Results 41 to 50 of about 67,612 (348)

Contribution of common and rare variants to bipolar disorder susceptibility in extended pedigrees from population isolates. [PDF]

, 2020
Current evidence from case/control studies indicates that genetic risk for psychiatric disorders derives primarily from numerous common variants, each with a small phenotypic impact. The literature describing apparent segregation of bipolar disorder (BP)
Aldana, Ileana, Araya, Carmen, Araya, Xinia, Bearden, Carrie E, Bedoya, Gabriel, Bejarano, Julio, Cantor, Rita M, Castrillón, Gabriel, Coppola, Giovanni, Escobar, Javier I, Fears, Scott C, Freimer, Nelson B, Gomez-Makhinson, Juliana, Huang, Alden Y, Hwang, Sun-Goo, Kremeyer, Barbara, Lopez, Maria C, Lopez-Jaramillo, Carlos, Macaya, Gabriel, Molina, Julio, Montoya, Claudia P, Montoya, Gabriel, Mullins, Niamh, Olde Loohuis, Loes M, Ophoff, Roel A, Ori, Anil PS, Ospina-Duque, Jorge, Park, YoungJun, Ramensky, Vasily, Ramirez, Margarita, Reus, Victor, Ruiz-Linares, Andres, Sabatti, Chiara, Service, Susan K, Spesny, Mitzi, Sul, Jae Hoon, Teshiba, Terri M, Zhang, Zhongyang   +37 more
core   +3 more sources

Traumatic Stress Interacts With Bipolar Disorder Genetic Risk to Increase Risk for Suicide Attempts [PDF]

, 2017
Objective Bipolar disorder (BD) is one of the most heritable psychiatric conditions and is associated with high suicide risk. To explore the reasons for this link, this study examined the interaction between traumatic stress and BD polygenic risk ...
Benke, Kelly, Brucksch, Christine, Edenberg, Howard J., Fisher, Carrie, Frankland, Andrew, Fullerton, Janice M., Ghaziuddin, Neera, Glowinski, Anne L., Hulvershorn, Leslie A., Kamali, Masoud, Kastelic, Elizabeth, McInnis, Melvin G., Miller, Leslie, Mitchell, Philip B., Nurnberger, John I., Jr., Roberts, Gloria M. P., Shaw, Alex D., Stapp, Emma K., Toma, Claudio, Wilcox, Holly C.   +19 more
core   +1 more source

GenoRisk: A polygenic risk score for Alzheimer's disease

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2021
Introduction Recent clinical trials are considering inclusion of more than just apolipoprotein E (APOE) ε4 genotype as a way of reducing variability in analysis of outcomes.
Samuel P. Dickson, Suzanne B. Hendrix, Bruce L. Brown, Perry G. Ridge, Jessie Nicodemus‐Johnson, Marci L. Hardy, Allison M. McKeany, Steven B. Booth, Ryan R. Fortna, John S.K. Kauwe, NIAGADS   +10 more
doaj   +1 more source

Assessing thyroid cancer risk using polygenic risk scores [PDF]

Proceedings of the National Academy of Sciences, 2020
Genome-wide association studies (GWASs) have identified at least 10 single-nucleotide polymorphisms (SNPs) associated with papillary thyroid cancer (PTC) risk. Most of these SNPs are common variants with small to moderate effect sizes. Here we assessed the combined genetic effects of these variants on PTC risk by using summarized GWAS ...
Sandya Liyanarachchi, Julius Gudmundsson, Egil Ferkingstad, Huiling He, Jon G. Jonasson, Vinicius Tragante, Folkert W. Asselbergs, Li Xu, Lambertus A. Kiemeney, Romana T. Netea-Maier, Jose I. Mayordomo, Theo S. Plantinga, Hannes Hjartarson, Jon Hrafnkelsson, Erich M. Sturgis, Pamela Brock, Fadi Nabhan, Gudmar Thorleifsson, Matthew D. Ringel, Kari Stefansson, Albert de la Chapelle   +20 more
openaire   +5 more sources

Genetic predisposition, Aβ misfolding in blood plasma, and Alzheimer’s disease

Translational Psychiatry, 2021
Alzheimer’s disease is highly heritable and characterized by amyloid plaques and tau tangles in the brain. The aim of this study was to investigate the association between genetic predisposition, Aβ misfolding in blood plasma, a unique marker of ...
Hannah Stocker, Andreas Nabers, Laura Perna, Tobias Möllers, Dan Rujescu, Annette M. Hartmann, Bernd Holleczek, Ben Schöttker, Julia Stockmann, Klaus Gerwert, Hermann Brenner   +10 more
doaj   +1 more source

