Results 21 to 30 of about 37,616 (263)

Pleiotropic Meta-Analysis of Age-Related Phenotypes Addressing Evolutionary Uncertainty in Their Molecular Mechanisms

Frontiers in Genetics, 2019
Age-related phenotypes are characterized by genetic heterogeneity attributed to an uncertain role of evolution in establishing their molecular mechanisms.
Alexander M. Kulminski, Yury Loika, Jian Huang, Konstantin G. Arbeev, Olivia Bagley, Svetlana Ukraintseva, Anatoliy I. Yashin, Irina Culminskaya   +7 more
doaj   +1 more source

The genetic pleiotropy of musculoskeletal aging [PDF]

Frontiers in Physiology, 2012
Musculoskeletal aging is detrimental to multiple bodily functions and starts early, probably in the fourth decade of an individual's life. Sarcopenia is a health problem that is expected to only increase as a greater portion of the population lives longer; prevalence of the related musculoskeletal diseases is similarly expected to increase.
Karasik, David, Cohen-Zinder, Miri
openaire   +3 more sources

Bayesian methods for multivariate modeling of pleiotropic SNP associations and genetic risk prediction

Frontiers in Genetics, 2012
Genome-wide association studies (GWAS) have identified numerous associations between genetic loci and individual phenotypes; however, relatively few GWAS have attempted to detect pleiotropic associations, in which loci are simultaneously associated with ...
Stephen W Hartley, Stefano eMonti, Ching-Ti eLiu, Martin H. Steinberg, Paola eSebastiani   +4 more
doaj   +1 more source

Phonetic indices of syllabic organization in German stop-lateral clusters

Laboratory Phonology, 2022
Using articulatory data from five German speakers, we study how segmental sequences under different syllabic organizations respond to perturbations of phonetic parameters in the segments that compose them.
Adamantios I. Gafos, Stavroula Sotiropoulou   +1 more
doaj   +2 more sources

Pleiotropy-robust Mendelian randomization [PDF]

International Journal of Epidemiology, 2016
Abstract Background The potential of Mendelian Randomization studies is rapidly expanding due to (i) the growing power of GWAS meta-analyses to detect genetic variants associated with several exposures, and (ii) the increasing availability of these genetic variants in large-scale surveys.
van Kippersluis, Hans, Rietveld, Cornelius A   +1 more
openaire   +3 more sources

The role of structural pleiotropy and regulatory evolution in the retention of heteromers of paralogs

eLife, 2019
Gene duplication is a driver of the evolution of new functions. The duplication of genes encoding homomeric proteins leads to the formation of homomers and heteromers of paralogs, creating new complexes after a single duplication event. The loss of these
Axelle Marchant, Angel F Cisneros, Alexandre K Dubé, Isabelle Gagnon-Arsenault, Diana Ascencio, Honey Jain, Simon Aubé, Chris Eberlein, Daniel Evans-Yamamoto, Nozomu Yachie, Christian R Landry   +10 more
doaj   +1 more source

Genotype-by-diet effects on co-variation in Lp-PLA2 activity and LDL-cholesterol concentration in baboons fed an atherogenic diet*

Journal of Lipid Research, 2008
Both lipoprotein-associated phospholipase A2 (Lp-PLA2) activity, a biomarker of inflammation, and concentration of its primary associated lipoprotein, LDL, are correlated with adverse coronary outcomes.
Amanda Vinson, Michael C. Mahaney, Vince P. Diego, Laura A. Cox, Jeffrey Rogers, John L. VandeBerg, David L. Rainwater   +6 more
doaj   +1 more source

Genetic Correlations Between Photosynthetic and Yield Performance in Maize Are Different Under Two Heat Scenarios During Flowering

Frontiers in Plant Science, 2019
Chlorophyll fluorescence (ChlF) parameters are reliable early stress indicators in crops, but their relations with yield are still not clear. The aims of this study are to examine genetic correlations between photosynthetic performance of JIP-test during
Vlatko Galic, Mario Franic, Antun Jambrovic, Antun Jambrovic, Tatjana Ledencan, Andrija Brkic, Zvonimir Zdunic, Zvonimir Zdunic, Domagoj Simic, Domagoj Simic   +9 more
doaj   +1 more source

Pleiotropy, “sexy” traits, and speciation [PDF]

Behavioral Ecology, 2011
The evolution of mating signals and preferences assists speciation by facilitating assortative mating within diverging lineages, thereby closing down conduits of gene flow between lineages. However, sexual communication traits are frequently subject to stabilizing selection, suggesting that new variants will be selected against, thereby discouraging ...
Kerry L. Shaw, Christopher K. Ellison, Kevin P. Oh, Chris Wiley   +3 more
openaire   +2 more sources

Divergence in Coding Sequences and Expression Patterns Among the Functional Categories of Secretory Genes Between Two Aphid Species

Biology
Disparities in the functional classification of secretory genes among aphid taxa may be attributed to variations in coding sequences and gene expression profiles. However, the driving factors that regulate sequence evolution remain unclear.
Atsbha Gebreslasie Gebrekidan, Yong Zhang, Julian Chen   +2 more
doaj   +1 more source