Results 61 to 70 of about 445,590 (261)

Genetic risk score for ovarian cancer based on chromosomal-scale length variation

BioData Mining, 2021
Introduction Twin studies indicate that a substantial fraction of ovarian cancers should be predictable from genetic testing. Genetic risk scores can stratify women into different classes of risk.
Christopher Toh, James P. Brody
doaj   +1 more source

Personalized Zebrafish Models for Fusion‐Positive Pediatric Sarcomas

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Clinical sequencing efforts have revolutionized our approaches to categorizing pediatric cancers in real time. This has dramatically improved our ability to profile pediatric tumors, identify actionable vulnerabilities, and influence clinical care.
Lisa H. Hall, Emma N. Harrison, Genevieve C. Kendall   +2 more
wiley   +1 more source

The necessity of incorporating non-genetic risk factors into polygenic risk score models

Scientific Reports, 2023
The growing public interest in genetic risk scores for various health conditions can be harnessed to inspire preventive health action. However, current commercially available genetic risk scores can be deceiving as they do not consider other, easily ...
Sipko van Dam, Pytrik Folkertsma, Jose Castela Forte, Dylan H. de Vries, Camila Herrera Cunillera, Rahul Gannamani, Bruce H. R. Wolffenbuttel   +6 more
doaj   +1 more source

Health Literacy, Self‐Efficacy and Knowledge of Sickle Cell Disease Among Caregivers

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Sickle cell disease (SCD) is a hereditary blood disorder in which abnormal haemoglobin leads to severe anaemia, painful crises and organ failure. Caregivers’ health literacy (HL) – their ability to assess, understand and apply information, and interact with healthcare professionals – is crucial for managing children with SCD, yet ...
Melanie Bruinooge, Maite E. Houwing, Rowena L. Grohssteiner, Ferdows Atiq, Sonja A. M. C. Teuben, Mirjam P. Fransen, Marjon H. Cnossen   +6 more
wiley   +1 more source

Additional value of a combined genetic risk score to standard cardiovascular stratification

Genetics and Molecular Biology
The utility of genetic risk scores (GRS) as independent risk predictors remains inconclusive. Here, we evaluate the additive value of a multi-locus GRS to the Framingham risk score (FRS) in coronary artery disease (CAD) risk prediction.
Andreia Pereira, Maria Isabel Mendonca, Sofia Borges, Ana Célia Sousa, Sónia Freitas, Eva Henriques, Mariana Rodrigues, Ana Isabel Freitas, Graça Guerra, Carolina Freitas, Décio Pereira, António Brehm, Roberto Palma Dos Reis   +12 more
doaj   +1 more source

Leukemia and Exposure to Potential Benzene Sources in Children From the Mexico City Metropolitan Area, 2010–2021: A Geospatial Analysis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Leukemia is the most common childhood cancer in Mexico, and acute lymphoblastic leukemia (ALL) is the most frequent subtype. Exposure to high concentrations of benzene has been associated with ALL incidence, particularly in urban areas. This study evaluated the relationship between distance to benzene emission sources and the number
Orlando Rivera Zurita, Norma Candelaria López Santiago, Claudia Maria García Cuellar, Karla Maldonado Silva, Nancy Reynoso Noverón, Leticia Hernández Cadena   +5 more
wiley   +1 more source

Insulin resistance genetic risk score and burden of coronary artery disease in patients referred for coronary angiography.

PLoS ONE, 2021
AimsInsulin resistance associates with development of metabolic syndrome and risk of cardiovascular disease. The link between insulin resistance and cardiovascular disease is complex and multifactorial.
Regitze Skals, Maria Lukács Krogager, Emil Vincent R Appel, Theresia M Schnurr, Christian Theil Have, Gunnar Gislason, Henrik Enghusen Poulsen, Lars Køber, Thomas Engstrøm, Steen Stender, Torben Hansen, Niels Grarup, Christina Ji-Young Lee, Charlotte Andersson, Christian Torp-Pedersen, Peter E Weeke   +15 more
doaj   +1 more source

Early Impact of Childhood Opportunity on Neurocognitive Outcomes in Sickle Cell Disease

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Neurocognitive impairment is a well‐recognized complication of sickle cell disease (SCD) that begins early in childhood and persists across development. While cerebrovascular injury contributes substantially to risk, neurocognitive deficits are also observed in children without overt or silent cerebral infarctions, suggesting ...
Julia E. LaMotte, Hannah Koch, Olivia A. Coughlin, Jillian R. Bouck, Allie Carter, Seethal A. Jacob   +5 more
wiley   +1 more source

Validation of genetic risk scores for coronary artery disease, developed on European population samples, in Russian population

Кардиоваскулярная терапия и профилактика, 2023
Aim. To evaluate the information content of genetic risk scores (GRSs) for coronary artery disease (CAD), previously developed on European populations, in representatives of the Russian population.Material and methods.
A. I. Ershova, A. N. Meshkov, V. A. Kutsenko, Yu. V. Vyatkin, A. V. Kiseleva, E. A. Sotnikova, A. S. Limonova, E. V. Garbuzova, G. A. Muromtseva, M. Zaicenoka, A. A. Zharikova, V. E. Ramensky, O. А. Belova, S. A. Rachkova, M. S. Pokrovskaya, S. A. Shalnova, S. A. Boytsov, O. M. Drapkina   +17 more
doaj   +1 more source

Genetic Testing and Risk Scores: Impact on Familial Hypercholesterolemia [PDF]

Frontiers in Cardiovascular Medicine, 2019
Familial Hypercholesterolemia (FH) is an inherited lipid disorder affecting 1 in 220 individuals resulting in highly elevated low-density lipoprotein levels and risk of premature coronary disease. Pathogenic variants causing FH typically involve the LDL receptor (LDLR), apolipoprotein B-100 (APOB), and proprotein convertase subtulisin/kexin type 9 ...
Ashish Sarraju, Joshua W. Knowles, Joshua W. Knowles, Joshua W. Knowles   +3 more
openaire   +3 more sources