Results 31 to 40 of about 7,071,839 (288)
Polygenic risk scores in epilepsy
Medizinische Genetik, 2022 Abstract An epilepsy diagnosis has large consequences for an individual but is often difficult to make in clinical practice. Novel biomarkers are thus greatly needed. Here, we give an overview of how thousands of common genetic factors that increase the risk for epilepsy can be summarized as epilepsy polygenic risk scores (PRS).
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, 2022 Additional file 3: Polygenic risk score methodology and reclassification ...
Lang Wu (540806) +4 more
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Association Between Polygenic Risk Score and Risk of Myopia [PDF]
JAMA Ophthalmology, 2020 Myopia is a leading cause of untreatable visual impairment and is increasing in prevalence worldwide. Interventions for slowing childhood myopia progression have shown success in randomized clinical trials; hence, there is a need to identify which children would benefit most from treatment intervention.To examine whether genetic information alone can ...
Mojarrad, Neema Ghorbani +76 more
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Identifying individuals with high risk of Alzheimer’s disease using polygenic risk scores
Nature Communications, 2021 While polygenic risk scores have been shown to be correlated with disease risk, there is little agreement on how the score should be calculated. Here the authors investigate risk scores for Alzheimer’s disease, finding that the most effective approach ...
Ganna Leonenko +7 more
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Association between a polygenic risk score (PRS) and type 2 diabetes at baseline.
, 2023 Association between a polygenic risk score (PRS) and type 2 diabetes at baseline.
Dale S. Hardy (3708508) +2 more
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Seminars in Arthritis and RheumatismPolygenic risk scores (PRS) estimate an individual's genetic risk for a disease or trait compared to a matched population. For many rheumatic diseases PRS have been developed that have discriminatory capacity better than some widely used biomarkers, and in some cases are the most discriminatory tests available.
Brian T. Palmisano, Joshua W. Knowles
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, 2021 Additional file 2: Fig. S1 Ancestry PCA of HapMap and our samples. Fig. S2 Distribution of the polygenic risk score according to the different 7 risk groups by sex. Fig. S3 Distribution of the polygenic risk score according to the different 7 risk groups
Elisabet Guinó (90345) +14 more
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Box plot of the polygenic risk score in HCC progressors vs. non-progressors.
, 2023 Box plot of the polygenic risk score in HCC progressors vs. non-progressors.
Fasiha Kanwal (4737003) +14 more
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Polygenic transcriptome risk scores (PTRS) can improve portability of polygenic risk scores across ancestries [PDF]
Genome Biology, 2022 Abstract Background Polygenic risk scores (PRS) are valuable to translate the results of genome-wide association studies (GWAS) into clinical practice. To date, most GWAS have been based on individuals of European-ancestry leading to poor performance in populations of non-European ancestry.
Yanyu Liang +6 more
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Polygenic Risk Score and Risk Factors for Gestational Diabetes
Journal of Personalized Medicine, 2022 Gestational diabetes mellitus (GDM) is a common complication of pregnancy that adversely affects maternal and offspring health. A variety of risk factors, such as BMI and age, have been associated with increased risks of gestational diabetes. However, in many cases, gestational diabetes occurs in healthy nulliparous women with no obvious risk factors ...
Perišić, Marija Majda +5 more
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