Results 41 to 50 of about 48,688 (297)
Emerging infectious disease selects for darker plumage coloration in greenfinches
Frontiers in Ecology and Evolution, 2014 Outbreaks of emerging infectious disease offer a unique chance to study viability selection in action in short time windows. Finch trichomonosis, caused by a protozoan Trichomonas gallinae emerged in Great Britain in 2005 and led to epidemic mortality ...
Marju eMänniste, Peeter eHõrak
doaj +1 more source
Dominance, Pleiotropy and Metabolic Structure [PDF]
Genetics, 1987 ABSTRACT It is a common observation that most mutants have similar dominance relations for all the characters they are known to affect. As a model of pleiotropic effects we investigate a branched pathway where the two outputs represent two characters whose variation is affected by changes in any of the genetically specified enzymes in ...
P D, Keightley, H, Kacser
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Environmental pleiotropy and demographic history direct adaptation under antibiotic selection [PDF]
, 2018 Evolutionary rescue following environmental change requires mutations permitting population growth in the new environment. If change is severe enough to prevent most of the population reproducing, rescue becomes reliant on mutations already present.
Knight, Christopher; id_orcid +11 more
core +4 more sources
Pleiotropy as the Mechanism for Evolving Novelty: Same Signal, Different Result
Biology, 2015 In contrast to the probabilistic way of thinking about pleiotropy as the random expression of a single gene that generates two or more distinct phenotypic traits, it is actually a deterministic consequence of the evolution of complex physiology from the ...
John S. Torday
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The ubiquity of pleiotropy in human disease [PDF]
Human Genetics, 2017 Pleiotropy has long been thought to be a common phenomenon in the human genome; however, until recently appropriate data was unavailable to test this hypothesis. Prior studies focused on assessing the prevalence of pleiotropy in only small subsets of phenotypes (≤ 53 phenotypes), without a truly comprehensive assessment of pleiotropy in the human ...
Kevin Chesmore +2 more
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Frontiers in Cardiovascular Medicine, 2023 Immune checkpoint inhibitors (ICIs) and Janus kinase inhibitors (JAKis) have raised concerns over serious unexpected cardiovascular adverse events.
Nhu Ngoc Le +4 more
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Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
Pleiotropy, “sexy” traits, and speciation [PDF]
Behavioral Ecology, 2011 The evolution of mating signals and preferences assists speciation by facilitating assortative mating within diverging lineages, thereby closing down conduits of gene flow between lineages. However, sexual communication traits are frequently subject to stabilizing selection, suggesting that new variants will be selected against, thereby discouraging ...
Kerry L. Shaw +3 more
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Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Progression independent of relapse activity is a major determinant of long‐term disability in multiple sclerosis, but its immunopathologic basis remains incompletely understood. We investigated whether relapse‐independent progression in radiologically stable relapsing–remitting multiple sclerosis is associated with distinct ...
Antonio Bruno +19 more
wiley +1 more source
mBio, 2019 High-level resistance often evolves when populations of bacteria are exposed to antibiotics, by either mutations or horizontally acquired genes. There is also variation in the intrinsic resistance levels of different bacterial strains and species that is
Otmane Lamrabet +3 more
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