Results 41 to 50 of about 7,704,969 (300)
, 2023 Exome association studies to date have generally been underpowered to systematically evaluate the phenotypic impact of very rare coding variants. We leveraged extensive haplotype sharing between 49,960 exome-sequenced UK Biobank participants and the ...
Loh, Po-Ru +3 more
core +1 more source
Nature Communications, 2018 The UK Biobank provides data for three depression-related phenotypes. Here, Howard et al. perform a genome-association study for broad depression, probable major depressive disorder (MDD) and hospital record-coded MDD in up to 322,580 UK Biobank ...
David M. Howard +21 more
doaj +1 more source
Insulin‐like growth factor‐1 and site‐specific cancers: A Mendelian randomization study
Cancer Medicine, 2020 Insulin‐like growth factor‐1 (IGF‐1) is involved in several processes relevant to carcinogenesis. We used 416 single‐nucleotide polymorphisms robustly associated with serum IGF‐1 levels to assess the potential causal associations between this hormone and
Susanna C. Larsson +5 more
doaj +1 more source
Quantile Regression for biomarkers in the UK Biobank
, 2023 Abstract Genome-wide association studies (GWAS) for biomarkers important for clinical phenotypes can lead to clinically relevant discoveries. GWAS for quantitative traits are based on simplified regression models modeling the conditional mean of a phenotype as a linear function of genotype.
Wang, Chen +4 more
openaire +2 more sources
Familial Influences on Neuroticism and Education in the UK Biobank [PDF]
Behavior Genetics, 2019 Abstract Genome-wide studies often exclude family members, even though they are a valuable source of information. We identified parent–offspring pairs, siblings and couples in the UK Biobank and implemented a family-based DNA-derived heritability method to capture additional genetic effects and multiple sources of environmental ...
Cheesman, R. +8 more
openaire +4 more sources
Anxiety disorders and age-related changes in physiology
European Psychiatry, 2022 Introduction Anxiety disorders are leading contributors to the global disease burden, highly prevalent across the lifespan, and associated with substantially increased morbidity and early mortality.
J. Mutz, T. Hoppen, C. Fabbri, C. Lewis
doaj +1 more source
UK Biobank Motor Neurone Disease (MND) phenotype
, 2019 UK Biobank Motor Neurone Disease (MND ...
UK Biobank Outcome Adjudication Group (7239638) +3 more
core +1 more source
Frontiers in Oncology, 2022 BackgroundGenetic factors increase the individual risk of colorectal cancer (CRC); however, the extent to which a healthy lifestyle can offset increased genetic risk is unknown. This study investigated whether a healthy lifestyle is associated with lower
E. Wu +10 more
doaj +1 more source
UK Biobank's cardiovascular magnetic resonance protocol [PDF]
Journal of Cardiovascular Magnetic Resonance, 2016 UK Biobank's ambitious aim is to perform cardiovascular magnetic resonance (CMR) in 100,000 people previously recruited into this prospective cohort study of half a million 40-69 year-olds.We describe the CMR protocol applied in UK Biobank's pilot phase, which will be extended into the main phase with three centres using the same equipment and ...
Petersen, SE +13 more
openaire +3 more sources
UK Biobank Data: Come and Get It
Science Translational Medicine, 2014 UK Biobank invites scientists to make use of the vast (and growing) amounts of data in this open-access resource for public health research.
Allen, N +3 more
openaire +3 more sources