Results 41 to 50 of about 445,590 (261)
Genetic Risk Scores for Complex Disease Traits in Youth [PDF]
Circulation: Genomic and Precision Medicine, 2020 Background: For most disease-related traits the magnitude of the contribution of genetic factors in adolescents remains unclear. Methods: Twenty continuous traits related to anthropometry, cardiovascular and renal function, metabolism, and inflammation were selected from the ongoing
Tian Xie +6 more
openaire +3 more sources
Combined accelerometer and genetic analysis to differentiate essential tremor from Parkinson’s disease [PDF]
PeerJ, 2018 Essential tremor (ET) and Parkinson’s disease (PD) are among the most common adult-onset tremor disorders. Clinical and pathological studies suggest that misdiagnosis of PD for ET, and vice versa, occur in anywhere from 15% to 35% of cases.
Bhuvan Molparia +8 more
doaj +2 more sources
Arquivos Brasileiros de Cardiologia, 2018 Background: Genetic risk score can quantify individual’s predisposition to coronary artery disease; however, its usefulness as an independent risk predictor remains inconclusive.
Andreia Pereira +9 more
doaj +1 more source
Polygenic scores for low lung function and the future risk of adverse health outcomes
Cardiovascular Diabetology, 2022 Aims Reduced lung function and adverse health outcomes are often observed. This study characterizes genetic susceptibility for reduced lung function and risk of developing a range of adverse health outcomes.
Suneela Zaigham +4 more
doaj +1 more source
Genetics in Medicine Open, 2023 Purpose: As polygenic risk scores (PRSs) enter clinical practice, health care providers’ and the publics’ comprehension of PRS results are of great importance; yet, they are poorly understood.
Doug Stubbs +4 more
doaj +1 more source
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016 Background A lifestyle cardiovascular risk score (LCRS) and a genetic risk score (GRS) have been independently associated with myocardial infarction (MI) in Hispanics/Latinos.
Mercedes Sotos‐Prieto +4 more
doaj +1 more source
Multivariable prognostic model for heart failure in Chinese Han population‐based setting
ESC Heart Failure, 2022 Aims The prognosis of heart failure (HF) depends on genetic predisposition, and recent studies have shown that impaired autophagy is involved in HF.
Man Huang +6 more
doaj +1 more source
Genetic Risk Scores for the Clinical Rheumatologist
JCR: Journal of Clinical RheumatologyBackground/Historical Perspective The advent of genome-wide sequencing and large-scale genetic epidemiological studies has led to numerous opportunities for the application of genetics in clinical medicine. Leveraging this information toward the formation of clinically useful tools has been an ongoing research goal in this area.
Austin M. Wheeler +2 more
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Genetic Risk Scores and Missing Heritability in Ovarian Cancer
Genes, 2023 Ovarian cancers are curable by surgical resection when discovered early. Unfortunately, most ovarian cancers are diagnosed in the later stages. One strategy to identify early ovarian tumors is to screen women who have the highest risk. This opinion article summarizes the accuracy of different methods used to assess the risk of developing ovarian cancer,
James P Brody, Yasaman Fatapour
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Frontiers in MedicineIntroductionPolygenic risk scores (PRS) have emerged as a central tool in genomic medicine, enabling risk prediction for common, complex diseases. Despite rapid methodological and clinical advances, concerns remain regarding the structural organization ...
Fouad Bitar +10 more
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