Results 91 to 100 of about 8,823,949 (205)

Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist : a Mendelian randomisation analysis [PDF]

open access: yes, 2015
Funded by: UK Medical Research Council, British Heart Foundation, UK National Institute for Health Research, National Institute for Health Research Cambridge Biomedical Research Centre, European Research Council, and European Commission Framework ...
D. F. Easton (7608179)   +874 more
core   +5 more sources

Polygenic Risk Scores and Genetically Complex Eye Disease

open access: yesAnnual Review of Vision Science
The success of genome-wide association studies (GWASs) in uncovering genetic variants associated with complex eye diseases has paved the way for the development of risk prediction approaches based on disease genetics. Derived from GWAS data, polygenic risk scores (PRSs) have been emerging as a promising indicator of an individual's genetic liability to
Le, Ngoc-Quynh   +2 more
openaire   +4 more sources

Genetic risk score for intracranial aneurysms

open access: yes, 2023
Background:Recently, common genetic risk factors for intracranial aneurysm (IA) and aneurysmal subarachnoid hemorrhage (ASAH) were found to explain a large amount of disease heritability and therefore have potential to be used for genetic risk prediction. We constructed a genetic risk score to (1) predict ASAH incidence and IA presence (combined set of
Bakker, M.K.   +27 more
openaire   +1 more source

Public Awareness of Genetic Influence on Chronic Disease Risk: Are Genetic and Lifestyle Causal Beliefs Compatible? [PDF]

open access: yes, 2011
Background/Aims: There is concern that raising awareness about the role of genetics in chronic disease etiology could undermine public belief that lifestyles are important, leading to adverse effects on public health. We tested the hypothesis that people
Sanderson, SC   +3 more
core  

Genetic markers used in the polygenic risk score calculation.

open access: yes, 2023
Genetic markers used in the polygenic risk score calculation.
Christofer Toumazou (571395)   +1 more
core   +1 more source

Estimating Exposome Score for Schizophrenia Using Predictive Modeling Approach in Two Independent Samples: The Results From the EUGEI Study [PDF]

open access: yes, 2019
Exposures constitute a dense network of the environment: exposome. Here, we argue for embracing the exposome paradigm to investigate the sum of nongenetic "risk" and show how predictive modeling approaches can be used to construct an exposome score (ES ...
Petrovic, S. A.   +43 more
core   +1 more source

Genetic Regulation of Maternal Oxytocin Response and Its Influences on Maternal Behavior

open access: yesNeural Plasticity, 2016
We interrogated the genetic modulation of maternal oxytocin response and its association with maternal behavior using genetic risk scores within the oxytocin receptor (OXTR) gene.
Divya Mehta   +6 more
doaj   +1 more source

Polygenic risk score: use in migraine research

open access: yesThe Journal of Headache and Pain, 2018
Background The latest Genome-Wide Association Study identified 38 genetic variants associated with migraine. In this type of studies the significance level is very difficult to achieve (5 × 10− 8) due to multiple testing.
Mona Ameri Chalmer   +3 more
doaj   +1 more source

Validation of a genetic risk score for Arkansas women of color

open access: yesPLOS ONE, 2018
African American women in the state of Arkansas have high breast cancer mortality rates. Breast cancer risk assessment tools developed for African American underestimate breast cancer risk. Combining African American breast cancer associated single-nucleotide polymorphisms (SNPs) into breast cancer risk algorithms may improve individualized estimates ...
Athena Starlard-Davenport   +8 more
openaire   +5 more sources

Adjusted effect estimatesa of patella lead, genetic score and interaction between patella lead and genetic risk score.

open access: yes, 2016
Adjusted effect estimatesa of patella lead, genetic score and interaction between patella lead and genetic risk score.
Howard Hu (60464)   +6 more
core   +1 more source

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