Results 11 to 20 of about 67,612 (348)

Polygenic Score Models for Alzheimer’s Disease: From Research to Clinical Applications

Frontiers in Neuroscience, 2021
The high prevalence of Alzheimer’s disease (AD) among the elderly population and its lack of effective treatments make this disease a critical threat to human health.
Xiaopu Zhou, Xiaopu Zhou, Xiaopu Zhou, Yolanda Y. T. Li, Amy K. Y. Fu, Amy K. Y. Fu, Amy K. Y. Fu, Nancy Y. Ip, Nancy Y. Ip, Nancy Y. Ip   +9 more
doaj   +1 more source

Development of risk prediction models for depression combining genetic and early life risk factors

Frontiers in Neuroscience, 2023
BackgroundBoth genetic and early life risk factors play important roles in the pathogenesis and progression of adult depression. However, the interplay between these risk factors and their added value to risk prediction models have not been fully ...
Tianyuan Lu, Patrícia Pelufo Silveira, Patrícia Pelufo Silveira, Celia M. T. Greenwood, Celia M. T. Greenwood, Celia M. T. Greenwood, Celia M. T. Greenwood   +6 more
doaj   +1 more source

Calculating Polygenic Risk Scores (PRS) in UK Biobank: A Practical Guide for Epidemiologists

Frontiers in Genetics, 2022
A polygenic risk score estimates the genetic risk of an individual for some disease or trait, calculated by aggregating the effect of many common variants associated with the condition.
Jennifer A. Collister, Xiaonan Liu, Lei Clifton   +2 more
doaj   +1 more source

Polygenic Risk Scores and Physical Activity [PDF]

Medicine & Science in Sports & Exercise, 2020
ABSTRACT Purpose Polygenic risk scores (PRS) summarize genome-wide genotype data into a single variable that produces an individual-level risk score for genetic liability. PRS has been used for prediction of chronic diseases and some risk factors. As PRS has been studied less for physical activity (PA), we constructed
Kujala, Urho M., Palviainen, Teemu, Pesonen, Paula, Waller, Katja, Sillanpää, Elina, Niemelä, Maisa, Kangas, Maarit, Vähä-Ypyä, Henri, Sievänen, Harri, Korpelainen, Raija, Jämsä, Timo, Männikkö, Minna, Kaprio, Jaakko   +13 more
openaire   +6 more sources

Performance of polygenic risk scores in screening, prediction, and risk stratification: secondary analysis of data in the Polygenic Score Catalog

BMJ Medicine, 2023
Objective To clarify the performance of polygenic risk scores in population screening, individual risk prediction, and population risk stratification.Design Secondary analysis of data in the Polygenic Score Catalog.Setting Polygenic Score Catalog, April ...
Harry Hemingway, Riyaz Patel, Joan K Morris, Aroon D Hingorani, Reecha Sofat, Claudia Langenberg, Nicholas J Wald, Valerie Kuan, Chris Finan, Jasmine Gratton, A Floriaan Schmidt   +10 more
doaj   +1 more source

Association of Joint Genetic and Social Environmental Risks With Incident Myocardial Infarction: Results From the Health and Retirement Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background Myocardial infarction (MI) is a significant clinical and public health problem worldwide. However, little research has assessed the interplay between genetic susceptibility and social environment in the development of MI.
Junhan Tang, Chen Sheng, Yan Yan Wu, Lijing L. Yan, Chenkai Wu   +4 more
doaj   +1 more source

Polygenic hazard score to guide screening for aggressive prostate cancer: development and validation in large scale cohorts. [PDF]

, 2018
OBJECTIVES: To develop and validate a genetic tool to predict age of onset of aggressive prostate cancer (PCa) and to guide decisions of who to screen and at what age.
Al Olama, Ali Amin, Aly, Markus, Andreassen, Ole A, Batra, Jyotsna, Bisbjerg, Rasmus, Brenner, Hermann, Cannon-Albright, Lisa, Clements, Judith A, Cuk, Katarina, Cybulski, Cezary, Dale, Anders M, Donovan, Jenny L, Easton, Douglas F, Eeles, Rosalind A, Fan, Chun Chieh, Garcia, Sara Benlloch, Grönberg, Henrik, Hamdy, Freddie C, Herkommer, Kathleen, Iversen, Peter, Kaneva, Radka, Karow, David S, Karunamuni, Roshan, Key, Tim J, Khaw, Kay-Tee, Kibel, Adam S, Kierzek, Andrzej, Kluzniak, Wojciech, Kote-Jarai, ZSofia, Luedeke, Manuel, Maia, Sofia, Maier, Christiane, Michael, Agnieszka, Mills, Ian G, Mitev, Vanio, Muir, Kenneth, Neal, David E, Nielsen, Sune F, Nordestgaard, Børge G, Pandha, Hardev, Park, Jong Y, Parsons, J Kellogg, Pashayan, Nora, Paulo, Paula, Pharoah, Paul, PRACTICAL Consortium*, Røder, M Andreas, Saum, Kai-Uwe, Schleutker, Johanna, Seibert, Tyler M, Sellers, Thomas A, Sipeky, Csilla, Slavov, Chavdar, Spurdle, Amanda, Tammela, Teuvo Lj, Teixeira, Manuel R, Travis, Ruth C, Vogel, Walther, Wang, Yunpeng, Weischer, Maren, Wiklund, Fredrik, Wokolorczyk, Dominika, Zuber, Verena   +62 more
core   +7 more sources

Germline genetic variation in prostate susceptibility does not predict outcomes in the chemoprevention trials PCPT and SELECT [PDF]

, 2020
Background The development of prostate cancer can be influenced by genetic and environmental factors. Numerous germline SNPs influence prostate cancer susceptibility.
Ahmed, M, Cieza-Borrella, C, Eeles, R, Goh, C, Kote-Jarai, Z, PRACTICAL consortium, Saunders, E, Schumacher, FR   +7 more
core   +2 more sources

PRSice: Polygenic Risk Score software [PDF]

Bioinformatics, 2014
Abstract Summary: A polygenic risk score (PRS) is a sum of trait-associated alleles across many genetic loci, typically weighted by effect sizes estimated from a genome-wide association study. The application of PRS has grown in recent years as their utility for detecting shared genetic aetiology among traits has become appreciated; PRS ...
Euesden, Jack, Lewis, Cathryn M, O'Reilly, Paul F   +2 more
openaire   +5 more sources

Polygenic risk score improves the accuracy of a clinical risk score for coronary artery disease

BMC Medicine, 2022
Background The value of polygenic risk scores (PRSs) towards improving guideline-recommended clinical risk models for coronary artery disease (CAD) prediction is controversial.
Austin King, Lang Wu, Hong-Wen Deng, Hui Shen, Chong Wu   +4 more
doaj   +1 more source