Results 31 to 40 of about 37,616 (263)
Frontiers in Genetics, 2021 The role of common genetic variation in susceptibility to acute myeloid leukemia (AML), and myelodysplastic syndrome (MDS), a group of rare clonal hematologic disorders characterized by dysplastic hematopoiesis and high mortality, remains unclear.
Junke Wang +26 more
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Nontrivial Replication of Loci Detected by Multi-Trait Methods
Frontiers in Genetics, 2021 The ever-growing genome-wide association studies (GWAS) have revealed widespread pleiotropy. To exploit this, various methods that jointly consider associations of a genetic variant with multiple traits have been developed.
Zheng Ning +21 more
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Frontiers in Plant Science, 2018 Aluminum (Al) toxicity on acidic soils significantly damages plant roots and inhibits root growth. Hence, crops intoxicated by Al become more sensitive to drought stress and mineral nutrient deficiencies, particularly phosphorus (P) deficiency, which is ...
Jurandir V. Magalhaes +5 more
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What Is Antagonistic Pleiotropy? [PDF]
Biochemistry (Moscow), 2018 Antagonistic Pleiotropy has been the dominant theory for evolution of aging since it was first proposed 60 years ago. Indeed, examples of pleiotropy have been observed, but there are also many examples of mutations that lead to longer lifespan without apparent cost.
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Mapping Floral Genetic Architecture in Prunus mume, an Ornamental Woody Plant
Frontiers in Plant Science, 2022 Floral traits are both evolutionarily and economically relevant for ornamental plants. However, their underlying genetic architecture, especially in woody ornamental plants, is still poorly understood.
Mingyu Li +7 more
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The mysteries of LETM1 pleiotropy
Pharmacological ResearchLETM1 is a nuclear-encoded protein located in the inner mitochondrial membrane, playing a critical role in regulating mitochondrial cation and volume homeostasis. However, numerous studies on functional features, molecular interactions, and disease-associated effects of LETM1 revealed that LETM1 is also involved in other metabolic functions including ...
Mohammed, Sami E. M., Nowikovsky, Karin
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Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
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Frontiers in Genetics, 2018 Lumbar disc degeneration (LDD) is age-related break-down in the fibrocartilaginous joints between lumbar vertebrae. It is a major cause of low back pain and is conventionally assessed by magnetic resonance imaging (MRI).
Xueya Zhou +21 more
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Unveiling Lactylation: A Novel Frontier in Cancer Stemness and Therapy
Advanced Science, EarlyView.Tumor metabolism and epigenetic regulation are intrinsically linked. This review highlights lactylation as a pivotal bridge connecting these processes, acting as an active epigenetic effector in cancer stemness. We delineate how lactylation orchestrates the cancer stem cell landscape and evaluate its regulatory networks.
Ting Li +9 more
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Frontiers in Physiology, 2019 Pleiotropic genes are genes that affect more than one trait. For example, many genes required for pigmentation in the fruit fly Drosophila melanogaster also affect traits such as circadian rhythms, vision, and mating behavior.
Jonathan H. Massey +11 more
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