Results 11 to 20 of about 50,540 (257)
Pleiotropy facilitates parallel adaptation in sticklebacks [PDF]
, 2022 Highly pleiotropic genes are predicted to be used less often during adaptation, as mutations in these loci are more likely to have negative fitness consequences. Following this logic, we tested whether pleiotropy impacts the probability that a locus will
Diana J. Rennison +5 more
core +2 more sources
Frontiers in Genetics, 2021 The role of common genetic variation in susceptibility to acute myeloid leukemia (AML), and myelodysplastic syndrome (MDS), a group of rare clonal hematologic disorders characterized by dysplastic hematopoiesis and high mortality, remains unclear.
Junke Wang +26 more
doaj +1 more source
Nontrivial Replication of Loci Detected by Multi-Trait Methods
Frontiers in Genetics, 2021 The ever-growing genome-wide association studies (GWAS) have revealed widespread pleiotropy. To exploit this, various methods that jointly consider associations of a genetic variant with multiple traits have been developed.
Zheng Ning +21 more
doaj +1 more source
Mapping Floral Genetic Architecture in Prunus mume, an Ornamental Woody Plant
Frontiers in Plant Science, 2022 Floral traits are both evolutionarily and economically relevant for ornamental plants. However, their underlying genetic architecture, especially in woody ornamental plants, is still poorly understood.
Mingyu Li +7 more
doaj +1 more source
Bidirectional Relation Between Parkinson's Disease and Glioblastoma Multiforme
Frontiers in Neurology, 2020 Cancer and Parkinson's disease (PD) define two disease entities that include opposite concepts. Indeed, the involved mechanisms are at different ends of a spectrum related to cell survival - one due to enhanced cellular proliferation and the other due to
Pauline Mencke +7 more
doaj +1 more source
eLife, 2020 Building a genotype-phenotype-fitness map of adaptation is a central goal in evolutionary biology. It is difficult even when adaptive mutations are known because it is hard to enumerate which phenotypes make these mutations adaptive.
Grant Kinsler +2 more
doaj +1 more source
Pleiotropy, cooperation, and the social evolution of genetic architecture [PDF]
, 2018 Pleiotropy has been suggested as a novel mechanism for stabilising cooperation in bacteria and other microbes. The hypothesis is that linking cooperation with a trait that provides a personal (private) benefit can outweigh the cost of cooperation in ...
Ghoul, Melanie +8 more
core +4 more sources
Frontiers in Genetics, 2021 Aging has provided fruitful challenges for evolutionary theory, and evolutionary theory has deepened our understanding of aging. A great deal of genetic and molecular data now exists concerning mortality regulation and there is a growing body of ...
Stewart Frankel, Blanka Rogina
doaj +1 more source
eLife, 2023 Adaptation is driven by the selection for beneficial mutations that provide a fitness advantage in the specific environment in which a population is evolving. However, environments are rarely constant or predictable.
Vivian Chen +10 more
doaj +1 more source
Cross-Cancer Pleiotropic Analysis Reveals Novel Susceptibility Loci for Lung Cancer
Frontiers in Oncology, 2020 Genome-wide association studies (GWASs) have identified hundreds of single nucleotide polymorphisms (SNPs) associated with cancer risk, several of which have shown pleiotropic effects across cancers.
Lijuan Wang +17 more
doaj +1 more source