Results 91 to 100 of about 50,540 (257)

Lower mutation rates increases cooperation but pleiotropy still evolves.

, 2022
We varied the loss-of-function mutation rate, μ, using values 10-fold lower than the typical value used in the main text. Heatmaps show average trait values among the global population of cells (across all groups) at steady state in our model.
Kevin R. Foster (8893457), Gail M. Preston (8780690), Michael A. Bentley (3079278), Christian A. Yates (12462891), Jotun Hein (27177)   +4 more
core   +1 more source

The causal relationship between systemic lupus erythematosus and juvenile myoclonic epilepsy: A Mendelian randomization study and mediation analysis

Ibrain, Volume 11, Issue 1, Page 98-105, Spring 2025.
Mendelian randomization (MR) studies were conducted using the inverse‐variance weighted (IVW) method, MR‐Egger and weighted median on juvenile myoclonic epilepsy (JME), and systemic lupus erythematosus (SLE) data from the Integrative Epidemiology Unit (IEU) Open genome‐wide association study (GWAS) database and the International League Against Epilepsy
Sirui Chen, Ningning Zhang, Ruirui Zhang, Lan Zhang, Dadong Luo, Junqiang Li, Yaqing Liu, Yunan Wang, Xinyue Duan, Xin Tian, Tiancheng Wang   +10 more
wiley   +1 more source

The mitochondrial DNA copy number and ovary‐related reproductive disorders: A bidirectional two‐sample Mendelian randomization study

International Journal of Gynecology &Obstetrics, Volume 169, Issue 1, Page 112-120, April 2025.
Abstract Objective In the present study, a bidirectional two‐sample Mendelian randomization approach was utilized to explore potential causal relationships between mitochondrial DNA copy number (mtDNA‐CN) and ovary‐related reproductive disorders (ORRDs), including ovarian dysfunction, ovarian cyst, polycystic ovary syndrome (PCOS), premature ovarian ...
Ke Peng, Xiao Han, Congquan Wu, Qiaowen Lu, Shujun Gao   +4 more
wiley   +1 more source

Shared Genetic Pathways Linking Oral Diseases to Gastrointestinal Disorders: An Integrative Multi‐Omics Study

iMetaMed, EarlyView.
Shared genetics pathways connect oral diseases and gut disorders. ABSTRACT Oral diseases are highly prevalent and increasingly recognized as contributors to gastrointestinal disorders. Despite clinical observations of oral–gut comorbidity, the underlying genetic architecture and causal mechanisms remain poorly understood.
Rui Zhang, Yuelan Gao, Yuyang Zhao, Wanyang Zhong, Xingxiang Duan, Yan He, Qingsong Ye   +6 more
wiley   +1 more source

Chronic Prostatitis/Chronic Pelvic Pain Syndrome: Research Progress and Precision Diagnosis‐Therapy Under the Integrated Neuro–Immune–Metabolic–Microbiota Axis Framework

iMetaMed, EarlyView.
Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is increasingly recognized as a systemic disorder rather than a purely local prostate disease. The diagram illustrates the transition from the traditional local prostate‐centered model to a multi‐axis systemic framework involving clinical heterogeneity, local prostatic inflammation, systemic ...
Kun Wang, Jinfei Liu, Qiangsheng Wang, Lei Fan, Ziang Li, Xuexin Yu, Yonghao Chen, Xiaofan Lu, Guiyi Liao, Jialin Meng, Yu Guan   +10 more
wiley   +1 more source

Elucidating the patterns of pleiotropy and its biological relevance in maize.

, 2023
Pleiotropy-when a single gene controls two or more seemingly unrelated traits-has been shown to impact genes with effects on flowering time, leaf architecture, and inflorescence morphology in maize.
Anju Giri, Brandon Monier, Guillaume Ramstein, Merritt Khaipho-Burch, Taylor Ferebee, Emily Yi, M Cinta Romay, Edward S Buckler, M. Cinta Romay, Edward S. Buckler   +9 more
core   +1 more source

Iqcm Is Dispensable for Male Fertility in Mice

iNew Medicine, EarlyView.
Schematic overview of the experimental workflow. Iqcm is highly expressed in mice testis (left). Iqcm−/− mice were generated via CRISPR/Cas9 (second panel). Phenotypic analyses including testis/epididymis histology (H&E), sperm morphology, and litter size revealed no significant differences between Iqcm+/+ and Iqcm−/− mice (third panel).
Zhaojuan Yu, Yuhui Ye, Mingfei Xiang, Zhaolian Wei, Zhen Lu, Jia Peng, Yunxia Cao   +6 more
wiley   +1 more source

Pleiotropy vs. Close Linkage in the Diversity Outbred Mouse Population

, 2016
Likelihood ratio test to distinguish pleiotropy from close linkage in Diversity Outbred Mouse ...
Frederick Boehm (2919734)
core   +1 more source

Shared genetics between ADHD and reading/language abilities: Genome‐wide correlations, stratified enrichment, cross‐trait association, and mendelian randomization

JCPP Advances, EarlyView.
Abstract Background Attention‐deficit/hyperactivity disorder (ADHD) and language/reading difficulties frequently co‐occur. The extent of shared genetic architecture remains incompletely defined. We investigated genome‐wide overlap between ADHD and four core skills: word reading, nonword reading, spelling, and phoneme awareness.
Jinzhu Zhao, Shi Huang, Wei Liu, Feng Wang, Hong Qian, Xiaolin Hu   +5 more
wiley   +1 more source

Atorvastatin Confers Renoprotection and Modulates Inflammation in Diabetic Rats on a High-Fat Diet

Life
Objective: Uncovering the renoprotective and anti-inflammatory effects of atorvastatin treatment in diabetic-and-obese rats by employing traditional renal function indicators (urea and creatinine) and four prototypical cytokines (IL-1β, il-6, IL-17α ...
Minela Aida Maranduca, Andreea Clim, Daniela Maria Tanase, Cristian Tudor Cozma, Mariana Floria, Ioana Adelina Clim, Dragomir Nicolae Serban, Ionela Lacramioara Serban   +7 more
doaj   +1 more source