Results 1 to 10 of about 3,918 (69)

Genetic risk score correlates with immune profile and risk of HCC and cirrhosis development in Hispanics with MASLD

JHEP Reports
Background & Aims: Genetic risk score and immune dysregulations have been separately associated with the development of hepatocellular carcinoma (HCC) and cirrhosis in the context of metabolic dysfunction-associated steatotic liver disease (MASLD ...
Siyu Fu, Zwier M.A. Groothuismink, Domingo Balderramo, Angelo Z. Mattos, Lisia Hoppe, Enrique Carrera, Javier Diaz-Ferrer, Jhon Prieto, Jesus M. Banales, Marco Arrese, Bettina E. Hansen, Andre Boonstra, José D. Debes   +12 more
doaj   +3 more sources

Assessment of polygenic risk of hypertension

Кардиоваскулярная терапия и профилактика, 2023
Hypertension (HTN) is a leading risk factor for the development of cardiovascular diseases. In recent decades, the rapid development of genetic tests, in particular genome-wide association study (GWAS), has made it possible to identify hundreds of ...
A. S. Limonova, A. I. Ershova, A. V. Kiseleva, V. E. Ramensky, Yu. V. Vyatkin, V. A. Kutsenko, A. N. Meshkov, O. M. Drapkina   +7 more
doaj   +1 more source

Genetic risk scores used in cardiovascular disease prediction models: a systematic review [PDF]

Reviews in Cardiovascular Medicine, 2022
Background: Cardiovascular disease is caused by a combination of genetic and environmental risk factors. Some risk factors can change with age, but a genetic predisposition is permanent.
Hyunok Yun, Nan Iee Noh, Eun Young Lee
doaj   +1 more source

Calculating Polygenic Risk Scores (PRS) in UK Biobank: A Practical Guide for Epidemiologists

Frontiers in Genetics, 2022
A polygenic risk score estimates the genetic risk of an individual for some disease or trait, calculated by aggregating the effect of many common variants associated with the condition.
Jennifer A. Collister, Xiaonan Liu, Lei Clifton   +2 more
doaj   +1 more source

Genotype-based prediction for cardiovascular disease risk using polymorphism in rs10757278 at 9p21 locus

Journal of Clinical and Preventive Cardiology, 2021
Background and Aims: Along with the conventional risk factors and based on the Framingham risk score, a preventive measure can be targeted in those subjects who are in risk category.
Geetha Bhaktha, Shivananda Nayak
doaj   +1 more source

Body Mass Index Genetic Risk Score and Endometrial Cancer Risk. [PDF]

PLoS ONE, 2015
Genome-wide association studies (GWAS) have identified common variants that predispose individuals to a higher body mass index (BMI), an independent risk factor for endometrial cancer.
Jennifer Prescott, Veronica W Setiawan, Nicolas Wentzensen, Fredrick Schumacher, Herbert Yu, Ryan Delahanty, Leslie Bernstein, Stephen J Chanock, Chu Chen, Linda S Cook, Christine Friedenreich, Monserrat Garcia-Closas, Christopher A Haiman, Loic Le Marchand, Xiaolin Liang, Jolanta Lissowska, Lingeng Lu, Anthony M Magliocco, Sara H Olson, Harvey A Risch, Xiao-Ou Shu, Giske Ursin, Hannah P Yang, Peter Kraft, Immaculata De Vivo   +24 more
doaj   +1 more source

Air pollution, genetic factors and the risk of osteoporosis: A prospective study in the UK biobank

Frontiers in Public Health, 2023
PurposeTo reveal relationship between air pollution exposure and osteoporosis (OP) risk.MethodsBased on large-scale data from the UK Biobank, we evaluated the relationship between OP risk and several air pollutants.
Xing-Hao Yu, Xing-Hao Yu, Han-Wen Cao, Han-Wen Cao, Lin Bo, Shu-Feng Lei, Shu-Feng Lei, Shu-Feng Lei, Fei-Yan Deng, Fei-Yan Deng   +9 more
doaj   +1 more source

Incorporating genetic and clinical data into the prediction of thromboembolism risk in patients with lymphoma

Cancer Medicine, 2021
Background The incorporation of genetic variables into risk scores for predicting venous thromboembolic events (VTE) could improve their capacity to identify those patients for whom thromboprophylaxis would be most beneficial. Proof‐of‐concept of this is
Mariana Bastos‐Oreiro, Javier Ortiz, Virginia Pradillo, Eduardo Salas, Carolina Marínez‐Laperche, Andrés Muñoz, Ismael Buño, José Luis Diéz‐Martin, Jose Manuel Soria, Cristina Pascual Izquierdo   +9 more
doaj   +1 more source

The relationship of genetic risk score with cardiometabolic risk factors: a cross-sectional study

BMC Cardiovascular Disorders, 2022
Background & aims For more than eight decades, cardiovascular disease (CVD) has remained the leading cause of death in the world. CVD risk factors are multifaceted, with genetics and lifestyle both playing a role. The aim of this study was to investigate
Fatemeh Gholami, Niloufar Rasaei, Mahsa Samadi, Mir Saeid Yekaninejad, Seyed Ali Keshavarz, Gholamali Javdan, Zahra Karimi, Khadijeh Mirzaei   +7 more
doaj   +1 more source

Increasing insulin resistance accentuates the effect of triglyceride-associated loci on serum triglycerides during 5 years[S]

Journal of Lipid Research, 2016
Blood concentrations of triglycerides are influenced by genetic factors as well as a number of environmental factors, including adiposity and glucose homeostasis.
Johanne M. Justesen, Ehm A. Andersson, Kristine H. Allin, Camilla H. Sandholt, Torben Jørgensen, Allan Linneberg, Marit E. Jørgensen, Torben Hansen, Oluf Pedersen, Niels Grarup   +9 more
doaj   +1 more source