Results 81 to 90 of about 8,823,949 (205)

Genetic risk score for ovarian cancer based on chromosomal-scale length variation

BioData Mining, 2021
Introduction Twin studies indicate that a substantial fraction of ovarian cancers should be predictable from genetic testing. Genetic risk scores can stratify women into different classes of risk.
Christopher Toh, James P. Brody
doaj   +1 more source

Polygenic risk scores in imaging genetics: Usefulness and applications [PDF]

Journal of Psychopharmacology, 2015
Genetic factors account for up to 80% of the liability for schizophrenia and bipolar disorder. Genome-wide association studies (GWAS) have successfully identified several single nucleotide polymorphisms (SNPs) and genes associated with increased risk for both disorders.
Dima, Danai, Breen, Gerome
openaire   +4 more sources

Cardiovascular risk factor mediation of the effects of education and Genetic Risk Score on cardiovascular disease: a prospective observational cohort study of the Framingham Heart Study.

, 2021
OBJECTIVES: Level of education and genetic risk are key predictors of cardiovascular disease (CVD). While several studies have explored the causal mechanisms of education effects, it remains uncertain to what extent genetic risk is mediated by ...
Powell, Katie L, Stephens, Sebastien R, Stephens, Alexandre S   +2 more
core  

Effect of genetic group and feed system on locomotion score, clinical lameness and hoof disorders of pasture-based Holstein–Friesian cows [PDF]

, 2009
peer-reviewedThe aim of the present study was to determine the effect of the genetic group of the Holstein–Friesian (HF) and pasture-based feeding system (3 × 2 factorial arrangement) on locomotion score (six gait aspects scored from one to five ...
Mee, John F, G. Olmos, P. O’Connor, D.P. Berry, A. Hanlon, L. Boyle, Hanlon, A., B. Horan, Olmos, G., O'Connor, Paula M., J.F. Mee, Boyle, Laura, Horan, Brendan, Berry, Donagh   +13 more
core   +1 more source

Dietary and genetic risk scores and incidence of type 2 diabetes

Genes & Nutrition, 2018
Background Both lifestyle and genetic predisposition determine the development of type 2 diabetes (T2D), and studies have indicated interactions between specific dietary components and individual genetic variants.
Ulrika Ericson, George Hindy, Isabel Drake, Christina-Alexandra Schulz, Louise Brunkwall, Sophie Hellstrand, Peter Almgren, Marju Orho-Melander   +7 more
doaj   +1 more source

Validity of TIMI Risk Score and HEART Score for Risk Assessment of Patients with Unstable Angina/Non-ST Elevation Myocardial Infarction Presented to an Emergency Department in Jordan

, 2023
Muhannad J Ababneh,1 Mahmoud Mustafa Smadi,2 Abdullah Al-Kasasbeh,1 Qutaiba Ali Jawarneh,3 Mohammad Nofal,3 Mohanad El-Bashir,4 Mohamad Ismail Jarrah,1 Liqaa A Raffee5 1Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Jordan ...
Jarrah MI, Raffee LA, Smadi MM, Nofal M, Al-Kasasbeh A, El-Bashir M, Jawarneh QA, Ababneh MJ   +7 more
core  

Distribution of genetic risk score.

, 2013
Distribution of the seven SNPs-based genetic risk score in 1,387 NPC cases (black bars) and 1,459 controls (grey bars). Individual risk for NPC was calculated by weighting each risk allele with its corresponding risk coefficient, which was derived from ...
Yin Yao Shugart (73599), Wei-Hua Jia (20884), Hai-De Qin (78238), Jin-Xin Bei (151461), Fu-Tian Luo (282457), Hong-Lian Ruan (166118), Yi-Xin Zeng (20896)   +6 more
core   +1 more source

Schizophrenia polygenic risk score influence on white matter microstructure [PDF]

