Results 21 to 30 of about 48,688 (297)
mGWAS-Explorer: Linking SNPs, Genes, Metabolites, and Diseases for Functional Insights
Metabolites, 2022 Tens of thousands of single-nucleotide polymorphisms (SNPs) have been identified to be significantly associated with metabolite abundance in over 65 genome-wide association studies with metabolomics (mGWAS) to date.
Le Chang +3 more
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Exploring the pleiotropy of hos1 [PDF]
Journal of Experimental Botany, 2015 Understanding of the roles that HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENE 1 (HOS1) plays in the plant's ability to sense and respond to environmental signals has grown dramatically. Mechanisms through which HOS1 affects plant development have been uncovered, and the broader consequences of hos1 on the plant's ability to perceive and respond to its
Dana R, MacGregor, Steven, Penfield
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Frontiers in Genetics, 2021 How pleiotropy influences evolution of protein sequence remains unclear. The male-specific lethal (MSL) complex in Drosophila mediates dosage compensation by 2-fold upregulation of the X chromosome in males.
Aimei Dai +4 more
doaj +1 more source
Relationship between NAFLD and coronary artery disease: A Mendelian randomization study
Hepatology, EarlyView., 2022 Abstract Background and Aims There is an ongoing debate on whether NAFLD is an active contributor or an innocent bystander in the pathogenesis of coronary artery disease (CAD). The aim of the present study was to assess the causal relationship between NAFLD and CAD.
Zhewen Ren +4 more
wiley +1 more source
, 2022 We varied the gain-of-function mutation rate, μ, using values 10-fold lower than the typical value used in the main text, and assumed that the evolution of pleiotropy decreases group function by 2%.
Kevin R. Foster (8893457) +4 more
core +1 more source
Stroke and Alzheimer’s Disease: A Mendelian Randomization Study
Frontiers in Genetics, 2020 Stroke and Alzheimer’s disease (AD) are common neurological diseases. Several exiting studies indicated that late onset-AD and ischemic stroke have shared genetic links. Different kinds of stroke have different mechanisms.
Tao Wang +5 more
doaj +1 more source
Antagonistic Pleiotropy: Disease Isn’t All Bad [PDF]
, 2023 George C. William’s theory of antagonistic pleiotropy suggested that some diseases include benefits that could aid in the survival of an individual which perpetuates the existence of that disease in the population.
Ott, Paige
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PLEIOTROPY AND PARAPATRIC SPECIATION [PDF]
Evolution, 1982 Parapatric speciation as described by Murray (1972), Bush (1975), and Endler (1977) is the process of species formation from two or more populations that initially have some gene flow among them. This process is different from allopatric speciation, which requires that there first be a complete absence of gene flow, and sympatric speciation, which ...
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The genetic pleiotropy of musculoskeletal aging [PDF]
Frontiers in Physiology, 2012 Musculoskeletal aging is detrimental to multiple bodily functions and starts early, probably in the fourth decade of an individual's life. Sarcopenia is a health problem that is expected to only increase as a greater portion of the population lives longer; prevalence of the related musculoskeletal diseases is similarly expected to increase.
Karasik, David, Cohen-Zinder, Miri
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The evolution of pleiotropy promotes cooperation.
, 2022 Heatmaps show average trait values among the global population of cells (across all groups) at steady state in our model. Results are shown for 3 group sizes (increasing from top to bottom).
Kevin R. Foster (8893457) +4 more
core +1 more source