Results 31 to 40 of about 39,899,172 (210)

Genome-phenome wide association study of broadly defined headache. [PDF]

Brain Commun, 2023
Abstract Until recently, most genetic studies of headache have been conducted on participants with European ancestry. We therefore conducted a large-scale genome-wide association study of self-reported headache in individuals of East Asian ancestry (specifically those who were identified as Han Chinese).
Hsu WT, Lee YT, Tan J, Chang YH, Qian F, Liu KY, Hsiung JC, Yo CH, Tang SC, Jiang X, Lee CC.   +10 more
europepmc   +3 more sources

A deep learning phenome wide association study of the electrocardiogram. [PDF]

Eur Heart J Digit Health
Abstract Aims Deep learning methods have shown impressive performance in detecting a range of diseases from electrocardiogram (ECG) waveforms, but the breadth of diseases that can be detected with high accuracy remains unknown, and in many cases the changes to the ECG allowing these classifications ...
Hughes JW, Theurer J, Vukadinovic M, Rogers AJ, Somani S, Kang G, Ghazizadeh Z, O'Sullivan JW, Jain SS, Gomes B, Salerno M, Ashley E, Zou JY, Perez MV, Ouyang D.   +14 more
europepmc   +3 more sources

Identification of Druggable Genes for Asthma by Integrated Genomic Network Analysis

Biomedicines, 2022
Asthma is a common and heterogeneous disease characterized by chronic airway inflammation. Currently, the two main types of asthma medicines are inhaled corticosteroids and long-acting β2-adrenoceptor agonists (LABAs).
Wirawan Adikusuma, Wan-Hsuan Chou, Min-Rou Lin, Jafit Ting, Lalu Muhammad Irham, Dyah Aryani Perwitasari, Wei-Pin Chang, Wei-Chiao Chang   +7 more
doaj   +1 more source

How data science and AI-based technologies impact genomics

Singapore Medical Journal, 2023
Advancements in high-throughput sequencing have yielded vast amounts of genomic data, which are studied using genome-wide association study (GWAS)/phenome-wide association study (PheWAS) methods to identify associations between the genotype and phenotype.
Jing Lin, Kee Yuan Ngiam
doaj   +1 more source

Comorbidities in lichen planus by phenome-wide association study in two biobank population cohorts. [PDF]

, 2022
BACKGROUND Lichen planus (LP) is a relative frequent mucocutaneous inflammatory disease affecting the skin, skin appendages, and mucosae, including oral mucosae, and less frequently anogenital area, conjunctivae, esophagus, or larynx.
Schlapbach, Christoph, Borradori, Luca, Schneider, Carolin V, Fromme, Malin, Rader, Dan J, Trautwein, Christian, Cazzaniga, Simone, Strnad, Pavel   +7 more
core   +2 more sources

Genome-Wide Association Studies of Soybean Yield-Related Hyperspectral Reflectance Bands Using Machine Learning-Mediated Data Integration Methods

Frontiers in Plant Science, 2021
In conjunction with big data analysis methods, plant omics technologies have provided scientists with cost-effective and promising tools for discovering genetic architectures of complex agronomic traits using large breeding populations.
Mohsen Yoosefzadeh-Najafabadi, Sepideh Torabi, Dan Tulpan, Istvan Rajcan, Milad Eskandari   +4 more
doaj   +1 more source

Phenome-Wide Association Studies: Embracing Complexity for Discovery [PDF]

Human Heredity, 2015
The inherent complexity of biological systems can be leveraged for a greater understanding of the impact of genetic architecture on outcomes, traits, and pharmacological response. The genome-wide association study (GWAS) approach has well-developed methods and relatively straight-forward methodologies; however, the bigger picture of the impact of ...
Sarah A, Pendergrass, Anurag, Verma, Anna, Okula, Molly A, Hall, Dana C, Crawford, Marylyn D, Ritchie   +5 more
openaire   +2 more sources

Phenome-wide association studies (PheWASs) for functional variants [PDF]

European Journal of Human Genetics, 2014
The genome-wide association study (GWAS) is a powerful approach for studying the genetic complexities of human disease. Unfortunately, GWASs often fail to identify clinically significant associations and describing function can be a challenge. GWAS is a phenotype-to-genotype approach.
Zhan, Ye, John, Mayer, Lynn, Ivacic, Zhiyi, Zhou, Min, He, Steven J, Schrodi, David, Page, Murray H, Brilliant, Scott J, Hebbring   +8 more
openaire   +2 more sources

Current Scope and Challenges in Phenome-Wide Association Studies [PDF]

Current Epidemiology Reports, 2017
Over many decades, researchers have been designing studies to investigate the relationship between genotypes and phenotypes to gain an understanding about the effect of genetics on disease. Recently, a high-throughput approach called phenome-wide associations studies (PheWAS) have been extensively used to identify associations between genetic variants ...
Anurag, Verma, Marylyn D, Ritchie
openaire   +2 more sources

Genome-wide association study of hyperthyroidism based on electronic medical record from Taiwan

Frontiers in Medicine, 2022
Excess thyroid hormones have complex metabolic effects, particularly hyperthyroidism, and are associated with various cardiovascular risk factors. Previous candidate gene studies have indicated that genetic variants may contribute to this variable ...
Ting-Yuan Liu, Ting-Yuan Liu, Wen-Ling Liao, Wen-Ling Liao, Wen-Ling Liao, Tzu-Yuan Wang, Tzu-Yuan Wang, Chia-Jung Chan, Jan-Gowth Chang, Yu-Chia Chen, Yu-Chia Chen, Hsing-Fang Lu, Hsien-Hui Yang, Shih-Yin Chen, Shih-Yin Chen, Fuu-Jen Tsai, Fuu-Jen Tsai, Fuu-Jen Tsai   +17 more
doaj   +1 more source