Results 71 to 80 of about 50,540 (257)

Pleiotropy accelerates tooth phenotypic and genomic evolution - An in silico study under the lens of development

Pleiotropy, which can occur when a gene affects multiple traits, is a central property of living organisms, influencing their response to mutations and their evolutionary trajectories.
Beslon, Guillaume, Hagolani, Pascal Felix, Sémon, Marie, Pantalacci, Sophie   +3 more
core   +1 more source

Pleiotropy and synergistic cooperation.

, 2019
Some forms of stable cooperation can evolve though pleiotropy with a beneficial private trait. This Formal Comment addresses a recent challenge to this idea, arguing that for synergistic, frequency-dependent cooperation, pleiotropy can raise the ...
David C Queller
core   +1 more source

Trace Elements Genetics: A Potential Role in Treatment‐Resistant Major Psychoses and Related Traits?

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Trace elements are pivotal to key biological processes, with possible effects on psychopathology. We investigated the hypothesis of shared genetic factors between trace elements levels, treatment resistance and related traits. We used genome‐wide summary statistics for trace elements blood concentration, treatment‐resistant depression (TRD ...
Chiara Fabbri, Alessandro Serretti, Marco Menchetti, Benedetta Vai, Francesco Benedetti, Lidia Fortaner‐Uyà, Concetta Crisafulli   +6 more
wiley   +1 more source

Private trait evolution does not favour pleiotropy and vice versa.

, 2022
We explored a model in which the cooperative trait was replaced by another private trait. Heatmaps show average trait values of 2 private traits and pleiotropy among the global population of cells (across all groups) at steady state in our revised model.
Kevin R. Foster (8893457), Gail M. Preston (8780690), Michael A. Bentley (3079278), Christian A. Yates (12462891), Jotun Hein (27177)   +4 more
core   +1 more source

Exploring Genetic and Biological Interconnections Between Neuroticism, Psychological Distress, Insomnia, and C‐Reactive Protein: Insights From the UK Biobank

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Psychobehavioral and physical health traits often co‐occur. Although previous studies have identified associations between neuroticism, psychological distress, insomnia, and inflammatory biomarkers such as C‐reactive protein (CRP), it remains unclear whether there is a genetic basis to these associations, and which biological pathways are ...
Lydia M Li, Nina Adler, Cristina L. Abbatangelo, Mark Wade, Esteban J. Parra   +4 more
wiley   +1 more source

Code from "Niche specificity, polygeny and pleiotropy in herbivorous insects"

, 2022
What causes host-use specificity in herbivorous insects? Population genetic models predict specialization when habitat preference can evolve and there is antagonistic pleiotropy at a performance-affecting locus.
Hardy, Nate B, Forister, Matt L
core   +1 more source

Genetic and Population Analyses Implicate Thyroid‐Related Regulation of RNF144B in Chondrocalcinosis

Arthritis &Rheumatology, EarlyView.
Objective Chondrocalcinosis, characterized by calcium crystal deposition within articular cartilage, affects 5% to 15% of the general population and has recently been identified as an osteoarthritis risk factor. However, its biologic pathways remain unclear.
Yahong Wu, Yanning Xu, Paul C. Okoro, Sirine Saafi, Jard de Vries, Xiaoyi Qi, Edwin H. G. Oei, Sita Bierma‐Zeinstra, Trudy Voortman, David Felson, Joyce B. J. van Meurs, Layal Chaker, J. Mark Wilkinson, Michelle S. Yau, Jessica Bertrand, Cindy G. Boer   +15 more
wiley   +1 more source

Systematic Analysis of Pleiotropy in C. elegans Early Embryogenesis [PDF]

, 2008
Pleiotropy refers to the phenomenon in which a single gene controls several distinct, and seemingly unrelated, phenotypic effects. We use C. elegans early embryogenesis as a model to conduct systematic studies of pleiotropy.
Ross, Brian D, Sidow, Arend, Ge, Hui, Patrycja V Missiuro, Sriswasdi, Sira, Brian Ross, Jun Liu, Missiuro, Patrycja V., Lihua Zou, Zou, Lihua, Sira Sriswasdi, Liu, Jun, Hui Ge   +12 more
core   +2 more sources

Antimicrobial Peptides and Peptidomimetics in Foods – A Synthetic Foray

ChemFoodChem, EarlyView.
This Review discusses AMPs in foods and their syntheses. It espouses facile methods to make them accessible and suggests their utility in the mitigation and eradication of the burgeoning maladies of antimicrobial and multidrug resistance (AMR and MDR).
Josephat U. Izunobi, Adejoke D. Osinubi, Abosede A. Badeji   +2 more
wiley   +1 more source

Autism Spectrum Disorder, Attention‐Deficit/Hyperactivity Disorder, Tic Disorder, and Obsessive‐Compulsive Disorder in Individuals With Eating Disorders and Their Siblings: A Nationwide Finnish Cohort Study

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Neurodevelopmental conditions frequently co‐occur with eating disorders (EDs). This study aimed to investigate the occurrence of attention‐deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), tic disorder (TD), and obsessive‐compulsive disorder (OCD) in individuals with EDs and their full and half siblings.
Emma Saure, Pyry N. Sipilä, Susanna Hinkka‐Yli‐Salomäki, Andre Sourander, Elina Santti, Anu Raevuori   +5 more
wiley   +1 more source