Common polygenic risk for autism spectrum disorder (ASD) is associated with cognitive ability in the general population [PDF]

, 2015
Acknowledgements Generation Scotland has received core funding from the Chief Scientist Office of the Scottish Government Health Directorates CZD/16/6 and the Scottish Funding Council HR03006.
Clarke, T. K., Cox, S., Davies, G., Deary, I. J., Fernandez-Pujals, A. M., Hall, L. S., Hansell, N. K., Hayward, C., Hocking, L. J., Liewald, D. C., Lupton, M. K., MacIntyre, D. J., Martin, N. G., McIntosh, A. M., Medland, S. E., Montgomery, G. W., Padmanabhan, S., Pattie, A., Porteous, D. J., Smith, B. H., Starr, J., Thomson, P. A., Wright, M. J.   +22 more
core   +6 more sources

Are genetic risk factors for psychosis also associated with dimension-specific psychotic experiences in adolescence? [PDF]

, 2014
Psychosis has been hypothesised to be a continuously distributed quantitative phenotype and disorders such as schizophrenia and bipolar disorder represent its extreme manifestations.
A Boyd, A Fossati, AD Johnson, AG Cardno, AH Fanous, AH Fanous, AH Fanous, Alastair G. Cardno, Angelica Ronald, C M, Tuvblad, CCH Lin, CMA Haworth, Daniel Freeman, Dominika Sieradzka, E Cummings, E Cyhlarova, E Fonseca-Pedrero, EM Derks, Emma L. Meaburn, F Dudbridge, Frank Dudbridge, FV Rijsdijk, I Kelleher, J Van Os, J Welham, J Yang, James Bennett Potash, JTW Wigman, L Paternoster, M Trzaskowski, MG Vollema, NR Wray, P DeRosse, P DeRosse, P Lichtenstein, P McGuffin, PF Sullivan, Philip McGuire, R Plomin, R Poulton, RJ Pruim, Robert A. Power, Robert Plomin, S Purcell, S Zammit, SE Bergen, SH Lee, SH Lee, SM Purcell, TM Laursen, YM Hur   +50 more
core   +6 more sources

NAFLD‐related hepatocellular carcinoma: The growing challenge

Hepatology, EarlyView., 2022
Risk and protective factors for NAFLD‐related hepatocellular carcinoma Abstract Hepatocellular carcinoma (HCC) is a common cause of cancer‐related mortality and morbidity worldwide. With the obesity pandemic, NAFLD‐related HCC is contributing to the burden of disease exponentially.
Pir Ahmad Shah, Rashmee Patil, Stephen A. Harrison   +2 more
wiley   +1 more source

Polygenic risk score penetrance & recurrence risk in familial Alzheimer disease

Annals of Clinical and Translational Neurology, 2023
Objective To compute penetrance and recurrence risk using a genome‐wide PRS (including and excluding the APOE region) in families with Alzheimer's disease. Methods Genotypes from the National Institute on Aging Late‐Onset Alzheimer's Disease Family‐Based
Min Qiao, Annie J. Lee, Dolly Reyes‐Dumeyer, Giuseppe Tosto, Kelley Faber, Alison Goate, Alan Renton, Michael Chao, Brad Boeve, Carlos Cruchaga, Margaret Pericak‐Vance, Jonathan L. Haines, Roger Rosenberg, Debby Tsuang, Robert A. Sweet, David A. Bennett, Robert S. Wilson, Tatiana Foroud, Richard Mayeux, Badri N. Vardarajan   +19 more
doaj   +1 more source

Role of Polygenic Risk Score in Cancer Precision Medicine of Non-European Populations: A Systematic Review

Current Oncology, 2022
The development of new screening methods and diagnostic tests for traits, common diseases, and cancer is linked to the advent of precision genomic medicine, in which health care is individually adjusted based on a person’s lifestyle, environmental ...
Howard Lopes Ribeiro Junior, Lázaro Antônio Campanha Novaes, José Guilherme Datorre, Daniel Antunes Moreno, Rui Manuel Reis   +4 more
doaj   +1 more source