Results 31 to 40 of about 1,985,505 (274)
Pleiotropy facilitates parallel adaptation in sticklebacks [PDF]
, 2022 Highly pleiotropic genes are predicted to be used less often during adaptation, as mutations in these loci are more likely to have negative fitness consequences. Following this logic, we tested whether pleiotropy impacts the probability that a locus will Diana J. Rennison, Peichel, Catherine L., Catherine L. Peichel, Rennison, Diana J., Rennison, Diana J, Peichel, Catherine L +5 morecore +2 more sourcesMendelian randomization incorporating uncertainty about pleiotropy [PDF]
, 2017 Mendelian randomization (MR) requires strong assumptions about the genetic instruments, of which the most difficult to justify relate to pleiotropy.Bowden, J, Shapland, CY, Gill, D, Sheehan, NA, Minelli, C, Del Greco, FM, Jones, EM, Thompson, JR +7 morecore +6 more sourcesPleiotropy-robust Mendelian Randomization [PDF]
, 2018 BackgroundThe potential of Mendelian randomization studies is rapidly expanding due to: (i) the growing power of genome-wide association study (GWAS) meta-analyses to detect genetic variants associated with several exposures; and (ii) the increasing ...van Kippersluis, Hans, Rietveld, Niels, van Kippersluis, Hans; id_orcid, Rietveld, Niels; id_orcid +3 morecore +1 more sourceBenchmarking of univariate pleiotropy detection methods applied to epilepsy
, 2022 peer reviewedAbstractPleiotropy is a widespread phenomenon that may increase insight into the etiology of biological and disease traits. Since genome-wide association studies frequently provide information on a single trait only, only univariate ...Epilepsies, Ilae Consortium On Complex, Adesoji, Oluyomi M., MAY, Patrick, Lerche, Holger, KRAUSE, Roland, Schulz, Herbert, Nothnagel, Michael +6 morecore +1 more sourceBone and Muscle Pleiotropy: The Genetics of Associated Traits [PDF]
Clinical Reviews in Bone and Mineral Metabolism, 2014 Bone and muscle mass are highly correlated. In part, this is a consequence of both tissues sharing common genetic determinants. In addition, both tissues are responsive to their mechanical environments. New genetic tools in mice will allow genes of interest to be inactivated in experimentally defined contexts, thus allowing investigators to distinguish openaire +2 more sourcesGenetic architecture of rainbow trout survival from egg to adult [PDF]
, 2010 Survival from birth to a reproductive adult is a challenge that only robust individuals resistant to a variety of mortality factors will overcome. To assess whether survival traits share genetic architecture throughout the life cycle, we estimated ...Paananen, T., Quiton, C., Vehvilainen, H., Kuukka-Anttila, H., Koskinen, H., Kause, A. +5 morecore +1 more sourceJoint analysis of psychiatric disorders increases accuracy of risk prediction for schizophrenia, bipolar disorder, and major depressive disorder [PDF]
