Results 1 to 10 of about 1,985,505 (274)
Pleiotropy, cooperation, and the social evolution of genetic architecture. [PDF]
PLoS Biology, 2018 Pleiotropy has been suggested as a novel mechanism for stabilising cooperation in bacteria and other microbes. The hypothesis is that linking cooperation with a trait that provides a personal (private) benefit can outweigh the cost of cooperation in ...
Miguel Dos Santos +2 more
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Editorial: Genetic Pleiotropy in Complex Traits and Diseases [PDF]
Frontiers in Genetics, 2022 Qian Xu +4 more
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Hormonal pleiotropy structures genetic covariance [PDF]
Evolution Letters, 2021 Quantitative genetic theory proposes that phenotypic evolution is shaped by G, the matrix of genetic variances and covariances among traits. In species with separate sexes, the evolution of sexual dimorphism is also shaped by B, the matrix of between‐sex
Tyler N. Wittman +3 more
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Brain functional connectivity mirrors genetic pleiotropy in psychiatric conditions [PDF]
Brain, 2023 AbstractPleiotropy occurs when a genetic variant influences more than one trait. This is a key property of the genomic architecture of psychiatric disorders and has been observed for rare and common genomic variants. It is reasonable to hypothesize that the microscale genetic overlap (pleiotropy) across psychiatric conditions and cognitive traits may ...
Clara A Moreau +2 more
exaly +10 more sources
Circadian and Geotactic Behaviors: Genetic Pleiotropy in Drosophila Melanogaster [PDF]
Journal of Circadian Rhythms, 2016 Data presented in this paper test the hypotheses that Hirsch’s positive geotaxis ('Lo') and negative geotaxis ('Hi5') strains of Drosophila melanogaster (fruit fly) differ in length of the free-running circadian activity period (tau) as well as adult ...
Dale L Clayton
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Extent and context dependence of pleiotropy revealed by high-throughput single-cell phenotyping.
PLoS Biology, 2020 Pleiotropy-when a single mutation affects multiple traits-is a controversial topic with far-reaching implications. Pleiotropy plays a central role in debates about how complex traits evolve and whether biological systems are modular or are organized such
Kerry A Geiler-Samerotte +7 more
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Frontiers in Aging Neuroscience, 2022 BackgroundConsidered as the representatives of neurodegenerative diseases, Alzheimer’s disease (AD) and glaucoma are complex progressive neuropathies affected by both genetic and environmental risk factors and cause irreversible damages. Current research
Chunwen Zheng +20 more
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Frontiers in Endocrinology, 2023 Associations between lower birth weight and higher polycystic ovary syndrome (PCOS) risk have been reported in previous observational studies, however, the causal relationship is still unknown.
Dong Liu +9 more
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One Gene, Many Facets: Multiple Immune Pathway Dysregulation in SOCS1 Haploinsufficiency
Frontiers in Immunology, 2021 BackgroundInborn errors of immunity (IEI) present with a large phenotypic spectrum of disease, which can pose diagnostic and therapeutic challenges. Suppressor of cytokine signaling 1 (SOCS1) is a key negative regulator of cytokine signaling, and has ...
Julia Körholz +31 more
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Biomedicines, 2022 Accumulating evidence suggests a relationship between type 2 diabetes mellitus and sleep problems. A comprehensive study is needed to decipher whether shared polygenic risk variants exist between diabetic traits and sleep traits.
Yujia Ma +8 more
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