Results 11 to 20 of about 39,899,172 (210)

Phenome-wide association study on miRNA-related sequence variants: the UK Biobank [PDF]

Human Genomics, 2023
Background Genetic variants in the coding region could directly affect the structure and expression levels of genes and proteins. However, the importance of variants in the non-coding region, such as microRNAs (miRNAs), remain to be elucidated.
Rima Mustafa, Mohsen Ghanbari, Ville Karhunen, Marina Evangelou, Abbas Dehghan   +4 more
doaj   +6 more sources

Air pollution and human health: a phenome-wide association study [PDF]

BMJ Open
Objectives To explore the associations of long-term exposure to air pollution with onset of all human health conditions.Design Prospective phenome-wide association study.Setting Denmark.Participants All Danish residents aged ≥30 years on 1 January 2000 ...
Laust Hvas Mortensen, Amar J Mehta, Kees de Hoogh, Gerard Hoek, Bert Brunekreef, Youn-Hee Lim, Steffen Loft, Zorana J Andersen, Emilie Rune Hegelund   +8 more
doaj   +6 more sources

Sex-specific Mendelian randomization phenome-wide association study of basal metabolic rate [PDF]

Scientific Reports
Observationally, higher basal metabolic rate (BMR) is associated with metabolism-related disorders, cancer, aging, and mortality. In this Mendelian randomization (MR) phenome-wide association study, using two-sample MR methods, we systematically and ...
Jack C. M. Ng, C. Mary Schooling
doaj   +3 more sources

Methodology in phenome-wide association studies: a systematic review [PDF]

Journal of Medical Genetics, 2021
Phenome-wide association study (PheWAS) has been increasingly used to identify novel genetic associations across a wide spectrum of phenotypes. This systematic review aims to summarise the PheWAS methodology, discuss the advantages and challenges of PheWAS, and provide potential implications for future PheWAS studies.
Lijuan Wang, Xiaomeng Zhang, Xiangrui Meng, Fotios Koskeridis, Andrea Georgiou, Lili Yu, Harry Campbell, Evropi Theodoratou, Xue Li   +8 more
openaire   +4 more sources

Phenome‐Wide Association Study of Severe COVID‐19 Genetic Risk Variants [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Abstract Background Genetic loci associated with risk of severe COVID-19 infection have been identified and individuals with complicated COVID-19 infections often have multiple comorbidities.
Jessica A. Regan, Jawan W. Abdulrahim, Nathan A. Bihlmeyer, Carol Haynes, Lydia Coulter Kwee, Manesh R. Patel, Svati H. Shah   +6 more
doaj   +6 more sources

CoPheScan: phenome-wide association studies accounting for linkage disequilibrium [PDF]

Nature Communications, 2023
AbstractPhenome-wide association studies (PheWAS) facilitate the discovery of associations between a single genetic variant with multiple phenotypes. For variants which impact a specific protein, this can help identify additional therapeutic indications or on-target side effects of intervening on that protein.
Ichcha Manipur, Guillermo Reales, Jae Hoon Sul, Myung Kyun Shin, Simonne Longerich, Adrian Cortes, Chris Wallace   +6 more
openaire   +7 more sources

A phenome-wide association study of genetically mimicked statins [PDF]

BMC Medicine, 2021
Background Beyond their success in cardiovascular disease prevention, statins are increasingly recognized to have sex-specific pleiotropic effects. To gain additional insight, we characterized associations of genetically mimicked statins across the ...
Shun Li, C. M. Schooling
doaj   +3 more sources

A phenome-wide association study of ABO blood groups [PDF]

BMC Medicine, 2020
Background ABO blood group is associated with differences in lifespan, cardiovascular disease, and some cancers, for reasons which are incompletely understood.
Shun Li, C. M. Schooling
doaj   +3 more sources

DeepPheWAS: an R package for phenotype generation and association analysis for phenome-wide association studies

Bioinformatics, 2023
Abstract Summary DeepPheWAS is an R package for phenome-wide association studies that creates clinically curated composite phenotypes and integrates quantitative phenotypes from primary care data, longitudinal trajectories of quantitative measures, disease progression and drug response ...
Richard J Packer, Alex T Williams, William Hennah, Micaela T Eisenberg, Nick Shrine, Katherine A Fawcett, Willow Pearson, Anna L Guyatt, Ahmed Edris, Edward J Hollox, Mikko Marttila, Balasubramanya S Rao, John Raymond Bratty, Louise V Wain, Frank Dudbridge, Martin D Tobin   +15 more
openaire   +4 more sources

A phenome-wide association study of uterine fibroids reveals a marked burden of comorbidities. [PDF]

Commun Med (Lond)
Abstract Background The burden of comorbidities in those with uterine fibroids compared to those without fibroids is understudied. We performed a phenome-wide association study to systematically assess the association between fibroids and other conditions.
Jasper EA, Mautz BS, Hellwege JN, Piekos JA, Jones SH, Zhang Y, Torstenson ES, Pendergrass SA, Lee MTM, Edwards TL, Velez Edwards DR.   +10 more
europepmc   +5 more sources