, 2015 Genetic risk prediction has several potential applications in medical research and clinical practice and could be used, for example, to stratify a heterogeneous population of patients by their predicted genetic risk.Caesar, Sian, Strohmaier, Jana, Wray, Naomi R., Wiersma D., Puri, Vinay, McGough J. J., Collier, David A., Myin-Germeys, Inez, Absher D., Chen, G. B., Loo, Sandra K., Wijsman E. M., Hallmayer, Joachim, Berrettini, Wade, Paterson A. D., Black D. W., Lathrop, Mark, Leboyer, Marion, Craddock, Nicholas, Lee, S Hong; id_orcid, Maier, R., Pato, Carlos N., Coryell W. H., Franke B., Datta S., Smalley, Susan L., Hansen, Thomas F., Zhang, Peng, Parr JR, Moser G., Santangelo S. L., Pericak-Vance M. A., Mühleisen, Thomas W., Van Os, Jim, Holmans, Peter Alan, Madden P. A. F., Hakonarson, Hakon, Nyholt, Dale R., Krabbendam, Lydia, Moser, Gerhard, State, Matthew, Landen M, De Geus E. J., Roeyers H., Freedman, Robert, Kent, Lindsey, Klauck S. M., Mahon, Pamela B., Gross, Magdalena, Freedman R., Duketis E., Sanders S. J., Nievergelt, Caroline M., Caesar S., Rouleau, Guy, Moreno-De-Luca, Daniel, Elia J., Farmer, Anne E., Hamilton, Steven P., Lesch K. -P., Lawrence J., Hipolito, Maria, Raychaudhuri, Soumya, Vicente, Astrid M., Schalling, Martin, Thapar, Anita, Kwan P., Lee, Sang Hong, Blackwood D. H. R., Craig D. W., Etain, Bruno, Boomsma, Dorret I., Kendler K. S., De Geus, Eco J., et al., Foroud, Tatiana, Gejman, Pablo V., Hickie I. B., Raychaudhuri S., Kennedy, James L., McQuillin, Andrew, Rossin L., Thirumalai S., Van Grootheest G., Ripke, Stephan, Pato, Michele T., Landén, Mikael, Ruderfer, Douglas, Lohoff F. W., Green E. K., Propping P., Maier R, Oliveira G., Kuntsi, Jonna, Li, Jun, Grice D. E., Kahler A. K., van den Oord, Edwin J.C.G., Kendler, Kenneth, other, and, Ribases M., McIntosh, Andrew; id_orcid, Shilling, Paul D., Lord C., Klauck, Sabine M., Kuntsi J., Rasmussen H. B., Vincent J. B., Faraone S. V., Levinson DF, Xu, Wei, Kohli M. A., Banaschewski, Tobias, Agartz I., Gross M., Frank, Josef, Hakonarson H., Tozzi, Federica, Myers R. M., Farmer, Anne, Morrow, Eric M., Wray N. R., Penninx B. W., Gershon E. S., Hong Lee, S., Weissman, Myrna M, Schachar R., Farmer A. E., Levinson, D. F., Doyle, Alysa E., Pato M. T., Santangelo, Susan L., Schellenberg G. D., Leboyer M., Georgieva, Lyudmila, Geschwind D. H., Lewis, Catrin, Coryell, W.H., Middeldorp C. M., Ingason A., Willemsen G., Kuntsi, Jonna; id_orcid, Willsey, A. Jeremy, Watson S. J., Sutcliffe, James, Etain B., Szatmari, Peter, Schwarz, Markus, Smith, Erin N., Psychiatric Genomics Consortium, Cross-Disorder Working Group of the, Hamilton S. P., O'Donovan, Michael Conlon, Medeiros H., Cantor R. M., Amin, Farooq, Visscher, Peter M., Cantor, Rita M., Kenny, Elaine, Hottenga, J.J., Cormand B., Linszen D. H., Smalley S. L., Tzeng J. -Y., McGhee, Kevin A., Vincent, John B., Daly, Mark J., Tzeng, Jung-Ying, Scott L. J., Gill M., Kahn, René S., Middeldorp, C.M., Potash, James B, Stroup, T. Scott, Coryell, William, Hautzinger, Martin, Breen, Gerome, Pickard, Benjamin S., Yu T. W., Olsen, Line, Nurnberger J. I., Vieland V. J., Giegling, Ina, Zandi, Peter P., Smith E. N., Quinn E. M., Tozzi F., Sonuga-Barke, E, Chambert K., Bayés, Mònica, Sullivan P. F., Choudhury, Khalid, McKinney, Rebecca, Medeiros, Helena, Rice, John P., Mowry B. J., Parr J. R., Lewis, Cathryn; id_orcid, Bauer, Michael, Martin, Nicholas G., Hultman, Christina M., Sonuga-Barke, Edmund; id_orcid, Landén, M., Cormican P., Smit J. H., Ingason, Andrés, Kim, Yunjung, Malhotra A. K., Roeder, Kathryn, Betancur C., Nwulia E. A., Shi, J., Cook, Edwin H., Rietschel, Marcella, Wienker T. F., Lande´n, Mikael, Shyn, Stanley I., van den Oord E. J. C. G., Zitman F. G., Van Grootheest, Gerard, Levinson D. F., McGuffin P., Binder E. B., Bayes M., Gill, Michael, Corvin, Aiden, McIntosh A., Owen, Michael J., Young A. H., State M., Akil H., Konte