Results 11 to 20 of about 8,823,949 (205)

Cardiovascular disease: The rise of the genetic risk score. [PDF]

PLoS Medicine, 2018
In a Perspective, Joshua Knowles and Euan Ashley discuss the potential for use of genetic risk scores in clinical practice.
Joshua W Knowles, Euan A Ashley
doaj   +4 more sources

Genetic Risk Score and Risk of Myocardial Infarction in Hispanics [PDF]

Circulation, 2011
Background— Genome-wide association studies have identified loci associated with coronary heart disease in whites of European ancestry. This study evaluated whether genetic markers previously identified in whites are associated with nonfatal acute myocardial infarction (MI) in Hispanics ...
Lu, Qi, Jiantao, Ma, Qibin, Qi, Jaana, Hartiala, Hooman, Allayee, Hannia, Campos   +5 more
openaire   +3 more sources

Genetic Risk Score Predicts Late-Life Cognitive Impairment [PDF]

Journal of Aging Research, 2015
Introduction. A family history of Alzheimer’s disease is a significant risk factor for its onset, but the genetic risk associated with possessing multiple risk alleles is still poorly understood. Methods.
Mariegold E. Wollam, Andrea M. Weinstein, Judith A. Saxton, Lisa Morrow, Beth Snitz, Nicole R. Fowler, Barbara L. Suever Erickson, Kathryn A. Roecklein, Kirk I. Erickson   +8 more
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Exploring Random Forest in Genetic Risk Score Construction [PDF]

Genetic Epidemiology
ABSTRACT Genetic risk scores (GRS) are crucial tools for estimating an individual's genetic liability to various traits and diseases, computed as a weighted sum of trait‐associated allele counts. Traditionally, GRS models assume additive, linear effects of risk variants.
Vaishnavi Venkat, Kaylyn Clark, X. Jessie Jeng, Tsung‐Chieh Yao, Hui‐Ju Tsai, Tzu‐Pin Lu, Tzu‐Hung Hsiao, Ching‐Heng Lin, Shannon Holloway, Cathrine Hoyo, Shin‐Yi Chou, Hui Wang, Wan‐Ping Lee, Li‐San Wang, Jung‐Ying Tzeng   +14 more
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A Proposed Genetic Risk Score for Dilated Cardiomyopathy Susceptibility in the Chinese Han Population [PDF]

Texas Heart Institute Journal
Background: Dilated cardiomyopathy (DCM) is one of the most common types of cardiomyopathies. The current study constructs a proposed genetic risk score and assesses its potential as a predictive tool for individual DCM susceptibility.
Jianjun Lan, MD, Lin Wang, MD, Guoyuan Qiu, MD, Shihai Wang, MD, Chao Yang, MD, Mengnian Ran, MD, Hongyu Li, MD, Shiyang Li, MD   +7 more
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IgAN Genetic Risk Score in the Clinical Setting [PDF]

Kidney International Reports, 2020
No ...
Francesco Paolo Schena, Sharon Natasha Cox   +1 more
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Association Between a Multi-Locus Genetic Risk Score and Inflammatory Bowel Disease

Bioinformatics and Biology Insights, 2013
To date, the utility of single genetic markers to improve disease risk assessment still explains only a small proportion of genetic variance for many complex diseases.
Pingzhao Hu, Aleixo M. Muise, Xiang Xing, John H. Brumell, Mark S. Silverberg, Wei Xu   +5 more
doaj   +2 more sources

Transferability of genetic risk scores in African populations [PDF]

Nature Medicine, 2022
Abstract The poor transferability of genetic risk scores (GRSs) derived from European ancestry data in diverse populations is a cause of concern. We set out to evaluate whether GRSs derived from data of African American individuals and multiancestry data perform better in sub-Saharan Africa (SSA) compared to ...
Kamiza, Abram B, Toure, Sounkou M, Vujkovic, Marijana, Machipisa, Tafadzwa, Soremekun, Opeyemi S, Kintu, Christopher, Corpas, Manuel, Pirie, Fraser, Young, Elizabeth, Gill, Dipender, Sandhu, Manjinder S, Kaleebu, Pontiano, Nyirenda, Moffat, Motala, Ayesha A, Chikowore, Tinashe, Fatumo, Segun   +15 more
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Integrating Genetics and Social Science: Genetic Risk Scores [PDF]

Biodemography and Social Biology, 2014
The sequencing of the human genome and the advent of low-cost genome-wide assays that generate millions of observations of individual genomes in a matter of hours constitute a disruptive innovation for social science. Many public use social science datasets have or will soon add genome-wide genetic data.
Daniel W, Belsky, Salomon, Israel
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Genetic Risk Score for Essential Hypertension and Risk of Preeclampsia [PDF]

American Journal of Hypertension, 2015
Preeclampsia is a hypertensive complication of pregnancy characterized by novel onset of hypertension after 20 weeks gestation, accompanied by proteinuria. Epidemiological evidence suggests that genetic susceptibility exists for preeclampsia; however, whether preeclampsia is the result of underlying genetic risk for essential hypertension has yet to be
Caitlin J, Smith, Audrey F, Saftlas, Cassandra N, Spracklen, Elizabeth W, Triche, Andrew, Bjonnes, Brendan, Keating, Richa, Saxena, Patrick J, Breheny, Andrew T, Dewan, Jennifer G, Robinson, Josephine, Hoh, Kelli K, Ryckman   +11 more
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