Results 111 to 120 of about 37,616 (263)
This I believe: Gaining new insights through integrating ‘old’ data
Frontiers in Genetics, 2012 Ruth J.F. Loos, Eric E Schadt
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Aire and Fezf2 Shape the Medullary Thymic Epithelial Cell Immunopeptidome for Central Tolerance
Immunology, EarlyView.Central tolerance is shaped not merely by promiscuous gene expression in medullary thymic epithelial cells (mTECs), but by the subset of self‐peptides ultimately presented on MHC class II molecules. We propose a multilayered framework in which AIRE/Aire and FEZF2/Fezf2, together with specialised differentiation programmes—including thymic mimetic‐cell ...
Geraldo Aleixo Passos +5 more
wiley +1 more source
Journal of Animal Breeding and Genetics, EarlyView.ABSTRACT The Finnish Ayrshire cattle belong to the Nordic Red breeds. The basis of selection in Nordic Red breeds shifted from traditional pedigree‐based breeding values to genomic breeding values between 2011 and 2014. Joint genetic evaluation and admixture among the Nordic Red breeds have led to the formation of a composite Nordic Red population ...
Katri Sarviaho +4 more
wiley +1 more source
Challenging Statin Pleiotropy: Preeclampsia [PDF]
Circulation, 2021 Janet Wei +2 more
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Journal of Cardiovascular Electrophysiology, EarlyView.ABSTRACT Background Atrial fibrillation (AF) is one of the most common cardiac arrhythmias. It reduces quality of life and increases the risk of complications such as stroke. Although progress has been made in understanding its pathogenesis, the key cellular subtypes and therapeutic targets remain unclear. Methods We applied single‐cell transcriptomics
Xiangpeng Chen +5 more
wiley +1 more source
Journal of Child Psychology and Psychiatry, EarlyView.Background Genetic differences are robustly associated with educational outcomes, but how they become linked is poorly understood. A plausible hypothesis, yet to be thoroughly empirically tested, is that the school environment mediates the association. Methods Using structural equation models, we tested whether the student–teacher relationship at age 5
Chloe Austerberry +10 more
wiley +1 more source
Journal of Child Psychology and Psychiatry, EarlyView.Background Neurodevelopmental disorders (NDDs) are highly heritable, yet the pathways linking parental genetic liability to child outcomes remain poorly understood. Traditional designs cannot easily separate genes transmitted to the child from environmental influences shaped by parental genotypes.
Fin J. E. van Uum +10 more
wiley +1 more source
Journal of Diabetes Investigation, EarlyView.Using Mendelian randomization, TWAS/eQTL analysis, machine learning, and single‐cell RNA sequencing, this study identified gut microbiota taxa causally linked to type 2 diabetes, candidate mediator genes, and diagnostic markers (BEND7, BLVRA, C1orf85, and LAMC1).
Yu‐yang Chen +6 more
wiley +1 more source
14‐3‐3 proteins: Central hubs in plant development and stress adaptation
Journal of Integrative Plant Biology, EarlyView.This review highlights recent advances elucidating the important roles of 14‐3‐3 proteins in regulating phytohormone networks, biotic and abiotic stress tolerance, growth‐defense trade‐offs, and evolutionary adaptations. Furthermore, it provides a forward‐looking perspective on 14‐3‐3 biology and the development of climate‐resilient smart crops under ...
Jiale Yuan +6 more
wiley +1 more source
Editorial: Statistical Methods, Computing and Resources for Genome-Wide Association Studies
Frontiers in Genetics, 2021 Hailan Liu +4 more
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