Results 1 to 10 of about 61,679 (166)

Health Outcomes Linkage in UK Biobank [PDF]

International Journal of Population Data Science
UK Biobank is a biomedical database containing de-identified data for over 500,000 participants within the United Kingdom, made globally available to researchers for health-related research in the public interest.
Laura Bramley, Jo Gay, Christopher de Lacy, Howard Callen, Sean Rose, Amy Flaxman, Gemma Codner, Rachael Drake-Brockman, Ben Lacey, Naomi Allen   +9 more
doaj   +2 more sources

Associations between multimorbidity and adverse health outcomes in UK Biobank and the SAIL Databank: A comparison of longitudinal cohort studies

PLoS Medicine, 2022
Background Cohorts such as UK Biobank are increasingly used to study multimorbidity; however, there are concerns that lack of representativeness may lead to biased results. This study aims to compare associations between multimorbidity and adverse health
Peter Hanlon, Bhautesh D. Jani, Barbara Nicholl, Jim Lewsey, David A. McAllister, Frances S. Mair   +5 more
doaj   +3 more sources

Association of vitamin and/or nutritional supplements with fall among patients with diabetes: A prospective study based on ACCORD and UK Biobank

Frontiers in Nutrition, 2023
AimsTo assess the associations of vitamin and/or nutritional supplements (VNS) with falls among patients with diabetes.Methods9,141 and 21,489 middle-aged participants with diabetes from Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial ...
Lingfang He, Lingfang He, Tianqi Ma, Tianqi Ma, Guogang Zhang, Guogang Zhang, Xunjie Cheng, Xunjie Cheng, Yongping Bai, Yongping Bai   +9 more
doaj   +1 more source

Cohort profile: rationale and methods of UK Biobank repeat imaging study eye measures to study dementia

BMJ Open, 2023
Purpose The retina provides biomarkers of neuronal and vascular health that offer promising insights into cognitive ageing, mild cognitive impairment and dementia.
, Martin McKibbin, Tariq Aslam, Sarah Barman, Jenny Barrett, Paul Bishop, Roxana Carare, Usha Chakravarthy, Michelle Chan, Alexander Day, Parul Desai, Bal Dhillon, Andrew Dick, Cathy Egan, Sarah Ennis, Paul Foster, Marcus Fruttiger, John Gallacher, Jane Gibson, Jeremy Guggenheim, Chris Hammond, Alison Hardcastle, Simon Harding, Ruth Hogg, Pirro Hysi, Anthony Khawaja, Gerassimos Lascaratos, Andrew Lotery, Phil Luthert, Tom Macgillivray, Sarah Mackie, Bernadette Mcguinness, Gareth Mckay, Tony Moore, James Morgan, Eoin O’sullivan, Chris Owen, Praveen Patel, Euan Paterson, Axel Petzold, Alicja Rudnicka, Paul J Foster, Naomi Allen, Peng Tee Khaw, Praveen J Patel, Konstantinos Balaskas, Richard Oram, Robert Luben, Tasanee Braithwaite, Graeme Black, Christopher G Owen, Zihan Sun, David Garway-Heath, Thomas Littlejohns, Simon Sheard, Sharon Chua, Pearse Keane, Denize Atan, Savita Madhusudhan, Alexander Doney   +59 more
doaj   +1 more source

Reliability and validity of the UK Biobank cognitive tests.

PLoS ONE, 2020
UK Biobank is a health resource with data from over 500,000 adults. The cognitive assessment in UK Biobank is brief and bespoke, and is administered without supervision on a touchscreen computer. Psychometric information on the UK Biobank cognitive tests
Chloe Fawns-Ritchie, Ian J Deary
doaj   +1 more source

Quality control and removal of technical variation of NMR metabolic biomarker data in ~120,000 UK Biobank participants

Scientific Data, 2023
Metabolic biomarker data quantified by nuclear magnetic resonance (NMR) spectroscopy in approximately 121,000 UK Biobank participants has recently been released as a community resource, comprising absolute concentrations and ratios of 249 circulating ...
Scott C. Ritchie, Praveen Surendran, Savita Karthikeyan, Samuel A. Lambert, Thomas Bolton, Lisa Pennells, John Danesh, Emanuele Di Angelantonio, Adam S. Butterworth, Michael Inouye   +9 more
doaj   +1 more source

Plasma metabolomic profiles of dementia: a prospective study of 110,655 participants in the UK Biobank

BMC Medicine, 2022
Background Plasma metabolomic profile is disturbed in dementia patients, but previous studies have discordant conclusions. Methods Circulating metabolomic data of 110,655 people in the UK Biobank study were measured with nuclear magnetic resonance ...
Xinyu Zhang, Wenyi Hu, Yueye Wang, Wei Wang, Huan Liao, Xiayin Zhang, Katerina V. Kiburg, Xianwen Shang, Gabriella Bulloch, Yu Huang, Xueli Zhang, Shulin Tang, Yijun Hu, Honghua Yu, Xiaohong Yang, Mingguang He, Zhuoting Zhu   +16 more
doaj   +1 more source

Development and validation of a dementia risk score in the UK Biobank and Whitehall II cohorts

BMJ Mental Health, 2023
Background Current dementia risk scores have had limited success in consistently identifying at-risk individuals across different ages and geographical locations.Objective We aimed to develop and validate a novel dementia risk score for a midlife UK ...
Mika Kivimäki, Archana Singh-Manoux, Georgios Georgiopoulos, James H Cole, Anya Topiwala, Danielle Newby, Melis Anatürk, Raihaan Patel, Klaus P. Ebmeier, Ann-Marie G de Lange, Michelle G Jansen, Sana Suri   +11 more
doaj   +1 more source

Phenotypes and rates of cancer-relevant symptoms and tests in the year before cancer diagnosis in UK Biobank and CPRD Gold.

PLOS Digital Health, 2023
Early diagnosis of cancer relies on accurate assessment of cancer risk in patients presenting with symptoms, when screening is not appropriate. But recorded symptoms in cancer patients pre-diagnosis may vary between different sources of electronic health
Matthew Barclay, Cristina Renzi, Antonis Antoniou, Spiros Denaxas, Hannah Harrison, Samantha Ip, Nora Pashayan, Ana Torralbo, Juliet Usher-Smith, Angela Wood, Georgios Lyratzopoulos   +10 more
doaj   +1 more source

Identity-by-descent detection across 487,409 British samples reveals fine scale population structure and ultra-rare variant associations

Nature Communications, 2020
Accurately measuring genetic relatedness by Identical-By-Descent (IBD) segments is challenging in biobank-level genome data. The authors present IBD method FastSMC, which when applied to the UK Biobank gives a detailed picture of genetic relatedness and ...
Juba Nait Saada, Georgios Kalantzis, Derek Shyr, Fergus Cooper, Martin Robinson, Alexander Gusev, Pier Francesco Palamara   +6 more
doaj   +1 more source