Results 41 to 50 of about 7,071,839 (288)
NAFLD‐related hepatocellular carcinoma: The growing challenge
Hepatology, EarlyView., 2022 Risk and protective factors for NAFLD‐related hepatocellular carcinoma Abstract Hepatocellular carcinoma (HCC) is a common cause of cancer‐related mortality and morbidity worldwide. With the obesity pandemic, NAFLD‐related HCC is contributing to the burden of disease exponentially.
Pir Ahmad Shah +2 more
wiley +1 more source
Polygenic Risk Scores Expand to Obesity [PDF]
Cell, 2019 Obesity is one of the most serious health challenges of our time. In this issue of Cell, Khera and co-authors demonstrate the striking ability of genetics, in the form of a polygenic risk score, to identify those individuals at high risk for obesity.
Ali, Torkamani, Eric, Topol
openaire +2 more sources
A polygenic risk score for multiple myeloma risk prediction [PDF]
European Journal of Human Genetics, 2021 AbstractThere is overwhelming epidemiologic evidence that the risk of multiple myeloma (MM) has a solid genetic background. Genome-wide association studies (GWAS) have identified 23 risk loci that contribute to the genetic susceptibility of MM, but have low individual penetrance. Combining the SNPs in a polygenic risk score (PRS) is a possible approach
Federico Canzian +39 more
openaire +9 more sources
Hepatology, EarlyView., 2022 Hepatic APOF transcript levels correlate inversely with plasma TG and hepatic steatosis in humans. ApoF expression in mice promotes VLDL‐TG production and lipoprotein remnant clearance in mice. Abstract Background NAFLD affects nearly 25% of the global population. Cardiovascular disease (CVD) is the most common cause of death among patients with NAFLD,
Audrey Deprince +30 more
wiley +1 more source
Generalisation of genomic findings and applications of polygenic risk scores [PDF]
, 2023 Polygenic Risk Scores (PRS) (also known as polygenic scores, genetic risk scores or polygenic indexes) capture genetic contributions of a multitude of markers that characterise complex traits.
Corpas, Manuel, Fatumo, Segun
core +1 more source
PRSice: Polygenic Risk Score software [PDF]
Bioinformatics, 2014 Abstract Summary: A polygenic risk score (PRS) is a sum of trait-associated alleles across many genetic loci, typically weighted by effect sizes estimated from a genome-wide association study. The application of PRS has grown in recent years as their utility for detecting shared genetic aetiology among traits has become appreciated; PRS ...
Jack Euesden +2 more
openaire +5 more sources
Metrics for Evaluating Polygenic Risk Scores [PDF]
JNCI Cancer Spectrum, 2020 Abstract There is growing interest in the use of polygenic risk scores based on genetic variants to predict cancer incidence. The type of metric used to evaluate the predictive performance of polygenic risk scores plays a crucial role in their interpretation.
openaire +2 more sources
Polygenic risk score for ulcerative colitis predicts immune checkpoint inhibitor-mediated colitis
, 2023 <p>Weights from LDPred2 for the polygenic risk score for ulcerative colitis and Crohn's disease.</p ...
Quandt, Zoe +21 more
core +1 more source
Current Oncology, 2022 The development of new screening methods and diagnostic tests for traits, common diseases, and cancer is linked to the advent of precision genomic medicine, in which health care is individually adjusted based on a person’s lifestyle, environmental ...
Howard Lopes Ribeiro Junior +4 more
doaj +1 more source
Epistatic effect of TLR3 and cGAS‐STING‐IKKε‐TBK1‐IFN signaling variants on colorectal cancer risk
Cancer Medicine, 2020 Objective The TLR3/cGAS‐STING‐IFN signaling has recently been reported to be disturbed in colorectal cancer due to deregulated expression of the genes involved.
Calogerina Catalano +14 more
doaj +1 more source