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The many faces of pleiotropy [PDF]
Trends in Genetics, 2013 Pleiotropy is the well-established phenomenon of a single gene affecting multiple traits. It has long played a central role in theoretical, experimental, and clinical research in genetics, development, molecular biology, evolution, and medicine. In recent years, genomic techniques have brought data to bear on fundamental questions about the nature and ...
Matthew Rockman, Annalise Paaby
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Molecular Systems Biology, 2015 The concept of robustness in biology has gained much attention recently, but a mechanistic understanding of how genetic networks regulate phenotypic variation has remained elusive.
Mark L Siegal
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Frontiers in Genetics, 2021 The role of common genetic variation in susceptibility to acute myeloid leukemia (AML), and myelodysplastic syndrome (MDS), a group of rare clonal hematologic disorders characterized by dysplastic hematopoiesis and high mortality, remains unclear.
Junke Wang +26 more
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Nontrivial Replication of Loci Detected by Multi-Trait Methods
Frontiers in Genetics, 2021 The ever-growing genome-wide association studies (GWAS) have revealed widespread pleiotropy. To exploit this, various methods that jointly consider associations of a genetic variant with multiple traits have been developed.
Zheng Ning +21 more
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On the scent of pleiotropy [PDF]
Proceedings of the National Academy of Sciences, 2011 From bird songs to the great horn of the rhinoceros beetle, the gaudiest, and possibly most frequent, displays among animals occur in the context of sexual communication and reproduction. Testimony to the evolutionary importance of sexual communication is the recurring observation that signals are “tuned” to perception within species, and vice versa ...
Nadia D, Singh, Kerry L, Shaw
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Mapping Floral Genetic Architecture in Prunus mume, an Ornamental Woody Plant
Frontiers in Plant Science, 2022 Floral traits are both evolutionarily and economically relevant for ornamental plants. However, their underlying genetic architecture, especially in woody ornamental plants, is still poorly understood.
Mingyu Li +7 more
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Bidirectional Relation Between Parkinson's Disease and Glioblastoma Multiforme
Frontiers in Neurology, 2020 Cancer and Parkinson's disease (PD) define two disease entities that include opposite concepts. Indeed, the involved mechanisms are at different ends of a spectrum related to cell survival - one due to enhanced cellular proliferation and the other due to
Pauline Mencke +7 more
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eLife, 2020 Building a genotype-phenotype-fitness map of adaptation is a central goal in evolutionary biology. It is difficult even when adaptive mutations are known because it is hard to enumerate which phenotypes make these mutations adaptive.
Grant Kinsler +2 more
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Frontiers in Genetics, 2021 Aging has provided fruitful challenges for evolutionary theory, and evolutionary theory has deepened our understanding of aging. A great deal of genetic and molecular data now exists concerning mortality regulation and there is a growing body of ...
Stewart Frankel, Blanka Rogina
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eLife, 2023 Adaptation is driven by the selection for beneficial mutations that provide a fitness advantage in the specific environment in which a population is evolving. However, environments are rarely constant or predictable.
Vivian Chen +10 more
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