Results 1 to 10 of about 37,616 (263)

Mendelian Randomization: A Review of Methods for the Prevention, Assessment, and Discussion of Pleiotropy in Studies Using the Fat Mass and Obesity-Associated Gene as an Instrument for Adiposity

Frontiers in Genetics, 2022
Pleiotropy assessment is critical for the validity of Mendelian randomization (MR) analyses, and its management remains a challenging task for researchers. This review examines how the authors of MR studies address bias due to pleiotropy in practice.
Fiston Ikwa Ndol Mbutiwi, Fiston Ikwa Ndol Mbutiwi, Tatiana Dessy, Marie-Pierre Sylvestre, Marie-Pierre Sylvestre   +4 more
exaly   +3 more sources

Coupling and Uncoupling Pleiotropy Between Hypertension and Type 2 Diabetes Contribute to Exploring Potential Heterogeneity in Cardiovascular Risk in East Asian Population [PDF]

Biomedicines
Background/Objectives: This study aims to systematically deconstruct the shared genetic architecture underlying the comorbidity of hypertension (HTN) and type 2 diabetes (T2D) and evaluate how these divergent genetic architectures are associated with ...
Huan Yu, Liuyan Zheng, Jingxian Wu, Ruotong Yang, Kun Wang, Huairong Wang, Shuting Xie, Yalin Chen, Teng Li, Xueying Qin, Yonghua Hu, Yiqun Wu   +11 more
doaj   +2 more sources

Pleiotropic mutations can rapidly evolve to directly benefit self and cooperative partner despite unfavorable conditions

eLife, 2021
Cooperation, paying a cost to benefit others, is widespread. Cooperation can be promoted by pleiotropic ‘win-win’ mutations which directly benefit self (self-serving) and partner (partner-serving).
Samuel Frederick Mock Hart, Chi-Chun Chen, Wenying Shou   +2 more
doaj   +1 more source

Establishing plausibility of cardiovascular adverse effects of immunotherapies using Mendelian randomisation

Frontiers in Cardiovascular Medicine, 2023
Immune checkpoint inhibitors (ICIs) and Janus kinase inhibitors (JAKis) have raised concerns over serious unexpected cardiovascular adverse events.
Nhu Ngoc Le, Tran Quoc Bao Tran, Clea du Toit, Dipender Gill, Sandosh Padmanabhan   +4 more
doaj   +1 more source

On the scent of pleiotropy [PDF]

Proceedings of the National Academy of Sciences, 2011
From bird songs to the great horn of the rhinoceros beetle, the gaudiest, and possibly most frequent, displays among animals occur in the context of sexual communication and reproduction. Testimony to the evolutionary importance of sexual communication is the recurring observation that signals are “tuned” to perception within species, and vice versa ...
Nadia D, Singh, Kerry L, Shaw
openaire   +2 more sources

Transcriptomic Profiling Reveals Shared Signalling Networks Between Flower Development and Herbivory-Induced Responses in Tomato

Frontiers in Plant Science, 2021
Most flowering plants must defend themselves against herbivores for survival and attract pollinators for reproduction. Although traits involved in plant defence and pollinator attraction are often localised in leaves and flowers, respectively, they will ...
Lanlan Ke, Lanlan Ke, Yangzi Wang, Martin Schäfer, Thomas Städler, Rensen Zeng, Jörg Fabian, Hannier Pulido, Consuelo M. De Moraes, Yuanyuan Song, Shuqing Xu   +10 more
doaj   +1 more source

A Novel Method for Mendelian Randomization Analyses With Pleiotropy and Linkage Disequilibrium in Genetic Variants From Individual Data

Frontiers in Genetics, 2021
Mendelian randomization makes use of genetic variants as instrumental variables to eliminate the influence induced by unknown confounders on causal estimation in epidemiology studies.
Yuquan Wang, Tingting Li, Liwan Fu, Siqian Yang, Yue-Qing Hu, Yue-Qing Hu   +5 more
doaj   +1 more source

Improving Association Studies and Genomic Predictions for Climbing Beans With Data From Bush Bean Populations

Frontiers in Plant Science, 2022
Common bean (Phaseolus vulgaris L.) has two major origins of domestication, Andean and Mesoamerican, which contribute to the high diversity of growth type, pod and seed characteristics.
Beat Keller, Daniel Ariza-Suarez, Daniel Ariza-Suarez, Ana Elisabeth Portilla-Benavides, Hector Fabio Buendia, Johan Steven Aparicio, Winnyfred Amongi, Julius Mbiu, Susan Nchimbi Msolla, Phillip Miklas, Timothy G. Porch, James Burridge, Clare Mukankusi, Bruno Studer, Bodo Raatz   +14 more
doaj   +1 more source

White Matter Integrity and Nicotine Dependence: Evaluating Vertical and Horizontal Pleiotropy

Frontiers in Neuroscience, 2021
Tobacco smoking is an addictive behavior that supports nicotine dependence and is an independent risk factor for cancer and other illnesses. Its neurogenetic mechanisms are not fully understood but may act through alterations in the cerebral white matter
Zhenyao Ye, Zhenyao Ye, Chen Mo, Chen Mo, Song Liu, Kathryn S. Hatch, Si Gao, Yizhou Ma, L. Elliot Hong, Paul M. Thompson, Neda Jahanshad, Ashley Acheson, Hugh Garavan, Li Shen, Thomas E. Nichols, Peter Kochunov, Shuo Chen, Shuo Chen, Tianzhou Ma   +18 more
doaj   +1 more source

The many faces of pleiotropy [PDF]

Trends in Genetics, 2013
Pleiotropy is the well-established phenomenon of a single gene affecting multiple traits. It has long played a central role in theoretical, experimental, and clinical research in genetics, development, molecular biology, evolution, and medicine. In recent years, genomic techniques have brought data to bear on fundamental questions about the nature and ...
Annalise B, Paaby, Matthew V, Rockman
openaire   +2 more sources