Results 51 to 60 of about 67,612 (348)
Metrics for Evaluating Polygenic Risk Scores [PDF]
JNCI Cancer Spectrum, 2020 Abstract There is growing interest in the use of polygenic risk scores based on genetic variants to predict cancer incidence. The type of metric used to evaluate the predictive performance of polygenic risk scores plays a crucial role in their interpretation.
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Hepatology, EarlyView., 2022 Hepatic APOF transcript levels correlate inversely with plasma TG and hepatic steatosis in humans. ApoF expression in mice promotes VLDL‐TG production and lipoprotein remnant clearance in mice. Abstract Background NAFLD affects nearly 25% of the global population. Cardiovascular disease (CVD) is the most common cause of death among patients with NAFLD,
Audrey Deprince +30 more
wiley +1 more source
Polygenic risk score, healthy lifestyles, and risk of incident depression
Translational Psychiatry, 2021 Genetic factors increase the risk of depression, but the extent to which this can be offset by modifiable lifestyle factors is unknown. We investigated whether a combination of healthy lifestyles is associated with lower risk of depression regardless of ...
Zhi Cao +6 more
doaj +1 more source
Epistatic effect of TLR3 and cGAS‐STING‐IKKε‐TBK1‐IFN signaling variants on colorectal cancer risk
Cancer Medicine, 2020 Objective The TLR3/cGAS‐STING‐IFN signaling has recently been reported to be disturbed in colorectal cancer due to deregulated expression of the genes involved.
Calogerina Catalano +14 more
doaj +1 more source
Multi-Polygenic Risk Score Prediction Model for Bipolar Disorder
, 2019 Bipolar disorder (BP), a severe mental disorder characterized by recurring manic and depressive episodes, has been shown to have a strong genetic underpinning.
Mize, Travis
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Single-nucleotide polymorphism-based genetic risk score and patient age at prostate cancer diagnosis [PDF]
, 2019 Importance: Few studies have evaluated the association between a single-nucleotide polymorphism-based genetic risk score (GRS) and patient age at prostate cancer (PCa) diagnosis.
Andriole, Gerald L +10 more
core +2 more sources
Communications Biology, 2022 The Polygenic Risk Score Knowledge Base (PRSKB) is a web-based interface that stores data from >2,300 distinct genome-wide association studies, and can estimate polygenic risk scores for general use.
Madeline L. Page +8 more
doaj +1 more source
Polygenic risk scores and breast cancer risk prediction
The Breast, 2023 Polygenic Risk Scores (PRS) are a major component of accurate breast cancer risk prediction and have the potential to improve screening and prevention strategies. PRS combine the risk from Single nucleotide polymorphisms (SNPs) associated with breast cancer in Genome Wide Association Studies (GWAS) and explain over 30% of breast cancer heritability ...
Eleanor Roberts +2 more
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PGSXplorer: an integrated nextflow pipeline for comprehensive quality control and polygenic score model development [PDF]
PeerJThe rapid development of next-generation sequencing technologies and genomic data sharing initiatives during the post-Human Genome Project-era has catalyzed major advances in individualized medicine research.
Tutku Yaraş +2 more
doaj +2 more sources
Genome-wide association studies of the self-rating of effects of ethanol (SRE). [PDF]
, 2020 The level of response (LR) to alcohol as measured with the Self-Report of the Effects of Alcohol Retrospective Questionnaire (SRE) evaluates the number of standard drinks usually required for up to four effects. The need for a higher number of drinks for
Agrawal, Arpana +23 more
core +2 more sources