Wu, Hong-Wen Deng, Hui Shen, Chong Wu   +4 more
doaj   +1 more source

On cross-ancestry cancer polygenic risk scores [PDF]

PLOS Genetics, 2021
Polygenic risk scores (PRS) can provide useful information for personalized risk stratification and disease risk assessment, especially when combined with non-genetic risk factors. However, their construction depends on the availability of summary statistics from genome-wide association studies (GWAS) independent from the target sample.
Lars G. Fritsche, Ying Ma, Daiwei Zhang, Maxwell Salvatore, Seunggeun Lee, Xiang Zhou, Bhramar Mukherjee   +6 more
openaire   +4 more sources

Polygenic risk scores in epilepsy

Medizinische Genetik, 2022
Abstract An epilepsy diagnosis has large consequences for an individual but is often difficult to make in clinical practice. Novel biomarkers are thus greatly needed. Here, we give an overview of how thousands of common genetic factors that increase the risk for epilepsy can be summarized as epilepsy polygenic risk scores (PRS).
openaire   +2 more sources

Association Between Polygenic Risk Score and Risk of Myopia [PDF]

JAMA Ophthalmology, 2020
Myopia is a leading cause of untreatable visual impairment and is increasing in prevalence worldwide. Interventions for slowing childhood myopia progression have shown success in randomized clinical trials; hence, there is a need to identify which children would benefit most from treatment intervention.To examine whether genetic information alone can ...
Mojarrad, Neema Ghorbani, Plotnikov, Denis, Williams, Cathy, Guggenheim, Jeremy A, Aslam, Tariq, Barman, Sarah A, Barrett, Jenny H, Bishop, Paul, Blows, Peter, Bunce, Catey, Carare, Roxana O, Chakravarthy, Usha, Chan, Michelle, Chua, Sharon YL, Crabb, David P, Cumberland, Philippa M, Day, Alexander, Desai, Parul, Dhillon, Bal, Dick, Andrew D, Egan, Cathy, Ennis, Sarah, Foster, Paul, Fruttiger, Marcus, Gallacher, John EJ, Garway-Heath, David F, Gibson, Jane, Gore, Dan, Guggenheim, Jeremy A, Hammond, Chris J, Hardcastle, Alison, Harding, Simon P, Hogg, Ruth E, Hysi, Pirro, Keane, Pearse A, Khaw, Sir Peng T, Khawaja, Anthony P, Lascaratos, Gerassimos, Lotery, Andrew J, Macgillivray, Tom, Mackie, Sarah, Martin, Keith, McGaughey, Michelle, McGuinness, Bernadette, Mckay, Gareth J, McKibbin, Martin, Mitry, Danny, Moore, Tony, Morgan, James E, Muthy, Zaynah A, O'Sullivan, Eoin, Owen, Chris G, Patel, Praveen, Paterson, Euan, Peto, Tunde, Petzold, Axel, Rahi, Jugnoo S, Rudnikca, Alicja R, Self, Jay, Sivaprasad, Sobha, Steel, David, Stratton, Irene, Strouthidis, Nicholas, Sudlow, Cathie, Thomas, Dhanes, Trucco, Emanuele, Tufail, Adnan, Vitart, Veronique, Vernon, Stephen A, Viswanathan, Ananth C, Williams, Cathy, Williams, Katie, Woodside, Jayne V, Yates, Max M, Yip, Jennifer, Zheng, Yalin, Consortium, Uk Biobank Eye Vision   +76 more
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Identifying individuals with high risk of Alzheimer’s disease using polygenic risk scores

Nature Communications, 2021
While polygenic risk scores have been shown to be correlated with disease risk, there is little agreement on how the score should be calculated. Here the authors investigate risk scores for Alzheimer’s disease, finding that the most effective approach ...
Ganna Leonenko, Emily Baker, Joshua Stevenson-Hoare, Annerieke Sierksma, Mark Fiers, Julie Williams, Bart de Strooper, Valentina Escott-Price   +7 more
doaj   +1 more source