Results 21 to 30 of about 445,590 (261)

Genetic risk scores in life insurance underwriting

Journal of Health Economics, 2022
Genetic tests that predict the lifetime risk of common medical conditions are fast becoming more accurate and affordable. The life insurance industry is interested in using predictive genetic tests in the underwriting process, but more research is needed to establish whether this nascent form of genetic testing can refine the process over conventional ...
Karlsson Linnér, Richard, Koellinger, Philipp D.   +1 more
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Genetic Risk Scores

Current Protocols in Human Genetics, 2019
AbstractGenome‐wide variation data with millions of genetic markers have become commonplace. However, the potential for interpretation and application of these data for clinical assessment of outcomes of interest, and prediction of disease risk, is currently not fully realized.
Robert P, Igo, Tyler G, Kinzy, Jessica N, Cooke Bailey   +2 more
openaire   +3 more sources

Development and Evaluation of a Genetic Risk Score for Obesity [PDF]

Biodemography and Social Biology, 2013
Results from genome-wide association studies (GWAS) represent a potential resource for etiological and treatment research. GWAS of obesity-related phenotypes have been especially successful. To translate this success into a research tool, we developed and tested a “genetic risk score” (GRS) that summarizes an individual’s genetic predisposition to ...
Belsky, Daniel W., Moffitt, Terrie E., Sugden, Karen, Williams, Benjamin, Houts, Renate, McCarthy, Jeanette, Caspi, Avshalom   +6 more
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Increasing insulin resistance accentuates the effect of triglyceride-associated loci on serum triglycerides during 5 years[S]

Journal of Lipid Research, 2016
Blood concentrations of triglycerides are influenced by genetic factors as well as a number of environmental factors, including adiposity and glucose homeostasis.
Johanne M. Justesen, Ehm A. Andersson, Kristine H. Allin, Camilla H. Sandholt, Torben Jørgensen, Allan Linneberg, Marit E. Jørgensen, Torben Hansen, Oluf Pedersen, Niels Grarup   +9 more
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The genetic architecture of Alzheimer disease risk in the Ohio and Indiana Amish

HGG Advances, 2022
Summary: Alzheimer disease (AD) is the most common type of dementia and is currently estimated to affect 6.2 million Americans. It ranks as the sixth leading cause of death in the United States, and the proportion of deaths due to AD has been increasing ...
Michael D. Osterman, Yeunjoo E. Song, Larry D. Adams, Renee A. Laux, Laura J. Caywood, Michael B. Prough, Jason E. Clouse, Sharlene D. Herington, Susan H. Slifer, Audrey Lynn, M. Denise Fuzzell, Sarada L. Fuzzell, Sherri D. Hochstetler, Kristy Miskimen, Leighanne R. Main, Daniel A. Dorfsman, Paula Ogrocki, Alan J. Lerner, Jairo Ramos, Jeffery M. Vance, Michael L. Cuccaro, William K. Scott, Margaret A. Pericak-Vance, Jonathan L. Haines   +23 more
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The Application of Genetic Risk Scores in Rheumatic Diseases: A Perspective

Genes, 2023
Modest effect sizes have limited the clinical applicability of genetic associations with rheumatic diseases. Genetic risk scores (GRSs) have emerged as a promising solution to translate genetics into useful tools. In this review, we provide an overview of the recent literature on GRSs in rheumatic diseases. We describe six categories for which GRSs are
Lotta M. Vaskimo, Georgy Gomon, Najib Naamane, Heather J. Cordell, Arthur Pratt, Rachel Knevel   +5 more
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Race-specific genetic risk score is more accurate than nonrace-specific genetic risk score for predicting prostate cancer and high-grade diseases

Asian Journal of Andrology, 2016
Genetic risk score (GRS) based on disease risk-associated single nucleotide polymorphisms (SNPs) is an informative tool that can be used to provide inherited information for specific diseases in addition to family history.
Rong Na, Dingwei Ye, Jun Qi, Fang Liu, Xiaoling Lin, Brian T Helfand, Charles B Brendler, Carly Conran, Jian Gong, Yishuo Wu, Xu Gao, Yaqing Chen, S Lilly Zheng, Zengnan Mo, Qiang Ding, Yinghao Sun, Jianfeng Xu   +16 more
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Genetic and epigenetic factors determining NAFLD risk

Molecular Metabolism, 2021
Background: Hepatic steatosis is a common chronic liver disease that can progress into more severe stages of NAFLD or promote the development of life-threatening secondary diseases for some of those affected.
Wenke Jonas, Annette Schürmann
doaj   +1 more source

Reliability of Ancestry-specific Prostate Cancer Genetic Risk Score in Four Racial and Ethnic Populations

European Urology Open Science, 2022
Background: Reliability of prostate cancer (PCa) genetic risk score (GRS), that is, the concordance between its estimated risk and observed risk, is required for genetic testing at the individual level.
Zhuqing Shi, Jianan Zhan, Jun Wei, Skylar Ladson-Gary, Chi-Hsiung Wang, Peter J. Hulick, S. Lilly Zheng, Kathleen A. Cooney, William B. Isaacs, Brian T. Helfand, Bertram L. Koelsch, Jianfeng Xu   +11 more
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Genetic discovery and risk characterization in type 2 diabetes across diverse populations

HGG Advances, 2021
Summary: Genomic discovery and characterization of risk loci for type 2 diabetes (T2D) have been conducted primarily in individuals of European ancestry.
Linda M. Polfus, Burcu F. Darst, Heather Highland, Xin Sheng, Maggie C.Y. Ng, Jennifer E. Below, Lauren Petty, Stephanie Bien, Xueling Sim, Wei Wang, Pierre Fontanillas, Yesha Patel, Michael Preuss, Claudia Schurmann, Zhaohui Du, Yingchang Lu, Suhn K. Rhie, Joseph M. Mercader, Teresa Tusie-Luna, Clicerio González-Villalpando, Lorena Orozco, Cassandra N. Spracklen, Brian E. Cade, Richard A. Jensen, Meng Sun, Yoonjung Yoonie Joo, Ping An, Lisa R. Yanek, Lawrence F. Bielak, Salman Tajuddin, Aude Nicolas, Guanjie Chen, Laura Raffield, Xiuqing Guo, Wei-Min Chen, Girish N. Nadkarni, Mariaelisa Graff, Ran Tao, James S. Pankow, Martha Daviglus, Qibin Qi, Eric A. Boerwinkle, Simin Liu, Lawrence S. Phillips, Ulrike Peters, Chris Carlson, Lynne R. Wikens, Loic Le Marchand, Kari E. North, Steven Buyske, Charles Kooperberg, Ruth J.F. Loos, Daniel O. Stram, Christopher A. Haiman   +53 more
doaj   +1 more source