Results 81 to 90 of about 1,985,505 (274)

Genetic overlap between estimated glomerular filtration rate and cardiovascular disease identifies potential targets for cardiorenal syndrome

Renal Failure
Heart and kidney diseases frequently coexist, but the genetic basis of this relationship remains unclear. We analyzed genetic data from large-scale studies to investigate how kidney function (estimated glomerular filtration rate, eGFR) and six common ...
Wenhua Li, Yanghui Chen, Wenjing Xiong, Shuai Yuan   +3 more
doaj   +1 more source

Dissection of genetic variation and evidence for pleiotropy in male pattern baldness [PDF]

Nature Communications, 2018
AbstractMale pattern baldness (MPB) is a sex-limited, age-related, complex trait. We study MPB genetics in 205,327 European males from the UK Biobank. Here we show that MPB is strongly heritable and polygenic, with pedigree-heritability of 0.62 (SE = 0.03) estimated from close relatives, and SNP-heritability of 0.39 (SE = 0.01) from conventionally ...
Chloe X. Yap, Julia Sidorenko, Yang Wu, Kathryn E. Kemper, Jian Yang, Naomi R. Wray, Matthew R. Robinson, Peter M. Visscher   +7 more
openaire   +8 more sources

The contribution of epistatic pleiotropy to the genetic architecture of covariation among polygenic traits in mice

, 2006
The contribution that pleiotropic effects of individual loci make to covariation among traits is well understood theoretically and is becoming well documented empirically.
Eisen, Eugene J., Leamy, Larry J., Pomp, Daniel, Cheverud, James M., Wolf, Jason B.   +4 more
core   +1 more source

Role of soft tissue and bone interactions in the developmental integration and modularity of the skull in neural crest‐specific gap junction alpha‐1 knockout mice

The Anatomical Record, EarlyView.
Abstract The vertebrate skull is composed of bones derived from neural crest cells and mesoderm. The evolutionary capacity of the skull has been linked, in part, to the emergence of neural crest cells; however, this increased capacity for evolutionary change requires that variation within neural crest‐ and mesoderm‐derived bones remains partly ...
Alyssa C. Moore, Madeline Tourigny, Diana Quinonez, Kevin Barr, Matthew W. Grol, Katherine E. Willmore   +5 more
wiley   +1 more source

Leveraging pleiotropic clustering to address high proportion correlated horizontal pleiotropy in Mendelian randomization studies

Nature Communications
Mendelian randomization harnesses genetic variants as instrumental variables to infer causal relationships between exposures and outcomes. However, certain genetic variants can affect both the exposure and the outcome through a shared factor.
Bin Tang, Nan Lin, Junhao Liang, Guorong Yi, Liubin Zhang, Wenjie Peng, Chao Xue, Hui Jiang, Miaoxin Li   +8 more
doaj   +1 more source

Pleiotropy between Genetic Markers of Obesity and Risk of Prostate Cancer [PDF]

Cancer Epidemiology, Biomarkers & Prevention, 2013
Abstract Background: To address inconsistent findings of obesity and prostate cancer risk, we analyzed the association between prostate cancer and genetic markers of obesity and metabolism. Methods: Analyses included 176,520 single-nucleotide polymorphisms (SNP) associated with 23 metabolic traits.
Todd L, Edwards, Ayush, Giri, Saundra, Motley, Wynne, Duong, Jay H, Fowke   +4 more
openaire   +2 more sources

Strong genetic influence on a UK nationwide test of educational achievement at the end of compulsory education at age 16 [PDF]

, 2013
We have previously shown that individual differences in educational achievement are highly heritable in the early and middle school years in the UK. The objective of the present study was to investigate whether similarly high heritability is found at the
Shakeshaft, Nicholas G, Dale, Philip S, Plomin, Robert, Maciej Trzaskowski (185577), Krapohl, Eva, Andrew McMillan, Philip S Dale, Haworth, Claire M. A., Nicholas G. Shakeshaft (495940), Shakeshaft Nicholas G., Robert Plomin (27675), Haworth, Claire M A, Dale, Philip S., Eva Krapohl, Dale Philip S., McMillan, Andrew, Andrew McMillan (495941), Eva Krapohl (495943), Nicholas G Shakeshaft, Kaili Rimfeld (495942), Claire M. A. Haworth (185578), Plomin Robert, Shakeshaft, Nicholas G., Robert Plomin, Maciej Trzaskowski, Claire M A Haworth, Philip S. Dale (185582), McMillan Andrew, Rimfeld Kaili, Kaili Rimfeld, Haworth Claire M. A., Trzaskowski Maciej, Trzaskowski, Maciej, Rimfeld, Kaili, Krapohl Eva   +34 more
core   +1 more source

Genetic and population analyses implicate thyroid‐related regulation of RNF144B in chondrocalcinosis

Arthritis &Rheumatology, Accepted Article.
Objectives Chondrocalcinosis, characterized by calcium crystal deposition within articular cartilage, affects 5–15% of the general population and has recently been identified as an osteoarthritis risk factor. However, Its biological pathways remain unclear.
Yahong Wu, Yanning Xu, Paul C. Okoro, Sirine Saafi, Jard de Vries, Xiaoyi Qi, Edwin H.G. Oei, Sita Bierma‐Zeinstra, Trudy Voortman, David Felson, Joyce BJ van Meurs, Layal Chaker, J. Mark Wilkinson, Michelle S. Yau, Jessica Bertrand, Cindy G. Boer   +15 more
wiley   +1 more source

A genome-wide pleiotropy study between atopic dermatitis and neuropsychiatric disorders

Human Genomics
Atopic dermatitis (AD) frequently co-occurs with neuropsychiatric disorders, yet the genetic basis for this comorbidity is unclear. We performed a large-scale genome-wide pleiotropy approach to investigate the genetic correlations and causal associations
Charalabos Antonatos, Alexandros Pontikas, Adam Akritidis, Dimitra Mitsoudi, Sophia Georgiou, Alexander J. Stratigos, Aikaterini Zacharopoulou, Stamatis Gregoriou, Katerina Grafanaki, Yiannis Vasilopoulos   +9 more
doaj   +1 more source

Autism Spectrum Disorder, Attention‐Deficit/Hyperactivity Disorder, Tic Disorder, and Obsessive‐Compulsive Disorder in Individuals With Eating Disorders and Their Siblings: A Nationwide Finnish Cohort Study

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Neurodevelopmental conditions frequently co‐occur with eating disorders (EDs). This study aimed to investigate the occurrence of attention‐deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), tic disorder (TD), and obsessive‐compulsive disorder (OCD) in individuals with EDs and their full and half siblings.
Emma Saure, Pyry N. Sipilä, Susanna Hinkka‐Yli‐Salomäki, Andre Sourander, Elina Santti, Anu Raevuori   +5 more
wiley   +1 more source