Results 131 to 140 of about 50,540 (257)

The ‘big houses‐big cars dilemma’: How do we reconcile the prevalence of positive correlations among life history traits?

Functional Ecology, EarlyView.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Life history theory assumes that there are negative correlations among different components of the life history—investing more in reproduction now means taking resources away from growth, maintenance or the ability to reproduce in the future.
David Reznick, Joseph Travis, Ronald Bassar   +2 more
wiley   +1 more source

Pleiotropy estimated among five psychiatric disorders.

, 2014
The values in the brackets are standard errors of the estimates. The last two columns provide the LRT statistics and p-values of hypothesis testing (15).Pleiotropy estimated among five psychiatric disorders.
Dongjun Chung (213776), Can Yang (337581), Hongyu Zhao (4728), Cong Li (115171), Joel Gelernter (83619)   +4 more
core   +1 more source

Integrated Multi‐Omics Analysis Reveals the Genetic Basis of Phenotypic Variation in Tibetan Sheep

Integrative Zoology, EarlyView.
SNaPshot‐validated GWAS results demonstrated significant correlations between candidate single nucleotide polymorphisms (SNPs) and body size traits in Tibetan sheep. Concurrently, hematoxylin and eosin staining, alongside muscle fiber analysis, confirmed pronounced morphological differences in muscle tissue between sheep of varying conformation.
Dehui Liu, Xue Li, Fei Tian, Xuexia Li, Wenxia Li, Buying Han, Ming Jiang, Yanlan Liu, Xiliu Hu, Xue Xiang, Wulong Ma, Guangcai Bao, Rong Li, Guoxiang Bao, Sijia Liu, Kai Zhao, Dehong Tian   +16 more
wiley   +1 more source

Associations of cannabis use, tobacco use and co‐use with brain volume: A systematic review and meta‐analysis

Addiction, EarlyView.
Abstract Background and aims Cannabis is the most widely used illicit drug worldwide and is often co‐used with tobacco, the leading cause of preventable death. Although cannabis and tobacco have distinct neurobiological actions, their associations with brain volumes are unclear.
Katherine Sawyer, Tom P. Freeman, Martine Skumlien, Esther Walton, Thomas Lancaster, Jorien L. Treur, Valentina Lorenzetti, Anna K. M. Blackwell, Chloe Burke, Richie J. Carr, Constantinos Constantinides, Maisie Cox, Sarah Dance, Shadi Daryan, Sorcha Hamilton, Tom Jenkins, Gemma M. J. Taylor   +16 more
wiley   +1 more source

Polygenic prediction of cannabis‐related outcomes: Evidence from the Avon Longitudinal Study of Parents and Children longitudinal cohort and the European gene–environment interaction case–control study

Addiction, EarlyView.
Abstract Background and aims Polygenic risk scores (PRSs) for cannabis use disorder (CUD), major depressive disorder (MDD), insomnia and chronic pain, and early age at cannabis initiation might be linked to problematic cannabis use. We tested whether: (1) higher PRS for CUD, MDD, insomnia and chronic pain are associated with earlier initiation and ...
Edoardo Spinazzola, Isabelle Austin‐Zimmerman, Giulia Trotta, Zhikun Li, Perry B. M. Leung, Edward Chesney, Qiang Li, Luis Alameda, Celso Arango, Michael O'Donovan, Jim van Os, Pak C. Sham, Craig Morgan, Evangelos Vassos, Diego Quattrone, Tom Freeman, Marta Di Forti, Robin M. Murray   +17 more
wiley   +1 more source

The potential for biased signalling in the P2Y receptor family of GPCRs

British Journal of Pharmacology, EarlyView.
The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk, Simon Pitchford, Graham Ladds   +2 more
wiley   +1 more source

Re‐thinking peripheral dysfunctions in obesity: The emerging role of sulphaceutics and sulphanutraceutics

British Journal of Pharmacology, EarlyView.
Obesity is a chronic, relapsing, multisystem disease in which cardiometabolic risk arises from excess adiposity and progressive dysfunction of peripheral organs, ultimately disrupting endocrine and metabolic crosstalk among tissues. Within this network, sulphur‐based biology, centred on hydrogen sulphide and related reactive sulphur species, has ...
Martina Smimmo, Veronica Casale, Roberta d'Emmanuele di Villa Bianca, Valentina Vellecco, Mariarosaria Bucci   +4 more
wiley   +1 more source

Triangulating Evidence on Serum Uric Acid and Cancer Risk: Consistent Inverse Associations With Lung Cancer

Cancer Science, EarlyView.
Using both conventional observational and Mendelian randomization (MR) analyses in the same Japanese community‐dwelling population, the evidence consistently supported an inverse association between the serum uric acid level and lung cancer risk. ABSTRACT We examined the association between serum uric acid (UA) levels and cancer incidence through a ...
Takashi Matsunaga, Kenji Wakai, Takashi Tamura, Mako Nagayoshi, Rieko Okada, Itsuki Kageyama, Megumi Hara, Takuma Furukawa, Hiroaki Ikezaki, Yuji Matsumoto, Takeshi Nishiyama, Hiroko Nakagawa‐Senda, Chihaya Koriyama, Shiroh Tanoue, Naoyuki Takashima, Etsuko Ozaki, Katsuyuki Miura, Aya Kadota, Takeshi Watanabe, Masashi Ishizu, Kiyonori Kuriki, Masahiro Nakatochi, Yukihide Momozawa, Issei Imoto, Isao Oze, Keitaro Matsuo, the J‐MICC Study Group   +26 more
wiley   +1 more source

Genetic Architecture of Comorbidity Between Chronic Obstructive Pulmonary Disease and Cardiovascular Diseases: Exploring Shared Mechanisms and Potential Therapeutic Targets

International Journal of COPD
Shiyu Chen,1,* Xiaojian Li,1,* Rongfang Xie1,2 1Clinical Medical College,Jiangxi University of Chinese Medicine, Nanchang, 330004, People’s Republic of China; 2Department of Respiratory and Critical Care Medicine, Affiliated Hospital of ...
Chen S, Li X, Xie R
doaj  

Macrophage Lipid Homeostasis Drives IVDD via a Senescence‐Dependent Impairment of Efferocytosis

Cell Proliferation, EarlyView.
Intervertebral disc degeneration (IVDD) has been a leading cause of low back pain and lacks disease‐modifying therapies. Although dysregulated disc lipid metabolism is implicated, its impact on the immune microenvironment, particularly macrophages, remains unknown.
Jinyu Wang, Shiyong Ling, Qi Wang, Xuege Qiao, Jianpeng Xing, Siyang Ji, Linhui Han, Chen Yan, Zhishen Niu, Lei Yuan, Baolian Zhao, Kaiqiang Sun, Jiangang Shi   +12 more
wiley   +1 more source