Results 61 to 70 of about 65,328 (279)

Common Genetic Variants Explain the Majority of the Correlation Between Height and Intelligence : The Generation Scotland Study [PDF]

, 2014
Creative Commons Attribution LicensePeer reviewedPublisher ...
Archie Campbell, B Benyamin, BH Smith, BH Smith, C Gale, Caroline Hayward, CM Calvin, CM Calvin, CM Haworth, CM Lee, D Wechsler, D Wechsler, David J. Porteous, E Whitley, G Davies, G. David Batty, GD Batty, Ian J. Deary, IJ Deary, IJ Deary, J Yang, J Yang, JC Raven, JM Starr, JM Sundet, JP Beauchamp, K Silventoinen, K Silventoinen, KL Gunderson, LJ Whalley, Lynne J. Hocking, M Trzaskowski, MC Keller, MD Lezak, Peter M. Visscher, Riccardo E. Marioni, S Macgregor, SH Lee, Shona M. Kerr, SM Kerr, TA Paajanen   +40 more
core   +3 more sources

Complementary multi‐omics profiling of chronic thromboembolic pulmonary hypertension reveals immune cell alterations, epigenetic changes, and genetically supported candidate genes

Animal Models and Experimental Medicine, EarlyView.
This study presents an integrative multi‐omics framework to uncover the molecular mechanisms and potential biomarkers of chronic thromboembolic pulmonary hypertension (CTEPH). Anthropometric and biochemical data were correlated using canonical correlation analysis, revealing key cardiometabolic associations. Single‐cell RNA sequencing identified immune
Xiaopeng Liu, Xia Zheng, Yajun Zhang, Yinghui Fang, Yanan Zhen   +4 more
wiley   +1 more source

Evolution, Chance, and Aging

Frontiers in Genetics, 2021
Aging has provided fruitful challenges for evolutionary theory, and evolutionary theory has deepened our understanding of aging. A great deal of genetic and molecular data now exists concerning mortality regulation and there is a growing body of ...
Stewart Frankel, Blanka Rogina
doaj   +1 more source

Psychiatric genetics and the structure of psychopathology [PDF]

, 2018
For over a century, psychiatric disorders have been defined by expert opinion and clinical observation. The modern DSM has relied on a consensus of experts to define categorical syndromes based on clusters of symptoms and signs, and, to some extent ...
Andreassen, Ole A., Edenberg, Howard J., Faraone, Stephen V., Glatt, Stephen J., Kendler, Kenneth S., Smoller, Jordan W.   +5 more
core   +1 more source

Genetic prediction of blood cell reactivity and its potential causal influence on bone continuity and density disorders

Animal Models and Experimental Medicine, EarlyView.
We applied Mendelian randomization to explore causal links between blood cell traits and skeletal disorders. Using genetic instruments from large‐scale summary statistics, we assessed effects on bone continuity, density, and structural integrity. Sensitivity and reverse analyses confirmed robust associations, highlighting potential shared biological ...
Zhiqin Deng, Zhe Zhao, Wenting Jiang, Xiaoqiang Chen, Jianquan Liu, Xu Tao, Zhengyang Lin, Zhenhan Deng, Wencui Li   +8 more
wiley   +1 more source

Molecular evolution of HoxA13 and the multiple origins of limbless morphologies in amphibians and reptiles [PDF]

, 2015
Developmental processes and their results, morphological characters, are inherited through transmission of genes regulating development. While there is ample evidence that cis-regulatory elements tend to be modular, with sequence segments dedicated to ...
Bamshad M, Bell MA, Brakefield PM, Brakefield PM, Brayer KJ, Cohn M, Crow KD, Delport W, Di-Poï N, Dollé P, Dollé P, Fromental-Ramain C, Galant R, Gans C, Goodman FR, Gower DJ, Graur D, Günter P. Wagner, Hall BK, Head JJ, Hsieh-Li HM, Innis JW, Knosp WM, Knosp WM, Kobayashi A, Kohlsdorf T, Koryu Kin, Krumlauf R, Lande R, Lynch VJ, Lynch VJ, Mansfield JH, Mariana B. Grizante, Mariana F. Nery, Marina E. Singarete, Mortlock DP, Mortlock DP, Mortlock DP, Murrell B, Parra-Olea G, Pavlicev M, Pavlicev M, Pearson JC, Perez WD, Pyron AR, Pyron RA, Raff RA, Reno PL, Ronshaugen M, San Mauro D, Sarah R. Milograna, Shou S, Sivanantharajah L, Stadler HS, Stern DL, Taylor HS, Thompson JD, Tiana Kohlsdorf, Tschopp P, Warot X, Wiens JJ, Woltering JM, Woltering JM, Wray GA, Yang Z, Yang Z, Zhang J   +66 more
core   +4 more sources

Role of soft tissue and bone interactions in the developmental integration and modularity of the skull in neural crest‐specific gap junction alpha‐1 knockout mice

The Anatomical Record, EarlyView.
Abstract The vertebrate skull is composed of bones derived from neural crest cells and mesoderm. The evolutionary capacity of the skull has been linked, in part, to the emergence of neural crest cells; however, this increased capacity for evolutionary change requires that variation within neural crest‐ and mesoderm‐derived bones remains partly ...
Alyssa C. Moore, Madeline Tourigny, Diana Quinonez, Kevin Barr, Matthew W. Grol, Katherine E. Willmore   +5 more
wiley   +1 more source

Justification of Sexual Reproduction by Modified Penna Model of Ageing

, 2001
We generalize the standard Penna bit-string model of biological ageing by assuming that each deleterious mutation diminishes the survival probability in every time interval by a small percentage. This effect is added to the usual lethal but age-dependent
Bernardes, D. Stauffer, Dasgupta, J.S. Sá Martins, Medeiros, Penna, Redfield, Stauffer, Stauffer, Stauffer, Sá Martins, Sá Martins   +11 more
core   +2 more sources

Repurposing drugs to target nonalcoholic steatohepatitis [PDF]

, 2019
Nonalcoholic fatty liver disease (NAFLD) is a complex disorder that has evolved in recent years as the leading global cause of chronic liver damage.
Pirola, Carlos José, Sookoian, Silvia Cristina   +1 more
core   +1 more source

Pleiotropy of Presenilins [PDF]

Hereditary Genetics, 2013
Pleiotropy genes affect multiple and apparently unrelated phenotypes. Here we describe pleiotropy gene presenilins, mutations in which have been detected in three genetically heterogeneous diseases: early-onset familial Alzheimer’s disease, familial or sporadic dilated cardiomyopathy, and familial hidradenitis suppurativa.
openaire   +1 more source