Results 51 to 60 of about 8,823,949 (205)

Combined accelerometer and genetic analysis to differentiate essential tremor from Parkinson’s disease [PDF]

PeerJ, 2018
Essential tremor (ET) and Parkinson’s disease (PD) are among the most common adult-onset tremor disorders. Clinical and pathological studies suggest that misdiagnosis of PD for ET, and vice versa, occur in anywhere from 15% to 35% of cases.
Bhuvan Molparia, Brian N. Schrader, Eli Cohen, Jennifer L. Wagner, Sandeep R. Gupta, Sherrie Gould, Nelson Hwynn, Emily G. Spencer, Ali Torkamani   +8 more
doaj   +2 more sources

Genetic Risk Analysis of Coronary Artery Disease in a Population-based Study in Portugal, Using a Genetic Risk Score of 31 Variants

Arquivos Brasileiros de Cardiologia, 2018
Background: Genetic risk score can quantify individual’s predisposition to coronary artery disease; however, its usefulness as an independent risk predictor remains inconclusive.
Andreia Pereira, Maria Isabel Mendonça, Sofia Borges, Sónia Freitas, Eva Henriques, Mariana Rodrigues, Ana Isabel Freitas, Ana Célia Sousa, António Brehm, Roberto Palma dos Reis   +9 more
doaj   +1 more source

Polygenic scores for low lung function and the future risk of adverse health outcomes

Cardiovascular Diabetology, 2022
Aims Reduced lung function and adverse health outcomes are often observed. This study characterizes genetic susceptibility for reduced lung function and risk of developing a range of adverse health outcomes.
Suneela Zaigham, Isabel Gonçalves, Regeneron Genetics Center, Gunnar Engström, Jiangming Sun   +4 more
doaj   +1 more source

Development and validation of the Vanderbilt PRS-KS, an instrument to quantify polygenic risk score knowledge

Genetics in Medicine Open, 2023
Purpose: As polygenic risk scores (PRSs) enter clinical practice, health care providers’ and the publics’ comprehension of PRS results are of great importance; yet, they are poorly understood.
Doug Stubbs, Gillian W. Hooker, Yajing Li, Lucas Richter, Alexander Bick   +4 more
doaj   +1 more source

Genetic Risk Scores for the Clinical Rheumatologist

JCR: Journal of Clinical Rheumatology
Background/Historical Perspective The advent of genome-wide sequencing and large-scale genetic epidemiological studies has led to numerous opportunities for the application of genetics in clinical medicine. Leveraging this information toward the formation of clinically useful tools has been an ongoing research goal in this area.
Austin M. Wheeler, Thomas R. Riley, Tony R. Merriman   +2 more
openaire   +2 more sources

Lifestyle Cardiovascular Risk Score, Genetic Risk Score, and Myocardial Infarction in Hispanic/Latino Adults Living in Costa Rica

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
Background A lifestyle cardiovascular risk score (LCRS) and a genetic risk score (GRS) have been independently associated with myocardial infarction (MI) in Hispanics/Latinos.
Mercedes Sotos‐Prieto, Ana Baylin, Hannia Campos, Lu Qi, Josiemer Mattei   +4 more
doaj   +1 more source

Multivariable prognostic model for heart failure in Chinese Han population‐based setting

ESC Heart Failure, 2022
Aims The prognosis of heart failure (HF) depends on genetic predisposition, and recent studies have shown that impaired autophagy is involved in HF.
Man Huang, Lei Xiao, Yang Sun, Dong Hu, Yanghui Chen, Yan Wang, Dao Wen Wang   +6 more
doaj   +1 more source

Global trajectories of polygenic risk score research: a systematic bibliometric review of precision medicine, equity, and clinical translation

Frontiers in Medicine
IntroductionPolygenic risk scores (PRS) have emerged as a central tool in genomic medicine, enabling risk prediction for common, complex diseases. Despite rapid methodological and clinical advances, concerns remain regarding the structural organization ...
Fouad Bitar, Fouad Bitar, Rana Zareef, Roukoz Abou-Karam, Roukoz Abou-Karam, Georges Nemer, Fadi F. Bitar, Akl C. Fahed, Akl C. Fahed, Akl C. Fahed, Zahi Abdul Sater   +10 more
doaj   +1 more source

Genetic evaluation of fertility using direct and correlated traits [PDF]

, 2003
Poor fertility has become a major reason for involuntary culling of dairy cows in the United Kingdom. Calving interval (CI) and body condition score (BCS) are recorded, heritable, genetically correlated with each other, and could be used to extend the ...
Coffey, M.P., G. Banos, J.A. Woolliams, S. Brotherstone, Banos, Georgios, Wall, E; id_orcid, Brotherstone, S., Wall, E., Woolliams, JA, Coffey, MP, E. Wall, Woolliams, John, Brotherstone, S, Banos, G; id_orcid, M.P. Coffey   +14 more
core   +1 more source

Genetic profile of total body energy content of Holstein cows in the first three lactations [PDF]

, 2005
Weekly total body energy content (TBEC) was calculated for 444 Holstein cows in their first 3 lactations. These calculations were based on body lipid and protein changes predicted from weekly changes in body condition score and live weight of each cow ...
Banos, G, Coffey, MP, Brotherstone, S, Banos, G; id_orcid   +3 more
core   +1 more source