Results 11 to 20 of about 48,688 (297)
What Is Antagonistic Pleiotropy? [PDF]
Biochemistry (Moscow), 2018 Antagonistic Pleiotropy has been the dominant theory for evolution of aging since it was first proposed 60 years ago. Indeed, examples of pleiotropy have been observed, but there are also many examples of mutations that lead to longer lifespan without apparent cost.
Josh Mitteldorf
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Pleiotropy-robust Mendelian randomization [PDF]
International Journal of Epidemiology, 2016 Abstract Background The potential of Mendelian Randomization studies is rapidly expanding due to (i) the growing power of GWAS meta-analyses to detect genetic variants associated with several exposures, and (ii) the increasing availability of these genetic variants in large-scale surveys.
van Kippersluis, Hans +1 more
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Pleiotropy and synergistic cooperation
PLOS Biology, 2019 Some forms of stable cooperation can evolve though pleiotropy with a beneficial private trait. This Formal Comment addresses a recent challenge to this idea, arguing that for synergistic, frequency-dependent cooperation, pleiotropy can raise the frequency up to a point where cooperation is favoured on its own.
David C Queller
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Pleiotropy facilitates parallel adaptation in sticklebacks [PDF]
, 2022 Highly pleiotropic genes are predicted to be used less often during adaptation, as mutations in these loci are more likely to have negative fitness consequences. Following this logic, we tested whether pleiotropy impacts the probability that a locus will
Diana J. Rennison +5 more
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Site pleiotropy of a stickleback Bmp6 enhancer [PDF]
, 2022 Development and regeneration are orchestrated by gene regulatory networks that operate in part through transcriptional enhancers. Although many enhancers are pleiotropic and are active in multiple tissues, little is known about whether enhancer ...
Tyler A. Square +5 more
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, 2022 (A) One way to measure the strength of pleiotropy in real-world regulatory networks is to compute the ratio of those mutations in the network that simultaneously impact 2 terminal phenotypic traits to the number of genes. We call this measure ϕ.
Kevin R. Foster (8893457) +4 more
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Pleiotropy, cooperation, and the social evolution of genetic architecture [PDF]
, 2018 Pleiotropy has been suggested as a novel mechanism for stabilising cooperation in bacteria and other microbes. The hypothesis is that linking cooperation with a trait that provides a personal (private) benefit can outweigh the cost of cooperation in ...
West, Stuart +10 more
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Cross-Cancer Pleiotropic Analysis Reveals Novel Susceptibility Loci for Lung Cancer
Frontiers in Oncology, 2020 Genome-wide association studies (GWASs) have identified hundreds of single nucleotide polymorphisms (SNPs) associated with cancer risk, several of which have shown pleiotropic effects across cancers.
Lijuan Wang +17 more
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Antagonistic pleiotropy and p53 [PDF]
Mechanisms of Ageing and Development, 2009 George Williams' antagonistic pleiotropy theory of aging proposes that cellular damage and organismal aging are caused by pleiotrophic genes, or genes with multiple phenotypic effects [Williams, G.C., 1957. Pleiotropy, natural selection, and the evolution of senescence. Evolution 11, 398-411].
Erica, Ungewitter, Heidi, Scrable
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Frontiers in Plant Science, 2018 Major advances in wheat production are needed to address global food insecurity under future climate conditions, such as high temperatures. The grain yield of bread wheat (Triticum aestivum L.) is a quantitatively inherited complex trait that is strongly
Panfeng Guan +12 more
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