Results 41 to 50 of about 32,760 (257)

Polygenic transcriptome risk scores improve portability of polygenic risk scores across ancestries [PDF]

, 2020
Abstract Polygenic risk scores (PRS) are on course to translate the results of genome-wide association studies (GWAS) into clinical practice. To date, most GWAS have been based on individuals of European-ancestry, meaning that the utility of PRS for non-European populations is limited because SNP effects and LD patterns may not be ...
Yanyu Liang, Milton Pividori, Ani Manichaikul, Abraham A. Palmer, Nancy J. Cox, Heather Wheeler, Hae Kyung Im   +6 more
openaire   +1 more source

Fusogenic RNA Nanomodules for Fusion‐Mediated and Multiplexed siRNA Delivery

Advanced Functional Materials, EarlyView.
A fusogenic lipid‐layered RNA nanomodules (L‐CRAMs) enable high‐capacity and long‐lasting siRNA delivery through membrane fusion. These nanomodules carry exceptionally large siRNA payloads, avoid conventional endosomal uptake, and release multiple functional siRNAs through Dicer‐mediated processing.
Sunghyun Moon, Iksoo Jang, Taehyeon Kim, Nayoung Yoon, Kyuha Yum, Jong Bum Lee   +5 more
wiley   +1 more source

PRSet: Pathway-based polygenic risk score analyses and software.

PLoS Genetics, 2023
Polygenic risk scores (PRSs) have been among the leading advances in biomedicine in recent years. As a proxy of genetic liability, PRSs are utilised across multiple fields and applications.
Shing Wan Choi, Judit García-González, Yunfeng Ruan, Hei Man Wu, Christian Porras, Jessica Johnson, Bipolar Disorder Working group of the Psychiatric Genomics Consortium, Clive J Hoggart, Paul F O'Reilly   +8 more
doaj   +1 more source

Harnessing Large‐Scale Multi‐Omics Data for Risk Prediction and Deep Phenotyping of Valvular Heart Diseases in the General Population

Advanced Science, EarlyView.
Large‐scale UK Biobank analyses identify clinical and proteomic signatures for early prediction of valvular heart disease and its subtypes. Proteins add predictive value for VHD, AVS, and MVR, with outcome‐specific compact panels showing translational potential. Multi‐layer evidence highlights matrix remodeling, protease regulation, immune inflammation,
Zhihao Jiang, Yang Liu, Mingyu Song, Ning Chen, Canqing Yu, Jun Lv, Eric Yuk Fai Wan, Lu Qi, Liming Li, Dianjianyi Sun, Bang Zheng   +10 more
wiley   +1 more source

Admixture-informed polygenic risk reporting using the ePRS framework

Nature Communications
Polygenic risk score values vary with genetic ancestry due to differences in population-specific allele frequencies and linkage disequilibrium patterns. We present a framework to calibrate polygenic risk scores based on ancestral makeup.
Yu-Jyun Huang, Nuzulul Kurniansyah, Matthew O. Goodman, Brian W. Spitzer, Jiongming Wang, Adrienne Stilp, Cecelia Laurie, Paul S. de Vries, Han Chen, Yuan-I Min, Mario Sims, Gina M. Peloso, Xiuqing Guo, Joshua C. Bis, Jennifer A. Brody, Laura M. Raffield, Jennifer A. Smith, Wei Zhao, Jerome I. Rotter, Stephen S. Rich, Susan Redline, Myriam Fornage, Robert Kaplan, Nora Franceschini, Daniel Levy, Alanna C. Morrison, Eric Boerwinkle, Nicholas L. Smith, Charles Kooperberg, Bruce M. Psaty, Sebastian Zöllner, the Trans-Omics for Precision Medicine Consortium, Tamar Sofer   +32 more
doaj   +1 more source

Risk of Inflammatory Bowel Disease Following Hospital‐Treated Infections and Modulatory Role of Host Genetics to Support a Multi‐Hit Pathogenesis Model

Advanced Science, EarlyView.
Hospital‐treated infections are linked to increased risk of inflammatory bowel disease in a large prospective cohort. This risk differs by infection burden, time since infection, and host immune‐genetic susceptibility. The findings support a multi‐hit pathogenesis model in which severe infection and inherited susceptibility jointly shape inflammatory ...
Haiming Zhuang, Lintao Dan, Xin Xiang, Xixian Ruan, Shuai Yuan, Jialu Yao, Jiawei Geng, Jonas F. Ludvigsson, Tian Fu, Candida Abreu, Laurent Peyrin‐Biroulet, Xue Li, Yi Xiao, Fernando Magro, Xiaoyan Wang, Jing Sun, Jie Chen   +16 more
wiley   +1 more source

