Results 11 to 20 of about 121,766 (195)

Role of the UK Biobank Ethics and Governance Council [PDF]

Lancet, The, 2009
Laurie, Graeme
core   +3 more sources

Mental health in UK Biobank - development, implementation and results from an online questionnaire completed by 157 366 participants: a reanalysis [PDF]

, 2020
Background UK Biobank is a well-characterised cohort of over 500 000 participants including genetics, environmental data and imaging. An online mental health questionnaire was designed for UK Biobank participants to expand its potential.
Adams, M., Allen, N., Breen, G., Coleman, J. R. I., Cullen, B., Davis, K. A. S., Dickens, C., Fox, E., Graham, N., Holliday, J., Hotopf, M., Howard, L. M., John, A., Lee, W., McCabe, R., McIntosh, A., Pearsall, R., Smith, D. J., Sudlow, C., Ward, J., Zammit, S.   +20 more
core   +8 more sources

Membranous nephropathy in the UK Biobank

PLOS ONE, 2023
Background Despite MN being one of the most common causes of nephrotic syndrome worldwide, its biological and environmental determinants are poorly understood in large-part due to it being a rare disease. Making use of the UK Biobank, a unique resource holding a clinical dataset and stored DNA, serum and urine for ~500,000 participants, this study ...
Patrick Hamilton, Kieran Blaikie, Stephen A. Roberts, Matthew Gittins, Mallory L. Downie, Sanjana Gupta, Catalin Voinescu, Durga Kanigicherla, Horia Stanescu, Robert Kleta, Paul Brenchley   +10 more
openaire   +6 more sources

Plasma metabolomic profiles of dementia: a prospective study of 110,655 participants in the UK Biobank

BMC Medicine, 2022
Background Plasma metabolomic profile is disturbed in dementia patients, but previous studies have discordant conclusions. Methods Circulating metabolomic data of 110,655 people in the UK Biobank study were measured with nuclear magnetic resonance ...
Xinyu Zhang, Wenyi Hu, Yueye Wang, Wei Wang, Huan Liao, Xiayin Zhang, Katerina V. Kiburg, Xianwen Shang, Gabriella Bulloch, Yu Huang, Xueli Zhang, Shulin Tang, Yijun Hu, Honghua Yu, Xiaohong Yang, Mingguang He, Zhuoting Zhu   +16 more
doaj   +1 more source

Development and validation of a dementia risk score in the UK Biobank and Whitehall II cohorts

BMJ Mental Health, 2023
Background Current dementia risk scores have had limited success in consistently identifying at-risk individuals across different ages and geographical locations.Objective We aimed to develop and validate a novel dementia risk score for a midlife UK ...
Mika Kivimäki, Archana Singh-Manoux, Georgios Georgiopoulos, James H Cole, Anya Topiwala, Danielle Newby, Melis Anatürk, Raihaan Patel, Klaus P. Ebmeier, Ann-Marie G de Lange, Michelle G Jansen, Sana Suri   +11 more
doaj   +1 more source

UK Biobank's cardiovascular magnetic resonance protocol [PDF]

Journal of Cardiovascular Magnetic Resonance, 2016
UK Biobank's ambitious aim is to perform cardiovascular magnetic resonance (CMR) in 100,000 people previously recruited into this prospective cohort study of half a million 40-69 year-olds.We describe the CMR protocol applied in UK Biobank's pilot phase, which will be extended into the main phase with three centres using the same equipment and ...
Petersen, SE, Neubauer, S, Matthews, P, Francis, J, Robson, MD, Zemrak, F, Boubertakh, R, Young, A, Hudson, S, Weale, P, Garratt, S, Collins, R, Piechnik, S, Neubauer, S   +13 more
openaire   +4 more sources

UK Biobank: opportunities for cardiovascular research [PDF]

European Heart Journal, 2017
Cardiovascular diseases are a major cause of morbidity and mortality, accounting for 45% of all deaths in European countries in 20161 and almost a third of deaths worldwide in 2013.2 A similar pattern is observed in the UK where cardiovascular diseases were responsible for 27% of deaths in 2014, with coronary heart disease resulting in the largest ...
Littlejohns, Thomas J., Sudlow, Catherine, Allen, Naomi E, Collins, Rory   +3 more
openaire   +4 more sources

Phenotypes and rates of cancer-relevant symptoms and tests in the year before cancer diagnosis in UK Biobank and CPRD Gold.

PLOS Digital Health, 2023
Early diagnosis of cancer relies on accurate assessment of cancer risk in patients presenting with symptoms, when screening is not appropriate. But recorded symptoms in cancer patients pre-diagnosis may vary between different sources of electronic health
Matthew Barclay, Cristina Renzi, Antonis Antoniou, Spiros Denaxas, Hannah Harrison, Samantha Ip, Nora Pashayan, Ana Torralbo, Juliet Usher-Smith, Angela Wood, Georgios Lyratzopoulos   +10 more
doaj   +1 more source

Genome-wide and Mendelian randomisation studies of liver MRI yield insights into the pathogenesis of steatohepatitis [PDF]

, 2020
Background A non-invasive method to grade the severity of steatohepatitis and liver fibrosis is magnetic resonance imaging (MRI) based corrected T1 (cT1).
Banerjee, R, Banerjee, R, Bell, J.D., Bell, J.D., Hemingway, H., Hemingway, H., Hingorani, A.D., Hingorani, A.D., Kelly, M., Kelly, M., McGonigle, J., McGonigle, J., Neubauer, S., Neubauer, S., Nicholls, R.C., Nicholls, R.C., Parisinos, C.A., Parisinos, C.A., Patel, R.S., Patel, R.S., Thomas, E.L., Thomas, E.L., Wilman, H., Wilman, H., Yaghootkar, H., Yaghootkar, H.   +25 more
core   +3 more sources

Molecular profiling of signet ring cell colorectal cancer provides a strong rationale for genomic targeted and immune checkpoint inhibitor therapies [PDF]

, 2017
We would like to thank all patients whose samples were used in this study. We are also thankful to the Northern Ireland Biobank and Grampian Biorepository for providing us with tissue blocks and patient data; and Dr HG Coleman (Queen’s University Belfast)
A Gonçalves, Brendan Pang, Claire McGready, CM McCourt, D Barras, DT Le, E Vilar, Graeme I Murray, J Guinney, J Siehl, Jacqueline A James, K Masago, KJ Lastwika, M Arnold, M Lek, M Toyota, MA Alvi, Manuel Salto-Tellez, Marc-Aurel Fuchs, Mark Lawler, Maurice B Loughrey, MF Kane, ML Iacono, Muhammad A Alvi, NJ Llosa, Perry Maxwell, Philip Dunne, Richard H Wilson, Richard Turkington, RS Herbst, S Kakar, SC Casey, Stephen McQuaid, T Anthony, The Genomes Project C, U Nitsche, V Gopalan, Victoria Bingham, Wendy Moore, Y Xiao   +39 more
core   +2 more sources