Results 71 to 80 of about 7,071,839 (288)

Mental Health Stigma in Psychiatric Genetics: Insights and Recommendations From the ISPG Member Survey on Stigma

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Little is known about how stigma is perceived within psychiatric genetics, a field increasingly central to public discussions about heredity, neurodiversity, and psychiatric risk. Understanding how stigma is perceived and experienced by psychiatric geneticists is important for guiding responsible communication and future stigma‐reduction ...
Anaïs B. Thijssen, Elleke Tissink, Reeteka Sud, Mandy Johnstone, Richard Josiassen, Andrea Lahti, Laura Huckins, Ariana Page, Stigma Reduction Interest Group of the ISPG, Jordan W. Smoller, Jehannine Austin, Janneke Zinkstok, Sarah E. Medland, Rada Veeneman, Anna R. Docherty   +14 more
wiley   +1 more source

Trace Elements Genetics: A Potential Role in Treatment‐Resistant Major Psychoses and Related Traits?

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Trace elements are pivotal to key biological processes, with possible effects on psychopathology. We investigated the hypothesis of shared genetic factors between trace elements levels, treatment resistance and related traits. We used genome‐wide summary statistics for trace elements blood concentration, treatment‐resistant depression (TRD ...
Chiara Fabbri, Alessandro Serretti, Marco Menchetti, Benedetta Vai, Francesco Benedetti, Lidia Fortaner‐Uyà, Concetta Crisafulli   +6 more
wiley   +1 more source

Polygenic risk scores in the clinic: Translating risk into action

Human Genetics and Genomics Advances, 2021
Polygenic risk scores (PRSs) are heralded as useful tools for risk stratification and personalized preventive care, but they are clinically useful only if they can be translated into action. The risk information conveyed by a PRS must be contextualized to enable this.
Anna C.F. Lewis, Robert C. Green, Jason L. Vassy   +2 more
openaire   +3 more sources

Supplementary Figure for "Association of polygenic score with tumor molecular subtypes in papillary thyroid carcinoma"

, 2023
polygenic risk score and thyroid cancer ...
Jennifer Rui Wang (15160185)
core   +1 more source

The Role of Glutamatergic and Dopaminergic Genes in Resistant Schizophrenia: A Systematic Review

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Psychosis is a heterogeneous disorder, with approximately one‐third of patients experiencing treatment resistance, predominantly among individuals diagnosed with Schizophrenia. Treatment‐resistant schizophrenia (TRS) may stem from a distinct biological signature, involving abnormalities in the dopaminergic and glutamatergic systems.
Maria Teresa Moreno‐Calle, Silvia Iñiguez‐Barrio, Maria Aurora Arrue, Leire Erkoreka   +3 more
wiley   +1 more source

Common polygenic risk for autism spectrum disorder (ASD) is associated with cognitive ability in the general population [PDF]

, 2015
Cognitive impairment is common among individuals diagnosed with autism spectrum disorder (ASD) and attention-deficit hyperactivity disorder (ADHD). It has been suggested that some aspects of intelligence are preserved or even superior in people with ASD ...
Starr, J., D J Porteous, Hocking, L J, Porteous, D. J., Thomson, P A; id_orcid, Hocking, L. J., Davies, G., Medland, S E, S E Medland, Hocking, L.J., Wright, M.J., Porteous, D J, J Starr, Lupton, M. K., Hall, L.S., Montgomery, G W, Clarke, T.-K., Medland, S.E., Pattie, A., Martin, N.G., Liewald, D.C., Padmanabhan, S., Deary, I J, C Hayward, Smith, B.H., Hall, L S, Smith, B. H.; id_orcid, Fernandez-Pujals, A. M., Wright, M J, G W Montgomery, Hansell, N K, D C Liewald, Hall, L. S., N K Hansell, Wright, M. J., N G Martin, Hayward, C., S Cox, Liewald, D. C., Cox, S., Starr, J, Montgomery, G. W., I J Deary, Thomson, P. A., B H Smith, Deary, I. J., Fernandez-Pujals, A M, Lupton, M K, Hayward, C; id_orcid, M K Lupton, Davies, Gail, P A Thomson, Clarke, T-K, A M McIntosh, Hansell, N. K., Hansell, N.K., MacIntyre, D J; id_orcid, MacIntyre, D. J., L J Hocking, Smith, B. H., Cox, S, Fernandez-Pujals, A.M., Thomson, P.A., McIntosh, A M; id_orcid, M J Wright, Martin, N. G., Porteous, D.J., G Davies, Montgomery, G.W., Smith, B H, A M Fernandez-Pujals, McIntosh, A. M., A Pattie, D J MacIntyre, McIntosh, A.M., Clarke, T. K., S Padmanabhan, Medland, S. E., Pattie, A, Liewald, D C, L S Hall, Lupton, M.K., T-K Clarke, Padmanabhan, S, Martin, N G, MacIntyre, D.J., Deary, I.J.   +86 more
core   +1 more source

Exploring Genetic and Biological Interconnections Between Neuroticism, Psychological Distress, Insomnia, and C‐Reactive Protein: Insights From the UK Biobank

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Psychobehavioral and physical health traits often co‐occur. Although previous studies have identified associations between neuroticism, psychological distress, insomnia, and inflammatory biomarkers such as C‐reactive protein (CRP), it remains unclear whether there is a genetic basis to these associations, and which biological pathways are ...
Lydia M Li, Nina Adler, Cristina L. Abbatangelo, Mark Wade, Esteban J. Parra   +4 more
wiley   +1 more source

Post‐GWAS Polygenic Risk Score: Utility and Challenges

JBMR Plus, 2020
Over the past decade, through genome‐wide association studies, more than 300 genetic variants have been identified to be associated with either BMD or fracture risk.
Tuan V Nguyen, John A Eisman
doaj   +1 more source

Neurocognitive trajectory and proteomic signature of inherited risk for Alzheimer's disease.

PLoS Genetics, 2022
For Alzheimer's disease-a leading cause of dementia and global morbidity-improved identification of presymptomatic high-risk individuals and identification of new circulating biomarkers are key public health needs.
Manish D Paranjpe, Mark Chaffin, Sohail Zahid, Scott Ritchie, Jerome I Rotter, Stephen S Rich, Robert Gerszten, Xiuqing Guo, Susan Heckbert, Russ Tracy, John Danesh, Eric S Lander, Michael Inouye, Sekar Kathiresan, Adam S Butterworth, Amit V Khera   +15 more
doaj   +1 more source

Maternal Factors Modifying the Link Between Genetic Risk for Autism and Developmental Milestones

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Although common genetic liability—quantified through polygenic risk scores (PRS)—accounts for substantial variance in autism spectrum disorder (ASD) liability, how prenatal environmental exposures interact with genetic predisposition to shape developmental outcomes remains poorly understood. Using the data from Autism Genetic Resource Exchange
Liliana D'Alesio, Vishani Nimish Patel, McKenna Walsh, Erick Messias, Ping‐I Lin   +4 more
wiley   +1 more source