Results 11 to 20 of about 8,179,520 (254)
An atlas of genetic associations in UK Biobank [PDF]
Nature Genetics, 2018 Genome-wide association studies (GWAS) have identified many loci contributing to variation in complex traits, yet the majority of loci that contribute to the heritability of complex traits remain elusive.Canela-Xandri, Oriol, Rawlik, Konrad; id_orcid, Konrad Rawlik, Tenesa, Albert, Albert Tenesa, Oriol Canela-Xandri, Rawlik, Konrad +6 morecore +6 more sourcesThe sequences of 150,119 genomes in the UK biobank [PDF]
Nature, 2021 Abstract We describe the analysis of whole genome sequences (WGS) of 150,119 individuals from the UK biobank (UKB). This constitutes a set of high quality variants, including 585,040,410 SNPs, representing 7.0% of all possible human SNPs, and 58,707,036 indels.Bjarni V. Halldorsson, Hannes P. Eggertsson, Kristjan H. S. Moore, Hannes Hauswedell, Ogmundur Eiriksson, Magnus O. Ulfarsson, Gunnar Palsson, Marteinn T. Hardarson, Asmundur Oddsson, Brynjar O. Jensson, Snaedis Kristmundsdottir, Brynja D. Sigurpalsdottir, Olafur A. Stefansson, Doruk Beyter, Guillaume Holley, Vinicius Tragante, Arnaldur Gylfason, Pall I. Olason, Florian Zink, Margret Asgeirsdottir, Sverrir T. Sverrisson, Brynjar Sigurdsson, Sigurjon A. Gudjonsson, Gunnar T. Sigurdsson, Gisli H. Halldorsson, Gardar Sveinbjornsson, Kristjan Norland, Unnur Styrkarsdottir, Droplaug N. Magnusdottir, Steinunn Snorradottir, Kari Kristinsson, Emilia Sobech, Helgi Jonsson, Arni J. Geirsson, Isleifur Olafsson, Palmi Jonsson, Ole Birger Pedersen, Christian Erikstrup, Søren Brunak, Sisse Rye Ostrowski, Steffen Andersen, Karina Banasik, Kristoffer Burgdorf, Maria Didriksen, Khoa Manh Dinh, Christian Erikstrup, Daniel Gudbjartsson, Thomas Folkmann Hansen, Henrik Hjalgrim, Gregor Jemec, Poul Jennum, Pär Ingemar Johansson, Margit Anita Hørup Larsen, Susan Mikkelsen, Kasper Rene Nielsen, Mette Nyegaard, Sisse Rye Ostrowski, Susanne Sækmose, Erik Sørensen, Unnur Thorsteinsdottir, Mie Topholm Brun, Henrik Ullum, Thomas Werge, Gudmar Thorleifsson, Frosti Jonsson, Pall Melsted, Ingileif Jonsdottir, Thorunn Rafnar, Hilma Holm, Hreinn Stefansson, Jona Saemundsdottir, Daniel F. Gudbjartsson, Olafur T. Magnusson, Gisli Masson, Unnur Thorsteinsdottir, Agnar Helgason, Hakon Jonsson, Patrick Sulem, Kari Stefansson +78 moreopenaire +8 more sourcesDeveloping automated methods for disease subtyping in UK Biobank: an exemplar study on stroke [PDF]
, 2021 Background Better phenotyping of routinely collected coded data would be useful for research and health improvement. For example, the precision of coded data for hemorrhagic stroke (intracerebral hemorrhage [ICH] and subarachnoid hemorrhage [SAH]) may be Sudlow, Cathie L M; id_orcid, Allen, Naomi, the UK Biobank, Whiteley, William N; id_orcid, Rannikmäe, Rannikmäe, Cathie Sudlow, Kristiina Rannikmäe, Wu, H, Allen, N, Rannikmäe, K, Tominey, Steven, Honghan Wu, Steven Tominey, Rannikmae, Kristiina, Wu, Honghan, William Whiteley, Tominey, S, Sudlow, C, Sudlow, Cathie, Naomi Allen, Whiteley, W, UK Biobank, Whiteley, William, null null +23 morecore +1 more sourceGenetic variation affects morphological retinal phenotypes extracted from UK Biobank optical coherence tomography images. [PDF]
, 2021 Optical Coherence Tomography (OCT) enables non-invasive imaging of the retina and is used to diagnose and manage ophthalmic diseases including glaucoma.Chris J Hammond, Hewitt, Alex W., Choquet, Hélène, Pasquale, Louis R., Powell, Joseph E., Craig, Jamie, Currant, Hannah, Seyhan Yazar, Kubo, Michiaki, Charng, Jason, Reisman, Charles A., Thiadens, A., Jue-Sheng Ong, Birney, E., Alberta A H J Thiadens, Pasquale, L.R., Powell, J.E., Fitzgerald, T.W., Bonnemaijer, P.W.M., Simcoe, M.J., International Glaucoma Genetics Consortium, Duijn, C.M. van, Anne Senabouth, Daniszewski, M., Wiggs, Janey L., Ewan Birney, Atan, Denize, Hammond, C.J., Kubo, M., Alice Pébay, Pébay, A., Hysi, P., Bonnemaijer, Pieter W.M., Stuart MacGregor, Ong, Jue Sheng, Ong, J.S., Yazar, Seyhan, Paul J Foster, Jorgenson, Eric, Puya Gharahkhani, Daniszewski, Maciej, Pébay, Alice, Hannah Currant, Mark J Simcoe, David A Mackey, Aung, T., Cornelia M van Duijn, Mackey, D.A., UK Biobank Eye and Vision Consortium, Janey L Wiggs, Hélène