Results 81 to 90 of about 7,071,839 (288)

Association Between Genetic Ancestry and Multiple Sclerosis Severity

Annals of Neurology, EarlyView.
Objective The objective of this study was to determine whether genetic ancestry is associated with differences in the clinical course of multiple sclerosis (MS). Methods Participants with MS living in the United Kingdom >18 years old were recruited from 2021 to 2025 and genotyped from saliva using a commercial array. Genetic ancestry was inferred using
Benjamin M. Jacobs, Emily Tregaskis‐Daniels, Luisa Schalk, Jakub Nagrodski, ADAMS investigators, Michelle Peter, Rashmi Kaimal, Roxanne Murray, Sadid Hoque, Terri‐Louise Brown, Ghaniah Hassan‐Smith, Helen L. Ford, Bruno Gran, Karim L. Kreft, Cord Spilker, Outi Quinn, David Rog, Miriam Mattoscio, Elisa Visentin, Ramya Shamji, Grace Fawehinmi, Katila George, Maria Papachatzaki, Katharine Harding, Rod Middleton, Tarunya Arun, Waqar Rashid, Adil Harroud, Huw R. Morris, Eli Silber, Gavin Giovannoni, Alastair J. Noyce, Ruth Dobson   +32 more
wiley   +1 more source

Interplay between lifestyle factors and polygenic risk for incident coronary heart disease in a large multiethnic cohort

International Journal of Cardiology. Cardiovascular Risk and Prevention
Introduction: The objective of this study was to examine the interplay of polygenic risk and individual lifestyle factors (and a composite score of lifestyle) as antecedents of CHD in a large multiethnic cohort.
Carlos Iribarren, Meng Lu, Martha Gulati, Nathan D. Wong, Roberto Elosua, Jamal S. Rana   +5 more
doaj   +1 more source

Genomic risk prediction of coronary artery disease in women with breast cancer: a prospective cohort study

Breast Cancer Research, 2021
Background Advancements in cancer therapeutics have resulted in increases in cancer-related survival; however, there is a growing clinical dilemma. The current balancing of survival benefits and future cardiotoxic harms of oncotherapies has resulted in ...
Lathan Liou, Stephen Kaptoge, Joe Dennis, Mitul Shah, Jonathan Tyrer, Michael Inouye, Douglas F. Easton, Paul D. P. Pharoah   +7 more
doaj   +1 more source

Genetic Resilience and Resistance in Alzheimer's Disease Diagnosis and Pathology

Annals of Neurology, EarlyView.
Objective Some individuals avoid Alzheimer's disease (AD) pathology as they age, or retain cognition despite substantial pathology, suggesting mechanisms of resistance or resilience to neurodegeneration. Educational attainment (EA) is associated with reduced risk of cognitive decline, although the underlying mechanisms remain unclear.
Ganna Leonenko, Kalliopi Mavromati, Lynne Hughes, Jonas S. Sundarakumar, Keeley Brookes, Kevin Morgan, Terry Quinn, Valentina Escott‐Price, the Alzheimer's Disease Neuroimaging Initiative   +8 more
wiley   +1 more source

Variability of polygenic prediction for body mass index in Africa

Genome Medicine
Background Polygenic prediction studies in continental Africans are scarce. Africa’s genetic and environmental diversity pose a challenge that limits the generalizability of polygenic risk scores (PRS) for body mass index (BMI) within the continent ...
Tinashe Chikowore, Kristi Läll, Lisa K. Micklesfield, Zane Lombard, Julia H. Goedecke, Segun Fatumo, Shane A. Norris, Reedik Magi, Michele Ramsay, Paul W. Franks, Guillaume Pare, Andrew P. Morris   +11 more
doaj   +1 more source

Prediction of Prevalent Cardiovascular Disease Using Social, Environmental, and Behavioral Factors: A Vital Conditions Framework Approach

Chronic Diseases and Translational Medicine, EarlyView.
The Vital Conditions Framework. Graphical representation of the Vital Conditions for Health Framework with seven domains. Images used with permission from The Rippel Foundation: An Introduction to the Vital Conditions for Health and Well‐Being. https://rippel.org/events/webinar-an-introduction-to-the-vital-conditions-for-health-and-well-being/. Federal
Stephanie Kjelstrom, Richard Hass, Robert Vollbrecht, Brandon George, Sharon Larson   +4 more
wiley   +1 more source

Common variants in Alzheimer's disease and risk stratification by polygenic risk scores

, 2021
ARTICLE Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores Genetic discoveries of Alzheimer’s disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards ...
de Rojas, Itziar, Jansen, Iris E., Periñán Tocino, María Teresa, Moreno-Grau, Sonia, Tesi, Niccolo, Mir Rivera, Pablo, Andrade, Victor, Grenier-Boley, Benjamin, Rodriguez-Rodriguez, Eloy, Macías Sánchez, Juan, Real Navarrete, Luis Miguel   +10 more
core   +1 more source

Genomic Insights Into Risperidone Treatment Outcomes in Children and Adolescents: Experience From a Psychiatric Hospital Serving Rural Youth

Clinical Pharmacology &Therapeutics, EarlyView.
Risperidone is a commonly used antipsychotic for treating psychiatric illness in children and adolescents. There is a large variability in risperidone response and discontinuation rates remain high. Pharmacogenomics offers the opportunity to improve risperidone outcomes, yet studies in pediatric populations are limited.
Jack W. Staples, Shayna R. Killam, Karen E. Brown, Rachel Dalton, Elizabeth Sather, Qiang Chen, Joshua Loveland, Corbin Schwanke, Abdallah F. Elias, Kristin L. Bigos, Erica L. Woodahl   +10 more
wiley   +1 more source

Triglyceride Polygenic Score Identifies Individuals Who May Respond Differently to Aspirin in Primary Prevention

Clinical Pharmacology &Therapeutics, EarlyView.
Low‐dose aspirin is no longer routinely recommended for the primary prevention of cardiovascular disease in older adults due to a lack of net benefit over bleeding risk. We hypothesized that genetic subgroups may experience differential harm or benefit from aspirin therapy.
Peter D. Fransquet, Chenglong Yu, Cammie Tran, Sultana Monira Hussain, Chad A. Bousman, Mark R. Nelson, Andrew M. Tonkin, John J. McNeil, Paul Lacaze   +8 more
wiley   +1 more source

Corrigendum: Potential genetic overlap between insomnia and sleep symptoms in major depressive disorder: A polygenic risk score analysis

, 2022
A corrigendum on - Potential genetic overlap between insomnia and sleep symptoms in major depressive disorder: A polygenic risk score ...
Tiwari, Arun K., Breen, Gerome, Weissman, Myrna M., Awasthi, Swapnil, Marshe, Victoria S., Levinson, Doug F., Hamilton, Steve, Adams, Mark J., Jones, Lisa, Lewis, Cathryn M., Gonçalves, Vanessa F., Boomsma, Dorret I., Penninx, Brenda W. J. H., McIntosh, Andrew M., Ripke, Stephan, Martin, Nicholas G., Zai, Clement C., Baune, Bernhard T., Melhuish Beaupre, Lindsay M.   +18 more
core   +1 more source