Results 101 to 110 of about 1,985,505 (274)

Shared Genetic Links Between Nonalcoholic Fatty Liver Disease and Coronary Artery Disease

Global Heart
Background: Epidemiological and clinical studies have shown that there is a co-morbidity between nonalcoholic fatty liver disease (NAFLD) and coronary artery disease (CAD). Methods: In this study, we utilized linkage disequilibrium score regression (LDSC)
Hua Di, Shouhao Wang, Chengan Xu, Qiaoqiao Yin, Keyang Xu, Wei Zheng   +5 more
doaj   +1 more source

HOPS: a quantitative score reveals pervasive horizontal pleiotropy in human genetic variation is driven by extreme polygenicity of human traits and diseases

, 2018
Horizontal pleiotropy, where one variant has independent effects on multiple traits, is important for our understanding of the genetic architecture of human phenotypes.
Daniel M. Jordan, Ron Do, Marie Verbanck
core   +1 more source

Shared genetics between ADHD and reading/language abilities: Genome‐wide correlations, stratified enrichment, cross‐trait association, and mendelian randomization

JCPP Advances, EarlyView.
Abstract Background Attention‐deficit/hyperactivity disorder (ADHD) and language/reading difficulties frequently co‐occur. The extent of shared genetic architecture remains incompletely defined. We investigated genome‐wide overlap between ADHD and four core skills: word reading, nonword reading, spelling, and phoneme awareness.
Jinzhu Zhao, Shi Huang, Wei Liu, Feng Wang, Hong Qian, Xiaolin Hu   +5 more
wiley   +1 more source

A Review of Mendelian Randomization: Assumptions, Methods, and Application to Obesity-Related Diseases

Journal of Obesity & Metabolic Syndrome
Mendelian randomization (MR) is a statistical method that uses genetic variants as instrumental variables to estimate the causal effect of exposure on an outcome in the presence of unmeasured confounding.
Seungjae Lee, Woojoo Lee
doaj   +1 more source

Shared genetic and molecular architecture between neurodevelopmental disorders and type 1 diabetes

Journal of Intelligent Medicine, EarlyView.
Abstract Epidemiological and clinical studies have suggested possible associations between type 1 diabetes (T1D) and neurodevelopmental disorders (NDDs), but these relationships remain inconsistent across disorders and populations. To clarify whether such mixed findings, we investigated the genetic architecture linking T1D with autism spectrum disorder
Jingxuan Zhang, Zhentao Zhou, Lirong Zhu, Wei Liu   +3 more
wiley   +1 more source

Estimated Body Fat Percentage and Triglyceride‐Glucose Index for Identifying MASLD in Lean Asian Adults: A Cross‐Sectional Analysis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) is increasingly prevalent among lean Asian populations, yet effective strategies for identifying high‐risk individuals remain limited. We investigated the associations of body fat percentage (BF%) and the triglyceride‐glucose (TyG) index with lean MASLD and evaluated their ...
Xiang‐Ran Kong, Ya‐Li Chen, Rui Li, Lu‐Xiang Shang, Sha Sha   +4 more
wiley   +1 more source

Joint modeling of effect sizes for two correlated traits: Characterizing trait properties to enhance polygenic risk prediction.

PLoS Genetics
Recent years have witnessed a surge in the development of innovative polygenic score (PGS) methods, driving their extensive application in disease prevention, monitoring, and treatment.
Chi Zhang, Geyu Zhou, Tianqi Chen, Hongyu Zhao   +3 more
doaj   +1 more source

Disulfidptosis‐ and Ferroptosis‐Related Gene Signatures in Rheumatoid Arthritis: Association Analysis and Diagnostic Model Construction

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent synovial inflammation and progressive joint damage. Although ferroptosis has been implicated in RA progression, the role of disulfidptosis and its interaction with ferroptosis remains unclear.
Ting‐Ting Wang, Dong‐Mei Wang, Xue Li, Yuan‐Li Wei, Ping‐Dan Liu, Shi‐Lin Li, Si‐Ying Xiong, Cai‐Zhen Liu, Fan‐Xin Zeng, Jian‐Hong Wu, Lin Tang   +10 more
wiley   +1 more source

Genetic pleiotropy explains associations between musical auditory discrimination and intelligence.

PLoS ONE, 2014
Musical aptitude is commonly measured using tasks that involve discrimination of different types of musical auditory stimuli. Performance on such different discrimination tasks correlates positively with each other and with intelligence.
Miriam A Mosing, Nancy L Pedersen, Guy Madison, Fredrik Ullén   +3 more
doaj   +1 more source

Movement Disorders in Developmental and Epileptic Encephalopathies

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Monogenic developmental and epileptic encephalopathies (DEE) frequently feature co‐occurring movement disorders. Gene discovery has expanded epilepsy‐dyskinesia syndromes (EDS) from classic associations such as stereotypies in Rett syndrome to PRRT2‐related infantile seizures with paroxysmal dyskinesia and crouched gait in SCN1A ...
Shekeeb Mohammad, Darius Ebrahimi‐Fakhari, Hugo Morales‐Briceno   +2 more
wiley   +1 more source