Results 71 to 80 of about 65,328 (279)
Loss, persistence and reversal of phenotypic traits
Biological Reviews, EarlyView.ABSTRACT The irreversibility of complex trait loss has long been a tenet of evolutionary biology. However, this idea is increasingly at odds with the numerous documented exceptions across the Tree of Life. We synthesise this growing body of evidence across a diverse array of taxa and traits, exploring the evolutionary conditions that enable ...
Giobbe Forni +4 more
wiley +1 more source
eLife, 2023 Adaptation is driven by the selection for beneficial mutations that provide a fitness advantage in the specific environment in which a population is evolving. However, environments are rarely constant or predictable.
Vivian Chen +10 more
doaj +1 more source
Pleiotropy and synergistic cooperation
PLOS Biology, 2019 Some forms of stable cooperation can evolve though pleiotropy with a beneficial private trait. This Formal Comment addresses a recent challenge to this idea, arguing that for synergistic, frequency-dependent cooperation, pleiotropy can raise the frequency up to a point where cooperation is favoured on its own.
openaire +3 more sources
The costs of extra‐pair behaviours in birds
Biological Reviews, EarlyView.ABSTRACT Extra‐pair behaviours – reproductive behaviours, including those related to copulation and paternity of offspring, amongst animals outside of a social pair bond – have long intrigued behavioural ecologists, particularly from the female animal's perspective.
Jørgen S. Søraker, Jamie Dunning
wiley +1 more source
Cross-Cancer Pleiotropic Analysis Reveals Novel Susceptibility Loci for Lung Cancer
Frontiers in Oncology, 2020 Genome-wide association studies (GWASs) have identified hundreds of single nucleotide polymorphisms (SNPs) associated with cancer risk, several of which have shown pleiotropic effects across cancers.
Lijuan Wang +17 more
doaj +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Carfilzomib is highly effective in the treatment of multiple myeloma, but it has been associated with cardiovascular adverse events that impact patient outcomes. Our prior global metabolomic analyses indicated an association between hydrophilic bile acids and carfilzomib‐cardiotoxicity risk, although a causal relationship remained to be determined ...
Samia Shabnaz +15 more
wiley +1 more source
Shared genetic contribution of type 2 diabetes and cardiovascular disease: Implications for prognosis and treatment [PDF]
, 2018 Purpose of Review: The increased cardiovascular disease (CVD) risk in subjects with type 2 diabetes (T2D) is well established. This review collates the available evidence and assesses the shared genetic background between T2D and CVD: the causal ...
Strawbridge, Rona J. +1 more
core +1 more source
Mendelian randomization and pleiotropy analysis
Quantitative Biology, 2021 BackgroundMendelian randomization (MR) analysis has become popular in inferring and estimating the causality of an exposure on an outcome due to the success of genome wide association studies. Many statistical approaches have been developed and each of these methods require specific assumptions.ResultsIn this article, we review the pros and cons of ...
openaire +3 more sources
PleioGRiP: genetic risk prediction with pleiotropy [PDF]
Bioinformatics, 2013 AbstractMotivation: Although several studies have used Bayesian classifiers for risk prediction using genome-wide single nucleotide polymorphism (SNP) datasets, no software can efficiently perform these analyses on massive genetic datasets and can accommodate multiple traits.Results: We describe the program PleioGRiP that performs a genome-wide ...
Stephen W, Hartley, Paola, Sebastiani
openaire +2 more sources
ESC Heart Failure, Volume 12, Issue 2, Page 1374-1385, April 2025.Abstract Aims Inflammation plays a critical role in both the development and progression of heart failure (HF), which is a leading cause of morbidity and mortality worldwide. However, the causality between specific inflammation‐related proteins and HF risk remains unclear.
Xian‐Guan Zhu +9 more
wiley +1 more source