Results 61 to 70 of about 8,823,949 (205)

Genetic Risk for Osteoporosis and the Benefit of Adherence to Healthy Lifestyles

International Journal of Public Health, 2022
Objectives: We aimed to explore how healthy lifestyles and genetic factors influence the risk of Osteoporosis (OP).Methods: In this prospective cohort study, we first performed a genome-wide association study (GWAS) of estimated bone mineral density ...
Yi-Qun Yang, Yi-Qun Yang, Xing-Hao Yu, Xing-Hao Yu, Lin Bo, Shu-Feng Lei, Shu-Feng Lei, Fei-Yan Deng, Fei-Yan Deng   +8 more
doaj   +1 more source

Genetic Risk Scores for Diabetes Diagnosis and Precision Medicine [PDF]

Endocrine Reviews, 2019
Abstract During the last decade, there have been substantial advances in the identification and characterization of DNA sequence variants associated with individual predisposition to type 1 and type 2 diabetes. As well as providing insights into the molecular, cellular, and physiological mechanisms involved in disease pathogenesis, these
Miriam S Udler, Mark I McCarthy, Jose C Florez, Anubha Mahajan   +3 more
openaire   +2 more sources

Prediction of primary venous thromboembolism based on clinical and genetic factors within the U.K. Biobank

Scientific Reports, 2021
Both clinical and genetic factors drive the risk of venous thromboembolism. However, whether clinically recorded risk factors and genetic variants can be combined into a clinically applicable predictive score remains unknown.
David A. Kolin, Scott Kulm, Olivier Elemento   +2 more
doaj   +1 more source

Vitamin D genetic risk scores in multiple sclerosis

Journal of Neurology, 2022
AbstractBackgroundLow serum 25(OH)D3(vD) is an environmental risk factor for multiple sclerosis (MS). Lower vD levels during early disease may be associated with long-term disability. Determinants of serum vD levels in healthy individuals include supplementation behaviour and genetic factors.
Ashvin Kuri, Nicola Vickaryous, Amine Awad, Benjamin Meir Jacobs, Ruth Dobson   +4 more
openaire   +3 more sources

Genetic risk scores and hallucinations in patients with Parkinson disease [PDF]

Neurology Genetics, 2020
We examine the hypothesized overlap of genetic architecture for Alzheimer disease (AD), schizophrenia (SZ), and Parkinson disease (PD) through the use of polygenic risk scores (PRSs) with the occurrence of hallucinations in PD.We used 2 population-based studies (ParkWest, Norway, and Parkinson's Environment and Gene, USA) providing us with 399 patients
Cynthia D.J. Kusters, Kimberly C. Paul, Aline Duarte Folle, Adrienne M. Keener, Jeff M. Bronstein, Valerija Dobricic, Ole-Bjørn Tysnes, Lars Bertram, Guido Alves, Janet S. Sinsheimer, Christina M. Lill, Jodi Maple-Grødem, Beate R. Ritz   +12 more
openaire   +7 more sources

Genetic relationships between calving interval and body condition score conditional on milk yield [PDF]

, 2002
Body condition score (BCS) is a useful tool in assessing the energy status of dairy cattle. Previous research has shown that it is heritable and genetically correlated to reproductive performance.
Coffey, M.P., Pryce, J.E., Brotherstone, S.H., Woolliams, John   +3 more
core  

Utility of genetic risk scores in type 1 diabetes

Diabetologia, 2023
AbstractIterative advances in understanding of the genetics of type 1 diabetes have identified >70 genetic regions associated with risk of the disease, including strong associations across the HLA class II region that account for >50% of heritability. The increased availability of genetic data combined with the decreased costs of generating these
Amber M. Luckett, Michael N. Weedon, Gareth Hawkes, R. David Leslie, Richard A. Oram, Struan F. A. Grant   +5 more
openaire   +3 more sources

A Weighted Genetic Risk Score of Adult Glioma Susceptibility Loci Associated with Pediatric Brain Tumor Risk. [PDF]

, 2019
Genetic risk score (GRS) is used to demonstrate the genetic variants contributing to the polygenic architecture of complex diseases. By using a GRS, we have investigated the additive impact of the known adult glioma susceptibility loci on the pediatric ...
Tettamanti, Giorgio, Kjaerheim, Kristina, Feychting, Maria, Grotzer, Michael A, Lannering, Birgitta, Adel Fahmideh, Maral, Schmidt, Lisbeth S, Lannering, Birgitta,, Johansen, Christoffer, Röösli, Martin, Kuehni, Claudia E, Kuehni, Claudia E., Lavebratt, Catharina, Darabi, Hatef, Grotzer, Michael A., Schüz, Joachim, Schmidt, Lisbeth S.   +16 more
core   +2 more sources

The necessity of incorporating non-genetic risk factors into polygenic risk score models

Scientific Reports, 2023
The growing public interest in genetic risk scores for various health conditions can be harnessed to inspire preventive health action. However, current commercially available genetic risk scores can be deceiving as they do not consider other, easily ...
Sipko van Dam, Pytrik Folkertsma, Jose Castela Forte, Dylan H. de Vries, Camila Herrera Cunillera, Rahul Gannamani, Bruce H. R. Wolffenbuttel   +6 more
doaj   +1 more source

Genetic Testing and Risk Scores: Impact on Familial Hypercholesterolemia [PDF]

Frontiers in Cardiovascular Medicine, 2019
Familial Hypercholesterolemia (FH) is an inherited lipid disorder affecting 1 in 220 individuals resulting in highly elevated low-density lipoprotein levels and risk of premature coronary disease. Pathogenic variants causing FH typically involve the LDL receptor (LDLR), apolipoprotein B-100 (APOB), and proprotein convertase subtulisin/kexin type 9 ...
Ashish Sarraju, Joshua W. Knowles, Joshua W. Knowles, Joshua W. Knowles   +3 more
openaire   +3 more sources