Results 21 to 30 of about 8,823,949 (205)

Multilocus Genetic Risk Scores for Venous Thromboembolism Risk Assessment [PDF]

Journal of the American Heart Association, 2014
Background Genetics plays an important role in venous thromboembolism ( VTE ). Factor V Leiden ( FVL or rs6025) and prothrombin gene G20210A ( PT or rs1799963) are ...
Soria, José Manuel, Morange, Pierre-Emmanuel, Vila, Joan, Souto, Juan Carlos, Moyano, Manel, Trégouët, David-Alexandre, Mateo, José, Saut, Noémie, Salas, Eduardo, Elosua, Roberto   +9 more
openaire   +6 more sources

Genetic risk scores in life insurance underwriting

Journal of Health Economics, 2022
Genetic tests that predict the lifetime risk of common medical conditions are fast becoming more accurate and affordable. The life insurance industry is interested in using predictive genetic tests in the underwriting process, but more research is needed to establish whether this nascent form of genetic testing can refine the process over conventional ...
Karlsson Linnér, Richard, Koellinger, Philipp D.   +1 more
openaire   +3 more sources

Statistical genetics and polygenic risk score for precision medicine [PDF]

Inflammation and Regeneration, 2021
AbstractThe prediction of disease risks is an essential part of personalized medicine, which includes early disease detection, prevention, and intervention. The polygenic risk score (PRS) has become the standard for quantifying genetic liability in predicting disease risks.
Takahiro Konuma, Yukinori Okada
openaire   +3 more sources

Psychosis Endophenotypes: A Gene-Set-Specific Polygenic Risk Score Analysis [PDF]

, 2023
BACKGROUND AND HYPOTHESIS: Endophenotypes can help to bridge the gap between psychosis and its genetic predispositions, but their underlying mechanisms remain largely unknown.
Genetic Risk and Outcome of Psychosis (GROUP) Study
core  

Genetic Risk Scores

Current Protocols in Human Genetics, 2019
AbstractGenome‐wide variation data with millions of genetic markers have become commonplace. However, the potential for interpretation and application of these data for clinical assessment of outcomes of interest, and prediction of disease risk, is currently not fully realized.
Robert P, Igo, Tyler G, Kinzy, Jessica N, Cooke Bailey   +2 more
openaire   +3 more sources

The genetic architecture of Alzheimer disease risk in the Ohio and Indiana Amish

HGG Advances, 2022
Summary: Alzheimer disease (AD) is the most common type of dementia and is currently estimated to affect 6.2 million Americans. It ranks as the sixth leading cause of death in the United States, and the proportion of deaths due to AD has been increasing ...
Michael D. Osterman, Yeunjoo E. Song, Larry D. Adams, Renee A. Laux, Laura J. Caywood, Michael B. Prough, Jason E. Clouse, Sharlene D. Herington, Susan H. Slifer, Audrey Lynn, M. Denise Fuzzell, Sarada L. Fuzzell, Sherri D. Hochstetler, Kristy Miskimen, Leighanne R. Main, Daniel A. Dorfsman, Paula Ogrocki, Alan J. Lerner, Jairo Ramos, Jeffery M. Vance, Michael L. Cuccaro, William K. Scott, Margaret A. Pericak-Vance, Jonathan L. Haines   +23 more
doaj   +1 more source

Development and Evaluation of a Genetic Risk Score for Obesity [PDF]

Biodemography and Social Biology, 2013
Results from genome-wide association studies (GWAS) represent a potential resource for etiological and treatment research. GWAS of obesity-related phenotypes have been especially successful. To translate this success into a research tool, we developed and tested a “genetic risk score” (GRS) that summarizes an individual’s genetic predisposition to ...
Belsky, Daniel W., Moffitt, Terrie E., Sugden, Karen, Williams, Benjamin, Houts, Renate, McCarthy, Jeanette, Caspi, Avshalom   +6 more
openaire   +3 more sources

The Application of Genetic Risk Scores in Rheumatic Diseases: A Perspective

Genes, 2023
Modest effect sizes have limited the clinical applicability of genetic associations with rheumatic diseases. Genetic risk scores (GRSs) have emerged as a promising solution to translate genetics into useful tools. In this review, we provide an overview of the recent literature on GRSs in rheumatic diseases. We describe six categories for which GRSs are
Lotta M. Vaskimo, Georgy Gomon, Najib Naamane, Heather J. Cordell, Arthur Pratt, Rachel Knevel   +5 more
openaire   +4 more sources

Ethical concerns relating to genetic risk scores for suicide [PDF]

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2021
Abstract Genome‐wide association studies (GWAS) provide valuable information in research contexts regarding genomic changes that contribute to risks for complex psychiatric conditions like major depressive disorder. GWAS results can be used to calculate polygenic risk scores (PRS) for psychiatric conditions, such as bipolar disorder ...
Anna Docherty, Brent Kious, Teneille Brown, Leslie Francis, Louisa Stark, Brooks Keeshin, Jeffrey Botkin, Emily DiBlasi, Doug Gray, Hilary Coon   +9 more
openaire   +2 more sources

Race-specific genetic risk score is more accurate than nonrace-specific genetic risk score for predicting prostate cancer and high-grade diseases

Asian Journal of Andrology, 2016
Genetic risk score (GRS) based on disease risk-associated single nucleotide polymorphisms (SNPs) is an informative tool that can be used to provide inherited information for specific diseases in addition to family history.
Rong Na, Dingwei Ye, Jun Qi, Fang Liu, Xiaoling Lin, Brian T Helfand, Charles B Brendler, Carly Conran, Jian Gong, Yishuo Wu, Xu Gao, Yaqing Chen, S Lilly Zheng, Zengnan Mo, Qiang Ding, Yinghao Sun, Jianfeng Xu   +16 more
doaj   +1 more source