Results 21 to 30 of about 50,540 (257)

Global QTL Analysis Identifies Genomic Regions on Chromosomes 4A and 4B Harboring Stable Loci for Yield-Related Traits Across Different Environments in Wheat (Triticum aestivum L.)

Frontiers in Plant Science, 2018
Major advances in wheat production are needed to address global food insecurity under future climate conditions, such as high temperatures. The grain yield of bread wheat (Triticum aestivum L.) is a quantitatively inherited complex trait that is strongly
Panfeng Guan, Lahu Lu, Lijia Jia, Muhammad Rezaul Kabir, Jinbo Zhang, Tianyu Lan, Yue Zhao, Mingming Xin, Zhaorong Hu, Yingyin Yao, Zhongfu Ni, Qixin Sun, Huiru Peng   +12 more
doaj   +1 more source

mGWAS-Explorer: Linking SNPs, Genes, Metabolites, and Diseases for Functional Insights

Metabolites, 2022
Tens of thousands of single-nucleotide polymorphisms (SNPs) have been identified to be significantly associated with metabolite abundance in over 65 genome-wide association studies with metabolomics (mGWAS) to date.
Le Chang, Guangyan Zhou, Huiting Ou, Jianguo Xia   +3 more
doaj   +1 more source

Interval-level aggregated raw pleiotropy counts, adjusted pleiotropy counts, and values for all features used for analyses.

, 2023
Interval-level aggregated raw pleiotropy counts, adjusted pleiotropy counts, and values for all features used for analyses.
Emily Yi (14822592), M. Cinta Romay (9467168), Anju Giri (11520266), Edward S. Buckler (8844038), Merritt Khaipho-Burch (11520269), Taylor Ferebee (14019209), Guillaume Ramstein (14349513), Brandon Monier (6336209)   +7 more
core   +1 more source

Rapid Evolution of Autosomal Binding Sites of the Dosage Compensation Complex in Drosophila melanogaster and Its Association With Transcription Divergence

Frontiers in Genetics, 2021
How pleiotropy influences evolution of protein sequence remains unclear. The male-specific lethal (MSL) complex in Drosophila mediates dosage compensation by 2-fold upregulation of the X chromosome in males.
Aimei Dai, Yushuai Wang, Anthony Greenberg, Zhongqi Liufu, Tian Tang   +4 more
doaj   +1 more source

Modelling pleiotropy.

, 2022
(A) One way to measure the strength of pleiotropy in real-world regulatory networks is to compute the ratio of those mutations in the network that simultaneously impact 2 terminal phenotypic traits to the number of genes. We call this measure ϕ.
Kevin R. Foster (8893457), Gail M. Preston (8780690), Michael A. Bentley (3079278), Christian A. Yates (12462891), Jotun Hein (27177)   +4 more
core   +1 more source

Site pleiotropy of a stickleback Bmp6 enhancer [PDF]

, 2022
Development and regeneration are orchestrated by gene regulatory networks that operate in part through transcriptional enhancers. Although many enhancers are pleiotropic and are active in multiple tissues, little is known about whether enhancer ...
Tyler A. Square, Alyssa J. Rowley, Square, Tyler A, Craig T. Miller, Rowley, Alyssa J, Miller, Craig T   +5 more
core   +1 more source

Pleiotropy-robust Mendelian Randomization [PDF]

, 2018
BackgroundThe potential of Mendelian randomization studies is rapidly expanding due to: (i) the growing power of genome-wide association study (GWAS) meta-analyses to detect genetic variants associated with several exposures; and (ii) the increasing ...
van Kippersluis, Hans; id_orcid, Rietveld, Niels; id_orcid   +1 more
core   +1 more source

Evaluating the potential role of pleiotropy in Mendelian randomization studies [PDF]

, 2018
Pleiotropy, the phenomenon of a single genetic variant influencing multiple traits, is likely widespread in the human genome. If pleiotropy arises because the single nucleotide polymorphism (SNP) influences one trait, which in turn influences another ...
Bowden, Jack, Davey Smith, George, Gibran Hemani, George Davey Smith, Hemani, Gibran, Jack Bowden   +5 more
core   +1 more source

Pleiotropy evolves to stabilise cooperation even when costly.

, 2022
We explored a model in which pleiotropy carries a cost on multicellular function. We assumed multicellular group function is reduced by a factor , where ζ is the cost of pleiotropy, and is the average pleiotropy in a group.
Kevin R. Foster (8893457), Gail M. Preston (8780690), Michael A. Bentley (3079278), Christian A. Yates (12462891), Jotun Hein (27177)   +4 more
core   +1 more source

Relationship between NAFLD and coronary artery disease: A Mendelian randomization study

Hepatology, EarlyView., 2022
Abstract Background and Aims There is an ongoing debate on whether NAFLD is an active contributor or an innocent bystander in the pathogenesis of coronary artery disease (CAD). The aim of the present study was to assess the causal relationship between NAFLD and CAD.
Zhewen Ren, Pomme I. H. G. Simons, Anke Wesselius, Coen D. A. Stehouwer, Martijn C. G. J. Brouwers   +4 more
wiley   +1 more source