Results 11 to 20 of about 7,704,969 (300)

United Kingdom Biobank (UK Biobank) [PDF]

Journal of the American College of Cardiology, 2021
An increasing number of people are now living with cardiovascular disease (CVD), with concomitant CVD-related hospitalisations, operations and prescriptions. To ultimately deliver optimal cardiovascular care, access to population-based biobanks with data on multi-omics, phenotypes, and lifestyle risk factors are crucial.
Caleyachetty, R, Littlejohns, T, Lacey, B, Bešević, J, Conroy, M, Collins, R, Allen, N   +6 more
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The sequences of 150,119 genomes in the UK biobank [PDF]

Nature, 2021
Abstract We describe the analysis of whole genome sequences (WGS) of 150,119 individuals from the UK biobank (UKB). This constitutes a set of high quality variants, including 585,040,410 SNPs, representing 7.0% of all possible human SNPs, and 58,707,036 indels.
Bjarni V. Halldorsson, Hannes P. Eggertsson, Kristjan H. S. Moore, Hannes Hauswedell, Ogmundur Eiriksson, Magnus O. Ulfarsson, Gunnar Palsson, Marteinn T. Hardarson, Asmundur Oddsson, Brynjar O. Jensson, Snaedis Kristmundsdottir, Brynja D. Sigurpalsdottir, Olafur A. Stefansson, Doruk Beyter, Guillaume Holley, Vinicius Tragante, Arnaldur Gylfason, Pall I. Olason, Florian Zink, Margret Asgeirsdottir, Sverrir T. Sverrisson, Brynjar Sigurdsson, Sigurjon A. Gudjonsson, Gunnar T. Sigurdsson, Gisli H. Halldorsson, Gardar Sveinbjornsson, Kristjan Norland, Unnur Styrkarsdottir, Droplaug N. Magnusdottir, Steinunn Snorradottir, Kari Kristinsson, Emilia Sobech, Helgi Jonsson, Arni J. Geirsson, Isleifur Olafsson, Palmi Jonsson, Ole Birger Pedersen, Christian Erikstrup, Søren Brunak, Sisse Rye Ostrowski, Steffen Andersen, Karina Banasik, Kristoffer Burgdorf, Maria Didriksen, Khoa Manh Dinh, Christian Erikstrup, Daniel Gudbjartsson, Thomas Folkmann Hansen, Henrik Hjalgrim, Gregor Jemec, Poul Jennum, Pär Ingemar Johansson, Margit Anita Hørup Larsen, Susan Mikkelsen, Kasper Rene Nielsen, Mette Nyegaard, Sisse Rye Ostrowski, Susanne Sækmose, Erik Sørensen, Unnur Thorsteinsdottir, Mie Topholm Brun, Henrik Ullum, Thomas Werge, Gudmar Thorleifsson, Frosti Jonsson, Pall Melsted, Ingileif Jonsdottir, Thorunn Rafnar, Hilma Holm, Hreinn Stefansson, Jona Saemundsdottir, Daniel F. Gudbjartsson, Olafur T. Magnusson, Gisli Masson, Unnur Thorsteinsdottir, Agnar Helgason, Hakon Jonsson, Patrick Sulem, Kari Stefansson   +78 more
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Developing automated methods for disease subtyping in UK Biobank: an exemplar study on stroke [PDF]

, 2021
Background Better phenotyping of routinely collected coded data would be useful for research and health improvement. For example, the precision of coded data for hemorrhagic stroke (intracerebral hemorrhage [ICH] and subarachnoid hemorrhage [SAH]) may be
Sudlow, Cathie L M; id_orcid, Allen, Naomi, the UK Biobank, Whiteley, William N; id_orcid, Rannikmäe, Rannikmäe, Cathie Sudlow, Kristiina Rannikmäe, Wu, H, Allen, N, Rannikmäe, K, Tominey, Steven, Honghan Wu, Steven Tominey, Rannikmae, Kristiina, Wu, Honghan, William Whiteley, Tominey, S, Sudlow, C, Sudlow, Cathie, Naomi Allen, Whiteley, W, UK Biobank, Whiteley, William   +22 more
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Membranous nephropathy in the UK Biobank

PLOS ONE, 2023
Background Despite MN being one of the most common causes of nephrotic syndrome worldwide, its biological and environmental determinants are poorly understood in large-part due to it being a rare disease. Making use of the UK Biobank, a unique resource holding a clinical dataset and stored DNA, serum and urine for ~500,000 participants, this study ...
Patrick Hamilton, Kieran Blaikie, Stephen A. Roberts, Matthew Gittins, Mallory L. Downie, Sanjana Gupta, Catalin Voinescu, Durga Kanigicherla, Horia Stanescu, Robert Kleta, Paul Brenchley   +10 more
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Genetic variation affects morphological retinal phenotypes extracted from UK Biobank optical coherence tomography images. [PDF]

