Results 61 to 70 of about 48,688 (297)
Frontiers in Plant ScienceIntroductionThroughout domestication, crop plants have gone through strong genetic bottlenecks, dramatically reducing the genetic diversity in today’s available germplasm.
Deisiany Ferreira Neres +9 more
doaj +1 more source
Horizontal pleiotropy and heterogeneity of results.
, 2023 Horizontal pleiotropy and heterogeneity of results.
Yi Zheng (113896) +4 more
core +1 more source
Advanced Science, EarlyView.A cytokinin pathway transcription factor, RR2b, was artificially selected during soybean domestication and improvement based on its differential transcriptional activity, which correlates with ATT repeat polymorphisms in its promoter. RR2b balances yield and defense by fine‐tuning its expression level and offers a promising target for decoupling trade ...
Qun Ma +11 more
wiley +1 more source
Frontiers in Plant Science, 2022 Common bean (Phaseolus vulgaris L.) has two major origins of domestication, Andean and Mesoamerican, which contribute to the high diversity of growth type, pod and seed characteristics.
Beat Keller +14 more
doaj +1 more source
Pleiotropy evolves to stabilise cooperation even when costly.
, 2022 We explored a model in which pleiotropy carries a cost on multicellular function. We assumed multicellular group function is reduced by a factor , where ζ is the cost of pleiotropy, and is the average pleiotropy in a group.
Kevin R. Foster (8893457) +4 more
core +1 more source
Systematic Multi‐Level Analyses Decode the Arthritis‐Neurodegeneration Axis With In Vivo Validation
Advanced Science, EarlyView.Arthritis and neurodegeneration are usually studied as separate disorders, but this study connects them through population evidence, genetic inference, transcriptomic mapping, and mouse models. It highlights RNF40 as a context‐dependent joint‐brain candidate, induced in inflammatory joints yet functionally linked to dopamine‐neuron vulnerability ...
Jinwen Wang +7 more
wiley +1 more source
Private trait evolution does not favour pleiotropy and vice versa.
, 2022 We explored a model in which the cooperative trait was replaced by another private trait. Heatmaps show average trait values of 2 private traits and pleiotropy among the global population of cells (across all groups) at steady state in our revised model.
Kevin R. Foster (8893457) +4 more
core +1 more source
Interleukin‐39 is a Prognostic Biomarker and Therapy Target for Sepsis
Advanced Science, EarlyView.Sepsis triggers a significant increase in IL‐39 production, with circulating levels markedly elevated and positively correlated with disease severity and poor clinical prognosis in sepsis patients. Mechanistically, macrophage‐derived IL‐39 activates the GP130 signaling pathway via a ligand‐receptor interaction, thereby fueling the pro‐inflammatory ...
Feng‐zhi Zhang +9 more
wiley +1 more source
Code from "Niche specificity, polygeny and pleiotropy in herbivorous insects"
, 2022 What causes host-use specificity in herbivorous insects? Population genetic models predict specialization when habitat preference can evolve and there is antagonistic pleiotropy at a performance-affecting locus.
Hardy, Nate B, Forister, Matt L
core +1 more source
Advanced Science, EarlyView.SOX30 drives triple‐negative breast cancer (TNBC) metastasis through a dual mechanism: direct activation of the TNFR2/NF‐κB signaling cascade and subsequent CCL20‐mediated recruitment of tumor‐associated macrophages (TAMs) into the tumor microenvironment.
Pingping Gao +10 more
wiley +1 more source