Polygenic risk score prediction accuracy convergence

HGG Advances
Summary: Polygenic risk scores (PRSs) models trained from genome-wide association study (GWAS) results are set to play a pivotal role in biomedical research addressing multifactorial human diseases.
Léo Henches, Jihye Kim, Zhiyu Yang, Simone Rubinacci, Gabriel Pires, Clara Albiñana, Christophe Boetto, Hanna Julienne, Arthur Frouin, Antoine Auvergne, Yuka Suzuki, Sarah Djebali, Olivier Delaneau, Andrea Ganna, Bjarni Vilhjálmsson, Florian Privé, Hugues Aschard   +16 more
doaj   +1 more source

Polygenic risk scores in familial Alzheimer disease [PDF]

Neurology, 2017
To investigate the association between a genetic risk score (GRS) and familial late-onset Alzheimer disease (LOAD) and its predictive value in families multiply affected by the disease.Using data from the National Institute on Aging Genetics Initiative for Late-Onset Alzheimer Disease (National Institute on Aging-Late-Onset Alzheimer's Disease Family ...
Tosto, Giuseppe, Bird, Thomas D., Tsuang, Debby, Bennett, David A., Boeve, Bradley F., Cruchaga, Carlos, Faber, Kelley, Foroud, Tatiana M., Farlow, Martin, Goate, Alison M., Bertlesen, Sarah, Graff-Radford, Neill R., Medrano, Martin, Lantigua, Rafael, Manly, Jennifer, Ottman, Ruth, Rosenberg, Roger, Schaid, Daniel J., Schupf, Nicole, Stern, Yaakov, Sweet, Robert A., Mayeux, Richard   +21 more
openaire   +3 more sources

Herbicide Metabolic Resistance in Poaceae Plants via the GA‐GID1/DELLA‐DOF2‐P450s Module

Advanced Science, EarlyView.
Plant hormone signaling modulates herbicide resistance in Echinochloa crus‐galli. The GA–DELLA–DOF2 cascade directly activates P450 detoxification genes in two Poaceae species, uncovering a core mechanism of metabolic herbicide resistance. ABSTRACT Barnyard grass (Echinochloa crus‐galli) is one of the world's most important weeds, and the evolution of ...
Junzhi Wang, Jiale Qi, Lin Wei, Qin Yu, Zhongyuan Liu, Lianyang Bai, Lang Pan   +6 more
wiley   +1 more source

Polygenic risk score for type 2 diabetes shows context-dependent effects across populations

Nature Communications
Polygenic risk scores hold prognostic value for identifying individuals at higher risk of type 2 diabetes. However, further characterization is needed to understand the generalizability of type 2 diabetes polygenic risk scores in diverse populations ...
Boya Guo, Yanwei Cai, Daeeun Kim, Roelof A. J. Smit, Zhe Wang, Kruthika R. Iyer, Austin T. Hilliard, Jeffrey Haessler, Ran Tao, K. Alaine Broadaway, Yujie Wang, Nikita Pozdeyev, Frederik F. Stæger, Chaojie Yang, Brett Vanderwerff, Amit D. Patki, Lauren Stalbow, Meng Lin, Nicholas Rafaels, Jonathan Shortt, Laura Wiley, Maggie Stanislawski, Jack Pattee, Lea Davis, Peter S. Straub, Megan M. Shuey, Nancy J. Cox, Nanette R. Lee, Marit E. Jørgensen, Peter Bjerregaard, Christina Larsen, Torben Hansen, Ida Moltke, James B. Meigs, Daniel O. Stram, Xianyong Yin, Xiang Zhou, Kyong-Mi Chang, Shoa L. Clarke, Rodrigo Guarischi-Sousa, Joanna Lankester, Philip S. Tsao, Steven Buyske, Mariaelisa Graff, Laura M. Raffield, Quan Sun, Lynne R. Wilkens, Christopher S. Carlson, Charles B. Easton, Simin Liu, JoAnn E. Manson, Loïc L. Marchand, Christopher A. Haiman, Karen L. Mohlke, Penny Gordon-Larsen, Anders Albrechtsen, Michael Boehnke, Stephen S. Rich, Ani Manichaikul, Jerome I. Rotter, Noha A. Yousri, Ryan M. Irvin, The biobank at the Colorado Center for Personalized Medicine (CCPM), VA Million Veteran Program (MVP), Chris Gignoux, Kari E. North, Ruth J. F. Loos, Themistocles L. Assimes, Ulrike Peters, Charles Kooperberg, Sridharan Raghavan, Heather M. Highland, Burcu F. Darst   +72 more
doaj   +1 more source