Results 11 to 20 of about 35,658 (190)
Phenome-wide association studies across large population cohorts support drug target validation [PDF]
Nature Communications, 2018 Testing the association between genetic variants and a range of phenotypes can assist drug development. Here, in a phenome-wide association study in up to 697,815 individuals, Diogo et al.
Dorothée Diogo +33 more
doaj +5 more sources
A phenome-wide association study of genetically mimicked statins [PDF]
BMC Medicine, 2021 Background Beyond their success in cardiovascular disease prevention, statins are increasingly recognized to have sex-specific pleiotropic effects. To gain additional insight, we characterized associations of genetically mimicked statins across the ...
Shun Li, C. M. Schooling
doaj +3 more sources
A phenome-wide association study of ABO blood groups [PDF]
BMC Medicine, 2020 Background ABO blood group is associated with differences in lifespan, cardiovascular disease, and some cancers, for reasons which are incompletely understood.
Shun Li, C. M. Schooling
doaj +3 more sources
Phenome-Wide Association Studies as a Tool to Advance Precision Medicine [PDF]
Annual Review of Genomics and Human Genetics, 2016 Beginning in the early 2000s, the accumulation of biospecimens linked to electronic health records (EHRs) made possible genome-phenome studies (i.e., comparative analyses of genetic variants and phenotypes) using only data collected as a by-product of typical health care.
Joshua C, Denny +2 more
openaire +4 more sources
A simulation study investigating power estimates in phenome-wide association studies [PDF]
BMC Bioinformatics, 2018 Background Phenome-wide association studies (PheWAS) are a high-throughput approach to evaluate comprehensive associations between genetic variants and a wide range of phenotypic measures.
Anurag Verma +6 more
doaj +3 more sources
Joint mouse–human phenome-wide association to test gene function and disease risk
Nature Communications, 2016 Phenome-wide association is a novel method that links sequence variants to a spectrum of phenotypes and diseases. Here the authors generate detailed mouse genetic and phenome data which links their phenome-wide association study (PheWAS) of mouse to ...
Xusheng Wang +25 more
doaj +2 more sources
The challenges, advantages and future of phenome‐wide association studies
Immunology, 2014 SummaryOver the last decade, significant technological breakthroughs have revolutionized human genomic research in the form of genome‐wide association studies (GWASs). GWASs have identified thousands of statistically significant genetic variants associated with hundreds of human conditions including many with immunological aetiologies (e.g.
openaire +4 more sources
Phenome-wide association study (PheWAS) in EMR-linked pediatric cohorts
Frontiers in Genetics, 2014 Objective: We report the first pediatric specific Phenome-Wide Association Study (PheWAS) using electronic medical records (EMRs). Given the early success of PheWAS in adult populations, we investigated the feasibility of this approach in pediatric ...
Bahram eNamjou +23 more
doaj +2 more sources
Genome-phenome wide association study of broadly defined headache. [PDF]
Brain Commun, 2023 Abstract Until recently, most genetic studies of headache have been conducted on participants with European ancestry. We therefore conducted a large-scale genome-wide association study of self-reported headache in individuals of East Asian ancestry (specifically those who were identified as Han Chinese).
Hsu WT +10 more
europepmc +3 more sources