Results 21 to 30 of about 1,985,505 (274)
Statistical Methods for Testing Genetic Pleiotropy. [PDF]
Genetics, 2016 AbstractGenetic pleiotropy is when a single gene influences more than one trait. Detecting pleiotropy and understanding its causes can improve the biological understanding of a gene in multiple ways, yet current multivariate methods to evaluate pleiotropy test the null hypothesis that none of the traits are associated with a variant; departures from ...
Schaid DJ +5 more
europepmc +4 more sources
Multivariate generalized linear model for genetic pleiotropy. [PDF]
Biostatistics, 2019 When a single gene influences more than one trait, known as pleiotropy, it is important to detect pleiotropy to improve the biological understanding of a gene. This can lead to improved screening, diagnosis, and treatment of diseases. Yet, most current multivariate methods to evaluate pleiotropy test the null hypothesis that none of the traits are ...
Schaid DJ +5 more
europepmc +4 more sources
Impacts of pleiotropy and migration on repeated genetic adaptation [PDF]
GENETICS, 2021 Abstract Observations of genetically repeated evolution (repeatability) in complex organisms are incongruent with the Fisher–Orr model, which implies that repeated use of the same gene should be rare when mutations are pleiotropic (i.e. affect multiple traits).
Paul Battlay +2 more
openaire +2 more sources
PleioGRiP: genetic risk prediction with pleiotropy [PDF]
Bioinformatics, 2013 AbstractMotivation: Although several studies have used Bayesian classifiers for risk prediction using genome-wide single nucleotide polymorphism (SNP) datasets, no software can efficiently perform these analyses on massive genetic datasets and can accommodate multiple traits.Results: We describe the program PleioGRiP that performs a genome-wide ...
Stephen W. Hartley, Paola Sebastiani
openaire +3 more sources
Neurobiology of Language, 2022 Using individual differences approaches, a growing body of literature finds positive associations between musicality and language-related abilities, complementing prior findings of links between musical training and language skills.
Srishti Nayak +7 more
doaj +1 more source
How much can the orientation of G's eigenvectors tell us about genetic constraints? [PDF]
, 2012 A key goal in evolutionary quantitative genetics is to understand how evolutionary trajectories are constrained by pleiotropic coupling among multiple traits.
Daniel Berner, Berner, Daniel
core +1 more source
Genome Biology, 2019 Horizontal pleiotropy, where one variant has independent effects on multiple traits, is important for our understanding of the genetic architecture of human phenotypes.
Daniel M. Jordan, Marie Verbanck, Ron Do
doaj +1 more source
Nature Communications, 2021 Thus far, pleiotropy analysis using individual-level Electronic Health Records data has been limited to data from one site. Here, the authors introduce Sum-Share, a method designed to efficiently and losslessly integrate EHR and genetic data from ...
Ruowang Li +18 more
doaj +1 more source
Revealing polygenic pleiotropy using genetic risk scores for asthma
HGG Advances, 2023 Summary: In this study we examined how genetic risk for asthma associates with different features of the disease and with other medical conditions and traits.
Matthew Dapas +5 more
doaj +1 more source
Relationship between NAFLD and coronary artery disease: A Mendelian randomization study
Hepatology, EarlyView., 2022 Abstract Background and Aims There is an ongoing debate on whether NAFLD is an active contributor or an innocent bystander in the pathogenesis of coronary artery disease (CAD). The aim of the present study was to assess the causal relationship between NAFLD and CAD.
Zhewen Ren +4 more
wiley +1 more source