Results 41 to 50 of about 65,328 (279)

Bivariate causal mixture model quantifies polygenic overlap between complex traits beyond genetic correlation. [PDF]

, 2019
Accumulating evidence from genome wide association studies (GWAS) suggests an abundance of shared genetic influences among complex human traits and disorders, such as mental disorders.
Andreassen, Ole A, Dale, Anders M, Djurovic, Srdjan, Fan, Chun Chieh, Frei, Oleksandr, Holland, Dominic, Maeland, Steffen, O'Connell, Kevin S, Shadrin, Alexey A, Smeland, Olav B, Thompson, Wesley K, Wang, Yunpeng   +11 more
core   +3 more sources

Statin Pleiotropy Against Renal Injury

Journal of the CardioMetabolic Syndrome, 2009
Statins may exhibit significant renoprotective effects beyond their lipid‐lowering capacity. Herein, the authors review data from human and animal models of renal disease as well as from studies in cultured renal cells with regard to extralipid renoprotective properties of statins.
Kostapanos, M. S., Liberopoulos, E. N., Elisaf, M. S.   +2 more
openaire   +3 more sources

Emerging Pleiotropic Mechanisms Underlying Aluminum Resistance and Phosphorus Acquisition on Acidic Soils

Frontiers in Plant Science, 2018
Aluminum (Al) toxicity on acidic soils significantly damages plant roots and inhibits root growth. Hence, crops intoxicated by Al become more sensitive to drought stress and mineral nutrient deficiencies, particularly phosphorus (P) deficiency, which is ...
Jurandir V. Magalhaes, Jurandir V. Magalhaes, Miguel A. Piñeros, Laiane S. Maciel, Laiane S. Maciel, Leon V. Kochian   +5 more
doaj   +1 more source

On the scent of pleiotropy [PDF]

Proceedings of the National Academy of Sciences, 2011
From bird songs to the great horn of the rhinoceros beetle, the gaudiest, and possibly most frequent, displays among animals occur in the context of sexual communication and reproduction. Testimony to the evolutionary importance of sexual communication is the recurring observation that signals are “tuned” to perception within species, and vice versa ...
Nadia D, Singh, Kerry L, Shaw
openaire   +2 more sources

Improving genetic risk prediction by leveraging pleiotropy

, 2013
An important task of human genetics studies is to accurately predict disease risks in individuals based on genetic markers, which allows for identifying individuals at high disease risks, and facilitating their disease treatment and prevention.
Gelernter, Joel, Li, Cong, Yang, Can, Zhao, Hongyu   +3 more
core   +1 more source

A Common Variant in CLDN14 is Associated with Primary Biliary Cirrhosis and Bone Mineral Density. [PDF]

, 2016
Primary biliary cirrhosis (PBC), a chronic autoimmune liver disease, has been associated with increased incidence of osteoporosis. Intriguingly, two PBC susceptibility loci identified through genome-wide association studies are also involved in bone ...
Bian, Zhaolian, Chen, Haoyan, Gershwin, M Eric, Jiang, Xiang, Li, Enling, Li, Zhiqiang, Lian, Min, Liao, Wilson, Ma, Xiong, Miao, Qi, Seldin, Michael F, Shi, Yongyong, Tang, Ruqi, Wang, Qixia, Wang, Zhaoyue, Wei, Yiran, Yang, Fan, Yang, Yue, Zhang, Haiyan   +18 more
core   +2 more sources

Androgen Receptor‐Induced Lactoferrin Accelerates Prostate Tumorigenesis Through Modulating Ferroptosis

Advanced Science, EarlyView.
This study demonstrates that transcription factor androgen receptor (AR) directly binds the LF promoter, driving lactoferrin overexpression to promote ferritin (FTH1/FTL) upregulation and inhibit p53‐ALOX12‐mediated ferroptosis in prostate cancer. Lactoferrin could be a new potential therapeutic target in prostate cancer.
Can Liu, Qiu Peng, Xiaoyue Zhang, Zhengshuo Li, Yangge Wu, Yuqing Wen, Run Zheng, Shuanglong Wu, Chenfei Zhou, Zhengyu Hu, Lanjun Shu, Xinyi Ma, Qiuyang Li, Ya Ma, Chunlin Ou, Ming Zhao, Songqing Fan, Lingyu Wei, Jian Ma   +18 more
wiley   +1 more source

Trans-Ethnic Polygenic Analysis Supports Genetic Overlaps of Lumbar Disc Degeneration With Height, Body Mass Index, and Bone Mineral Density

Frontiers in Genetics, 2018
Lumbar disc degeneration (LDD) is age-related break-down in the fibrocartilaginous joints between lumbar vertebrae. It is a major cause of low back pain and is conventionally assessed by magnetic resonance imaging (MRI).
Xueya Zhou, Xueya Zhou, Ching-Lung Cheung, Ching-Lung Cheung, Tatsuki Karasugi, Jaro Karppinen, Dino Samartzis, Yi-Hsiang Hsu, Yi-Hsiang Hsu, Yi-Hsiang Hsu, Timothy Shin-Heng Mak, You-Qiang Song, You-Qiang Song, Kazuhiro Chiba, Yoshiharu Kawaguchi, Yan Li, Danny Chan, Kenneth Man-Chee Cheung, Shiro Ikegawa, Kathryn Song-Eng Cheah, Pak Chung Sham, Pak Chung Sham   +21 more
doaj   +1 more source

Exploring pleiotropy using principal components [PDF]

BMC Genetics, 2003
AbstractA standard multivariate principal components (PCs) method was utilized to identify clusters of variables that may be controlled by a common gene or genes (pleiotropy). Heritability estimates were obtained and linkage analyses performed on six individual traits (total cholesterol (Chol), high and low density lipoproteins, triglycerides (TG ...
Bensen, Jeannette T, Lange, Leslie A, Langefeld, Carl D, Chang, Bao-Li, Bleecker, Eugene R, Meyers, Deborah A, Xu, Jianfeng   +6 more
openaire   +2 more sources

Pleiotropy of autism-associated chromatin regulators

Development, 2023
ABSTRACT Gene ontology analyses of high-confidence autism spectrum disorder (ASD) risk genes highlight chromatin regulation and synaptic function as major contributors to pathobiology. Our recent functional work in vivo has additionally implicated tubulin biology and cellular proliferation.
Micaela Lasser, Nawei Sun, Yuxiao Xu, Sheng Wang, Sam Drake, Karen Law, Silvano Gonzalez, Belinda Wang, Vanessa Drury, Octavio Castillo, Yefim Zaltsman, Jeanselle Dea, Ethel Bader, Kate E. McCluskey, Matthew W. State, A. Jeremy Willsey, Helen Rankin Willsey   +16 more
openaire   +2 more sources