B., Duan, Jubao, Konte, Bettina, Moran J. L., Shi, J. X., Craddock N., Flickinger, Matthew, Nimgaonkar V., McKinney R., Gurling, Hugh, Hoefels, Susanne, Middleton, Lefkos, Schwarz M., Medland, Sarah E., Dawson G., Scott, Laura J., Lieberman J. A., Edenberg, Howard J., Edenberg H. J., Asherson, Philip, Nicol Ferrier I, Mattheisen, Manuel, Buccola N. G., Klei, Lambertus, Andreassen, Ole A., Nikolov I., Malhotra, Anil K., Pericak-Vance, Margaret A., Guan W., Purcell S. M., Nimgaonkar, Vishwajit, Young, Allan H., Kendler KS, Lichtenstein, Paul, Matthews K., Schalling M., Kendler, K. S., Coon H., Kohli, Martin A., Doyle A. E., Maier, Wolfgang, Langstrom N., Montgomery G. W., Franke, B., Backlund L., Smit, Johannes H., Breen G., MacIntyre D. J., Hultman CM, Palotie, Aarno, Hickie, Ian B., Kelsoe J. R., Nievergelt C. M., Heath A. C., Moskvina V., Kenny E., Lin, Dan-Yu, Collier D. A., Backlund, Lena, Shyn S. I., Quested D. J., Weissman, M.M., McCarroll S. A., Lucae S., Buccola, Nancy G., Levinson, Douglas, Holsboer F., Moreno-De-Luca D., Milanova V., Gordon, Scott D., Miranda, Ana, O’Donovan, Michael C., Wray, Naomi, Lencz T., Boehnke, Michael, Meyer, Jobst, Gordon-Smith, Katherine, Reif, Andreas, Kent L., Badner J. A., Lathrop M., Chen, G.B., Smoller, J. W., Amin F., Li J., Landen M., Coryell, W., Binder, Elisabeth B., Hartmann, Annette M., Hipolito M., Murtha M., Robert Cloninger C., Chen G-B, Lencz, Todd, Czamara, Darina, Frisén, Louise, McGrath P. J., Lichtenstein P., Middleton L., Nelson, Stan F., Green, Elaine K., St Clair D., Perlis, Roy H., Scherer S. W., Sanders A. R., Jones, Leslie, de Geus, E.J.C., Grice, Dorothy E., Willemsen, G.; id_orcid, Anjorin, Adebayo, Bettecken, Thomas, Keller, Matthew C., Morken G., Cook E. H., Gallagher L., Ennis S., Treutlein, Jens, Battaglia A., Schumacher J., Weissman MM, Hultman, Christina, Hoogendijk W. J., Cross-Disorder Working Group, of the Psychiatric Genomics Consortium, Myin-Germeys I., Anjorin A., Morrow E. M., Nolen W. A., Kwan, Phoenix, Neale, Benjamin M., Haines, Jonathan L., Grozeva, Detelina, Holmans P. A., Coryell, William H., Ebstein R. P., Freitag C. M., Cormican, Paul, Daly M. J., Cross-Disorder Working Group of the Psychiatric Genomics Consort,, Neale B. M., Frank J., McMahon W. M., McIntosh, Andrew, Kandaswamy, Radhika, Purcell, Shaun M., Friedl M., Buitelaar, J.K., Jones, Lisa, Bergen, Sarah E., Liu, Chunyu, Anney R., Steinhausen H. -C., Bass, Nicholas, Piven J., Fraser C., Chakravarti, Aravinda, Gershon, Elliot S., Rujescu, Dan, Rouleau G., Badner, Judith A., Foroud T., Frisen L., Schatzberg A. F., Bellivier F., Ramos-Quiroga, Josep Antoni, Strauss, John S., Scolnick E., Freimer N. B., Kahn R. S., Xu W., Shilling P. D., Hultman, C. M., Kirov, George K., Zollner S., Cuccaro M. L., Hottenga, Jouke-Jan, Thapar A., Lin D. -Y., Barchas J. D., Posthuma D., Williams, Nigel, Potash J. B., Lewis, Cathryn M., Osby, Urban, Cloninger, C. Robert, Wassink, Thomas H., Lee, S Hong, Jones I., Arking D. E., Fraser, Christine, Banaschewski T., Gurling H., Uhr M., Coryell W., Owen M. J., Dudbridge, Frank, Holmans, Peter A., Nurnberger, John I., Boehnke M., Lee, S. H., Scolnick, Edward, Breen, Gerome; id_orcid, Potash, James, Nöthen, Markus M., Holsboer, Florian, Nyholt, Dale, Klei L., Craig, David W., Van Os J., Henders, Anjali K., Puri V., Maier W., Zandi P. P., Maier, Robert, Scheftner, William