Results 21 to 30 of about 61,679 (166)
Scientific Reports, 2021 Hereditary transthyretin-mediated (hATTR) amyloidosis is an underdiagnosed, progressively debilitating disease caused by mutations in the transthyretin (TTR) gene.
Margaret M. Parker +21 more
doaj +1 more source
Algorithms for the Capture and Adjudication of Prevalent and Incident Diabetes in UK Biobank.
PLoS ONE, 2016 ObjectivesUK Biobank is a UK-wide cohort of 502,655 people aged 40-69, recruited from National Health Service registrants between 2006-10, with healthcare data linkage. Type 2 diabetes is a key exposure and outcome.
Sophie V Eastwood +8 more
doaj +1 more source
ACR Open Rheumatology, 2021 Objectives The objectives for this study were to assess whether gout and/or rheumatoid arthritis (RA) are risk factors for coronavirus disease 2019 (COVID‐19) diagnosis and to assess whether gout and/or RA are risk factors for death from COVID‐19 ...
Ruth K. Topless +6 more
doaj +1 more source
Frontiers in Endocrinology, 2023 IntroductionNonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) are both chronic multisystem diseases that cause tremendous health burdens worldwide.
Yuetian Yu +6 more
doaj +1 more source
An atlas of genetic associations in UK Biobank [PDF]
Nature Genetics, 2017 ABSTRACT Genome-wide association studies have revealed many loci contributing to the variation of complex traits, yet the majority of loci that contribute to the heritability of complex traits remain elusive. Large study populations with sufficient statistical power are required to detect the small effect sizes of the
Oriol Canela-Xandri +2 more
openaire +4 more sources
Education is power: preserving cognition in the UK biobank
Frontiers in Public Health, 2023 IntroductionDementia is a debilitating syndrome characterized by the gradual loss of memory and cognitive function. Although there are currently limited, largely symptomatic treatments for the diseases that can lead to dementia, its onset may be prevented by identifying and modifying relevant life style risk factors.
Benjamin Tari +5 more
openaire +3 more sources
Identification and validation of myocardial infarction and stroke outcomes at scale in UK Biobank
International Journal of Population Data Science, 2017 Aims We aimed (i) to create algorithms for identifying stroke and acute myocardial infarction (MI) cases in a large prospective population-based study (UK Biobank), using linked data from national hospital admissions data and death registers, combined ...
Christian Schnier +8 more
doaj +1 more source
Nature Communications, 2020 Between 2014 and 2023, 100,000 UK Biobank participants are undergoing brain, heart and abdominal MRI, as well as DXA and carotid ultrasound scans. In this review, authors provide a detailed overview of the rationale for the collection of these imaging ...
Thomas J. Littlejohns +23 more
doaj +1 more source
Overestimated prediction using polygenic prediction derived from summary statistics
BMC Genomic Data, 2023 Background When polygenic risk score (PRS) is derived from summary statistics, independence between discovery and test sets cannot be monitored. We compared two types of PRS studies derived from raw genetic data (denoted as rPRS) and the summary ...
David Keetae Park +8 more
doaj +1 more source
Epidemiology of Cholesteatoma in the UK Biobank [PDF]
Clinical OtolaryngologyLevel of Evidence: 3 Objective(s) To identify the risk factors for Cholesteatoma in a large UK cohort. Although some risk factors are well established (male sex, history of chronic otitis media), others require further evidence (deprivation, smoking). Design and Setting
Emma Wilson +5 more
openaire +3 more sources