Results 1 to 10 of about 445,590 (261)

Genetic risk score correlates with immune profile and risk of HCC and cirrhosis development in Hispanics with MASLD [PDF]

JHEP Reports
Background & Aims: Genetic risk score and immune dysregulations have been separately associated with the development of hepatocellular carcinoma (HCC) and cirrhosis in the context of metabolic dysfunction-associated steatotic liver disease (MASLD ...
Siyu Fu, Zwier M.A. Groothuismink, Domingo Balderramo, Angelo Z. Mattos, Lisia Hoppe, Enrique Carrera, Javier Diaz-Ferrer, Jhon Prieto, Jesus M. Banales, Marco Arrese, Bettina E. Hansen, Andre Boonstra, José D. Debes   +12 more
doaj   +4 more sources

IgAN Genetic Risk Score in the Clinical Setting [PDF]

Kidney International Reports, 2020
No ...
Francesco Paolo Schena, Sharon Natasha Cox   +1 more
doaj   +4 more sources

Cardiovascular disease: The rise of the genetic risk score. [PDF]

PLoS Medicine, 2018
In a Perspective, Joshua Knowles and Euan Ashley discuss the potential for use of genetic risk scores in clinical practice.
Joshua W Knowles, Euan A Ashley
doaj   +4 more sources

A Proposed Genetic Risk Score for Dilated Cardiomyopathy Susceptibility in the Chinese Han Population [PDF]

Texas Heart Institute Journal
Background: Dilated cardiomyopathy (DCM) is one of the most common types of cardiomyopathies. The current study constructs a proposed genetic risk score and assesses its potential as a predictive tool for individual DCM susceptibility.
Jianjun Lan, MD, Lin Wang, MD, Guoyuan Qiu, MD, Shihai Wang, MD, Chao Yang, MD, Mengnian Ran, MD, Hongyu Li, MD, Shiyang Li, MD   +7 more
doaj   +2 more sources

Genetic Risk Score for Coronary Heart Disease: Review [PDF]

Journal of Personalized Medicine, 2020
The present review deals with the stages of creation, methods of calculation, and the use of a genetic risk score for coronary heart disease in various populations. The concept of risk factors is generally recognized on the basis of the results of epidemiological studies in the 20th century; according to this concept, the high prevalence of diseases of
Elena Shakhtshneider, Sergey Semaev
exaly   +3 more sources

Assessment of polygenic risk of hypertension

Кардиоваскулярная терапия и профилактика, 2023
Hypertension (HTN) is a leading risk factor for the development of cardiovascular diseases. In recent decades, the rapid development of genetic tests, in particular genome-wide association study (GWAS), has made it possible to identify hundreds of ...
A. S. Limonova, A. I. Ershova, A. V. Kiseleva, V. E. Ramensky, Yu. V. Vyatkin, V. A. Kutsenko, A. N. Meshkov, O. M. Drapkina   +7 more
doaj   +1 more source

Genetic risk scores used in cardiovascular disease prediction models: a systematic review [PDF]

Reviews in Cardiovascular Medicine, 2022
Background: Cardiovascular disease is caused by a combination of genetic and environmental risk factors. Some risk factors can change with age, but a genetic predisposition is permanent.
Hyunok Yun, Nan Iee Noh, Eun Young Lee
doaj   +1 more source

Transferability of genetic risk scores in African populations [PDF]

Nature Medicine, 2022
Abstract The poor transferability of genetic risk scores (GRSs) derived from European ancestry data in diverse populations is a cause of concern. We set out to evaluate whether GRSs derived from data of African American individuals and multiancestry data perform better in sub-Saharan Africa (SSA) compared to ...
Kamiza, Abram B, Toure, Sounkou M, Vujkovic, Marijana, Machipisa, Tafadzwa, Soremekun, Opeyemi S, Kintu, Christopher, Corpas, Manuel, Pirie, Fraser, Young, Elizabeth, Gill, Dipender, Sandhu, Manjinder S, Kaleebu, Pontiano, Nyirenda, Moffat, Motala, Ayesha A, Chikowore, Tinashe, Fatumo, Segun   +15 more
openaire   +3 more sources

Association of Vitamin D Genetic Risk Score with Noncommunicable Diseases: A Systematic Review. [PDF]

Nutrients, 2023
Almaghrbi H, Al-Shafai M, Al-Asmakh M, Bawadi H.   +3 more
europepmc   +2 more sources

Calculating Polygenic Risk Scores (PRS) in UK Biobank: A Practical Guide for Epidemiologists

Frontiers in Genetics, 2022
A polygenic risk score estimates the genetic risk of an individual for some disease or trait, calculated by aggregating the effect of many common variants associated with the condition.
Jennifer A. Collister, Xiaonan Liu, Lei Clifton   +2 more
doaj   +1 more source