Results 31 to 40 of about 31,405 (257)
Hepatology, EarlyView., 2022 Hepatic APOF transcript levels correlate inversely with plasma TG and hepatic steatosis in humans. ApoF expression in mice promotes VLDL‐TG production and lipoprotein remnant clearance in mice. Abstract Background NAFLD affects nearly 25% of the global population. Cardiovascular disease (CVD) is the most common cause of death among patients with NAFLD,
Audrey Deprince +30 more
wiley +1 more source
GenoRisk: A polygenic risk score for Alzheimer's disease
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2021 Introduction Recent clinical trials are considering inclusion of more than just apolipoprotein E (APOE) ε4 genotype as a way of reducing variability in analysis of outcomes.
Samuel P. Dickson +10 more
doaj +1 more source
Metrics for Evaluating Polygenic Risk Scores [PDF]
JNCI Cancer Spectrum, 2020 Abstract There is growing interest in the use of polygenic risk scores based on genetic variants to predict cancer incidence. The type of metric used to evaluate the predictive performance of polygenic risk scores plays a crucial role in their interpretation.
openaire +2 more sources
A polygenic risk score for multiple myeloma risk prediction [PDF]
European Journal of Human Genetics, 2021 AbstractThere is overwhelming epidemiologic evidence that the risk of multiple myeloma (MM) has a solid genetic background. Genome-wide association studies (GWAS) have identified 23 risk loci that contribute to the genetic susceptibility of MM, but have low individual penetrance. Combining the SNPs in a polygenic risk score (PRS) is a possible approach
Federico Canzian +39 more
openaire +9 more sources
Polygenic risk score penetrance & recurrence risk in familial Alzheimer disease
Annals of Clinical and Translational Neurology, 2023 Objective To compute penetrance and recurrence risk using a genome‐wide PRS (including and excluding the APOE region) in families with Alzheimer's disease. Methods Genotypes from the National Institute on Aging Late‐Onset Alzheimer's Disease Family‐Based
Min Qiao +19 more
doaj +1 more source
Current Oncology, 2022 The development of new screening methods and diagnostic tests for traits, common diseases, and cancer is linked to the advent of precision genomic medicine, in which health care is individually adjusted based on a person’s lifestyle, environmental ...
Howard Lopes Ribeiro Junior +4 more
doaj +1 more source
PRSice: Polygenic Risk Score software [PDF]
Bioinformatics, 2014 Abstract Summary: A polygenic risk score (PRS) is a sum of trait-associated alleles across many genetic loci, typically weighted by effect sizes estimated from a genome-wide association study. The application of PRS has grown in recent years as their utility for detecting shared genetic aetiology among traits has become appreciated; PRS ...
Jack Euesden +2 more
openaire +4 more sources
Polygenic risk score, healthy lifestyles, and risk of incident depression
Translational Psychiatry, 2021 Genetic factors increase the risk of depression, but the extent to which this can be offset by modifiable lifestyle factors is unknown. We investigated whether a combination of healthy lifestyles is associated with lower risk of depression regardless of ...
Zhi Cao +6 more
doaj +1 more source
Genetic predisposition, Aβ misfolding in blood plasma, and Alzheimer’s disease
Translational Psychiatry, 2021 Alzheimer’s disease is highly heritable and characterized by amyloid plaques and tau tangles in the brain. The aim of this study was to investigate the association between genetic predisposition, Aβ misfolding in blood plasma, a unique marker of ...
Hannah Stocker +10 more
doaj +1 more source
Epistatic effect of TLR3 and cGAS‐STING‐IKKε‐TBK1‐IFN signaling variants on colorectal cancer risk
Cancer Medicine, 2020 Objective The TLR3/cGAS‐STING‐IFN signaling has recently been reported to be disturbed in colorectal cancer due to deregulated expression of the genes involved.
Calogerina Catalano +14 more
doaj +1 more source