Results 51 to 60 of about 1,985,505 (274)

Evaluating the potential role of pleiotropy in Mendelian randomization studies [PDF]

, 2018
Pleiotropy, the phenomenon of a single genetic variant influencing multiple traits, is likely widespread in the human genome. If pleiotropy arises because the single nucleotide polymorphism (SNP) influences one trait, which in turn influences another ...
Bowden, Jack, Davey Smith, George, Gibran Hemani, George Davey Smith, Hemani, Gibran, Jack Bowden   +5 more
core   +1 more source

Code from "Niche specificity, polygeny and pleiotropy in herbivorous insects"

, 2022
What causes host-use specificity in herbivorous insects? Population genetic models predict specialization when habitat preference can evolve and there is antagonistic pleiotropy at a performance-affecting locus.
Hardy, Nate B, Forister, Matt L
core   +1 more source

CSF Cytokine Network Organization Predicts Progression Independent of Relapse and MRI Activity in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Progression independent of relapse activity is a major determinant of long‐term disability in multiple sclerosis, but its immunopathologic basis remains incompletely understood. We investigated whether relapse‐independent progression in radiologically stable relapsing–remitting multiple sclerosis is associated with distinct ...
Antonio Bruno, Matteo Conti, Ettore Dolcetti, Federica Azzolini, Angela Borrelli, Roberta Fantozzi, Mario Stampanoni Bassi, Giovanni Galifi, Giuseppe Maccarrone, Luca Montaguti, Marco Cervigni, Maddalena Dal Pozzo, Roberto Furlan, Annamaria Finardi, Girolama Alessandra Marfia, Marco Salvetti, Antonella Conte, Fabio Buttari, Diego Centonze, Luana Gilio   +19 more
wiley   +1 more source

Pleiotropy increases parallel selection signatures during adaptation from standing genetic variation

eLife
The phenomenon of parallel evolution, whereby similar genomic and phenotypic changes occur across replicated pairs of populations or species, is widely studied.
Wei-Yun Lai, Sheng-Kai Hsu, Andreas Futschik, Christian Schlötterer   +3 more
doaj   +1 more source

Antagonistic pleiotropy, dominance, and genetic variation [PDF]

Heredity, 1982
Although the importance of antagonistic pleiotropy of genes affecting components of fitness has long been argued, explicit population genetic models involving pleiotropy have only recently been developed. Simple, deterministic models of this kind are given, and then analyzed for conditions sufficient for protected polymorphism.
openaire   +1 more source

Whole‐Genome Sequencing Pilot of the Central Asian Genomic Diversity Project Reveals Distinct Histories, Adaptation, and Introgression

Advanced Science, EarlyView.
As a pilot phase of the Central Asian Genomic Diversity Project, whole‐genome sequencing of 166 individuals from 20 Central Asian and Afghan Hazara populations reveals fine‐scale substructure shaped by repeated trans‐Eurasian migration and admixture. Integrated analyses uncover post‐admixture adaptation, archaic introgression, and medically relevant ...
Mengge Wang, Shuhan Duan, Qiuxia Sun, Renkuan Tang, Lintao Luo, Jie Zhong, Zhaxylyk Sabitov, CAGDP Consortium†, Lan‐Hai Wei, Chao Liu, Maxat Zhabagin, Guanglin He   +11 more
wiley   +1 more source

Are genetic risk factors for psychosis also associated with dimension-specific psychotic experiences in adolescence? [PDF]

, 2014
Psychosis has been hypothesised to be a continuously distributed quantitative phenotype and disorders such as schizophrenia and bipolar disorder represent its extreme manifestations.
Plomin, Robert, Freeman, D, Daniel Freeman, Angelica Ronald (346752), Sieradzka, D., Robert Plomin (27675), Dominika Sieradzka (549507), Cardno, Alastair G., Power Robert A., Power, Robert, Cardno, A.G., McGuire, P, McGuire, Philip, Angelica Ronald, Sieradzka Dominika, Alastair G Cardno, Ronald, Angelica, Ronald, A, Philip McGuire (325649), Robert Plomin, Sieradzka, Dominika, Freeman, Daniel, Power, RA, Power, R.A., Cardno Alastair G., Ronald Angelica, Robert A. Power (549508), Meaburn, Emma L, McGuire, P., Cardno, AG, Dudbridge Frank, Freeman Daniel, Dominika Sieradzka, Frank Dudbridge, Robert A Power, Meaburn Emma L., Meaburn, EL, Sieradzka, D, Alastair G. Cardno (549510), Plomin, R., Dudbridge, Frank, Daniel Freeman (549509), Meaburn, Emma L., Plomin Robert, Freedman, D., Power, Robert A, Plomin, R, Cardno, Alastair G, Emma L. Meaburn (397318), McGuire Philip, Philip McGuire, Dudbridge, F, Frank Dudbridge (102283), Emma L Meaburn   +53 more
core   +1 more source

Harnessing Large‐Scale Multi‐Omics Data for Risk Prediction and Deep Phenotyping of Valvular Heart Diseases in the General Population

Advanced Science, EarlyView.
Large‐scale UK Biobank analyses identify clinical and proteomic signatures for early prediction of valvular heart disease and its subtypes. Proteins add predictive value for VHD, AVS, and MVR, with outcome‐specific compact panels showing translational potential. Multi‐layer evidence highlights matrix remodeling, protease regulation, immune inflammation,
Zhihao Jiang, Yang Liu, Mingyu Song, Ning Chen, Canqing Yu, Jun Lv, Eric Yuk Fai Wan, Lu Qi, Liming Li, Dianjianyi Sun, Bang Zheng   +10 more
wiley   +1 more source

Mendelian Randomization: A Review of Methods for the Prevention, Assessment, and Discussion of Pleiotropy in Studies Using the Fat Mass and Obesity-Associated Gene as an Instrument for Adiposity

Frontiers in Genetics, 2022
Pleiotropy assessment is critical for the validity of Mendelian randomization (MR) analyses, and its management remains a challenging task for researchers. This review examines how the authors of MR studies address bias due to pleiotropy in practice.
Fiston Ikwa Ndol Mbutiwi, Fiston Ikwa Ndol Mbutiwi, Tatiana Dessy, Marie-Pierre Sylvestre, Marie-Pierre Sylvestre   +4 more
doaj   +1 more source

Investigation Of Genetic Pleiotropy Between Body Mass Index And Systolic Blood Pressure

, 2022
This study sought to characterize patterns of pleiotropy at the genome-wide level between Body Mass Index (BMI) and Systolic Blood Pressure (SBP) associated with the same single nucleotide polymorphism (SNP).
Kang, Esther
core   +1 more source