, 2020
Schizophrenia (SZ) and bipolar disorder (BD) are highly heritable, share symptomatology, and have a polygenic architecture. The impact of recent polygenic risk scores (PRS) for psychosis, which combine multiple genome-wide associated risk variations ...
Sukhi Shergill, Elvira Bramon, Colm McDonald, Beatriz Simões, Timothea Toulopoulou, Robin Murray, Hugo Ferreira, Evangelos Vassos, Diana Prata, Fergus Kane, Sridevi Kalidindi   +10 more
core   +1 more source

A polygenic resilience score moderates the genetic risk for schizophrenia [PDF]

Molecular Psychiatry, 2019
AbstractBased on the discovery by the Resilience Project (Chen R. et al. Nat Biotechnol 34:531–538, 2016) of rare variants that confer resistance to Mendelian disease, and protective alleles for some complex diseases, we posited the existence of genetic variants that promote resilience to highly heritable polygenic disorders1,0 such as schizophrenia ...
Hess, Jonathan L, Tylee, Daniel S, Mors, Ole, Duan, Jubao, Dudbridge, Frank, Duncanson, Audrey, Durmishi, Naser, Edkins, Sarah, Ehrenreich, Hannelore, Eichhammer, Peter, Eriksson, Johan, Escott-Price, Valentina, Esko, Tõnu, Nordentoft, Merete, Essioux, Laurent, Fanous, Ayman H, Farh, Kai-How, Farrell, Martilias S, Frank, Josef, Franke, Lude, Freedman, Robert, Freeman, Colin, Freimer, Nelson B, Friedl, Marion, Hougaard, David M, Friedman, Joseph I, Fromer, Menachem, Gejman, Pablo V, Genovese, Giulio, Georgieva, Lyudmila, Giannoulatou, Eleni, Giegling, Ina, Gill, Michael, Gillman, Matthew, Giusti-Rodríguez, Paola, Byberg-Grauholm, Jonas, Godard, Stephanie, Goldstein, Jacqueline I, Golimbet, Vera, Gopal, Srihari, Gratten, Jacob, Gray, Emma, Gurling, Hugh, Gwilliam, Rhian, de Haan, Lieuwe, Hall, Jeremy, Bækvad-Hansen, Marie, Hammer, Christian, Hammond, Naomi, Hamshere, Marian L, Hansen, Mark, Hansen, Thomas, Haroutunian, Vahram, Hartmann, Annette M, Hellenthal, Garrett, Henskens, Frans A, Herms, Stefan, Greenwood, Tiffany A, Hirschhorn, Joel N, Hoffmann, Per, Hofman, Andrea, Hollegaard, Mads V, Huang, Hailiang, Hultman, Christina M, Hunt, Sarah E, Ikeda, Masashi, Iwata, Nakao, Iyegbe, Conrad, Tsuang, Ming T, Jablensky, Assen V, Jankowski, Janusz, Jayakumar, Alagurevathi, Joa, Inge, Jönsson, Erik G, Julià, Antonio, Kähler, Anna K, Kahn, René S, Kalaydjieva, Luba, Karachanak-Yankova, Sena, Curtis, David, Karjalainen, Juha, Kavanagh, David, Keller, Matthew C, Kendler, Kenneth S, Kennedy, James L, Khrunin, Andrey, Kim, Yunjung, Kirov, George, Klovins, Janis, Knight, Jo, Steinberg, Stacy, Knowles, James A, Konte, Bettina, Kucinskas, Vaidutis, Kucinskiene, Zita Ausrele, Kuzelova-Ptackova, Hana, Langford, Cordelia, Laurent, Claudine, Lawrie, Stephen, Lee, S Hong, Lee, Phil, Sigurdsson, Engilbert, Lee, Jimmy, Legge, Sophie E, Lencz, Todd, Lerer, Bernard, Levinson, Douglas F, Lewis, Cathryn M, Li, Tao, Li, Qingqin