, 2021
Optical Coherence Tomography (OCT) enables non-invasive imaging of the retina and is used to diagnose and manage ophthalmic diseases including glaucoma.
Mark J Simcoe, David A Mackey, Cornelia M van Duijn, Chris J Hammond, UK Biobank Eye and Vision Consortium, Janey L Wiggs, Hewitt, Alex W., Hélène Choquet, Jamie Craig, Choquet, Hélène, Fitzgerald, Tomas W., Denize Atan, Pasquale, Louis R., Powell, Joseph E., Craig, Jamie, Patel, Praveen J., van Duijn, Cornelia M., Currant, Hannah, Pirro Hysi, Seyhan Yazar, Kubo, Michiaki, Charng, Jason, Reisman, Charles A., Mackey, David A, Khawaja, Anthony P., Hewitt, Alex W, Jue-Sheng Ong, Ong, Jue-Sheng, Alberta A H J Thiadens, Pasquale, Louis R, Alex W Hewitt, Reisman, Charles A, Hammond, Chris J., Fitzgerald, Tomas W, Caroline C W Klaver, Bonnemaijer, Pieter WM, International Glaucoma Genetics Consortium, Joseph E Powell, Pieter W M Bonnemaijer, Hysi, Pirro, Patel, Praveen J, Anne Senabouth, Tin Aung, Klaver, Caroline CW, Powell, Joseph E, Wiggs, Janey L., Simcoe, Mark J., Ewan Birney, Atan, Denize, Maciej Daniszewski, Louis R Pasquale, Praveen J Patel, Simcoe, Mark J, Birney, Ewan, Alice Pébay, Gharahkhani, Puya, Mackey, David A., Thiadens, Alberta AHJ, Hammond, Chris J, Bonnemaijer, Pieter W.M., Stuart MacGregor, Senabouth, Anne, Foster, Paul J, Ong, Jue Sheng, Charles A Reisman, Jason Charng, van Duijn, Cornelia M, Eric Jorgenson, Khawaja, Anthony P, Klaver, Caroline C.W., Peng T Khaw, Foster, Paul J., Yazar, Seyhan, Anthony P Khawaja, Aung, Tin, Khaw, Peng T., Khaw, Peng T, Wiggs, Janey L, Thiadens, Alberta A.H.J., Paul J Foster, Jorgenson, Eric, MacGregor, Stuart, Puya Gharahkhani, Tomas W Fitzgerald, Daniszewski, Maciej, Pébay, Alice, Michiaki Kubo, Hannah Currant   +87 more
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The UK Biobank [PDF]

Brain, 2015
In this issue, Natalie Ryan, Martin Rossor and Nick Fox commemorate the centenary of the death of Alois Alzheimer by looking at how his eponymous disease has evolved from a rare, early-onset dementia to a major focus of global public health concern (Ryan et al. , 2015).
Paul M, Matthews, Cathie, Sudlow
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Pharmacogenetics at Scale: An Analysis of the UK Biobank [PDF]

Clinical Pharmacology & Therapeutics, 2020
Pharmacogenetics (PGx) studies the influence of genetic variation on drug response. Clinically actionable associations inform guidelines created by the Clinical Pharmacogenetics Implementation Consortium (CPIC), but the broad impact of genetic variation on entire populations is not well understood.
Greg McInnes, Adam Lavertu, Katrin Sangkuhl, Teri E. Klein, Michelle Whirl-Carrillo, Russ B. Altman   +5 more
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UK Biobank: opportunities for cardiovascular research [PDF]

European Heart Journal, 2017
Cardiovascular diseases are a major cause of morbidity and mortality, accounting for 45% of all deaths in European countries in 20161 and almost a third of deaths worldwide in 2013.2 A similar pattern is observed in the UK where cardiovascular diseases were responsible for 27% of deaths in 2014, with coronary heart disease resulting in the largest ...
Littlejohns, Thomas J., Sudlow, Catherine; id_orcid 0000-0002-7725-7520, Allen, Naomi E, Collins, Rory   +3 more
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Modification effect of ideal cardiovascular health metrics on genetic association with incident heart failure in the China Kadoorie Biobank and the UK Biobank [PDF]

, 2021
Background Both genetic and cardiovascular factors contribute to the risk of developing heart failure (HF), but whether idea cardiovascular health metrics (ICVHMs) offset the genetic association with incident HF remains unclear. Objectives To investigate
Ran Tao, on behalf of the China Kadoorie Biobank Collaborative Group, Li, Liming, Canqing Yu, Huang, Tao, Tao Huang, Tao, Ran, Iona Y. Millwood, Robert Clarke, Pei, Pei, Du, Huaidong, Liming Li, Yu, Canqing, Robin G. Walters, Huaidong Du, Chen, Yiping, Yu Guo, Ling Yang, Guo, Yu, Zhengming Chen, Yang, Ruotong, Ruotong Yang, Millwood, Iona, Pei Pei, Millwood, Iona Y, Yiping Chen, Jun Lv, Junshi Chen, Walters, Robin G, Lv, Jun, Walters, Robin, Clarke, Robert, Ninghao Huang, Huang, Ninghao, Chen, Junshi, Yang, Ling, Chen, Zhengming   +36 more
core   +1 more source

The landscape of health disparities in the UK Biobank

Database, 2023
Abstract The UK Biobank (UKB), a large-scale biomedical database that includes demographic and electronic health record data for more than half a million ethnically diverse participants, is a potentially valuable resource for the study of health disparities.
Shashwat Deepali Nagar, I. King Jordan, Leonardo Mariño-Ramírez   +2 more
openaire   +3 more sources