Results 11 to 20 of about 61,679 (166)

The sequences of 150,119 genomes in the UK biobank [PDF]

Nature, 2021
Abstract We describe the analysis of whole genome sequences (WGS) of 150,119 individuals from the UK biobank (UKB). This constitutes a set of high quality variants, including 585,040,410 SNPs, representing 7.0% of all possible human SNPs, and 58,707,036 indels.
Bjarni V. Halldorsson, Hannes P. Eggertsson, Kristjan H. S. Moore, Hannes Hauswedell, Ogmundur Eiriksson, Magnus O. Ulfarsson, Gunnar Palsson, Marteinn T. Hardarson, Asmundur Oddsson, Brynjar O. Jensson, Snaedis Kristmundsdottir, Brynja D. Sigurpalsdottir, Olafur A. Stefansson, Doruk Beyter, Guillaume Holley, Vinicius Tragante, Arnaldur Gylfason, Pall I. Olason, Florian Zink, Margret Asgeirsdottir, Sverrir T. Sverrisson, Brynjar Sigurdsson, Sigurjon A. Gudjonsson, Gunnar T. Sigurdsson, Gisli H. Halldorsson, Gardar Sveinbjornsson, Kristjan Norland, Unnur Styrkarsdottir, Droplaug N. Magnusdottir, Steinunn Snorradottir, Kari Kristinsson, Emilia Sobech, Helgi Jonsson, Arni J. Geirsson, Isleifur Olafsson, Palmi Jonsson, Ole Birger Pedersen, Christian Erikstrup, Søren Brunak, Sisse Rye Ostrowski, Steffen Andersen, Karina Banasik, Kristoffer Burgdorf, Maria Didriksen, Khoa Manh Dinh, Christian Erikstrup, Daniel Gudbjartsson, Thomas Folkmann Hansen, Henrik Hjalgrim, Gregor Jemec, Poul Jennum, Pär Ingemar Johansson, Margit Anita Hørup Larsen, Susan Mikkelsen, Kasper Rene Nielsen, Mette Nyegaard, Sisse Rye Ostrowski, Susanne Sækmose, Erik Sørensen, Unnur Thorsteinsdottir, Mie Topholm Brun, Henrik Ullum, Thomas Werge, Gudmar Thorleifsson, Frosti Jonsson, Pall Melsted, Ingileif Jonsdottir, Thorunn Rafnar, Hilma Holm, Hreinn Stefansson, Jona Saemundsdottir, Daniel F. Gudbjartsson, Olafur T. Magnusson, Gisli Masson, Unnur Thorsteinsdottir, Agnar Helgason, Hakon Jonsson, Patrick Sulem, Kari Stefansson   +78 more
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Membranous nephropathy in the UK Biobank

PLOS ONE, 2023
Background Despite MN being one of the most common causes of nephrotic syndrome worldwide, its biological and environmental determinants are poorly understood in large-part due to it being a rare disease. Making use of the UK Biobank, a unique resource holding a clinical dataset and stored DNA, serum and urine for ~500,000 participants, this study ...
Patrick Hamilton, Kieran Blaikie, Stephen A. Roberts, Matthew Gittins, Mallory L. Downie, Sanjana Gupta, Catalin Voinescu, Durga Kanigicherla, Horia Stanescu, Robert Kleta, Paul Brenchley   +10 more
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The UK Biobank [PDF]

Brain, 2015
In this issue, Natalie Ryan, Martin Rossor and Nick Fox commemorate the centenary of the death of Alois Alzheimer by looking at how his eponymous disease has evolved from a rare, early-onset dementia to a major focus of global public health concern (Ryan et al. , 2015).
Paul M, Matthews, Cathie, Sudlow
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United Kingdom Biobank (UK Biobank)

Journal of the American College of Cardiology, 2021
An increasing number of people are now living with cardiovascular disease (CVD), with concomitant CVD-related hospitalisations, operations and prescriptions. To ultimately deliver optimal cardiovascular care, access to population-based biobanks with data on multi-omics, phenotypes, and lifestyle risk factors are crucial.
Caleyachetty, R, Littlejohns, T, Lacey, B, Bešević, J, Conroy, M, Collins, R, Allen, N   +6 more
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Pharmacogenetics at Scale: An Analysis of the UK Biobank [PDF]

Clinical Pharmacology & Therapeutics, 2020
Pharmacogenetics (PGx) studies the influence of genetic variation on drug response. Clinically actionable associations inform guidelines created by the Clinical Pharmacogenetics Implementation Consortium (CPIC), but the broad impact of genetic variation on entire populations is not well understood.
Greg McInnes, Adam Lavertu, Katrin Sangkuhl, Teri E. Klein, Michelle Whirl-Carrillo, Russ B. Altman   +5 more
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UK Biobank: opportunities for cardiovascular research [PDF]

European Heart Journal, 2017
Cardiovascular diseases are a major cause of morbidity and mortality, accounting for 45% of all deaths in European countries in 20161 and almost a third of deaths worldwide in 2013.2 A similar pattern is observed in the UK where cardiovascular diseases were responsible for 27% of deaths in 2014, with coronary heart disease resulting in the largest ...
Littlejohns, Thomas J., Sudlow, Catherine; id_orcid 0000-0002-7725-7520, Allen, Naomi E, Collins, Rory   +3 more
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A frailty index for UK Biobank participants [PDF]

The Journals of Gerontology: Series A, 2017
Abstract Background Frailty indices (FIs) measure variation in health between aging individuals. Researching FIs in resources with large-scale genetic and phenotypic data will provide insights into the causes and consequences of frailty. Thus, we aimed to develop an FI using UK Biobank data, a cohort
Dylan M Williams, Juulia Jylhävä, Nancy L Pedersen, Sara Hägg   +3 more
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The landscape of health disparities in the UK Biobank

Database, 2023
Abstract The UK Biobank (UKB), a large-scale biomedical database that includes demographic and electronic health record data for more than half a million ethnically diverse participants, is a potentially valuable resource for the study of health disparities.
Shashwat Deepali Nagar, I. King Jordan, Leonardo Mariño-Ramírez   +2 more
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Genetic stratification of depression in UK Biobank [PDF]

Translational Psychiatry, 2020
AbstractDepression is a common and clinically heterogeneous mental health disorder that is frequently comorbid with other diseases and conditions. Stratification of depression may align sub-diagnoses more closely with their underling aetiology and provide more tractable targets for research and effective treatment. In the current study, we investigated
David M. Howard, Lasse Folkersen, Jonathan R. I. Coleman, Mark J. Adams, Kylie Glanville, Thomas Werge, Saskia P. Hagenaars, Buhm Han, David Porteous, Archie Campbell, Toni-Kim Clarke, Gerome Breen, Patrick F. Sullivan, Naomi R. Wray, Cathryn M. Lewis, Andrew M. McIntosh   +15 more
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Two separate, large cohorts reveal potential modifiers of age-associated variation in visual reaction time performance

npj Aging and Mechanisms of Disease, 2021
To identify potential factors influencing age-related cognitive decline and disease, we created MindCrowd. MindCrowd is a cross-sectional web-based assessment of simple visual (sv) reaction time (RT) and paired-associate learning (PAL).
J. S. Talboom, M. D. De Both, M. A. Naymik, A. M. Schmidt, C. R. Lewis, W. M. Jepsen, A. K. Håberg, T. Rundek, B. E. Levin, S. Hoscheidt, Y. Bolla, R. D. Brinton, N. J. Schork, M. Hay, C. A. Barnes, E. Glisky, L. Ryan, M. J. Huentelman   +17 more
doaj   +1 more source