Results 51 to 60 of about 31,405 (257)

The Polygenic Risk Score Knowledge Base offers a centralized online repository for calculating and contextualizing polygenic risk scores

Communications Biology, 2022
The Polygenic Risk Score Knowledge Base (PRSKB) is a web-based interface that stores data from >2,300 distinct genome-wide association studies, and can estimate polygenic risk scores for general use.
Madeline L. Page, Elizabeth L. Vance, Matthew E. Cloward, Ed Ringger, Louisa Dayton, Mark T. W. Ebbert, The Alzheimer’s Disease Neuroimaging Initiative, Justin B. Miller, John S. K. Kauwe   +8 more
doaj   +1 more source

Harnessing Large‐Scale Multi‐Omics Data for Risk Prediction and Deep Phenotyping of Valvular Heart Diseases in the General Population

Advanced Science, EarlyView.
Large‐scale UK Biobank analyses identify clinical and proteomic signatures for early prediction of valvular heart disease and its subtypes. Proteins add predictive value for VHD, AVS, and MVR, with outcome‐specific compact panels showing translational potential. Multi‐layer evidence highlights matrix remodeling, protease regulation, immune inflammation,
Zhihao Jiang, Yang Liu, Mingyu Song, Ning Chen, Canqing Yu, Jun Lv, Eric Yuk Fai Wan, Lu Qi, Liming Li, Dianjianyi Sun, Bang Zheng   +10 more
wiley   +1 more source

Patient Perspectives on Personalized Risk Communication Using Polygenic Risk Scores to Inform Colorectal Cancer Screening Decisions

AJPM Focus
Introduction: Colorectal cancer is increasingly diagnosed in people aged
Shauna R. Goldberg, MPH, Linda K. Ko, PhD, Li Hsu, PhD, Hang Yin, MS, Charles Kooperberg, PhD, Ulrike Peters, PhD, MPH, Andrea N. Burnett-Hartman, PhD, MPH   +6 more
doaj   +1 more source

Quantifying portable genetic effects and improving cross-ancestry genetic prediction with GWAS summary statistics

Nature Communications, 2023
Polygenic risk scores are used to improve risk prediction for common diseases but typically have reduced accuracy for individuals of non-European ancestry.
Jiacheng Miao, Hanmin Guo, Gefei Song, Zijie Zhao, Lin Hou, Qiongshi Lu   +5 more
doaj   +1 more source

Polygenic risk scores in the clinic: Translating risk into action

Human Genetics and Genomics Advances, 2021
Polygenic risk scores (PRSs) are heralded as useful tools for risk stratification and personalized preventive care, but they are clinically useful only if they can be translated into action. The risk information conveyed by a PRS must be contextualized to enable this.
Anna C.F. Lewis, Robert C. Green, Jason L. Vassy   +2 more
openaire   +3 more sources

Risk of Inflammatory Bowel Disease Following Hospital‐Treated Infections and Modulatory Role of Host Genetics to Support a Multi‐Hit Pathogenesis Model

Advanced Science, EarlyView.
Hospital‐treated infections are linked to increased risk of inflammatory bowel disease in a large prospective cohort. This risk differs by infection burden, time since infection, and host immune‐genetic susceptibility. The findings support a multi‐hit pathogenesis model in which severe infection and inherited susceptibility jointly shape inflammatory ...
Haiming Zhuang, Lintao Dan, Xin Xiang, Xixian Ruan, Shuai Yuan, Jialu Yao, Jiawei Geng, Jonas F. Ludvigsson, Tian Fu, Candida Abreu, Laurent Peyrin‐Biroulet, Xue Li, Yi Xiao, Fernando Magro, Xiaoyan Wang, Jing Sun, Jie Chen   +16 more
wiley   +1 more source

Adaptive Responses of Tropical Crops: A Multi‐Scale Omics Integrated Perspective

Advanced Science, EarlyView.
Tropical crops integrate genomic, morphological, physiological, and ecological adaptations to thrive under extreme and variable environments. This review highlights how natural selection, domestication, and breeding shape stress resilience, resource‐use strategies, and productivity in sugarcane, banana, cassava, rubber and oil palm, offering new routes
Peilin Wang, Chenhui Li, Dongjiao Wang, Qibin Wu, Zhen Zeng, Huiming Guo, Han Cheng, Songbi Chen, Hongxing Cao, Hongmei Cheng, Jianghui Xie, Youxiong Que   +11 more
wiley   +1 more source

Neurocognitive trajectory and proteomic signature of inherited risk for Alzheimer's disease.

PLoS Genetics, 2022
For Alzheimer's disease-a leading cause of dementia and global morbidity-improved identification of presymptomatic high-risk individuals and identification of new circulating biomarkers are key public health needs.
Manish D Paranjpe, Mark Chaffin, Sohail Zahid, Scott Ritchie, Jerome I Rotter, Stephen S Rich, Robert Gerszten, Xiuqing Guo, Susan Heckbert, Russ Tracy, John Danesh, Eric S Lander, Michael Inouye, Sekar Kathiresan, Adam S Butterworth, Amit V Khera   +15 more
doaj   +1 more source

Herbicide Metabolic Resistance in Poaceae Plants via the GA‐GID1/DELLA‐DOF2‐P450s Module

Advanced Science, EarlyView.
Plant hormone signaling modulates herbicide resistance in Echinochloa crus‐galli. The GA–DELLA–DOF2 cascade directly activates P450 detoxification genes in two Poaceae species, uncovering a core mechanism of metabolic herbicide resistance. ABSTRACT Barnyard grass (Echinochloa crus‐galli) is one of the world's most important weeds, and the evolution of ...
Junzhi Wang, Jiale Qi, Lin Wei, Qin Yu, Zhongyuan Liu, Lianyang Bai, Lang Pan   +6 more
wiley   +1 more source

Post‐GWAS Polygenic Risk Score: Utility and Challenges

JBMR Plus, 2020
Over the past decade, through genome‐wide association studies, more than 300 genetic variants have been identified to be associated with either BMD or fracture risk.
Tuan V Nguyen, John A Eisman
doaj   +1 more source