Results 11 to 20 of about 1,985,505 (274)
Genetic variation in adaptability and pleiotropy in budding yeast [PDF]
eLife, 2017 Evolution can favor organisms that are more adaptable, provided that genetic variation in adaptability exists. Here, we quantify this variation among 230 offspring of a cross between diverged yeast strains.
Elizabeth R Jerison +5 more
doaj +8 more sources
Genetic Pleiotropy between Nicotine Dependence and Respiratory Outcomes. [PDF]
Sci Rep, 2017 AbstractSmoking is a major cause of respiratory conditions. To date, the genetic pleiotropy between smoking behavior and lung function/chronic obstructive pulmonary disease (COPD) have not been systematically explored. We leverage large data sets of smoking behavior, lung function and COPD, and addressed two questions, (1) whether the genetic ...
Zhang J +5 more
europepmc +5 more sources
The Genetic Pleiotropy of Musculoskeletal Aging [PDF]
Frontiers in Physiology, 2012 Musculoskeletal aging is detrimental to multiple bodily functions and starts early, probably in the fifth decade of an individual’s life. Sarcopenia is a health problem that is expected to only increase as a greater portion of the population lives longer;
David eKarasik, Miri eZinder
doaj +3 more sources
Improving genetic risk prediction by leveraging pleiotropy [PDF]
Human Genetics, 2013 An important task of human genetics studies is to accurately predict disease risks in individuals based on genetic markers, which allows for identifying individuals at high disease risks, and facilitating their disease treatment and prevention. Although hundreds of genome-wide association studies (GWAS) have been conducted on many complex human traits ...
Li, Cong +3 more
core +6 more sources
Antagonistic pleiotropy, mutation accumulation, and human genetic disease [PDF]
Genetica, 1993 The antagonistic pleiotropy theory of senescence is the most convincing theoretical explanation of the existence of aging. As yet, no locus or allele has been identified in a wild population with the features predicted by the pleiotropic theory. Human genetic diseases offer the opportunity to identify potentially pleiotropic alleles/loci.
Albin, Roger L., Roger L. Albin
core +6 more sources
A global overview of pleiotropy and genetic architecture in complex traits [PDF]
Nature Genetics, 2019 After a decade of genome-wide association studies (GWASs), fundamental questions in human genetics, such as the extent of pleiotropy across the genome and variation in genetic architecture across traits, are still unanswered. The current availability of hundreds of GWASs provides a unique opportunity to address these questions.
Kyoko Watanabe +9 more
openaire +7 more sources
Antagonistic pleiotropy as a widespread mechanism for the maintenance of polymorphic disease alleles
BMC Medical Genetics, 2011 Background Many serious diseases have a genetic basis which, from an evolutionary point of view, should have been selected against, resulting in very low frequencies.
Carter Ashley JR, Nguyen Andrew Q
doaj +2 more sources
Use of pleiotropy to model genetic interactions in a population. [PDF]
PLoS Genetics, 2012 Systems-level genetic studies in humans and model systems increasingly involve both high-resolution genotyping and multi-dimensional quantitative phenotyping.
Gregory W Carter +3 more
doaj +5 more sources
Pleiotropy in Enhancer Function Is Encoded through Diverse Genetic Architectures [PDF]
SSRN Electronic Journal, 2017 Abstract Developmental genes can have complex c/s-regulatory regions, with multiple enhancers scattered across stretches of DNA spanning tens or hundreds of kilobases. Early work revealed remarkable modularity of enhancers, where distinct regions of DNA, bound by combinations of transcription factors, drive gene ...
Preger-Ben Noon, Ella +6 more
openaire +2 more sources
Polygenic risk and pleiotropy in neurodegenerative diseases [PDF]
Neurobiology of Disease, 2020 In this paper we explore the phenomenon of pleiotropy in neurodegenerative diseases, focusing on Alzheimer's disease (AD). We summarize the various techniques developed to investigate pleiotropy among traits, elaborating in the polygenic risk scores (PRS)
Eftychia Bellou +2 more
doaj +2 more sources