Results 71 to 80 of about 8,823,949 (205)

Clinical validity assessment of a breast cancer risk model combining genetic and clinical information [PDF]

, 2010
_Background:_ The extent to which common genetic variation can assist in breast cancer (BCa) risk assessment is unclear. We assessed the addition of risk information from a panel of BCa-associated single nucleotide polymorphisms (SNPs) on risk ...
Renee P. Stokowski, Mary Pettinger, Brian K. Rhees, Ross L. Prentice, Matthew E. Mealiffe, David A. Hinds   +5 more
core  

Additional value of a combined genetic risk score to standard cardiovascular stratification

Genetics and Molecular Biology
The utility of genetic risk scores (GRS) as independent risk predictors remains inconclusive. Here, we evaluate the additive value of a multi-locus GRS to the Framingham risk score (FRS) in coronary artery disease (CAD) risk prediction.
Andreia Pereira, Maria Isabel Mendonca, Sofia Borges, Ana Célia Sousa, Sónia Freitas, Eva Henriques, Mariana Rodrigues, Ana Isabel Freitas, Graça Guerra, Carolina Freitas, Décio Pereira, António Brehm, Roberto Palma Dos Reis   +12 more
doaj   +1 more source

Statistical Methods For Detecting Genetic Risk Factors of a Disease with Applications to Genome-Wide Association Studies [PDF]

, 2015
This thesis aims to develop various statistical methods for analysing the data derived from genome wide association studies (GWAS). The GWAS often involves genotyping individual human genetic variation, using high-throughput genome-wide single ...
Ali, Fadhaa, Ministry of Higher Education and Scientific Research- Republic of Iraq   +1 more
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Genetic risk variants in intestinal inflammatory disorders [PDF]

, 2010
PhDThis thesis includes work on the genetics of intestinal inflammatory disorders, concentrating on coeliac disease and Crohn’s disease. It explores how common genetic variants influence risk of complex phenotypes including immunological intolerance to
Dubois, Patrick Charles Alexander
core   +4 more sources

Are genetic risk factors for psychosis also associated with dimension-specific psychotic experiences in adolescence? [PDF]

, 2014
Psychosis has been hypothesised to be a continuously distributed quantitative phenotype and disorders such as schizophrenia and bipolar disorder represent its extreme manifestations.
Plomin, Robert, Freeman, D, Daniel Freeman, Angelica Ronald (346752), Sieradzka, D., Robert Plomin (27675), Dominika Sieradzka (549507), Cardno, Alastair G., Power Robert A., Power, Robert, Cardno, A.G., McGuire, P, McGuire, Philip, Angelica Ronald, Sieradzka Dominika, Alastair G Cardno, Ronald, Angelica, Ronald, A, Philip McGuire (325649), Robert Plomin, Sieradzka, Dominika, Freeman, Daniel, Power, RA, Power, R.A., Cardno Alastair G., Ronald Angelica, Robert A. Power (549508), Meaburn, Emma L, McGuire, P., Cardno, AG, Dudbridge Frank, Freeman Daniel, Dominika Sieradzka, Frank Dudbridge, Robert A Power, Meaburn Emma L., Meaburn, EL, Sieradzka, D, Alastair G. Cardno (549510), Plomin, R., Dudbridge, Frank, Daniel Freeman (549509), Meaburn, Emma L., Plomin Robert, Freedman, D., Power, Robert A, Plomin, R, Cardno, Alastair G, Emma L. Meaburn (397318), McGuire Philip, Philip McGuire, Dudbridge, F, Frank Dudbridge (102283), Emma L Meaburn   +53 more
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Insulin resistance genetic risk score and burden of coronary artery disease in patients referred for coronary angiography.

PLoS ONE, 2021
AimsInsulin resistance associates with development of metabolic syndrome and risk of cardiovascular disease. The link between insulin resistance and cardiovascular disease is complex and multifactorial.
Regitze Skals, Maria Lukács Krogager, Emil Vincent R Appel, Theresia M Schnurr, Christian Theil Have, Gunnar Gislason, Henrik Enghusen Poulsen, Lars Køber, Thomas Engstrøm, Steen Stender, Torben Hansen, Niels Grarup, Christina Ji-Young Lee, Charlotte Andersson, Christian Torp-Pedersen, Peter E Weeke   +15 more
doaj   +1 more source

Validation of genetic risk scores for coronary artery disease, developed on European population samples, in Russian population

Кардиоваскулярная терапия и профилактика, 2023
Aim. To evaluate the information content of genetic risk scores (GRSs) for coronary artery disease (CAD), previously developed on European populations, in representatives of the Russian population.Material and methods.
A. I. Ershova, A. N. Meshkov, V. A. Kutsenko, Yu. V. Vyatkin, A. V. Kiseleva, E. A. Sotnikova, A. S. Limonova, E. V. Garbuzova, G. A. Muromtseva, M. Zaicenoka, A. A. Zharikova, V. E. Ramensky, O. А. Belova, S. A. Rachkova, M. S. Pokrovskaya, S. A. Shalnova, S. A. Boytsov, O. M. Drapkina   +17 more
doaj   +1 more source

Genetic Risk Scores in Stroke Research and Care

Stroke
Stroke remains a leading cause of death and disability worldwide. While well-established risk factors play a major role, genetic predisposition is a crucial determinant of stroke susceptibility, with heritability estimates up to 39% for ischemic stroke and 29% for intracerebral hemorrhage.
Nicola Luigi Bragazzi, Lanyue Zhang, Murad Omarov, Marios K. Georgakis   +3 more
openaire   +3 more sources

The genetic relationship between commencement of luteal activity and calving interval, body condition score, production, and linear type traits in Holstein-Friesian dairy cattle [PDF]

, 2002
The decline of fertility in the UK dairy herd and the unfavorable genetic correlation (r(a)) between fertility and milk yield has necessitated the broadening of breeding goals to include fertility.
Flint, APF, Pryce, J.E., Woolliams, JA, Royal, M.D., Pryce, JE, Flint, A.P.F., Woolliams, John, Royal, MD   +7 more
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Genetic parameters for milk somatic cell score and relationships with production traits in primiparous dairy sheep [PDF]

, 2007
A total of 13,066 first-lactation test-day records of 2,277 Valle del Belice ewes from 17 flocks were used to estimate genetic parameters for somatic cell scores (SCS) and milk production traits, using a repeatability test-day animal model.
van Kaam, J. B. C. H. M., Portolano, B., Bovenhuis, H., van Kaam, J.B.C.H.M., Kaam, J.B.C.H.M., van, Finocchiaro, R., BOVENHUIS H., FINOCCHIARO, Raffaella, VAN KAAM JBCHM, Riggio, V.; id_orcid, RIGGIO, Valentina, PORTOLANO, Baldassare, Riggio, V.   +12 more
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