Results 21 to 30 of about 41,823,825 (180)

The associations between diet-induced inflammation and health outcomes: a population-based phenome-wide association study. [PDF]

NPJ Sci Food
Evidence linking the dietary inflammatory index (DII) to health outcomes remains inconsistent and limited. This study assessed the associations between DII and 845 health outcomes (N = 78,390 to 207,832), identifying 133 outcomes significantly associated
Chen W, Liu K, Jing X, Qian Y, Liu B, Chen Y, Li J, Sun X, Mao Y, Ye D.   +9 more
europepmc   +2 more sources

A phenome-wide association study of genetically mimicked statins

BMC Medicine, 2021
Background Beyond their success in cardiovascular disease prevention, statins are increasingly recognized to have sex-specific pleiotropic effects. To gain additional insight, we characterized associations of genetically mimicked statins across the ...
Shun Li, C. M. Schooling
doaj   +1 more source

Genome-wide association study of hyperthyroidism based on electronic medical record from Taiwan

Frontiers in Medicine, 2022
Excess thyroid hormones have complex metabolic effects, particularly hyperthyroidism, and are associated with various cardiovascular risk factors. Previous candidate gene studies have indicated that genetic variants may contribute to this variable ...
Ting-Yuan Liu, Ting-Yuan Liu, Wen-Ling Liao, Wen-Ling Liao, Wen-Ling Liao, Tzu-Yuan Wang, Tzu-Yuan Wang, Chia-Jung Chan, Jan-Gowth Chang, Yu-Chia Chen, Yu-Chia Chen, Hsing-Fang Lu, Hsien-Hui Yang, Shih-Yin Chen, Shih-Yin Chen, Fuu-Jen Tsai, Fuu-Jen Tsai, Fuu-Jen Tsai   +17 more
doaj   +1 more source

Visually integrating and exploring high throughput Phenome-Wide Association Study (PheWAS) results using PheWAS-View

BioData Mining, 2012
Background Phenome-Wide Association Studies (PheWAS) can be used to investigate the association between single nucleotide polymorphisms (SNPs) and a wide spectrum of phenotypes.
Pendergrass Sarah A, Dudek Scott M, Crawford Dana C, Ritchie Marylyn D   +3 more
doaj   +1 more source

Biobanking across the phenome - at the center of chronic disease research [PDF]

, 2013
Recognized public health relevant risk factors such as obesity, physical inactivity, smoking or air pollution are common to many non-communicable diseases (NCDs). NCDs cluster and co-morbidities increase in parallel to age.
Nicole M Probst-Hensch, Imboden, Medea, Medea Imboden, Probst-Hensch, Nicole M., Imboden M, Probst-Hensch NM   +5 more
core   +2 more sources

Summary statistics for: Phenome-wide analyses identify an association between the parent-of-origin effects dependent methylome and the rate of aging in humans

, 2023
Summary statistics of single POE-CpG based and POE-CpG co-methylation module based phenome-wide association analyses for the manuscript "Phenome-wide analyses identify an association between the parent-of-origin effects dependent methylome and the rate ...
Chenhao,Gao, Kathryn, Evans, Xueyi, Shen, Pau, Navarro, Mark, Adams, Rosie, Walker, Ying, Liu, Carmen, Amador, Xiaomeng, Bai, Archie, Campbell, Rebecca, Madden, Miaoxin, Li, David, Porteous, Andrew, McIntosh, Caroline, Hayward, Yanni, Zeng, Chris, Haley   +16 more
core   +1 more source

Phenome-wide associations with genetically predicted height in non-Hispanic White individuals.

, 2022
Plot of phecodes versus -log10(p-value) for association with genetically-predicted height in non-Hispanic White participants in MVP. Phecodes were limited to single decimal place for clarity (e.g., 427.2 for atrial fibrillation or flutter is shown but ...
Kyong-Mi Chang (267170), Hongyu Zhao (4728), Eirini Marouli (4585735), Kari E. North (6733304), Themistocles L. Assimes (7658045), Kelly Cho (289664), J. Michael Gaziano (12032696), Saiju Pyarajan (66900), Chang Liu (35901), Leslie A. Lange (8661951), Christopher J. O’Donnell (110479), Jie Huang (104235), Elizabeth Litkowski (10821435), Philip S. Tsao (8636055), Catherine Tcheandjieu (8379342), Jennifer E. Huffman (7665404), Benjamin F. Voight (8543690), Elizabeth R. Hauser (10713513), Sridharan Raghavan (83847), Yuk-Lam A. Ho (12732738), Haley Hunter-Zinck (711979), Ethan Lange (3457229), Yan V. Sun (7437632), Peter W. F. Wilson (8636052)   +23 more
core   +1 more source

A multi-population phenome-wide association study of genetically-predicted height in the Million Veteran Program [PDF]

, 2022
Background Height has been associated with many clinical traits but whether such associations are causal versus secondary to confounding remains unclear in many cases.
Raghavan, S., Lange, E., Tsao, P.S., Hunter-Zinck, H., Marouli, E., Sun, Y.V., Huffman, J.E., Pyarajan, S., Voight, B.F., Tcheandjieu, C., Cho, K., North, K.E., Lange, L.A., Assimes, T.L., Gaziano, J.M., Wilson, P.W.F., Ho, Y.-L.A., O'Donnell, C.J., Liu, C., Chang, K.-M., Zhao, H., Huang, J., Litkowski, E., Hauser, E.R.   +23 more
core   +1 more source

Phenome-wide associations with genetically predicted height in non-Hispanic Black individuals.

, 2022
Plot of phecodes versus -log10(p-value) for association with genetically-predicted height in non-Hispanic Black participants in MVP. Phecodes were limited to single decimal place for clarity (e.g., 427.2 for atrial fibrillation or flutter is shown but ...
Kyong-Mi Chang (267170), Hongyu Zhao (4728), Eirini Marouli (4585735), Kari E. North (6733304), Themistocles L. Assimes (7658045), Kelly Cho (289664), J. Michael Gaziano (12032696), Saiju Pyarajan (66900), Chang Liu (35901), Leslie A. Lange (8661951), Christopher J. O’Donnell (110479), Jie Huang (104235), Elizabeth Litkowski (10821435), Philip S. Tsao (8636055), Catherine Tcheandjieu (8379342), Jennifer E. Huffman (7665404), Benjamin F. Voight (8543690), Elizabeth R. Hauser (10713513), Sridharan Raghavan (83847), Yuk-Lam A. Ho (12732738), Haley Hunter-Zinck (711979), Ethan Lange (3457229), Yan V. Sun (7437632), Peter W. F. Wilson (8636052)   +23 more
core   +1 more source

Polygenic risk score-based phenome-wide association study identifies novel associations for Tourette syndrome [PDF]

, 2022
Tourette Syndrome (TS) is a complex neurodevelopmental disorder characterized by vocal and motor tics lasting more than a year. It is highly polygenic in nature with both rare and common previously associated variants.
et al, Walitza, Susanne; https://orcid.org/, Miller-Fleming, Tyne, Jain, Pritesh; https://orcid.org/, Topaloudi, Apostolia   +4 more
core   +1 more source