S, Li, Miaoxin, Liang, Kung-Yee, Mattheisen, Manuel, Stefánsson, Hreinn, Liddle, Jennifer, Lieberman, Jeffrey, Limborska, Svetlana, Lin, Kuang, Linszen, Don H, Liu, Jianjun, Lönnqvist, Jouko, Loughland, Carmel M, Lubinski, Jan, Macek, Milan, Stefánsson, Kári, Magnusson, Patrik K E, Maher, Brion S, Maier, Wolfgang, Malhotra, Anil K, Mallet, Jacques, Markus, Hugh S, Marsal, Sara, Mata, Ignacio, Mathew, Christopher G, Mattingsdal, Morten, Edenberg, Howard J, McCann, Owen T, McCarley, Robert W, McCarroll, Steven A, McCarthy, Mark I, McDonald, Colm, McIntosh, Andrew M, McQuillin, Andrew, Meier, Sandra, Meijer, Carin J, Melegh, Bela, Holmans, Peter, Melle, Ingrid, Mesholam-Gately, Raquelle I, Metspalu, Andres, Michie, Patricia T, Milani, Lili, Milanova, Vihra, Mokrab, Younes, Moran, Jennifer L, Morris, Derek W, Mowry, Bryan J, Faraone, Stephen V, Müller-Myhsok, Bertram, Murphy, Kieran C, Murray, Robin M, Myin-Germeys, Inez, Neale, Benjamin M, Nelis, Mari, Nenadic, Igor, Nertney, Deborah A, Nestadt, Gerald, Nicodemus, Kristin K, Glatt, Stephen J, Nikitina-Zake, Liene, Nisenbaum, Laura, Nordin, Annelie, Nöthen, Markus M, O'Callaghan, Eadbhard, O'Donovan, Michael C, O'Dushlaine, Colm, O'Neill, F Anthony, Oh, Sang-Yun, Olincy, Ann, Adolfsson, Rolf, Olsen, Line, Ophoff, Roel A, Van Os, Jim, Owen, Michael J, Palmer, Colin N A, Palotie, Aarno, Pantelis, Christos, Papadimitriou, George N, Papiol, Sergi, Parkhomenko, Elena, Agartz, Ingrid, Pato, Michele T, Pato, Carlos N, Paunio, Tiina, Pearson, Richard, Cairns, Murray J, DeLisi, Lynn E, Gershon, Elliot S, Kelly, Brian J, Lam, Max, Norgren, Nina, Agerbo, Esben, Tooney, Paul A, Pejovic-Milovancevic, Milica, Petryshen, Tracey L, Plomin, Robert, Posthuma, Danielle, Powell, John, Roussos, Panos, Schall, Ulrich, Scott, Rodney J, Sim, Kang, Slominsky, Petr, So, Hon-Cheong, Stogmann, Elisabeth, Bacanu, Silviu A, Stroup, T Scott, Tosato, Sarah, Visscher, Peter M, Walters, James T R, Webb, Bradley T, Witt, Stephanie H, Wood, Nicholas W, Wray, Naomi R, Zai, Clement C, Bellenguez, Céline, Black, Donald W, Børglum, Anders D, Bramon, Elvira, Brown, Matthew A, Buccola, Nancy G, Buxbaum, Joseph D, Als, Thomas D, Grove, Jakob, Chen, Eric Y H, Cichon, Sven, Collier, David A, Corvin, Aiden, Crespo-Facorro, Benedicto, Mortensen, Preben Bo, Deloukas, Panos, Demontis, Ditte, Donohoe, Gary   +242 more
openaire   +14 more sources

A polygenetic risk score combined with environmental factors better predict susceptibility to hepatocellular carcinoma in Chinese population

Cancer Medicine
Aims This study aimed to investigate environmental factors and genetic variant loci associated with hepatocellular carcinoma (HCC) in Chinese population and construct a weighted genetic risk score (wGRS) and polygenic risk score (PRS).
Yuanlin Zou, Jicun Zhu, Caijuan Song, Tiandong Li, Keyan Wang, Jianxiang Shi, Hua Ye, Peng Wang   +7 more
doaj   +1 more source