Results 31 to 40 of about 65,328 (279)
Nontrivial Replication of Loci Detected by Multi-Trait Methods
Frontiers in Genetics, 2021 The ever-growing genome-wide association studies (GWAS) have revealed widespread pleiotropy. To exploit this, various methods that jointly consider associations of a genetic variant with multiple traits have been developed.
Zheng Ning +21 more
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Exploring tradeoffs in pleiotropy and redundancy using evolutionary computing
, 2004 Evolutionary computation algorithms are increasingly being used to solve optimization problems as they have many advantages over traditional optimization algorithms.
Abbott, Derek +5 more
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What Is Antagonistic Pleiotropy? [PDF]
Biochemistry (Moscow), 2018 Antagonistic Pleiotropy has been the dominant theory for evolution of aging since it was first proposed 60 years ago. Indeed, examples of pleiotropy have been observed, but there are also many examples of mutations that lead to longer lifespan without apparent cost.
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The many faces of pleiotropy [PDF]
Trends in Genetics, 2013 Pleiotropy is the well-established phenomenon of a single gene affecting multiple traits. It has long played a central role in theoretical, experimental, and clinical research in genetics, development, molecular biology, evolution, and medicine. In recent years, genomic techniques have brought data to bear on fundamental questions about the nature and ...
Annalise B, Paaby, Matthew V, Rockman
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Effects of Epistasis and Pleiotropy on Fitness Landscapes
, 2013 The factors that influence genetic architecture shape the structure of the fitness landscape, and therefore play a large role in the evolutionary dynamics. Here the NK model is used to investigate how epistasis and pleiotropy -- key components of genetic
A Dawid +15 more
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A benign juvenile environment reduces the strength of antagonistic pleiotropy and genetic variation in the rate of senescence [PDF]
, 2015 The environment can play an important role in the evolution of senescence because the optimal allocation between somatic maintenance and reproduction depends on external factors influencing life expectancy.
Gonzalez G. +3 more
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BiologyDisparities in the functional classification of secretory genes among aphid taxa may be attributed to variations in coding sequences and gene expression profiles. However, the driving factors that regulate sequence evolution remain unclear.
Atsbha Gebreslasie Gebrekidan +2 more
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Mapping Floral Genetic Architecture in Prunus mume, an Ornamental Woody Plant
Frontiers in Plant Science, 2022 Floral traits are both evolutionarily and economically relevant for ornamental plants. However, their underlying genetic architecture, especially in woody ornamental plants, is still poorly understood.
Mingyu Li +7 more
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An Unusual Antagonistic Pleiotropy in the Penna Model for Biological Ageing
, 2001 We combine the Penna Model for biological aging, which is based on the mutation-accumulation theory, with a sort of antagonistic pleiotropy. We show that depending on how the pleiotropy is introduced, it is possible to reproduce both the humans mortality,
Bernardes +15 more
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Maintenance of Microbial Cooperation Mediated by Public Goods in Single- and Multiple-Trait Scenarios [PDF]
, 2017 Microbes often form densely populated communities, which favor competitive and cooperative interactions. Cooperation among bacteria often occurs through the production of metabolically costly molecules produced by certain individuals that become ...
Balbontín, Roberto +3 more
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