Results 11 to 20 of about 65,328 (279)
Pleiotropy-robust Mendelian randomization [PDF]
International Journal of Epidemiology, 2016 AbstractBackgroundThe potential of Mendelian Randomization studies is rapidly expanding due to (i) the growing power of GWAS meta-analyses to detect genetic variants associated with several exposures, and (ii) the increasing availability of these genetic variants in large-scale surveys.
van Kippersluis, Hans +1 more
openaire +3 more sources
Hormonal pleiotropy structures genetic covariance [PDF]
Evolution Letters, 2021 AbstractQuantitative genetic theory proposes that phenotypic evolution is shaped by G, the matrix of genetic variances and covariances among traits. In species with separate sexes, the evolution of sexual dimorphism is also shaped by B, the matrix of between-sex genetic variances and covariances. Despite considerable focus on estimating these matrices,
Tyler N. Wittman +3 more
openaire +4 more sources
Antagonistic pleiotropy and p53 [PDF]
Mechanisms of Ageing and Development, 2009 George Williams' antagonistic pleiotropy theory of aging proposes that cellular damage and organismal aging are caused by pleiotrophic genes, or genes with multiple phenotypic effects [Williams, G.C., 1957. Pleiotropy, natural selection, and the evolution of senescence. Evolution 11, 398-411].
Erica, Ungewitter, Heidi, Scrable
openaire +2 more sources
Relationship between NAFLD and coronary artery disease: A Mendelian randomization study
Hepatology, EarlyView., 2022 Abstract Background and Aims There is an ongoing debate on whether NAFLD is an active contributor or an innocent bystander in the pathogenesis of coronary artery disease (CAD). The aim of the present study was to assess the causal relationship between NAFLD and CAD.
Zhewen Ren +4 more
wiley +1 more source
Aggressive behaviours, food deprivation and the foraging gene [PDF]
Royal Society Open Science, 2017 A pleiotropic gene governs multiple traits, which might constrain the evolution of complexity due to conflicting selection on these traits. However, if the pleiotropic effect is modular, then this can facilitate synergistic responses to selection on ...
Silu Wang, Marla B. Sokolowski
doaj +1 more source
European Psychiatry, 2023 Background Individuals with a first episode of psychosis (FEP) show rapid weight gain during the first months of treatment, which is associated with a reduction in general physical health.
Gerard Muntané +8 more
doaj +1 more source
Pleiotropy of FRIGIDA enhances the potential for multivariate adaptation. [PDF]
, 2013 An evolutionary response to selection requires genetic variation; however, even if it exists, then the genetic details of the variation can constrain adaptation.
Easlon, Hsien M +9 more
core +1 more source
Testing for direct genetic effects using a screening step in family-based association studies
Frontiers in Genetics, 2013 In genome wide association studies (GWAS), families based studies tend to have less power to detect genetic associations than population based studies, such as case-control studies.
Sharon M Lutz +2 more
doaj +1 more source
Frontiers in Genetics, 2019 Age-related phenotypes are characterized by genetic heterogeneity attributed to an uncertain role of evolution in establishing their molecular mechanisms.
Alexander M. Kulminski +7 more
doaj +1 more source
Frontiers in Genetics, 2012 Genome-wide association studies (GWAS) have identified numerous associations between genetic loci and individual phenotypes; however, relatively few GWAS have attempted to detect pleiotropic associations, in which loci are simultaneously associated with ...
Stephen W Hartley +4 more
doaj +1 more source