Results 71 to 80 of about 1,985,505 (274)

The genetic architecture of adaptation: convergence and pleiotropy in Heliconius wing pattern evolution [PDF]

, 2019
This is genotype and phenoytype data from the QTL analyses for the paper:THE GENETIC ARCHITECTURE OF ADAPTATION: CONVERGENCE AND PLEIOTROPY IN HELICONIUS WING PATTERN EVOLUTIONEach Zip archive, contains R scripts and data needed for each ...
Lauren D. Rawlins (6235139), Rawlins, LD, Nicolas Navarro, Mallet, James, Mallet, J, Dasmahapatra, Kanchon K., Navarro, Nicolas, Rastas, P, Pasi Rastas (3287856), Morris, Jake, Rawlins, Lauren Danielle, Pasi Rastas, Jim Mallet (253574), Navarro, N, Joshua Sammy, Dasmahapatra, KK, Kanchon K. Dasmahapatra, Dasmahapatra, Kanchon Kumar, Jake Morris, Morris, J, Lauren D. Rawlins, Sammy, Joshua Moon, Nicolas Navarro (202115), Jake Morris (4890937), Rastas, Pasi, Joshua Sammy (6235138), Sammy, Joshua, Rawlins, Lauren D., James Mallet, Kanchon K. Dasmahapatra (433053), Sammy, J   +30 more
core   +1 more source

Interleukin‐39 is a Prognostic Biomarker and Therapy Target for Sepsis

Advanced Science, EarlyView.
Sepsis triggers a significant increase in IL‐39 production, with circulating levels markedly elevated and positively correlated with disease severity and poor clinical prognosis in sepsis patients. Mechanistically, macrophage‐derived IL‐39 activates the GP130 signaling pathway via a ligand‐receptor interaction, thereby fueling the pro‐inflammatory ...
Feng‐zhi Zhang, Hai‐jun Liu, Yan Yue, Jun‐jie Gao, Jin Zhang, Wen‐wu Zhang, Yun‐long Zhang, Wei‐hua Lu, Sheng‐wei Jin, Pu‐hong Zhang   +9 more
wiley   +1 more source

A survey of genetic improvement search spaces [PDF]

, 2019
Genetic Improvement (GI) uses automated search to improve existing software. Most GI work has focused on empirical studies that successfully apply GI to improve software's running time, fix bugs, add new features, etc. There has been little research into
Alexander, B, Petke, Justyna, Alexander, Brad, Petke, J, White, DR, Wagner, M., Barr, ET, White, David R, Wagner, M, Barr, Earl T, Alexander, B., White, D.R., Petke, J., Barr, E.T., Brownlee, AEI, Brownlee, Alexander E I, Wagner, Markus, Brownlee, A.E.I.   +17 more
core   +1 more source

Pleiotropy robust methods for multivariable Mendelian randomization. [PDF]

, 2021
Mendelian randomization is a powerful tool for inferring the presence, or otherwise, of causal effects from observational data. However, the nature of genetic variants is such that pleiotropy remains a barrier to valid causal effect estimation. There are

core   +5 more sources

SOX30 Facilitates Triple‐Negative Breast Cancer Metastasis via TNFR2–NF‐κB Signaling and Tumor Microenvironment Remodeling

Advanced Science, EarlyView.
SOX30 drives triple‐negative breast cancer (TNBC) metastasis through a dual mechanism: direct activation of the TNFR2/NF‐κB signaling cascade and subsequent CCL20‐mediated recruitment of tumor‐associated macrophages (TAMs) into the tumor microenvironment.
Pingping Gao, Na Sun, Ning Yang, Tingting Zhao, Rui Fu, Zhenyu Wu, Yuqin Zhou, Xuanni Tan, Yi Zhang, Fei Han, Xiaowei Qi   +10 more
wiley   +1 more source

Pleiotropy accelerates tooth phenotypic and genomic evolution - An in silico study under the lens of development

Pleiotropy, which can occur when a gene affects multiple traits, is a central property of living organisms, influencing their response to mutations and their evolutionary trajectories.
Beslon, Guillaume, Hagolani, Pascal Felix, Sémon, Marie, Pantalacci, Sophie   +3 more
core   +1 more source

Trace Elements Genetics: A Potential Role in Treatment‐Resistant Major Psychoses and Related Traits?

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Trace elements are pivotal to key biological processes, with possible effects on psychopathology. We investigated the hypothesis of shared genetic factors between trace elements levels, treatment resistance and related traits. We used genome‐wide summary statistics for trace elements blood concentration, treatment‐resistant depression (TRD ...
Chiara Fabbri, Alessandro Serretti, Marco Menchetti, Benedetta Vai, Francesco Benedetti, Lidia Fortaner‐Uyà, Concetta Crisafulli   +6 more
wiley   +1 more source

Foxg1 and companions: Not only transcription factors

Neural Regeneration Research
Moving from the most recent results on Foxg1 biology, we first summarize the available information on some special pleiotropic effectors of neurodevelopmental interest, involved in controlling both transcription and post-transcriptional steps of gene ...
Antonello Mallamaci, Osvaldo Artimagnella, Gabriele Liuzzi   +2 more
doaj   +1 more source

LPG: A four-group probabilistic approach to leveraging pleiotropy in genome-wide association studies

BMC Genomics, 2018
Background To date, genome-wide association studies (GWAS) have successfully identified tens of thousands of genetic variants among a variety of traits/diseases, shedding light on the genetic architecture of complex disease.
Yi Yang, Mingwei Dai, Jian Huang, Xinyi Lin, Can Yang, Min Chen, Jin Liu   +6 more
doaj   +1 more source

Review of the Molecular and Developmental Basis of Myhre Syndrome, Bench Research

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Myhre syndrome (MS) is a connective‐tissue disorder within the acromelic dysplasia spectrum. It is characterized by congenital craniofacial, skeletal, cutaneous anomalies, respiratory, cardiovascular along with intellectual disability, deafness, and progressive fibrosis.
Camille Viaut, Valerie Cormier‐Daire
wiley   +1 more source