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Diabetic Peripheral Neuropathy: Molecular Staging, Risk Factors, Therapeutics, and Emerging Trends

Med Research, EarlyView.
The heterogeneous landscape of DPN can be unified through a tripartite pathogenic model encompassing progressive stages of metabolic dysregulation, chronic inflammation, and overt neuronal damage. Within this framework, six clinical subtypes were identified, namely, hyperglycemia‐driven, dyslipidemia‐driven, inflammation‐driven, dysvascularity‐driven ...
Xiaofeng Dai, Mingze Tang
wiley +1 more source

Differential pleiotropy and HOX functional organization

Developmental Biology, 2015
Key studies led to the idea that transcription factors are composed of defined modular protein motifs or domains, each with separable, unique function. During evolution, the recombination of these modular domains could give rise to transcription factors with new properties, as has been shown using recombinant molecules. This archetypic, modular view of
Sivanantharajah, Lovesha, Percival-Smith, Anthony +1 more
openaire +2 more sources

Genome‐Wide Assessment Reveals Ancestral Differences in Homozygosity Patterns Potentially Linked to Parkinson's Disease Etiology

Movement Disorders, EarlyView.
Abstract Background Recessive genetic variation and extended runs of homozygosity (ROHs) may contribute to the unexplained heritability of Parkinson's disease (PD), particularly in diverse and understudied populations. Objective We conducted the first large‐scale, multi‐ancestral investigation of PD to examine the impact of genome‐wide homozygosity on ...
Kathryn Step +680 more
wiley +1 more source

QTL Landscape for Oil Content in Brassica juncea: Analysis in Multiple Bi-Parental Populations in High and “0” Erucic Background

Frontiers in Plant Science, 2018
Increasing oil content in oilseed mustard (Brassica juncea) is a major breeding objective—more so, in the lines that have “0” erucic acid content (< 2% of the seed oil) as earlier studies have shown negative pleiotropic effect of erucic acid loci on ...
Kadambini Rout +7 more
doaj +1 more source

Smart Integration of Structural Biology and Medicinal Chemistry to Unlock Target‐Driven Drug Discovery

Medicinal Research Reviews, EarlyView.
ABSTRACT To enhance drug discovery efforts, medicinal chemists should evaluate, filter, and utilize relevant structural information about target proteins. Acquiring and interpreting protein structures is crucial for elucidating ligand‐receptor interactions and addressing ADME‐related considerations, making it an essential aspect of medicinal chemistry.
Matteo Rossi Sebastiano +4 more
wiley +1 more source

Modeling APOE, morbidity, and mortality: a reproducibility challenge for genetic epidemiology

Frontiers in Genetics
APOE is among the most extensively studied genetic loci in research on aging, morbidity, and mortality. Despite its well-established biological roles, empirical findings on the association between APOE and mortality remain inconsistent across studies ...
Erling Häggström Gunfridsson
doaj +1 more source

Identification of pleiotropic genes and gene sets underlying growth and immunity traits: a case study on Meishan pigs

Animal, 2016
Both growth and immune capacity are important traits in animal breeding. The animal quantitative trait loci (QTL) database is a valuable resource and can be used for interpreting the genetic mechanisms that underlie growth and immune traits. However, QTL
Z. Zhang +12 more
doaj +1 more source

Correlation Between Gut Microbiota, Metabolites, and Diabetic Complications: A Two‐Sample Mendelian Randomization Study

Medicine Advances, EarlyView.
Fang et al. demonstrate a significant causal relationship among gut microbiota, gut metabolites, and diabetic complications, highlighting a biological link underlying mechanisms of diabetic vascular diseases. These findings provide important implications for future therapeutic strategy and risk prediction.
Jiaxi Fang +6 more
wiley +1 more source

Assessing the Association Between Animal Color and Behavior: A Meta‐Analysis of Experimental Studies

Ecology and Evolution
Color varies in pattern and degree across the tree of life. In animals, genetic variation in color is hypothesized to have pleiotropic effects on a variety of behaviors due to shared dependence on underlying biochemical pathways.
Sarah N. Ruckman +5 more
doaj +1 more source

Self-adaptive exploration in evolutionary search

, 2001
We address a primary question of computational as well as biological research on evolution: How can an exploration strategy adapt in such a way as to exploit the information gained about the problem at hand?
Toussaint, Marc
core +3 more sources

gwas
genome-wide association study
causal inference

mendelian randomization
epistasis