Results 1 to 10 of about 50,540 (257)

Identification of potential auxin response candidate genes for soybean rapid canopy coverage through comparative evolution and expression analysis

Frontiers in Plant Science
IntroductionThroughout domestication, crop plants have gone through strong genetic bottlenecks, dramatically reducing the genetic diversity in today’s available germplasm.
Deisiany Ferreira Neres, Deisiany Ferreira Neres, Joseph S. Taylor, Joseph S. Taylor, John A. Bryant, John A. Bryant, Bastiaan O. R. Bargmann, Bastiaan O. R. Bargmann, R. Clay Wright, R. Clay Wright   +9 more
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Improving Association Studies and Genomic Predictions for Climbing Beans With Data From Bush Bean Populations

Frontiers in Plant Science, 2022
Common bean (Phaseolus vulgaris L.) has two major origins of domestication, Andean and Mesoamerican, which contribute to the high diversity of growth type, pod and seed characteristics.
Beat Keller, Daniel Ariza-Suarez, Daniel Ariza-Suarez, Ana Elisabeth Portilla-Benavides, Hector Fabio Buendia, Johan Steven Aparicio, Winnyfred Amongi, Julius Mbiu, Susan Nchimbi Msolla, Phillip Miklas, Timothy G. Porch, James Burridge, Clare Mukankusi, Bruno Studer, Bodo Raatz   +14 more
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Multi-Phenotype Association Decomposition: Unraveling Complex Gene-Phenotype Relationships

Frontiers in Genetics, 2019
Various patterns of multi-phenotype associations (MPAs) exist in the results of Genome Wide Association Studies (GWAS) involving different topologies of single nucleotide polymorphism (SNP)-phenotype associations.
Deborah Weighill, Deborah Weighill, Piet Jones, Piet Jones, Carissa Bleker, Carissa Bleker, Priya Ranjan, Priya Ranjan, Manesh Shah, Nan Zhao, Madhavi Martin, Stephen DiFazio, David Macaya-Sanz, Jeremy Schmutz, Jeremy Schmutz, Avinash Sreedasyam, Timothy Tschaplinski, Gerald Tuskan, Daniel Jacobson, Daniel Jacobson   +19 more
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Essential gene disruptions reveal complex relationships between phenotypic robustness, pleiotropy, and fitness

Molecular Systems Biology, 2015
The concept of robustness in biology has gained much attention recently, but a mechanistic understanding of how genetic networks regulate phenotypic variation has remained elusive.
Christopher R Bauer, Shuang Li, Mark L Siegal   +2 more
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Adaptive substitutions underlying cardiac glycoside insensitivity in insects exhibit epistasis in vivo

eLife, 2019
Predicting how species will respond to selection pressures requires understanding the factors that constrain their evolution. We use genome engineering of Drosophila to investigate constraints on the repeated evolution of unrelated herbivorous insects to
Andrew M Taverner, Lu Yang, Zachary J Barile, Becky Lin, Julie Peng, Ana P Pinharanda, Arya S Rao, Bartholomew P Roland, Aaron D Talsma, Daniel Wei, Georg Petschenka, Michael J Palladino, Peter Andolfatto   +12 more
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Editorial: Statistical Methods, Computing and Resources for Genome-Wide Association Studies

Frontiers in Genetics, 2021
Hailan Liu, Lide Han, Guolian Kang, Min Zhang, Riyan Cheng   +4 more
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Testing for direct genetic effects using a screening step in family-based association studies

Frontiers in Genetics, 2013
In genome wide association studies (GWAS), families based studies tend to have less power to detect genetic associations than population based studies, such as case-control studies.
Sharon M Lutz, Stijn eVansteelandt, Christoph eLange   +2 more
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Pleiotropic Meta-Analysis of Age-Related Phenotypes Addressing Evolutionary Uncertainty in Their Molecular Mechanisms

Frontiers in Genetics, 2019
Age-related phenotypes are characterized by genetic heterogeneity attributed to an uncertain role of evolution in establishing their molecular mechanisms.
Alexander M. Kulminski, Yury Loika, Jian Huang, Konstantin G. Arbeev, Olivia Bagley, Svetlana Ukraintseva, Anatoliy I. Yashin, Irina Culminskaya   +7 more
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Bayesian methods for multivariate modeling of pleiotropic SNP associations and genetic risk prediction

Frontiers in Genetics, 2012
Genome-wide association studies (GWAS) have identified numerous associations between genetic loci and individual phenotypes; however, relatively few GWAS have attempted to detect pleiotropic associations, in which loci are simultaneously associated with ...
Stephen W Hartley, Stefano eMonti, Ching-Ti eLiu, Martin H. Steinberg, Paola eSebastiani   +4 more
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fastMETA: a fast and efficient tool for multivariate meta-analysis of GWAS

Frontiers in Genetics
Genome-Wide Association Studies (GWAS) have transformed human genetics by identifying thousands of loci associated with complex traits and diseases. Yet, individual GWAS are often underpowered, and traditional meta-analysis methods - though widely used ...
Georgios A. Manios, Dionysios Kandylas, Athanasios Kylonis, Pantelis G. Bagos, Panagiota I. Kontou   +4 more
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