Results 31 to 40 of about 50,540 (257)
Stroke and Alzheimer’s Disease: A Mendelian Randomization Study
Frontiers in Genetics, 2020 Stroke and Alzheimer’s disease (AD) are common neurological diseases. Several exiting studies indicated that late onset-AD and ischemic stroke have shared genetic links. Different kinds of stroke have different mechanisms.
Tao Wang +5 more
doaj +1 more source
Horizontal pleiotropy and heterogeneity of results.
, 2023 Horizontal pleiotropy and heterogeneity of results.
Yi Zheng (113896) +4 more
core +1 more source
Environmental pleiotropy and demographic history direct adaptation under antibiotic selection [PDF]
, 2018 Evolutionary rescue following environmental change requires mutations permitting population growth in the new environment. If change is severe enough to prevent most of the population reproducing, rescue becomes reliant on mutations already present.
Knight, Christopher; id_orcid +18 more
core +4 more sources
Frontiers in Genetics, 2019 Artificial selection is often associated with numerous changes in seemingly unrelated phenotypic traits. The genetic mechanisms of correlated phenotypes probably involve pleiotropy or linkage of genes related to such phenotypes.
Xianggui Dong +7 more
doaj +1 more source
, 2022 We varied the gain-of-function mutation rate, μ, using values 10-fold lower than the typical value used in the main text, and assumed that the evolution of pleiotropy decreases group function by 2%.
Kevin R. Foster (8893457) +4 more
core +1 more source
Frontiers in Plant Science, 2018 Increasing oil content in oilseed mustard (Brassica juncea) is a major breeding objective—more so, in the lines that have “0” erucic acid content (< 2% of the seed oil) as earlier studies have shown negative pleiotropic effect of erucic acid loci on ...
Kadambini Rout +7 more
doaj +1 more source
A genotype and phenotype analysis of SMAD6 mutant patients with radioulnar synostosis
Molecular Genetics & Genomic Medicine, 2022 Background SMAD6 variants have been reported in patients with radioulnar synostosis (RUS). This study aimed to investigate the genotypes and phenotypes for a large cohort of patients with RUS having mutant SMAD6. Methods Genomic DNA samples were isolated
Fang Shen +9 more
doaj +1 more source
Animal, 2016 Both growth and immune capacity are important traits in animal breeding. The animal quantitative trait loci (QTL) database is a valuable resource and can be used for interpreting the genetic mechanisms that underlie growth and immune traits. However, QTL
Z. Zhang +12 more
doaj +1 more source
Evolutionary Applications, 2021 Trade‐offs between life history traits are expected to occur due to the limited amount of resources that organisms can obtain and share among biological functions, but are of least concern for selection responses in nutrient‐rich or benign environments ...
Frédéric Douhard +5 more
doaj +1 more source
The Gene scb-1 Underlies Variation in Caenorhabditis elegans Chemotherapeutic Responses
G3: Genes, Genomes, Genetics, 2020 Pleiotropy, the concept that a single gene controls multiple distinct traits, is prevalent in most organisms and has broad implications for medicine and agriculture.
Kathryn S. Evans, Erik C. Andersen
doaj +1 more source