Results 11 to 20 of about 37,616 (263)
Antagonistic pleiotropy and p53 [PDF]
Mechanisms of Ageing and Development, 2009 George Williams' antagonistic pleiotropy theory of aging proposes that cellular damage and organismal aging are caused by pleiotrophic genes, or genes with multiple phenotypic effects [Williams, G.C., 1957. Pleiotropy, natural selection, and the evolution of senescence. Evolution 11, 398-411].
Erica, Ungewitter, Heidi, Scrable
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Evolutionary Applications, 2023 Most marine organisms have complex life histories, where the individual stages of a life cycle are often morphologically and ecologically distinct. Nevertheless, life‐history stages share a single genome and are linked phenotypically (by “carry‐over ...
Dustin J. Marshall, Tim Connallon
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Frontiers in Genetics, 2021 Lameness is an animal welfare issue that incurs substantial financial and environmental costs. This condition is commonly caused by digital dermatitis (DD), sole ulcers (SU), and white line disease (WLD).
Ellen Lai +3 more
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eLife, 2019 Predicting how species will respond to selection pressures requires understanding the factors that constrain their evolution. We use genome engineering of Drosophila to investigate constraints on the repeated evolution of unrelated herbivorous insects to
Andrew M Taverner +12 more
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Aggressive behaviours, food deprivation and the foraging gene [PDF]
Royal Society Open Science, 2017 A pleiotropic gene governs multiple traits, which might constrain the evolution of complexity due to conflicting selection on these traits. However, if the pleiotropic effect is modular, then this can facilitate synergistic responses to selection on ...
Silu Wang, Marla B. Sokolowski
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European Psychiatry, 2023 Background Individuals with a first episode of psychosis (FEP) show rapid weight gain during the first months of treatment, which is associated with a reduction in general physical health.
Gerard Muntané +8 more
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Exploring the pleiotropy of hos1 [PDF]
Journal of Experimental Botany, 2015 Understanding of the roles that HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENE 1 (HOS1) plays in the plant's ability to sense and respond to environmental signals has grown dramatically. Mechanisms through which HOS1 affects plant development have been uncovered, and the broader consequences of hos1 on the plant's ability to perceive and respond to its
Dana R, MacGregor, Steven, Penfield
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Testing for direct genetic effects using a screening step in family-based association studies
Frontiers in Genetics, 2013 In genome wide association studies (GWAS), families based studies tend to have less power to detect genetic associations than population based studies, such as case-control studies.
Sharon M Lutz +2 more
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PLEIOTROPY AND PARAPATRIC SPECIATION [PDF]
Evolution, 1982 Parapatric speciation as described by Murray (1972), Bush (1975), and Endler (1977) is the process of species formation from two or more populations that initially have some gene flow among them. This process is different from allopatric speciation, which requires that there first be a complete absence of gene flow, and sympatric speciation, which ...
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Relationship between NAFLD and coronary artery disease: A Mendelian randomization study
Hepatology, EarlyView., 2022 Abstract Background and Aims There is an ongoing debate on whether NAFLD is an active contributor or an innocent bystander in the pathogenesis of coronary artery disease (CAD). The aim of the present study was to assess the causal relationship between NAFLD and CAD.
Zhewen Ren +4 more
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