A, Långström, Niklas, Datta, Susmita, Melle I., Herms, Stefan, Potash, James B., Wray, Naomi R, Scheftner, William, Propping, Peter, Boomsma D. I., Krasucki R., Krabbendam L., Ebstein, Richard P., Muglia P., McMahon, Francis J., Sklar, Pamela, Ledbetter, David H., Lowe, Jennifer K., Donohoe G. J., Middeldorp, Christel M., Ising M., Schork, Nicholas J., McGhee K. A., Kelsoe, John R., Hottenga J. -J., Young AH, Hoefels S., Azevedo M. H., Hallmayer J., Scheftner, W. A., Schulze T. G., Kendler, Kenneth S, Steinhausen, Hans-Christoph, Biederman, Joseph, Bergen S. E., Rujescu D., Jones L., Scheftner W. A., Hansen T. F., Mahon P. B., Silverman J. M., Ising, Marcus, Medland S. E., Cross-Disorder Working Group of the Psychiatric Genomics Consortium (incl Kent L), Fanous A., Magnusson, Patrik K.E., McMahon F. J., Andreassen O. A., Pimm J., Werge, Thomas, Kähler, Anna K., Weissman, Myrna M., Walsh, Christopher A., Kirov G. K., Shi, Jianxin, Barchas, Jack D., Szelinger, Szabocls, Roeder K., Bellivier, Frank, Olincy, Ann, Visscher P. M., Hultman, C.M., Jamain, Stéphane, Werge T., Georgieva L., Moran, Jennifer L., ?, ?, McMahon, William M., Thompson, Robert C., Maier R., Buxbaum, Joseph D., Guan, Weihua, Barrett, Thomas B., Moser, G., Zhang P., Smoller, J.W., Black, Donald W., Craig I. W., Ripke S, Milanova, Vihra, Landén, Mikael,, Ripke S., Day R., Rehnström, Karola, Day, Richard, Martin C. L., Cichon, Sven, Ribasés, Marta, Coryell W, Lord, Catherine, Wray, N.R., Zammit S., Kirov, George, Nikolov, Ivan, Penninx, Brenda W., Schulze, Thomas G., Todorov, Alexandre A., Cuccaro, Michael L., Keller M. C., Sanders, Alan R., Bass N., Sullivan, Patrick F., Moskvina, Valentina, Oades, Robert D., St Clair, David, Freimer, Nelson B., Bunney, William E., Lee P. H., Byerley, William F., Moser G, Arking, Dan E., Mane, Shrikant M., Weiss L. A., O'Dushlaine C., Lee, Phil H., Smoller J. W., Rice J. P., Absher, Devin, Choudhury K., Craig, Ian, Cross-Disorder Working Group of the Psychiatric Genomics Consortium, Scheftner WA, Chen G. -B., Pimm, Jonathan, Smoller, Jordan, Linszen, Don H., Wienker, Thomas F., Koller, Daniel L., Müller-Myhsok, Bertram, Scheftner, W.A., Ferrier, I. Nicol, Loo S. K., Liu C., Slager, Susan L., Byerley W. F., Maestrini E., Ennis, Sean, Paterson, Andrew D., Breuer R., Lee, S. Hong, Lucae, Susanne, Jamain S., Craig, Ian W., Young, Allan; id_orcid, Korszun, Ania, Casas M., Pergadia, Michele L., Koller D. L., Muglia, Pierandrea, Thirumalai, Srinivasa, Giegling I., McQuillin A., Maestrini, Elena, Flickinger M., Corvin A., Schellenberg, Gerard D., Cichon S., Donohoe, Gary J., Rasmussen, Henrik B., Steffens, Michael, Witt, Stephanie H., Djurovic S., Posthuma, Danielle, Wijsman, Ellen M., Hus V., Martin N. G., Meyer J., Slager S. L., Kendler, Kenneth S., Lesch, Klaus-Peter, Potash, J.B., Asherson P., Dawson, Geraldine, Mattheisen M., Hamshere M. L., Ledbetter D. H., Hultman, Christina M, Cormand, Bru, Duan J., Weissman, M. M., Monaco, Anthony P., Zöllner, Sebastian, Djurovic, Srdjan, Coon, Hilary, Lawrence, Jacob, McLean, Alan W., Barnes M. R., Yu, Timothy W., Sonuga-Barke, Edmund J.S., Williams N., Ripke, S, Silverman, Jeremy M., Franke, Barbara, Jones, Ian Richard, Ophoff, Roel A., Azevedo, Maria H., Chen, G., Pato C. N., Cahn W., Jeremy Willsey A., Todorov A. A., Buitelaar J. K., Schumacher, Johannes, Ophoff R. A., Scott Stroup T., Buitelaar, Jan K., Potash