Results 101 to 110 of about 50,540 (257)

Categories or dimensions? A critical systematic review of taxometric evidence in autism, ADHD, and language disorders

JCPP Advances, EarlyView.
Abstract Background Taxometric analysis is designed to test whether the latent structure underlying clinical conditions is categorical (taxonic) or dimensional. Despite its relevance to ongoing debates on neurodevelopmental conditions, its application to this field remains limited.
Enrico Toffalini, Margherita Calderan, Riccardo Pagan, Valentina Tobia, Edmund Sonuga‐Barke   +4 more
wiley   +1 more source

Navigating Mendelian Randomization in Sleep Medicine: Challenges, Opportunities, and Best Practices

Nature and Science of Sleep
Ahmed S BaHammam,1,2 Haitham Jahrami3,4 1The University Sleep Disorders Center, Department of Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia; 2King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia ...
BaHammam AS, Jahrami H
doaj  

Shared genetic and molecular architecture between neurodevelopmental disorders and type 1 diabetes

Journal of Intelligent Medicine, EarlyView.
Abstract Epidemiological and clinical studies have suggested possible associations between type 1 diabetes (T1D) and neurodevelopmental disorders (NDDs), but these relationships remain inconsistent across disorders and populations. To clarify whether such mixed findings, we investigated the genetic architecture linking T1D with autism spectrum disorder
Jingxuan Zhang, Zhentao Zhou, Lirong Zhu, Wei Liu   +3 more
wiley   +1 more source

The role of structural pleiotropy and regulatory evolution in the retention of heteromers of paralogs

eLife, 2019
Gene duplication is a driver of the evolution of new functions. The duplication of genes encoding homomeric proteins leads to the formation of homomers and heteromers of paralogs, creating new complexes after a single duplication event. The loss of these
Axelle Marchant, Angel F Cisneros, Alexandre K Dubé, Isabelle Gagnon-Arsenault, Diana Ascencio, Honey Jain, Simon Aubé, Chris Eberlein, Daniel Evans-Yamamoto, Nozomu Yachie, Christian R Landry   +10 more
doaj   +1 more source

Association Between Genetically Predicted 25-Hydroxyvitamin D and Type 2 Diabetes Risk in South Asians: An Exploratory Two-Sample Mendelian Randomization Study. [PDF]

Endocrinol Diabetes Metab
Using two‐sample Mendelian randomization, we found no statistically significant association between genetically predicted 25‐hydroxyvitamin D and Type 2 diabetes risk in South Asians. However, the limited exposure GWAS, three‐instrument set, exploratory instrument threshold, and possible sample overlap warrant cautious interpretation and larger South ...
Zaka A, Khan S, Shah A, Khalid AA, Khalil I, Kamrul-Hasan ABM.   +5 more
europepmc   +2 more sources

Estimated Body Fat Percentage and Triglyceride‐Glucose Index for Identifying MASLD in Lean Asian Adults: A Cross‐Sectional Analysis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) is increasingly prevalent among lean Asian populations, yet effective strategies for identifying high‐risk individuals remain limited. We investigated the associations of body fat percentage (BF%) and the triglyceride‐glucose (TyG) index with lean MASLD and evaluated their ...
Xiang‐Ran Kong, Ya‐Li Chen, Rui Li, Lu‐Xiang Shang, Sha Sha   +4 more
wiley   +1 more source

Bridging the Divide: Integrating Cottonseed Oil Content with Agronomic Trait Improvement in Upland Cotton (Gossypium hirsutum)—A Review

Plants
Cotton (Gossypium hirsutum) is globally cultivated for its high-quality fiber; yet, its seed, rich in oil and protein, offers untapped potential for various applications, including food, feed, and industry.
Isah Mansur Aminu, Zeeshan Ahmad, Khadija Kamaluddeen Faruk, Muhammad Iyad Abdullahi, Jingwen Pan, Yan Li, Wei Chen, Jinbo Yao, Shengtao Fang, Shouhong Zhu, Yongshan Zhang   +10 more
doaj   +1 more source

Genotype-by-diet effects on co-variation in Lp-PLA2 activity and LDL-cholesterol concentration in baboons fed an atherogenic diet*

Journal of Lipid Research, 2008
Both lipoprotein-associated phospholipase A2 (Lp-PLA2) activity, a biomarker of inflammation, and concentration of its primary associated lipoprotein, LDL, are correlated with adverse coronary outcomes.
Amanda Vinson, Michael C. Mahaney, Vince P. Diego, Laura A. Cox, Jeffrey Rogers, John L. VandeBerg, David L. Rainwater   +6 more
doaj   +1 more source

Exploring the Pleiotropy of PCSK9: A Wide Range of Influences from Lipid Regulation to Extrahepatic Function [PDF]

Huaru Wang,1 Guodong Tang,2,3 Jianqiang Wu,4 Xuzhen Qin1 1Department of Laboratory Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, People’s Republic of China ...
Wu J, Qin X, Wang H, Tang G
core  

Disulfidptosis‐ and Ferroptosis‐Related Gene Signatures in Rheumatoid Arthritis: Association Analysis and Diagnostic Model Construction

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent synovial inflammation and progressive joint damage. Although ferroptosis has been implicated in RA progression, the role of disulfidptosis and its interaction with ferroptosis remains unclear.
Ting‐Ting Wang, Dong‐Mei Wang, Xue Li, Yuan‐Li Wei, Ping‐Dan Liu, Shi‐Lin Li, Si‐Ying Xiong, Cai‐Zhen Liu, Fan‐Xin Zeng, Jian‐Hong Wu, Lin Tang   +10 more
wiley   +1 more source