Choquet, Jamie Craig, Yazar, S., Fitzgerald, Tomas W., Denize Atan, Patel, Praveen J., van Duijn, Cornelia M., Hewitt, A.W., MacGregor, S., Pirro Hysi, Charng, J., Khawaja, Anthony P., Patel, P.J., Alex W Hewitt, Hammond, Chris J., Jorgenson, E., Caroline C W Klaver, Gharahkhani, P., Craig, J., Joseph E Powell, Pieter W M Bonnemaijer, Hysi, Pirro, Atan, D., Tin Aung, Currant, H., Senabouth, A., Simcoe, Mark J., Klaver, C.C.W., Maciej Daniszewski, Louis R Pasquale, Praveen J Patel, Birney, Ewan, Khawaja, A.P., Gharahkhani, Puya, Mackey, David A., Senabouth, Anne, Charles A Reisman, Jason Charng, Eric Jorgenson, Klaver, Caroline C.W., Peng T Khaw, Foster, Paul J., Anthony P Khawaja, Aung, Tin, Khaw, Peng T., Thiadens, Alberta A.H.J., MacGregor, Stuart, Tomas W Fitzgerald, Khaw, P.T., Reisman, C.A., Foster, P.J., Wiggs, J.L., Choquet, H., Michiaki Kubo, Peng T. Khaw, Praveen J. Patel, Alberta A. H. J. Thiadens, null null, Joseph E. Powell, Paul J. Foster, Cornelia M. van Duijn, Pieter W. M. Bonnemaijer, Alex W. Hewitt, Louis R. Pasquale, Mark J. Simcoe, Chris J. Hammond, Anthony P. Khawaja, Charles A. Reisman, Janey L. Wiggs, Caroline C. W. Klaver, David A. Mackey, Tomas W. Fitzgerald +121 morecore +3 more sourcesMembranous nephropathy in the UK Biobank
PLOS ONE, 2023 Background Despite MN being one of the most common causes of nephrotic syndrome worldwide, its biological and environmental determinants are poorly understood in large-part due to it being a rare disease. Making use of the UK Biobank, a unique resource holding a clinical dataset and stored DNA, serum and urine for ~500,000 participants, this study ...Patrick Hamilton, Kieran Blaikie, Stephen A. Roberts, Matthew Gittins, Mallory L. Downie, Sanjana Gupta, Catalin Voinescu, Durga Kanigicherla, Horia Stanescu, Robert Kleta, Paul Brenchley +10 moreopenaire +5 more sourcesThe UK Biobank [PDF]
Brain, 2015 In this issue, Natalie Ryan, Martin Rossor and Nick Fox commemorate the centenary of the death of Alois Alzheimer by looking at how his eponymous disease has evolved from a rare, early-onset dementia to a major focus of global public health concern (Ryan et al. , 2015).Paul M, Matthews, Cathie, Sudlowopenaire +2 more sourcesUnited Kingdom Biobank (UK Biobank)
Journal of the American College of Cardiology, 2021 An increasing number of people are now living with cardiovascular disease (CVD), with concomitant CVD-related hospitalisations, operations and prescriptions. To ultimately deliver optimal cardiovascular care, access to population-based biobanks with data on multi-omics, phenotypes, and lifestyle risk factors are crucial.Caleyachetty, R, Littlejohns, T, Lacey, B, Bešević, J, Conroy, M, Collins, R, Allen, N +6 moreopenaire +1 more sourcePharmacogenetics at Scale: An Analysis of the UK Biobank [PDF]
Clinical Pharmacology & Therapeutics, 2020 Pharmacogenetics (PGx) studies the influence of genetic variation on drug response. Clinically actionable associations inform guidelines created by the Clinical Pharmacogenetics Implementation Consortium (CPIC), but the broad impact of genetic variation on entire populations is not well understood.Greg McInnes, Adam Lavertu, Katrin Sangkuhl, Teri E. Klein, Michelle Whirl-Carrillo, Russ B. Altman +5 moreopenaire +2 more sourcesUK Biobank: opportunities for cardiovascular research [PDF]
European Heart Journal, 2017 Cardiovascular diseases are a major cause of morbidity and mortality, accounting for 45% of all deaths in European countries in 20161 and almost a third of deaths worldwide in 2013.2 A similar pattern is observed in the UK where cardiovascular diseases were responsible for 27% of deaths in 2014, with coronary heart disease resulting in the largest ...Littlejohns, Thomas J., Sudlow, Catherine; id_orcid 0000-0002-7725-7520, Allen, Naomi E, Collins, Rory +3 moreopenaire +4 more sourcesUK Biobank Kinetic Energy Harvesting
, 2022 Software for processing the UK Biobank accelerometer datasets in the paper 'Estimation of kinetic energy harvesting potential for self-powered wearable devices with 67,000 participants from the UK ...EEE - Academic & Research, Institute of Electrical and Electronics Engineers, Inc. (IEEE), Beach, Christopher, Casson, Alex; id_orcid +3 morecore +2 more sources