JB, Uhr, Manfred, Meier S., Meier, Sandra, Korszun A., Breuer, René, Bloss, Cinnamon S., Montgomery, Grant W., Smoller, Jordan W., Anney, Richard, Weissman, Myrna, Murtha, Michael, De Haan, Lieuwe, Gordon-Smith K., Quinn, Emma M., Nelson S. F., Hoogendijk, Witte J., Degenhardt, Franziska, Lowe J. K., Rothenberger A., Quested, Digby J., Barrett T. B., Oades R. D., Devlin B., Szatmari P., Asherson, Philip; id_orcid, Nolen, Willem A., Knowles, James A., Grozeva D., Vieland, Veronica J., Thompson R. C., Gejman P. V., De Haan L., Vicente A. M., Perlis R. H., Knowles J. A., Freitag, Christine M., Hautzinger M., Nyholt D. R., Bruggeman, Richard, Ramos-Quiroga J. A., McInnis M. G., Chakravarti A., Meng F., Faraone, Stephen V., Martin, Christa L., Szelinger S., Lee SH, Fombonne E., Palotie A., Degenhardt F., Lawson, William B., Mowry, Bryan J., Devlin, Bernie, Levinson, D.F., Kendler, K.S., Olsen L., Sanders, Stephan J., Miranda A., Scheftner, William A., Potash, J. B., Sutcliffe J., Sergeant, Joseph A., Elia, Josephine, Krasucki, Robert, Morris, Derek W., MacIntyre, Donald J., Witt S. H., Scherer, Stephen W., Hus, Vanessa, Magnusson P. K. E., Duketis, Eftichia, Hamshere, Marian L., Piven, Joseph, Willemsen, Gonneke, Mattingsdal, Morten, Sonuga-Barke E. J. S., Bruggeman R., Nicol Ferrier I., Olincy A., de Geus, E.J.C.; id_orcid, Wiersma, Durk, Wray NR, Morris D. W., Wassink T. H., Madden, Pamela A.F., Hultman C. M., Curtis, David, Rietschel M., Czamara D., Schachar, Russell, Watson, Stanley J., Greenwood T. A., Treutlein J., Cahn, Wiepke, Lohoff, Falk W., Chambert, Kimberly, Biederman J., Hartmann A. M., Melle, Ingrid, Myers, Richard M., Chen, Guo-Bo, Boomsma, D.I.; id_orcid, Rossin, Lizzy, O'Donovan M. C., Poustka F., Crosbie J., Curtis D., Greenwood, Tiffany A., Bailey, Anthony J., Henders A. K., Zammit, Stanley, Friedl, Marion, O’Dushlaine, Colm, Owen, Michael John, Zitman, Frans G., Bloss C. S., Lewis C. M., Buxbaum J. D., Bauer M., Casas, Miguel, McGrath, Patrick J., Bailey A. J., Pergadia M. L., Morken, Gunnar, Levinson, Douglas F, Lee, S.H., Betancur, Catalina, Walsh C. A., Weissman M. M., Steffens M., Mane S. M., Muller-Myhsok B., Nothen M. M., Monaco A. P., Fombonne, Eric, Roeyers, Herbert, Agartz, Ingrid, Rehnstrom K., Weiss, Lauren A., Bettecken T., Strohmaier J., Schatzberg, Alan F., Reif A., Ripke, S., Rothenberger, Aribert, Schork N. J., Shi J, Poustka, Fritz, Wray, N. R., Lee S. H., Gallagher, Louise, Smoller JW, Weissmann, M.M., Kandaswamy R., Levinson, Douglas F., Gordon S. D., Parr, Jeremy R., Lieberman, Jeffrey A., Willemsen, G., Kennedy J. L., Cross-Disorder Working Group of the Psychiatric Genomics, Consortium., Sklar P., Barnes, Michael R., Boomsma, D.I., Lawson W. B., Meng, Fan, Smoller, Jordan W, Osby U., Akil, Huda, McGough, James J., Shi J., Jones, Ian, Muhleisen T. W., Matthews, Keith, Strauss J. S., Haines J. L., Mattingsdal M., Geschwind, Daniel H., Herms S., Sergeant J. A., Oliveira, Guiomar, Nwulia, Evaristus A., Ruderfer D., Battaglia, Agatino, McInnis, Melvin G., Berrettini W., Dudbridge F., Pickard B. S., McGuffin, Peter, McCarroll, Steven A., Bunney W. E., Kim Y., McLean A. W., Crosbie, Jennifer, Heath, Andrew C., Blackwood, Douglas H.R., Fanous, Ayman, Moser, G, Coryell, W, Hultman, CM, Scheftner, WA, Lencz, T., Weissman, MM, +7 additional authors, Smoller, J., Chen, G-B, Potash, JB, Maier, R, Shi, J +858 morecore +3 more sources
