Results 81 to 90 of about 50,540 (257)

Long-term evolutionary dynamics of cooperation and pleiotropy.

, 2022
Dynamics are shown for the global population of cells over time, t, which encompasses many generations of cell groups. These dynamics encompass both within-group and between-group selection dynamics.
Kevin R. Foster (8893457), Gail M. Preston (8780690), Michael A. Bentley (3079278), Christian A. Yates (12462891), Jotun Hein (27177)   +4 more
core   +1 more source

Integrative Genomic and Functional Investigation of the Multi‐Layered Genetic Architecture Between Anorexia Nervosa and Bone Loss

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Bone loss is a severe and often irreversible complication of anorexia nervosa (AN), yet the genetic mechanisms underlying this comorbidity remain underexplored. This study focuses on constructing a comprehensive genetic architecture between AN and estimated calcaneal bone mineral density (eBMD).
Tao Han, Yuke Wang, Yixiong Dang, Rong Xiang, Yan Zeng, Sheng He, Ye Ju, Zilan Chen, Ting Liu, Zihao Li, Yuqi Pang, Wanyi Tan, Jue Xu, Jingwen Jiang, Xia Jiang   +14 more
wiley   +1 more source

There is a small, negative relationship between interval-based adjusted pleiotropy and observed pleiotropy in the four population-trait categories.

, 2023
The scatter plots show the relationship between the adjusted and observed pleiotropy values for (a) NAM field, (b) GAP field, (c) GAP mass features, and (d) GAP expression traits.
Emily Yi (14822592), M. Cinta Romay (9467168), Anju Giri (11520266), Edward S. Buckler (8844038), Merritt Khaipho-Burch (11520269), Taylor Ferebee (14019209), Guillaume Ramstein (14349513), Brandon Monier (6336209)   +7 more
core   +1 more source

Causal correlations between inflammatory proteins and heart failure: A two‐sample Mendelian randomization analysis

ESC Heart Failure, Volume 12, Issue 2, Page 1374-1385, April 2025.
Abstract Aims Inflammation plays a critical role in both the development and progression of heart failure (HF), which is a leading cause of morbidity and mortality worldwide. However, the causality between specific inflammation‐related proteins and HF risk remains unclear.
Xian‐Guan Zhu, Gui‐Qin Liu, Ya‐Ping Peng, Li‐Ling Zhang, Xian‐Jin Wang, Liang‐Chuan Chen, Yuan‐Xi Zheng, Xue‐Jun Xiang, Rui Qiao, Xian‐He Lin   +9 more
wiley   +1 more source

Refining Genetic Instruments for Dietary Intake Mendelian Randomization Using Phenome-Wide Association Studies. [PDF]

Genet Epidemiol
ABSTRACT Most Mendelian randomization (MR) of dietary intake use the full set of genome‐wide significant (GWS) variants in the instrumental variable (IV), likely biasing causal estimates due to pleiotropy. To characterize the common methods to handle pleiotropy in dietary intake MR, we conducted a scoping review of the literature on dietary intake MR ...
Sutton KJ, Gervis JE, Jatoi M, Hwang LD, Hendricks AE, Ghosh D, Westerman KE, Cole JB.   +7 more
europepmc   +2 more sources

Pleiotropy evolves to stabilise cooperation even when group selection is weak.

, 2022
We explored a model in which the strength of group selection, sg, is varied. Heatmaps show average trait values among the global population of cells (across all groups) at steady state in our model.
Kevin R. Foster (8893457), Gail M. Preston (8780690), Michael A. Bentley (3079278), Christian A. Yates (12462891), Jotun Hein (27177)   +4 more
core   +1 more source

Interactions between lactobacillus and yeast: A recent update

Food Biomacromolecules, EarlyView.
Abstract Lactobacillus and yeast are microorganisms widely distributed in nature. Their interactions significantly impact fermentation processes, human health, and medical care. However, there is a lack of a systematic summary of the characteristics of these interactions, and the mechanisms underlying these interactions remain unclear.
Yang Chen, Mengyuan Liu, Mengchen Li, Zhiyun Yue, Yang Mu, Chao Wang, Lusha Xia, Junjun Gao, Mingye Peng, Ran Wang, Mengzhou Zhou   +10 more
wiley   +1 more source

The evolution of pleiotropy in multicellular groups with a germ line and delayed reproductive maturity.

, 2022
We varied α, the fraction of the expected life span λ groups must have aged to before they can reproduce. We also assumed a germ line, γ = 1, and that the evolution of pleiotropy carries a cost.
Kevin R. Foster (8893457), Gail M. Preston (8780690), Michael A. Bentley (3079278), Christian A. Yates (12462891), Jotun Hein (27177)   +4 more
core   +1 more source

Multi‐Cohort Analysis Reveals Genetic Predispositions to Clonal Hematopoiesis as Mutation‐Specific Risk Factors for Stroke

Advanced Genetics, Volume 6, Issue 1, March 2025.
This study comprehensively evaluated the differential effect of clonal hematopoiesis (CH) mutations on the risk of various stroke subtypes and functional recovery. It shows that TET2 is associated with small vessel stroke possibly via a pro‐inflammatory pathway. Abstract Recent observational studies have found an association between Clonal Hematopoesis
Shuyang Lin, Yang E. Li, Yan Wang
wiley   +1 more source

Interaction between mutation type and gene pleiotropy drives parallel evolution in the laboratory

, 2023
What causes evolution to be repeatable is a fundamental question in evolutionary biology. Pleiotropy, i.e. the effect of an allele on multiple traits, is thought to enhance repeatability by constraining the number of available beneficial mutations ...
Ruelens, Philip, de Visser, Arjan
core   +1 more source