Results 31 to 40 of about 445,590 (261)

Genetic Risk Score Predicts Late-Life Cognitive Impairment

Journal of Aging Research, 2015
Introduction. A family history of Alzheimer’s disease is a significant risk factor for its onset, but the genetic risk associated with possessing multiple risk alleles is still poorly understood. Methods.
Mariegold E. Wollam, Andrea M. Weinstein, Judith A. Saxton, Lisa Morrow, Beth Snitz, Nicole R. Fowler, Barbara L. Suever Erickson, Kathryn A. Roecklein, Kirk I. Erickson   +8 more
doaj   +1 more source

A genetic risk score combining ten psoriasis risk loci improves disease prediction. [PDF]

PLoS ONE, 2011
Psoriasis is a chronic, immune-mediated skin disease affecting 2-3% of Caucasians. Recent genetic association studies have identified multiple psoriasis risk loci; however, most of these loci contribute only modestly to disease risk.
Haoyan Chen, Annie Poon, Celestine Yeung, Cynthia Helms, Jennifer Pons, Anne M Bowcock, Pui-Yan Kwok, Wilson Liao   +7 more
doaj   +1 more source

Evaluation of a Genetic Risk Score for Diagnosis of Psoriatic Arthritis [PDF]

Journal of Psoriasis and Psoriatic Arthritis, 2020
Background: Diagnosis of psoriatic arthritis (PsA) can be challenging, resulting in delays that contribute to irreversible joint damage, reduced quality of life, and increased mortality. Objective: Use genetic markers to develop and ...
Mary Patricia Smith, Karen Ly, Quinn Thibodeaux, Kristen Beck, Eric Yang, Isabelle Sanchez, Joanne Nititham, Tina Bhutani, Wilson Liao   +8 more
openaire   +4 more sources

Traditional and Genetic Risk Score and Stroke Risk Prediction in Korea [PDF]

Korean Circulation Journal, 2018
Whether using both traditional risk factors and genetic variants for stroke as opposed to using either of the 2 alone improves the prediction of stroke risk remains unclear. The purpose of this study was to compare the predictability of stroke risk between models using traditional risk score (TRS) and genetic risk score (GRS).We used a case-cohort ...
Keum Ji Jung, Semi Hwang, Sunmi Lee, Hyeon Chang Kim, Sun Ha Jee   +4 more
openaire   +3 more sources

Genetic Risk Score for Prediction of Coronary Heart Disease in the Korean Genome and Epidemiology Study

Reviews in Cardiovascular Medicine, 2023
Background: Using a genetic risk score (GRS) to predict coronary heart disease (CHD) may detect disease earlier. The current study aims to assess whether GRS is associated with CHD incidence and whether it is clinically useful for improving prediction ...
Hyunok Yun, Ji Eun Lim, Eun Young Lee
doaj   +1 more source

Risk prediction for coronary heart disease by a genetic risk score - results from the Heinz Nixdorf Recall study

BMC Medical Genetics, 2020
Background A Genetic risk score for coronary artery disease (CAD) improves the ability of predicting coronary heart disease (CHD). It is unclear whether i) the use of a CAD genetic risk score is superior to the measurement of coronary artery ...
Sonali Pechlivanis, Nils Lehmann, Per Hoffmann, Markus M. Nöthen, Karl-Heinz Jöckel, Raimund Erbel, Susanne Moebus   +6 more
doaj   +1 more source

Ethical concerns relating to genetic risk scores for suicide [PDF]

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2021
Abstract Genome‐wide association studies (GWAS) provide valuable information in research contexts regarding genomic changes that contribute to risks for complex psychiatric conditions like major depressive disorder. GWAS results can be used to calculate polygenic risk scores (PRS) for psychiatric conditions, such as bipolar disorder ...
Anna Docherty, Brent Kious, Teneille Brown, Leslie Francis, Louisa Stark, Brooks Keeshin, Jeffrey Botkin, Emily DiBlasi, Doug Gray, Hilary Coon   +9 more
openaire   +2 more sources

Naïve Bayesian Classifier and Genetic Risk Score for Genetic Risk Prediction of a Categorical Trait: Not so Different After All!

Frontiers in Genetics, 2012
One of the most popular modeling approaches to genetic risk prediction is to use a summary of risk alleles in the form of an unweighted or a weighted genetic risk score, with weights that relate to the odds for the phenotype in carriers of the individual
Paola eSebastiani, Nadia eSolovieff, Jenny eSun   +2 more
doaj   +1 more source

Association of Joint Genetic and Social Environmental Risks With Incident Myocardial Infarction: Results From the Health and Retirement Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background Myocardial infarction (MI) is a significant clinical and public health problem worldwide. However, little research has assessed the interplay between genetic susceptibility and social environment in the development of MI.
Junhan Tang, Chen Sheng, Yan Yan Wu, Lijing L. Yan, Chenkai Wu   +4 more
doaj   +1 more source

Evaluation of a Genetic Risk Score to Improve Risk Prediction for Alzheimer’s Disease [PDF]

Journal of Alzheimer's Disease, 2016
Effective prevention of Alzheimer’s disease (AD) requires the development of risk prediction tools permitting preclinical intervention. We constructed a genetic risk score (GRS) comprising common genetic variants associated with AD, evaluated its association with incident AD and assessed its capacity to improve risk prediction over traditional models ...
Chouraki, Vincent, Reitz, Christiane, Maury, Fleur, Bis, Joshua C., Bellenguez, Celine, Yu, Lei, Jakobsdottir, Johanna, Mukherjee, Shubhabrata, Adams, Hieab H., Choi, Seung Hoan, Larson, Eric B., Fitzpatrick, Annette, Uitterlinden, Andre G., de Jager, Philip L., Hofman, Albert, Gudnason, Vilmundur, Vardarajan, Badri, Ibrahim-Verbaas, Carla, van der Lee, Sven J., Lopez, Oscar, Dartigues, Jean-François, Berr, Claudine, Amouyel, Philippe, Bennett, David A., van Duijn, Cornelia, DeStefano, Anita L., Launer, Lenore J., Ikram, M. Arfan, Crane, Paul K., Lambert, Jean-Charles, Mayeux, Richard, Seshadri, Sudha, for the International Genomics of Alzheimer’s Project   +32 more
openaire   +4 more sources